OVARIAN cancer is the most commonly fatal gynecologic neoplasm in the United States. At diagnosis, only 30 to 40 per cent of patients have localized disease amenable to complete surgical resection.^{1 , 2} Ovarian carcinoma with metastasis beyond the true ...

CYTOMEGALOVIRUS is the most common viral infection affecting the fetus or newborn, being acquired either transplacentally, intra partum, or post partum.¹ It is estimated that about 40,000 transplacentally acquired infections and 150,000 intra-partum-...

THE pathogenetic mechanisms of myocardial infarction are still largely speculative because, although the thrombotic hypothesis has been challenged by morphology^{1 2 3 4} and by studies with labeled fibrinogen,⁵ the actual role of alternative mechanisms^{6 7 8} ...

DURING the month of December, 1978, the Howard Hughes Medical Institute is celebrating the 25th anniversary of its founding. It is appropriate to review the circumstances that surrounded the conception of this research institute as well as some of the ...

(First of Two Parts)

IN the near future, new insights into the cellular control of immune reactivity may become important to physicians who manage patients with cancer. The objectives of this article are to provide an overview of the suppressor-cell ...

MENTAL illness has long carried a stigma that society has been slow to eradicate. Furthermore, since many mentally ill patients are unable to communicate normally, and others may be violent or disturbed, there is a distinct chance that they may be ...

THE functional adaptations that occur in the surviving nephrons as chronic renal disease advances are remarkable in their ultimate dimensions and lifesaving in their biologic effects. In an earlier seminar on these adaptations, we presented the hypothesis ...

Presentation of Case

A nine-year-old girl was admitted to the hospital because of progressive renal failure.

She was born of the sixth pregnancy in a mother aged 35 years. Parturition was complicated by persistent nausea and vomiting, but labor was ...

When, as a medical student, I first learned about acute myocardial infarction from the first edition of Harrison's textbook, Principles of Internal Medicine, the cause seemed straightforward enough. Acute thrombosis on an atherosclerotic plaque in a ...

For 25 years after its establishment, and for more than two years after the death of its founder and sole benefactor, the Howard Hughes Medical Institute (HHMI) has operated behind a veil of secrecy that has engendered legends, criticism and ...

No extract is available for articles shorter than 400 words.

It is widely perceived that physicians are maldistributed both geographically and by specialty. Problems in access to and the costs of medical care are thought to result from this maldistribution. In accord with these perceptions, means are being sought ...

The American Board of Internal Medicine appreciates more than most the "dilemma" in which internal medicine finds itself.¹ In setting standards for subspecialists the Board was responding to a trend set in motion 20 years earlier. Its erstwhile Chairman, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Recently, Newman et al.¹ reported decreased levels of properdin factor B in three homozygous C2-deficient children, an association attributed to the linkage between genes coding for the two proteins. The authors cite the papers by Glass² ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Within the last decade, Simone and his co-workers have demonstrated that acute lymphoblastic leukemia of childhood is a curable illness.¹ The same situation does not exist in adults, since most succumb to recurrent disease by 24 months.^{2 3} ...

To the Editor: Siber and his co-workers¹ raise doubt about the ability of pneumococcal vaccine to protect post-splenectomy patients with Hodgkin's disease from pneumococcal infection. The following case illustrates the reality of such concern.

A 25-year-...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The appearance of the article by Higginbottom et al. in the August 17 issue of the Journal was timely for us and helped with the diagnosis of a similar child, a 7 1/2-month-old girl admitted to the Children's Hospital of Philadelphia ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.