Patients who have undergone splenectomy and patients with sickle-cell disease have an increased risk of development of overwhelming infection with organisms producing polysaccharide capsules.^{1 2 3} In the majority of patients, these infections are the ...

Severe hypophosphatemia in man^{1 , 2} has in recent years been found to be associated with low intracellular stores of ATP.¹ Low concentrations of the energy-rich nucleotide have been found in the red^{3 4 5 6 7 8} and white blood cells,^{9 , 10} platelets¹¹ and ...

Cushing's disease (hypercortisolism secondary to inappropriate secretion of ACTH by the pituitary) is characterized by alterations in basal, circadian, stress-induced and feedback regulations of ACTH release. Current opinion on the steroid feedback ...

Both experimental evidence in animals and clinical observations in human beings suggest a major role of insulin in fetal growth and metabolism. The action of insulin on cells depends on receptor sites for insulin, and the degree of response to the hormone ...

Things are seldom what they seem, Skim milk masquerades as cream. —W.S. Gilbert (1878): H.M.S. Pinafore.

For decades, the slogan "Breast Is Best" has been in use as a pious medical incantation. It has been based on unassailable support for motherhood, and ...

The syndrome of acute myocardial infarction with angiographically normal coronary arteries has been more frequently recognized since the availability of coronary angiography. Most of the patients described are young, and the syndrome is said to have a ...

The syndrome of familial glucocorticoid deficiency is characterized by cutaneous pigmentation, muscular weakness, hypoglycemia and convulsions. Hormonal evaluation of patients afflicted with this syndrome reveals elevated endogenous ACTH levels and low ...

Acute urinary retention is an unusual presenting complaint in a previously well young adult. When retention is associated with minor neurologic symptoms and signs, lumbosacral disk herniation, spinal-cord compression, multiple sclerosis and psychogenic ...

I HEARD on the radio the other day that the weekly journal Punch was the first to describe the weeks of summer when Parliament is in recess and high society used to leave London for the South of France, or the grouse moors in Scotland, as the silly ...

(Second of Two Parts*)

For a tissue to maintain its cholesterol level, each of its cells must have a fairly constant cholesterol pool, and removal of cholesterol must be in equilibrium with input and cell synthesis. Clearly, the cells of the arterial ...

Presentation of Case

A 72-year-old woman was admitted to the hospital because of progressive dementia and a gait disorder.

She was well and of normal mental status until six months previously, when she fainted. On admission to another hospital examination ...

The pneumococcus (Streptococcus pneumoniae) is a major cause of pneumonia, otitis media and meningitis throughout the world. Although the mortality resulting from pneumococcal infection has declined strikingly since the introduction of the sulfonamides, ...

"Human milk is for the human infant; cow's milk is for the calf." The late Paul Gyorgy stated this point almost derisively 60 years ago and persisted in his opinion when others chuckled.

The Jelliffes, p. 912 in this issue, have summarized the evidence ...

Before 1930, medical schools in the United States were relatively simple institutions with small basic-science departments and largely volunteer clinical faculty members who donated time taken from their private practice of medicine. Education for the ...

Reducing exposure to lead and its consequences to health continues to be an important unfinished task in the public-health area. Recent recognition of lead in some glassware decorations has focused attention on the many sources of lead in the human ...

No extract is available for articles shorter than 400 words.

To the Editor: Dr. Edwin P. Maynard's fine discussion, in 1977, of Dr. Warren Point's 1966 patient with amebic colitis (Case 32–1977, N Engl J Med 297:322–330, 1977) includes the statement, "... There are reported cases with a duration of up to 12 years ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The report by Levo et al.¹ of an association between hepatitis B virus (HBV) and essential mixed cryoglobulinemia (EMC) describes yet another immune-complex-mediated illness related to hepatitis B. Several questions are raised by this ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Shapiro recently (N Engl J Med 296:1509–1514, 1977) proposed a measure to evaluate the accuracy of clinical predictions in binomial-choice situations, used it to test the prognosticative ability of various clinicians, decision rules and ...

To the Editor: The study by Egbert and Rothman on "Relation between the Race and Economic Status of Patients and Who Performs Their Surgery" (N Engl J Med 297:90–91, 1977) purports to prove that because more blacks than whites are treated by resident ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This textbook, written by three authors who have occupied the forefront of studies of hemoglobin, is divided into three roughly equal parts. The first deals, in separate chapters, with the structure and the function of hemoglobin and with the transport of ...

No extract is available for articles shorter than 400 words.

When physicians seek information about how to organize or expand a group practice, library research is usually an exercise in futility. This book begins to address that inadequacy. Unfortunately, the preface fails to include physicians among those for ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Statistics and Systems

Management ...

MEETING OF THE BOSTON CANCER RESEARCH ASSOCIATION

The Boston Cancer Research Association will meet on Tuesday, November 1 at 6:00 p.m. at the Countway Library of Medicine.

Further information may be obtained from Dr. Victor M. Rosenoer, Lahey Clinic, 605 ...