LIPOPROTEIN lipase is the enzyme mainly responsible for the hydrolysis of plasma triglycerides, permitting transfer of fatty acids to tissues. An inherited deficiency of lipoprotein lipase leads to chylomicronemia and hypertriglyceridemia.¹ The lipase ...

TANGIER disease is an uncommon genetic disorder characterized by a marked deficiency of normal plasma high-density lipoproteins (HDL) and the abnormal accumulation of cholesteryl esters in reticuloendothelial cells of many tissues.^{1 , 2} The abnormal ...

THE origins of the increased level of fetal hemoglobin (HbF) evident in most patients with sickle-cell anemia have not been well defined. It has been unclear to what extent such increase is due to selective production of HbF-bearing red blood cells (F ...

ALTHOUGH many cationic drugs are highly bound to plasma proteins their affinity to albumin is often only moderate.^{1 2 3 4 5} α₁ acid glycoprotein has recently emerged as a plasma protein that is able to bind a number of these drugs. Dipyridamole,⁶ ...

THE pathogenesis of diabetes mellitus has long been an enigma. Because of its familial pattern of transmission and the subtle chronicity of the disease, diabetes has been considered a degenerative process having a genetic basis. Since degeneration means ...

WITHIN the present decade, the outlook for cure of children with non-Hodgkin's lymphoma has improved greatly. The survival with conventional therapy in the previous two decades was roughly 30 per cent in several reported childhood series.¹ Current ...

EXTRASKELETAL manifestations of ankylosing spondylitis include aortitis with aortic^{1 , 2} and rarely mitral^{3 , 4} valvular insufficiency. Cardiac dysfunction usually develops late and progresses slowly.¹ The acute case of aortitis presented below required ...

IN laboratory animals both endogenously induced and passively administered interferon have inhibitory effects on a wide variety of tumors, including those caused by oncogenic viruses.^{1 2 3 4} Such effects are most striking when the interferon is ...

SOME months ago its was reported that Mr. Robert Burchfield, the chief editor of the Oxford English Dictionary, had said at a press conference¹ in Chicago that in another 200 years, English-speaking Americans and English-speaking Britons will not be able ...

Presentation of Case

A 65-year-old man was admitted to the hospital because of pain in the flank.

He was well until six months earlier, when anorexia, fatigue and malaise developed, associated with urinary urgency and frequency and a diminution of the ...

The holiday season is a good time for reflection. Looking back over the year now drawing to a close, the Journal's first entirely under the current editorial management, what new trends can be perceived? In general, very few. We have continued to follow ...

Disquiet over rising costs has come to dominate discussions of the health-care system. A major cause of the cost spiral, in the view of many policy makers, is the excessive and inefficient use of innovations such as CAT scanners and coronary-artery ...

After a lengthy investigation of specialization in medical care, the staff attorneys of the Federal Trade Commission (FTC) have decided to recommend that a formal complaint be issued against the American Society of Plastic and Reconstructive Surgeons. The ...

To the Editor: The intravenous administration of somatostatin, a naturally occurring tetradecapeptide, has recently been shown to reduce mesenteric and portal blood flow drastically, with no concomitant effect on cardiac output and arterial pressure (...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In 1977 Sutherland wrote a letter in the Journal ¹ describing a fragile site on the long arm of the X chromosome in X-linked mental retardation (Renpenning's syndrome) when the cells were cultured in a special medium. This fragile site ...

No extract is available for articles shorter than 400 words.

To the Editor: As chairman and staff director, respectively, of the National Academy of Sciences study on the Veterans Administration hospital system, we read Dr. Chase's Sounding Board article in the July 20 issue of the Journal with considerable ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Medicine

General

Recent Advances ...

In the bureaucracies that are responsible here for the government's dealings with health-care and scientific research, there is a strong measure of gloom about what lies ahead in the new year.

The reason is that the political lesson that has been ...