AN association between exogenous estrogens and endometrial cancer has been reported for postmenopausal women in five recent investigations^{1 2 3 4 5} that all employed the conventional methods of the "retrospective case–control" study.

In a case–control ...

THE major forms of porphyria are distinguishable by their unique pattern of porphyrin or porphyrin precursor accumulation,¹ implying that each is caused by a unique biochemical defect (or defects) in the heme biosynthetic pathway. Porphyria cutanea tarda ...

Relation of the Defect to Pulmonary Disease

It is clear that severely deficient subjects of phenotype PiZ and probably PiSZ are much more susceptible to the development of emphysema or chronic bronchitis (or both) than the general population, the large ...

ABOUT 70 per cent of prescriptions for tricyclic antidepressants are written by non-psychiatrists, largely physicians in family practice or internal medicine. Depressions seem to be a common problem in medical practice. Despite this widespread recognition ...

MALAKOPLAKIA, described in 1902,¹ is an unusual chronic inflammatory disease generally confined to the collecting system of the urinary tract. Renal parenchymal involvement is rare and was bilateral in only five^{2 3 4 5 6} of the 11 reported cases. Two of ...

CARDIAC tamponade is an acute, life-threatening complication of malignant pericardial effusions. There have been conflicting views on the management of this clinical situation¹; traditionally, the approach has been surgical, with establishment of a ...

INFECTIONS due to fungi of the class zygomycetes and order mucorales (rhizopus, mucor and absidia) are well recognized complications in the host compromised by underlying hematologic cancer or immunosuppressive therapy,^{1 2 3} diabetes mellitus⁴ or thermal ...

MUCH of the research and practice of clinical pharmacology depends on the measurement of drug concentrations in the serum.¹ The error of these measurements can be monitored by assaying samples containing known amounts of drug.² However, errors made in the ...

Presentation of Case

A 25-year-old man was admitted to the hospital because of abdominal pain.

He was well until three months earlier, when he experienced diffuse abdominal cramps that disappeared after several days. Twenty-five days before admission ...

Horwitz and Feinstein, in an article in this issue of the Journal, suggest that a selection bias explains the strong association between exogenous estrogens and endometrial cancer reported by many investigators. To correct this bias, they propose a method ...

In 1947 Belk and Sunderman¹ presented the results of a study of the quality of performance of clinical laboratories. Since that time a plethora of papers have appeared in the medical and scientific literature verifying, amending and extrapolating the ...

The spread of denturism has been the subject of increased attention by health professionals throughout the United States. Denturism can be defined as a movement of dental-laboratory technicians who are seeking to be licensed independently from other ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In the July 27 issue of the Journal Hunt and his colleagues do not give details of the patients with "vascular collapse." We do know if there is a type of reaction to stings with shock and low blood pressure, without atopic signs and ...

To the Editor: Long considered a childhood disease, cystic fibrosis has been recognized with increasing frequency in adults.¹ In the case reported below the diagnosis was made in an adult.

A 48-year-old housewife had an intractable paroxysmal cough ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: A recent editorial¹ suggests that reviewed journals act mainly as "sponges" rather than "filters" since most papers rejected by the Journal of Clinical Investigation ² and New England Journal of Medicine are subsequently published ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This textbook provides a concise and clinically oriented review of the major aspects of adult cardiovascular diseases. As the authors state in their preface, the text is primarily intended for medical students, house staff, trainees in cardiology, general ...

No extract is available for articles shorter than 400 words.

This book is a welcome addition to the literature on the social and psychologic aspects of kidney transplantation. It constitutes an empirical analysis of the abilities and behavior of recipients and donors, adults and children, individuals and families ...

The purpose of this book is clear enough: it is a brief for the defense. The great success of the wartime medical research that gave us penicillin and revolutionalized the treatment of the world's most lethal infectious disease, malaria, led to an ...

No extract is available for articles shorter than 400 words.

Unfortunately, an admirable topic plus a qualified author do not necessarily a good book make. In this case the topic is timely and important — the reader needs to know the varieties of health-care organization throughout the world to make good choices ...

No extract is available for articles shorter than 400 words.

Scholarship and theory in the anomalous field of bioethics are always in danger of being superficial, for the problems are deep and difficult to penetrate. One must range over diverse areas of inquiry (science, medicine, law, ethics and public policy), ...

No extract is available for articles shorter than 400 words.

THEODORE L. BADGER LECTURE

Dr. Edward A. Gaensler will deliver the annual Theodore L. Badger Lecture, "Adventures in Respiration," at the Countway Library of Medicine, Boston, on November 30, at 4:30 p.m.

Further information may be obtained from Margaret ...