IN 1932, Cushing reported pituitary adenomas at autopsy in six of eight patients with the clinical picture of hypercortisolism and postulated that these adenomas had primary etiologic implications.¹ However, the pathogenesis of pituitary ACTH ...

TRAVELERS' diarrhea, often thought to be one of the unavoidable risks of travel to developing countries, is a syndrome of acute watery diarrhea resulting from infection with one of a variety of enteropathogens, the most common of which are the ...

THIS report presents the results of a health survey conducted by telephone interview of mothers who received diethylstilbestrol during pregnancy. The subjects participated in a double-blind study during the years 1951 and 1952 whose purpose was to assess ...

IN 1965 we described an epidemic of poststreptococcal acute glomerulonephritis (PSAGN) involving 720 patients in South Trinidad.¹ Most patients were children with streptococcal skin infections.² Since then we have continued to study all patients admitted ...

MOST of us feel weighed down by the heavy and increasing burden of medical reading. Our inevitable failure in the struggle "to keep up with the literature" often generates anxiety and guilt. We are all aware that the situation has worsened in the past few ...

THE erythropoietic abnormality in patients with homozygous β-thalassemia results from a genetically determined defect in globin (β-chain synthesis. Erythroid activity is vastly increased, and estimates of the degree of hyperplasia vary from five to 30-...

DESPITE the concentrated attention given to legal regulation of human experimentation, including clinical medical investigation, in this country, there have been very few claims and even fewer actual lawsuits against investigators for any type of injury ...

THE main source of energy for the life process is the oxidation of dietary substrate in the mitochondria of cells, and the major catabolic end product is carbon dioxide. In a complex organism such as man, the ultimate source of oxygen and the "dump" for ...

Presentation of Case

First admission. A 53-year-old woman was admitted to the hospital because of disseminated intravascular coagulation.

She was well until one month earlier, when she entered another hospital because of deep thrombophlebitis of the left ...

Harvey Cushing suspected that the clinical syndrome that now bears his name was caused by a secretory pituitary tumor. In 1935, when one of his patients with evidence of the disease died, Cushing was able to persuade the family to exhume the body for ...

The report by Bibbo et al. in this issue of the Journal on mothers exposed to diethylstilbestrol (DES) is worthy of note since it is seldom possible to provide a follow-up comparison of the disease experience of a large group of subjects with their ...

That acute rheumatic fever secondary to streptococcal infection frequently results in chronic valvular heart disease, sometimes after a quiescent period of many years, inevitably suggests that acute poststreptococcal glomerulonephritis similarly may lead ...

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No extract is available for articles shorter than 400 words.

To the Editor: Although Palmer and his co-workers (N Engl J Med 297:1107–1110, 1977) found that sucrose can replace glucose in oral sugar-electrolyte therapy of cholera, it is interesting that failure to maintain adequate rehydration was more common at ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: A letter in these columns (N Engl J Med 298:172, 1978), purporting to correct misconceptions concerning the permissibility of autopsies according to Talmudic teaching, fails in this endeavor and indeed contributes to dissemination of ...

No extract is available for articles shorter than 400 words.