OBSTRUCTIVE sleep apnea is a disorder characterized by episodic hypoxia caused by upper-airway obstruction during sleep. Clinical manifestations include hypersomnolence, abnormal sleep behavior, hypercapnic respiratory failure and cardiovascular ...

A HARMONIOUS host-parasite relation characterizes the association of human beings with bacteria of the genus neisseria, whose many species abundantly colonize the nasopharyngeal mucous membranes. Two notable exceptions to this rule involve Neisseria ...

AT one time environmental factors causing deficiency of vitamin D constituted the principal cause of rickets seen in pediatric clinics. Since the discovery of vitamin D^{1 , 2} and its widespread use as a dietary supplement during infancy and childhood, the ...

THE familial form of medullary carcinoma of the thyroid gland, a tumor of C cells, is inherited as an autosomal dominant trait often associated with pheochromocytoma and parathyroid adenoma or hyperplasia (multiple endocrine adenomatosis Type II). A ...

THE influence of cellular immunity on the duration and severity of human herpes simplex virus (HSV) infections is suggested not only by increased susceptibility to protracted, severe mucocutaneous or disseminated infection in patients with impaired ...

WITH the synthesis of burimamide in 1972, Black and his colleagues¹ demonstrated the existence of two classes of histamine receptors, H₁ and H₂. In contrast to the H₁ type, H₂ receptors are not antagonized by "classic" or conventional antihistamines and ...

ISOVALERIC acidemia is an inborn error of leucine metabolism caused by a deficiency of isovaleryl-coenzyme A dehydrogenase.^{1 , 2} Affected patients are usually seen during the neonatal period with a syndrome of vomiting and lethargy progressing to coma, ...

AS both the number and cost of clinical laboratory tests continue to increase at an accelerating rate,¹ physicians are faced with the task of comprehending and acting on a rising flood tide of information. We conducted a small survey to obtain some idea ...

IT has been four or five years since the Department of Health, Education, and Welfare began working on new regulations for the control of medical and behavioral research on children. Now, a definitive stage seems to have been reached. A complete set of ...

Presentation of Case

A 28-year-old man was admitted to the hospital because of hypertension.

He was well until seven years previously, when mild hypertension was found; no treatment was prescribed. He began to experience fatigue, exertional dyspnea and ...

He sleeps well who knows not that he sleeps ill. (Latin proverb)

Clinical investigation has provided many examples of disturbances in normal physiology and biochemistry in which the function of a carefully integrated system is disrupted because of ...

Pathogenic micro-organisms that cause repeated episodes of acute infection must be able to evade a variety of host defenses. For this purpose, one standard microbial strategy is to evolve a variety of distinctive surface antigens. Recently, several ...

American students unable to gain admission to U.S. medical schools are flocking to foreign schools in record numbers. A report from the National Board of Medical Examiners (NBME) published in the Journal two weeks ago,¹ and an accompanying editorial,² ...

DEATHS

Ades — Felix Ades, M.D., of Winchester, died on June 7. He was in his 51st year.

Dr. Ades received his degree from the Faculty of Medicine, Alexandria University, Egypt, in 1952. He was a member of the American Society of Internal Medicine.

He is ...

No extract is available for articles shorter than 400 words.

To the Editor: Right-bundle-branch block occurs after repair of tetralogy of Fallot in about 90 per cent of the cases.^{1 , 2} The purpose of this letter is to describe technical surgical modifications that may lower the incidence of this complication.

...

No extract is available for articles shorter than 400 words.

Note: The provocative article by Moss, Deland and Maloney, and the accompanying editorial by Federman, stirred up more letters than we have received on any subject in a long time. From among a large number of excellent comments I have selected the ...

The "War against Cancer" is now supported by over a billion dollars per year, an impressive figure for biomedical research even against the disease most dreaded by our people, but a fraction of a percentage of the budget for deadly armaments with which we ...

There is much that is exciting on finding a diary. As we open it and begin to read we hope to encounter intrigue, gosssip, personal facts previously unknown about the diarist or his targets, and new scientific or historical insight. Too often, it turns ...

No extract is available for articles shorter than 400 words.

Medicine

Cardiovascular

Cardiac Adaptation. (Recent Advances in Studies on Cardiac Structure and Metabolism, Vol. 12.) Edited by Tachio Kobayashi; Yoshio Ito; and George Rona. 751 pp., illustrated. Baltimore: University Park Press, 1978. $57.50.

Cardiac ...

No extract is available for articles shorter than 400 words.