Until recently the hereditary character of hemochromatosis was debated,^{1 , 2} and its mode of transmission the object of controversy.^{3 , 4} Diverse studies with contradictory results, published in part in this journal,^{5 6 7 8} were aimed at detection of ...

Sulfite oxidase deficiency is a rare metabolic disorder in sulfur metabolism and has only been reported once, by Mudd and his co-workers in 1967.^{1 2 3 4} This patient was abnormal at birth and had many neurologic abnormalities, including severe mental ...

The diagnosis of factitious hypoglycemia may be difficult despite a high index of suspicion and increasing laboratory sophistication. Cases due to selfadministration of insulin^{1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16} or oral hypoglycemic drugs^{16 17 18 19 20} ...

Several studies indicate the clinical effectiveness of granulocyte transfusions.^{1 2 3 4 5 6 7} The dose of transfused granulocytes necessary to ameliorate the response to infection is unknown, but larger numbers are probably more effective. Pharmacologic ...

Neel has twice referred to the inheritance of diabetes mellitus as a "geneticist's nightmare."^{1 , 2} The bizarre patterns of familial aggregation do not fit Mendelian proportions, and pooled data from pedigree studies have suggested recessive, dominant, ...

(Second of Two Parts)

Assays for Vitamin D Metabolites

The basic advances in our understanding of the metabolism and mechanism of action of vitamin D not only are important in physiology and nutrition but have been successfully applied to the study of the ...

Ten, or even five years ago, the chief question concerning diet and pregnancy was, "Does it matter?" Currently, the question has become, To what degree does a good diet benefit pregnancy, and How can the benefits be measured?

The purpose of this paper is ...

Presentation of Case

A 39-year-old man was admitted to the hospital because of jaundice.

He was well until three months previously, when he began to have heartburn and frequent belching; he reduced his food intake and lost 7 kg in weight. Six weeks before ...

Several hundred papers, each reporting an increased frequency of one or more HLA antigens among patients with a particular human disease, have appeared in the medical literature in the last few years. This literary deluge, to which the New England Journal ...

The genetic basis for the familial predisposition to diabetes mellitus has been a controversial topic for decades. A prominent aspect of the controversy has been the relation between the brittle, juvenile-onset and the stable, maturity-onset types: do ...

IN its highest form medical controversy provides the energy for inquiry and progress. When controversy descends from the intellectual to the emotional plane, participants become more the advocates of belief than the seekers of truth. When the "experts" ...

The ability of hospitals to renovate and expand physical capacity and to develop new services is subject to state-conducted certificate-of-need programs as mandated by the National Health Planning and Resources Development Act of 1974 (P.L. 93–641). In ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Case 36–1977 of the Massachusetts General Hospital (N Engl J Med 297:546–551, 1977) raised but left undiscussed a question that may shed some light on the unsolved problem of the etiology of the patient's facial swelling and tooth pain.

...

To the Editor: Recently, we have had the opportunity to review the history of one of the patients described by Jeghers et al.¹ in their 1949 article in the Journal.

The patient is now a 73-year-old woman who was first admitted to our institution in 1938 ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Whose responsibility is it to ensure appropriate language in an article published in the Journal? Initially, of course, the authors attempt, through the original draft and subsequent revisions of a manuscript, to arrive at acceptable ...

To the Editor: The history of man's search for truth can be divided into eras according to the aspects of truth that were most prominent at the time. For instance, the primitive era of Aristotle, Vesalius and Leeuwenhoek, with its emphasis on collecting ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

WORKSHOP IN SOLID-STATE SENSORS IN BIOMEDICINE

Case Western Reserve University in Cleveland will present a workshop entitled "Solid State Physical Sensors for Biomedical Applications" on December 8 and 9. The workshop is sponsored by the Research ...

No extract is available for articles shorter than 400 words.