The Coronary Drug Project was planned during the period 1961–1965 as a randomized, doubleblind, prospective, large-scale clinical trial.¹ Two of its major objectives were "to evaluate the efficacy of cholesterol-lowering drugs in the long-term therapy of ...

Although genetically determined variability in the serum protease (Pi) system was discovered some 14 years ago, the relation of most of the Pi phenotypes to pulmonary disease is still uncertain. It has been clear since the initial studies that ...

Several studies have raised the possibility that regular consumption of alcoholic beverages is associated with hypertension. These investigations, which include prospective epidemiologic investigations,^{1 2 3} a case–control study of "problem drinkers,"⁴ ...

Although the clinical hallmark of osteogenesis imperfecta is fragility of the bones, other tissues such as skin, scleras and teeth are affected. This observation has suggested an association between osteogenesis imperfecta and collagen, the principal ...

The uses and possible misuses of recombinant DNA are so threatening, some believe, that research into that technology should now be stopped. But reasons good enough to justify prohibition of research in this sphere must, in fairness, apply equally to ...

Since the early 1950's the concept has evolved that certain serogroups of Escherichia coli, commonly designated enteropathogenic, are like shigellae and salmonellae, inherent enteric pathogens. This view is so widely held that many clinicians regard ...

Benign intracranial hypertension is associated with a variety of underlying disorders, but the pathophysiology of the process is poorly understood. We have encountered three children with benign intracranial hypertension and coexistent, otherwise typical, ...

The estimation of the number of doctors required to meet the medical needs of a country is a notoriously difficult and apparently unreliable exercise. Thus, in this country a committee¹ was set up in 1955 under the chairmanship of Sir Henry Willink "to ...

Presentation of Case

First admission. A 48-year-old man was admitted to the hospital because of fever.

He was well until 21 months previously, when he began to experience exertional dyspnea and fatigue. A physician found pancytopenia and referred him to ...

The issue of recombinant DNA research (i.e., gene manipulation) has been discussed widely in the public press and scientific journals. The controversy has been the focus of numerous meetings sponsored by the National Institutes of Health and most recently ...

IN medicine, as in the rest of this political world, there is nothing like a fiat to unite and give voice to the opposition. About a year ago, printed in this Journal as an editorial, a statement by the American Diabetes Association was intended to squash ...

Although few topics in medicine today share the interest generated by peer review, the impression is that programs to assure quality of health care have been received within the medical profession less than enthusiastically. Perhaps, if we look at the ...

Born in 1905 at Cohasset, Massachusetts, the son of Dr. Oliver H. Howe, a distinguished local physician, Henry graduated from Yale University in 1926 and from Harvard Medical School in 1930. Upon completion of internships at Boston City Hospital and ...

To the Editor: Lum and her co-workers¹ have recently reported prolonged survival of skin allografts in mice receiving the adenosine deaminase (ADA) inhibitor erythro-9(2-hydroxy-3-nonyl)-adenine hydrochloride (EHNA). We have been conducting studies on ...

No extract is available for articles shorter than 400 words.

To the Editor: In commenting on an article by Spector and his coworkers,¹ my transplant colleagues at the University of Minnesota point out that we do not seem to see the clinical perfusate nephropathy that is described.²

In answering, Dr. Spector³ ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Rosen and Austen conclude their recent editorial comments on androgen therapy of hereditary angioedema with the following sentences¹:

Because androgens in any form, impeded or unimpeded, are hazardous in children and pregnant women owing ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Breakthrough bleeding is quite common among users of oral contraceptives and is a frequent reason for discontinuing this method. The incidence of this side effect, however, varies from one study to another. Some of this variation may ...

No extract is available for articles shorter than 400 words.

To the Editor: Certain provisions in the Health Professions Educational Assistance Act of 1976 (PL 94–484) have effectively slowed or will completely eliminate the recent upsurge in the influx of foreign-trained physicians to this country. A peculiar ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The stated objective of this book, written by a well known investigator in the field of coronary disease, is "to marshal in one place the majority of the available information concerning the current practical aspects of coronary disease." The author ...

This book's primary thesis is that the healing professions must, and can, find methods of alleviating and preventing stress-related diseases. These methods cannot require people to drop out of their families, jobs or society, but should be incorporated ...

AWARD FROM THE MASSACHUSETTS CANCER PREVENTION AND DETECTION CENTER

The Massachusetts Cancer Prevention and Detection Center will award a prize at the graduate and undergraduate level for a paper on "Cancer Control through Early Detection — Fact or ...

No extract is available for articles shorter than 400 words.

When one is stumped for conversation in Washington or seeking clues to attach a forgotten name to a familiar face, it is usually safe to inquire, "How was the meeting?" or "How's the report coming along?" The reason is that a large portion of the working-...