Familial hemochromatosis is a well characterized clinical entity associated with progressive tissue iron deposition and damage.¹ Parenchymal iron accumulation is greatest in the liver, but the pancreas, intestinal tract, endocrine glands and heart also ...

Human plasma contains three distinct proteins capable of binding vitamin B₁₂, or, as it is currently designated, cobalamin.¹ Most of the unsaturated cobalamin-binding capacity of plasma results from the presence of transcobalamin II, a polypeptide that ...

When pulmonary embolism occurs, it may or may not cause pulmonary infarction.

Virchow¹ was the first to realize that necrosis of the lung may occur in areas distal to pulmonary embolic obstruction. Hampton and Castleman described pulmonary infarction with ...

A Number of epidemiologic studies have shown that the risk of development of clinically evident atherosclerosis correlates negatively with plasma concentrations of high-density lipoproteins.^{1 2 3} Since cholesterol accumulation is an integral feature of ...

Recurrent (chronic) urticaria is seldom recognized as an expression of cutaneous necrotizing venulitis.^{1 2 3 4 5} The syndrome consists of recurrent episodes of urticaria associated with episodic arthralgia and occasionally arthritis, abdominal pain and ...

Immune responses appear to be triggered by cell-surface events. Thus, in vitro systems that involve receptors at the cell surface are models of immunologic reactions.¹ A subpopulation of human peripheral blood T lymphocytes have a cell surface receptor (...

Although the exact pathogenesis of Coronary Artery disease remains obscure, certain risk factors have been elucidated by basic,¹ clinical² and epidemiologic^{3 , 4} research. Nevertheless, some investigators doubt the importance and utility of the risk-...

The biomedical research community is in an apprehensive mood these days. The apprehension began, I think, as only a vague uneasiness in the late 1960's when federal support of science "declined" for the first time in 20 years. There was no actual decline ...

Despite several decades of effort, the pathophysiology of nonspecific† acute renal failure is still uncertain. Two major points of view have emerged. One emphasizes tubular necrosis, and the other vasoconstriction as the principal cause of renal failure. ...

"Histamine, that decarboxylated son of histidine" — these poetic words of Carl Dragstedt, the pharmacologist and brother of Lester, the great surgeon, express beautifully the frustrations and disappointments of all who are confirmed histamine addicts. And ...

The phenomenon of altruism in biology has been argued over with such intensity of feeling that the very idea has lost much of its amiable aspect, and instead of being a newly recognized, rather delightful fact of life to be reflected on in puzzlement, it ...

The upgrading of district and regional hospitals was one of the outstanding achievements of the earlier years of the National Health Services (N.H.S.); the establishment of postgraduate medical centers in these hospitals has been one of the most ...

Presentation of Case

A 44-year-old woman was admitted to the hospital because of a thoracic mass.

She was well until five weeks earlier, when symptoms of a respiratory-tract infection developed. Fatigue and a nonproductive cough persisted. Ten days before ...

Franz Ingelfinger, soon to become editor emeritus of the New England Journal of Medicine, is honored by this commemorative issue.

Future students of medical history will regard his birth on August 20, 1910, in Dresden, Germany, as a highly significant ...

In medicine, a job that combines intellectual ferment and physical activity on a salubrious island with electricity, running water and a discerning wine merchant is, for the most part, recognized fantasy. It is enough prize for realistic people to realize ...

To the Editor: In their recent Sounding Board, Gross and Ennis (N Engl J Med 296:567, 1977) summarized data on the reactogenicity and antigenicity of inactivated whole-virus (WVV) and split-product (SPV) vaccines used in the National Influenza ...

To the Editor: The use of pooled human serum gamma globulin (SGG) has long been accepted as prophylaxis for hepatitis A virus (HAV) infection. Dosage levels have been based empirically upon volumes of SGG per body weight, with no scientific criterion, ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The Carter Administration is still too young and preoccupied with weightier matters to have had any serious effects on the federal government's mighty involvement with the research community. But it is proceeding with the Ford-initiated policy of washing ...