Patients with homozygous familial hypercholesterolemia die in adolescence or early adulthood from sequelae of rapidly progressive atherosclerosis.¹ Measures used to treat this disorder have not as yet proved successful in altering its natural history even ...

Since the description, in 1963, of C1̄ inhibitor deficiency in hereditary angioneurotic edema,¹ many defects of complement components have been described in man.^{2 3 4 5 6 7 8 9 10 11 12 13} Most of these abnormalities are genetically determined and are ...

Until recently, patients with severe acute respiratory failure died rapidly of hypoxemia, and little attention was paid to alterations of pulmonary hemodynamics. However, advances in respiratory care, including mechanical ventilation with positive end-...

The increase in the use of drugs for both short-term and long-term treatment during the past decades has led to a corresponding increase in concern about their potential for inducing serious illnesses.* As a result, the search for drug-induced disorders ...

This paper attempts to integrate the relevant quantitative and qualitative differences in the enzymology of the cancer cell discriminating it from that of the normal cell. In cancer cells an ordered pattern of enzymatic imbalance is linked with the ...

The oral hypoglycemic agents available in the United States (Fig. 1) include the sulfonylureas tolbutamide (Orinase), chlorpropamide (Diabinese), acetohexamide (Dymelor), tolazamide (Tolinase) and the biguanide phenformin hydrochloride (DBI, DBI-TD).

...

Miconazole, a phenethylimidazole,¹ is effective in vitro against several pathogenic fungi,^{1 , 2} and has cured systemic mycoses in man.^{3 , 5} In contrast to amphotericin B, miconazole does not appear to have renal or hematologic toxicity.^{3 , 4}

On the ...

Presentation of Case

A 51-year-old man was admitted to the hospital because of dyspnea.

He was in excellent health until 10 months previously, when a "pressing" pain developed in the anterior portion of the chest, with radiation to the left arm. He ...

Familial hypercholesterolemia is an unequivocal example of a single-gene defect that produces hypercholesterolemia followed by atherosclerosis. Although the disease is transmitted as a dominant trait, rare patients inherit two copies of the mutant gene ...

The classical complement pathway comprises nine serum proteins that interact sequentially to form a series of activated complexes and effectors of the immune response. In man, a number of inherited deficiency states of particular complement components are ...

The New England Journal of Medicine, like some ink-and-paper chameleon, is changing before our eyes. Once charged by and reflecting a sense of the power of the human mind to enhance the well-being of our species, the Journal now mirrors and intensifies ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Post-transfusion purpura is an acute episode of immune thrombocytopenia that follows the administration of certain blood products by seven to ten days. We have previously described the diagnostic use of the platelet aggregometer in this ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

When physicians refer in writing or speech to chronic hepatitis, chronic persistent hepatitis, chronic active hepatitis, aggressive hepatitis or CALD (chronic active liver disease), I get confused. Hence, the attempt of an international group of highly ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Neurology and Neurosurgery

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INTERNATIONAL SOCIETY OF PSYCHONEUROENDOCRINOLOGY

The International Congress of the International Society of Psychoneuroendocrinology will be held al the Atlanta Hilton Hotel, Atlanta, May 8–12.

Further information may he ohtained from Dr. Richard P. ...