THE high incidence of endocrine paraneoplastic syndromes with small-cell carcinoma of the lung has suggested a relation of this tumor to the APUD (A = amines, PU = amine precursor uptake, D = Laromatic amino acid decarboxylase) system of endocrine cells.¹ ...

DESPITE the upsurge in interest in human sexual functioning that began more than 10 years ago with the pioneering work of Masters and Johnson,^{1 , 2} relatively little attention has been paid to the prevalence of sexual dysfunction in couples not seeking ...

THE first few weeks after a subarachnoid hemorrhage represent a critical phase for patients with a ruptured intracranial aneurysm because death from the initial bleeding or a rebleeding or both are most likely to occur during that period.^{1 2 3 4 5} However,...

PATIENTS with temporomandibular-joint disorders fall into two large groups: those with organic joint abnormalities, including ankylosis, neoplasia, trauma, and arthritis; and those with facial pain, noise in the temporomandibular joint and restricted ...

UVEITIS, a term that is used rather loosely by ophthalmologists to connote inflammation not only of the uvea but also of the retina, optic nerve and vitreous body, has often proved an enigma to those interested in its cause. In its acute form, uveitis ...

OBSERVATIONS in laboratory animals suggested an association of experimental and spontaneous thyroiditis with histocompatibility genes.^{1 2 3} However, in contrast to the definite association between Graves' disease and specific human leukocyte (or ...

HYPOGLYCEMIA occurs in 90 per cent of patients with functioning islet-cell tumors and is difficult to manage.¹ Although diazoxide and streptozotocin are useful agents for treatment,² they are not uniformly successful. We report here the initially ...

IN a 1792 letter from the Boston physician John Warren to the father of a burned child one finds much that can still serve as a standard for the profession's responsibility to relieve parental anxiety. Dr. Warren was 39 years old when he penned his letter ...

Presentation of Case

A 70-year-old man was admitted to the hospital because of peripheral edema.

He was well until one year earlier, when he noticed slight ankle edema, which disappeared after a brief course of diuretic medication. One month before entry ...

The concept that the production of isoenzymes, isohormones, metabolites or other tumor-cell products could be employed to identify the neoplastic state in man through their measurement in serum, effusions, urine or tissue extracts has engendered ...

The perils facing patients with ruptured intracranial aneurysms are clearly charted by Sundt and Whisnant in this issue of the Journal. They underscore the real hazards of ischemic infarction or rebleeding that commonly afflict these patients. Rebleeding (...

Eli Ginzberg commented in a previous Sounding Board¹ that "Physicians are being harangued in many forums" on issues related to national health-care delivery. His choice of the word "harangue" is an apt one to describe the subject addressed by all three ...

To the Editor: The article of Alter et al., "Transmission of Hepatitis B Virus Infection by Transfusion of Frozen-Deglycerolized Red Blood Cells," which appeared in the March 23 issue of the Journal, demonstrates that such blood can transmit post-...

No extract is available for articles shorter than 400 words.

To the Editor: We report here an unusual association of Zollinger-Ellison syndrome with multiple endocrine adenomatosis Type II in a young man.

This 28-year-old man was admitted to the Yale–New Haven Hospital because of epigastric pain. There was no ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The cause of extreme pyrexia — that is, body temperature in excess of 41.1°C — is varied and includes infection, heat stroke, hypothalamic dysfunction and hypermetabolic states. Most patients with hyperpyrexia, regardless of its origin, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Though I was not misquoted in Dr. Van Woert's superb discussion of "Profitable and Nonprofitable Drugs" in the April 20 issue of the Journal, I was underquoted. He said that I had confirmed the views of the Commission to Combat Huntington'...

To the Editor: The response to my previous letter to the Editor¹ is gratifying, but it points out the need for some clarifications. First of all, it must be made clear that counting deaths in categories of "sentinel events" does not guarantee that all ...