IN 1952 we began a prospective longitudinal study of patients with chronic diffuse infiltrative lung diseases. Standardized clinical, physiologic, radiologic and histologic methods were emphasized to establish diagnostic and prognostic criteria and ...

SODIUM nitroprusside is widely used to treat severe hypertension,¹ to induce surgical hypotension,² to decrease myocardial oxygen demand after myocardial infraction^{3 , 4} or congestive heart failure^{5 , 6} and to treat cerebral vasospasm.⁷ With nitroprusside ...

IT is now well established that 20 to 30 per cent of patients with blastic chronic myelogenous leukemia are responsive to vincristine and prednisone therapy.^{1 2 3} At present, there are no clinical or laboratory features that allow for the unequivocal a ...

THE central nervous system appears to serve as a sanctuary for leukemic cells in that systemic treatment, though effective in preventing bone-marrow relapse, often fails to prevent meningeal leukemia. This circumstance appears to be due to inability of ...

PUBLIC Law 94–142, the Education for All Handicapped Children Act,¹ was enacted by large majorities in both the House and Senate in November, 1975, and went into effect in October, 1977. The new law emphasizes the right of handicapped children to free ...

TRANSMISSION of infectious agents by donor tissue is a recognized complication of transplantation. Bacterial and fungal infections have been transmitted by donated kidneys.^{1 , 2} Recently, the viral agent of Creutzfeldt-Jakob disease has been conveyed to ...

THE process of urine formation begins at the walls of the glomerular capillaries with the separation of as much as a third of the plasma entering the glomeruli of each kidney into a solution having the properties of a nearly ideal ultrafiltrate. Driven by ...

Presentation of Case

A 26-year-old woman was admitted to the hospital because of heart murmurs.

There was a history of scarlet fever at the age of seven years. At 21 years a cardiac murmur was heard, and a diagnosis of mitral stenosis was made. Because of ...

It all began with Hamman and Rich. Over a period of four years they encountered four patients with an acute respiratory illness of unknown cause that neither they nor their colleagues at Johns Hopkins Hospital had ever seen before. The disorder was short-...

Eventually, most patients with chronic myelocytic leukemia enter an aggressive phase of their illness, termed "blast crisis," that resembles acute leukemia except in its refractoriness to conventional chemotherapy. However, about 30 per cent of patients ...

Since joining the Food and Drug Administration, I have been exposed to a remarkable array of correspondence from well credentialed practicing physicians. Some of them are my former students from Stanford, others are former classmates at Harvard, and still ...

To the Editor: There are a number of items in the Current Concepts article on schistosomiasis (December 15, 1977) with which parasitologists and clinicians involved in the management of patients with tropical diseases might take issue.

The first concerns ...

To the Editor: Discovery of the causative organism of Legionnaires' disease is a laudable scientific accomplishment. But to a medical journalist who covered the epidemic in Pennsylvania, the editorial by Dr. Kass overlooks two crucial points.¹

First of ...

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No extract is available for articles shorter than 400 words.

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

CONVERSATION WITH F. J. INGELFINGER

A filmed interview highlighting Dr. Ingelfinger's observations on medical editing and education, the practice of medicine and the doctor–patient relationship will be presented during the 59th Annual Session of the ...