THE demonstration that the hepatic phenylalanine hydroxylating system is complex, consisting of several essential components — at least two enzymes, phenylalanine hydroxylase (catalyzing reaction 1) and dihydropteridine reductase (catalyzing reaction 2), ...

AMYOTROPHIC lateral sclerosis and Parkinsonism-dementia, two chronic degenerative diseases of the central nervous system, have shown striking concentrations among the Chamorro population on G-am.^{1 2 3} Environmental⁴ as well as hereditary factors^{5 , 6} have ...

EXCEPT for unusual problems occurring under conditions of severe hypoxia,^{1 2 3} sickle-cell trait is generally regarded as a benign condition, requiring attention mainly to genetic counseling and family planning. Hematuria,⁴ hyposthenuria,⁵ and papillary ...

THIRTY years have elapsed since the publication of the first clinical trials employing randomization.¹ Since then the randomized control trial has gradually become accepted as the most effective way of determining the relative efficacy and toxicity of a ...

OVER the past several years coronary-artery spasm, superimposed on either fixed arteriosclerotic coronary-artery disease or radiographically normal coronary arteries, has been shown clearly to be the cause of Prinzmetal's variant angina. More recently, ...

GALACTOSYLTRANSFERASE has been studied in human serum, and early reports failed to demonstrate an elevation of total serum galactosyltransferase in malignant disease.^{1 , 2} Subsequent electrophoretic studies from this laboratory revealed that, although the ...

THE successful extrauterine fertilization of a women's ovum with her husband's sperm, which was carried out in a laboratory by a Cambridge physiologist, Dr. Robert Edwards, in collaboration with Mr. Patrick Steptoe, a gynecologist in Oldham, Lancashire, ...

Presentation of Case

A 61-year-old man was admitted to the hospital because of carcinoma of the lung.

He was well until two years previously, when arthralgia of the feet, ankles and knees occurred; oxyphenbutazone was administered. Four months before ...

Elsewhere in this issue of the Journal is an instructive illustration of Murphy's Law applied to medicine: if anything can go wrong, it will. On the basis of biochemical principles, three possible defects would allow phenylalanine to escape metabolism and ...

Since 1953, when Spühler and Zollinger reported from Switzerland the association of chronic interstitial nephritis with the ingestion of certain analgesic drugs,¹ analgesic-associated nephropathy has been established as an important cause of chronic renal ...

As a consequence of the frustrations spawned by the escalating costs and the low returns of disease-oriented medicine, health education has begun to be touted as an antidote to the nation's health ills.

At the federal level, interest in health education ...

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This is an excellent book, and I congratulate the authors and the publishers. If you are interested in biochemistry, medicine, science, history, people and progress (and, of course, DNA) you will enjoy it as richly as did I.

I had read Watson's The Double ...

PROGRAM FROM TUFTS UNIVERSITY

Tufts University School of Medicine and the Military and Hospitalier Order of St. Lazarus of Jerusalem announce the third annual Conference on Aging to be held October 28 at the Tufts University Medford campus.

Further ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

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The perplexities that confront American scientists who value both human rights and collaboration with Soviet colleagues are nicely conveyed by a statement recently issued by the Committee on Human Rights of the National Academy of Sciences.

Urging ...