CANCER chemotherapy has improved substantially within the past decade. However, selection of effective chemotherapy for individual patients remains somewhat of a trial-and-error procedure. Predictive technics (similar to the culture and sensitivity assays ...

THE association between the attainment of a critical body composition and the onset of menarche has been shown by Frisch.¹ Her data suggest that a minimum weight for height is a necessary prerequisite for normal reproductive function in women. The ...

CANCER arising in breast tissue, an endocrine target organ dependent on several hormones for growth, development and function, does so in the setting of a hormonal milieu that in all likelihood is responsible for the promotion and dependency of the tumor ...

HEALTH-maintenance organizations, or HMO's, are receiving renewed interest from policy makers as a method to control medical-care expenditures. The argument for HMO's rests on a combination of economic theory, political rhetoric and some evidence. Given ...

(First of Two Parts)

Properties of Platelets

Biologic Properties

PLATELETS that circulate in the blood do not adhere to each other or to normal endothelium. However, they can adhere and spread on non-endothelial surfaces, aggregate in response to a ...

IT is a tragedy for patients, their families and their physicians when the physician fails to make the diagnosis of a progressive and fatal disorder that is treatable.

Wilson's disease is such a disorder.¹ All the clinical manifestations can be prevented ...

THE patient described below has been under observation for 11 years. Evidence to be presented suggests that she has the congenital deficiency of a factor in normal plasma that appears under some circumstances to be important in platelet and red-cell ...

Presentation of Case

A 55-year-old woman was admitted to the hospital because of a pulmonary lesion.

She was well until two months earlier, when she began to experience aching pain in the left posterior portion of the chest. A nonproductive cough ...

Elsewhere in this issue of the Journal Salmon and his associates describe an in vitro assay for the effectiveness of antitumor agents that strongly correlates with tumor response in man.

The capacity to determine the sensitivity of bacterial pathogens in ...

Few subjects provoke as heated debate among practicing physicians as health-maintenance organizations (HMO's), especially the closed-panel medical group form of HMO. At a time when efforts to control the rate of increase in health-care expenditures ...

American physicians, biomedical scientists and health workers are generally unaware that, in many parts of the world, our venerable unit of blood and other pressures, the millimeter of mercury, is scheduled to be removed from use. In its place will appear ...

To the Editor: We share the interest in the potential of sodium dichloroacetate as a therapeutic agent in lactic acidosis expressed in the editorial in the March 9 issue of the Journal. The logic of this approach requires careful scrutiny. It seems to us ...

To the Editor: The diagnostic problems of the patient with cholestatic jaundice have been raised in two recent case reports from the Massachusetts General Hospital (November 10, 1977, and February 23, 1978, issues of the Journal). These comments refer in ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: I take issue with Mr. Larrick's statement, in the March 16 issue of the Journal, that "magnetic fields and radiofrequency energy utilized in NMR [nuclear magnetic resonance] are harmless." Although earlier publications¹ may have given such ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

"Their learning is like bread in a besieged town; every man gets a little, but no man gets a full meal." This is always a potential problem in anthologies, but is generally avoided by the editors of Scientific Approaches to Clinical Neurology. These two ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Certain terms grate on the ear or, worse, have unfortunate associations. "Paramedical personnel" (the audience designated for this book) is for me such a term. It has a spacy sound, and its imagery is of soldiers jumping from airplanes. I know what the ...

Medical education maintains a dangerous inequity in permitting the dominance of facts over principles in course curricula. Thus, students are taught the nuances of molecular pathophysiology, but an understanding of the diagnostic process is left to chance ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Public argument over abortion is often intense and seldom refined. One would have to look to issues like capital punishment or gun control to match the misinformation, vituperation and ill conceived logic of public commentary on the practice of ...

STUDIES ON PROGERIA

The New York Hospital-Cornell Medical Center and the Sloan-Kettering Institute request the assistance of physicians in the referral of patients with progeria. A sample of heparinized blood is required; if a progeric patient cannot give ...