Children with either infantile X-linked or common variable forms of agammaglobulinemia are extremely susceptible to infections with pyogenic bacteria. Recurrent bacterial disease can be reduced considerably in these patients by administration of human ...

Cold-hemagglutinin disease is characterized by a high titer of cold agglutinin, hemolytic anemia and frequently intolerance to cold.^{1 2 3} The studies of Dacie,⁴ Evans⁵ and Logue⁶ and their co-workers have established the importance of the complement ...

Theophylline is commonly used and efficacious for the treatment of reversible airway obstruction.¹ Adverse effects such as cardiac arrhythmias and cerebra¹ seizures have been observed when plasma theophylline concentrations exceeded the therapeutic range ...

The diagnosis of venous thrombosis constitutes a perplexing problem both in and out of the hospital. Because more than 50 per cent of symptomatic patients fail to show thrombi on venography,^{1 2 3} anti-coagulant treatment of all patients with symptoms is ...

Essential mixed cryglobulinemia unassociated with a well defined connective-tissue dissease, lymphoreticular neoplasia or obvious infectious process¹ is a syndrome characterized by the clinical traid of purpura, arthralgia and weakness, frequently ...

In recent years a degenerative disorder of the nervous system has been described in three families descended from immigrants from the Portuguese Azores.^{1 2 3} The authors considered each one to represent a separate disease. Two of these families^{1 , 2} ...

Predictive thinking plays an essential part in clinical medicine. The ability to predict the future underlies medical practice and is basic to decisions concerning diagnosis, prognosis and therapy. But experience with clinical prediction from the time of ...

Standards for external cardiac compression include compression of the chest for 50 per cent of cycle time and a compression rate of 60 per minute.¹ Warnings are given against "quick jabs." Animal studies do, in fact, suggest that the duration of prolonged ...

The association of three uncommon neoplasms — gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma — in two patients and the occurrence of two of these tumors in two other patients suggests that this association is not ...

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Presentation of Case

A 46-year-old office worker was admitted to the hospital because of dyspnea.

He was in good health until five years previously, when a productive cough developed, accompanied by dyspnea. A physician made a diagnosis of bronchitis and ...

Several studies, including that by Piafsky and his colleagues on theophylline in the current issue of the Journal, have demonstrated that drug disposition can be altered in patients with liver disease.¹ Many of the reported changes can be rationalized in ...

Infection with the hepatitis B virus (HBV) can induce a variety of responses in human beings. Physicians generally think first of acute hepatitis, a disease characterized by a relatively long incubation period, the appearance in the blood, during the ...

The hereditary ataxias are obscure degenerative diseases of the nervous system. Motor structures of the pons, spinal cord, and cerebellum are principally affected. Most patients begin to have symptoms in early adult life, although childhood illness, ...

Ten years ago, Dr. Joseph Garland's final report of the editor surveyed the trends and events that marked the score of years during which he directed the affairs of the Journal. In following his example, I shall attempt a similar survey of the decade of ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The observation during a short time of two men who both had severe scleroderma and were welders by occupation raised the question of another environmental occupational association with scleroderma besides those already known, vinyl ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: I fear that Dr. Morgan's article (N Engl J Med 296:251–256, 1977), "Watching the Monitors: 'PAID' prescriptions, fiscal intermediaries and drug-utilization review," may unjustifiably detract from the praiseworthy efforts of PAID and create ...

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To the Editor: The recent letter, "Semantic Selectivity: The Fifth Pathway program" (N Engl J Med 296:950, 1977) over the signature of Larry W. Weathers, M.D., is sufficiently erroneous in both its content and its verbiage to belie its title.

The "Fifth ...

To the Editor: Dr. Jose M. Segarra (N Engl J Med 296:763, 1977) writes, "Nursing has become professionalized to excess," and accurately describes the sorry state of hospital nursing today. It is ironic that in the same issue of the Journal Vandam's ...

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The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Bio and Physical Chemistry

...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.