TANGIER disease is a rare familial disorder, characterized clinically by enlarged, orange tonsils, hepatosplenomegaly, transient peripheral motor-sensory neuropathy and lymphadenopathy.^{1 2 3 4} Cholesterol-ester-laden reticuloendothelial cells have been ...

CONGENITAL adrenal hyperplasia due to 21-hydroxylase deficiency is an inborn error of metabolism in which the hormonal pathophysiology is well defined.¹ Early studies provided evidence that the disorder is transmitted by an autosomal recessive gene.^{2 3 4}

REPORTS on renal function in burned patients are usually limited to the immediate period after the burn^{1 , 2} and to subsequent periods when the onset of acute renal failure is suspected — usually as a complication of sepsis.³ Routine determinations of ...

NEONATAL hyperammonemia leads to over-whelming, potentially fatal illness. Most reports of patients in whom hyperammonemia occurred in the immediate newborn period stress the grave prognosis of this condition.^{1 2 3 4 5} With rare exception,^{6 , 7} ...

CLINICAL investigations of the efficacy of diagnostic tests have often produced misleading results so that tests initially regarded as valuable were later rejected as worthless. The purpose of this review is to identify two important reasons for this ...

Estrogen Receptor and Endocrine Therapy of Breast Cancer

SINCE the pioneering work of George Beatson,¹ who induced tumor regressions in patients with advanced breast cancer by oophorectomy, it has been appreciated that some human breast cancers will ...

β-ADRENERGIC catecholamines, which modulate function of a variety of tissues, are assumed to act by initially binding to receptors on target-cell plasma membranes, thereby activating adenylate cyclase and stimulating generation of adenosine 3′:5′-...

MR. Enoch Powell may be remembered for having pointed out in his book on medicine and politics¹ that, because the demand for medical care is infinite but resources finite, some form of rationing is inevitable. Or he may be remembered for having remarked ...

Presentation of Case

A 35-year-old man was admitted to the hospital because of chest pain and fever.

He was first seen at this hospital six years previously because of an enlarged axillary lymph node, irregular fever and loss of 4 kg in weight. A biopsy ...

Diagnostic tests are expensive, and they are frequently used excessively and inappropriately. House officers, most of whom have little appreciation of test prices, order too many tests out of either insecurity or inexperience.¹ Practicing physicians are ...

Most present-day medical-school admissions committees eliminate from consideration all applicants whose transcripts fail to reflect a grade-point average within half a point of straight "A". This system simply means that the aspiring premedical student ...

No extract is available for articles shorter than 400 words.

The scientific revolution, which had its fundamental beginnings in the 16th century, generated a singularly productive method of investigating the natural world. The method entailed, basically, learning how things worked by the analysis of complex matter ...

To the Editor: The Canadian trial of aspirin and sulfinpyrazone in patients with transient ischemic attacks, which was published in the July 13 issue of the Journal, was a well designed study. The objectivity of the methodologists at McMaster and the ...

No extract is available for articles shorter than 400 words.

To the Editor: The report by Kent et al.¹ demonstrates convincingly that patients have, as a group, improved ventricular function at six months after coronary-artery bypass as compared to their status before operation. What the study does not show, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The requirements for specialty-board certification by the Israel Medical Association include completion of a five-year to six-year residency program in an approved Israeli institution and passing written and oral examinations. The written ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The launching of a new textbook in immunology is a considerable task in view of both the vast number of recent excellent contributions and the rate of growth of the field, which makes most such efforts virtually obsolete when published. In the face of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The liver, at last, seems to be coming into proper recognition as a major center of the body's metabolic processes and as an organ subject to many of man's most prevalent and serious diseases. Recently, the number of books devoted to the liver and its ...

For those with an interest in asthma this will be a fascinating volume, which might have been entitled "Research on the Biology of Asthma." Although treatment of asthma is included in the subtitle, there is little that will be helpful to the clinician in ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

It is unfortunate that Dr. Cesare G. Tedeschi, senior editor of this monumental three-volume set, died before its publication, for he would have been justifiably proud of this worthwhile contribution to the medicolegal literature. Fortunately, his son, ...

Genetics

Genetic Effects on Aging. (Proceedings of a conference held at the Jackson Laboratory September 12–17, 1976, sponsored by the National Foundation-March of Dimes) (The National Foundation-March of Dimes, Birth Defects: Original Article Series Vol. ...

MEETING OF THE AMERICAN MEDICAL WRITERS ASSOCIATION

The New England Chapter of the American Medical Writers Association will hold a dinner meeting at the Mill Falls Restaurant in Newton Upper Falls, Massachusetts, on November 15, at 6 p.m.

Further ...

"When I find myself in the company of scientists," W. H. Auden wrote some years ago, "I feel like a shabby curate who has strayed by mistake into a drawing room full of dukes."

If Mr. Auden had strayed into the main auditorium of the National Institutes ...