THE possibility that sickle-cell trait could be an aggravating factor in diseases associated with tissue hypoxia, acidosis and thrombotic phenomena has been repeatedly suggested in many anecdotal reports, recently reviewed by Sears.¹ Although it would be ...

IT has long been suspected that Hodgkin's disease is caused by an infectious agent.^{1 2 3} This notion received added impetus when Vianna et al. reported that 31 cases had occurred among members (and their "contacts") of one graduating class at Albany High ...

THE histamine H₂ receptor antagonist, cimetidine, has been shown to be an effective drug in the management of peptic-ulcer disease.^{1 2 3 4 5} In early clinical trials, few side effects of clinical importance, except for gynecomastia, have been recognized.⁶ ...

(First of Two Parts)

IN recent years, there has been a substantial increase in the application of mathematical modeling and dynamic systems analysis to quantitative studies of metabolic pathways. Such technics, when applied by those who fully appreciate ...

EARLY attempts to cure rectal cancer were restricted to local removal by the perineal or sacral approach. In 1908, Ernest Miles described a radical operation for rectal cancer that encompassed all zones of lymphatic spread of the tumor.¹ On the basis of ...

SURGICAL complications rarely occur late after renal transplantation. We have seen two patients with presumably spontaneous decapsulation of the kidney even while the grafts had excellent renal function. The decapsulation led to excessive fluid loss from ...

THE APPEARANCE in childhood of acute leukemia in one member of a monozygotic twin pair is frequently followed within a few months by the appearance of the same disease in the other twin. Concordance of acute leukemia in monozygotic twins can be as high as ...

DISPARITIES between biologic and immunologic potency estimates of several peptide hormones have been observed.^{1 , 2} The biologic implication of these differences is uncertain. Differences in estimates of the potency of serum luteinizing hormone have ...

Presentation of Case

A 34-year-old right-handed man was admitted to the hospital because of dysphasia.

He was in excellent health until nine months earlier, when he noticed difficulty with vision to the far right. One month later his gait became slightly ...

In this issue of the Journal, Van Thiel et al. describe effects of cimetidine that have not been reported previously in man. Their paper also provides an opportunity to consider the general problem of identifying previously unrecognized adverse effects of ...

Although increasing evidence suggests that there will be a surfeit of physicians in this country within the next three decades, many doctors deny the possibility. Many others believe that new restrictions on the entry of physicians trained abroad — as a ...

DEATHS

Alexander — Benjamin Alexander, M.D., formerly of Boston, died on February 13, 1978. He was in his 70th year.

Dr. Alexander received his degree from Harvard Medical School in 1934 and for many years was a member of the Department of Medicine, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: It is well known that a patient with Banter's syndrome is normotensive despite hyperactivity in the renin–angiotensin–aldosterone system. Unresponsiveness to exogenous angiotensin II is often suggested as a possible explanation for the ...

To the Editor: We should like to comment on a portion of Spencer's article entitled '''Code' or 'No Code.'''*

As psychiatrists, we often are called upon to make a declaration of competence or incompetence and have found ourselves in the de facto position ...

No extract is available for articles shorter than 400 words.

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Medicine

Neurology

Functions of ...

SEMINARS IN MEDICINE OF THE BETH ISRAEL HOSPITAL

Seminars in Medicine of the Beth Israel Hospital will be held in the George Sherman Auditorium, Beth Israel Hospital, Boston, on the following Tuesdays at 4 p.m.

MEDICALLEGAL SEMINAR

The Pittsburgh ...