Aspirin is an established anti-inflammatory drug. Although many effects, such as inhibition of prostaglandin synthesis¹ and stabilization of lysosomes² have been invoked, the bases for this property are unknown. Aspirin also has definite effects on ...

Somatostatin, a polypeptide hormone that inhibits growth hormone and thyrotropin release,^{1 , 2} has been shown to be secreted by specific hypothalamic somatostatinergic neural pathways in the brain^{3 4 5} and to be involved in the physiologic regulation of ...

IN 1942, Becker, Kahn and Rothman reported a case of pruritic, exudative dermatitis, glossitis, weight loss, anemia and abnormal glucose tolerance associated with an islet-cell carcinoma of the pancreas.¹ In 1966, McGavran et al. presented a well ...

Radiographic cholecystography with oral contrast agents is a popular and highly accurate examination for diagnosing gallstones.¹ However, 15 to 25 per cent of gallbladders are not visualized after a standard dose of oral contrast agent.^{2 , 3}

Ultrasonic ...

Carbohydrate Metabolism — Imbalance in Cancer Cells (Fig. 5)

Liver and hepatomas are freely permeable to glucose; thus, the activity and concentration of competing enzyme systems (in the presence of cofactors) determine the fate of the hexose. The ...

Angiographic visualization of the left ventricle makes it possible to determine left-ventricular-chamber dimensions, volume, stroke volume, wall thickness, mass and characteristics of regional wall motion. This information is of value for clinical ...

Whenx death from massive hepatic necrosis follows anesthesia, the anesthetic is usually indicted although other potential culprits may be cited. Alternative causes include hepatotoxic drugs¹ (e.g., phenelzine, antibiotics or tranquilizers), shock,^{1 , 2} ...

During the 30-month period from January 1, 1973, to June 30, 1975, a total of 15 infants in Wayne County, Michigan (population, 2.6 million), died suddenly in their cribs as a result of accidental asphyxia (smothering or strangulation). Ten cases of ...

As an academic clinician, I have not really been concerned with the rise in malpractice suits and the ballooning of medical insurance rates that followed. Of course, I have been aware of the ferment, but no more intoxicated by it than the neighbors of a ...

Presentation of Case

A 36-year-old man was admitted to the hospital because of a testicular seminoma.

The patient was an abuser of methamphetamine and heroin; six years previously he had hepatitis secondary to the injection of drugs. Four years before ...

The dissolution of clotted blood has captivated investigators since the phenomenon was recognized at the end of the last century. The currently conventional view ascribes fibrinolysis to the action of a protease, plasmin, that normally exists in plasma in ...

Although the swine-influenza-immunization campaign has been suspended for all but high-risk groups, it was attended by other problems besides the well publicized but very rare apparent association with Guillain-Barré syndrome. One of these other problems ...

Despite the concentration of wealth in the United States and its highly vaunted standard of living, when someone is disabled by injury or disease in this country it can be one of the worst of personal tragedies. The full extent of the tragedy is measured ...

To the Editor: Mudge and his associates are to be congratulated for their article on the cold-pressor response and the calculated coronary vascular resistance in patients with coronary-artery disease.¹ The amazing localization of atherosclerosis to the ...

No extract is available for articles shorter than 400 words.

To the Editor: Immune thrombocytopenia is a relatively frequent reaction to quinidine administration.^{1 , 2} Leukopenia and aplastic anemia are uncommon.³ In the following case marked leukopenia and thrombocytopenia occurred after quinidine therapy, and ...

No extract is available for articles shorter than 400 words.

To the Editor: During the past few years, there has been a sharp rise in the number of deliveries by cesarean section. One of the reasons for this increase is for prevention of neonatal herpes in women with genital disease. In pregnant women with active ...

No extract is available for articles shorter than 400 words.

To the Editor: We should like to comment on some of the points raised in Dr. Fishman's lucid editorial on the problems of detecting lung hemorrhage (N Engl J Med 295:1430, 1976). Since our paper was submitted, we have accumulated further experience of ...

To the Editor: The point of Dr. Ingelfinger's recent editorial "Seduction by Citation" (N Engl J Med 295:1075, 1976) is illustrated by a recent article in the Journal. In the case report entitled "Mercury Embolization of the Lung" (N Fngl J Med 295:883, ...

To the Editor: In follow-up to the report on the use of cyproheptadine in the treatment of Cushing's disease¹ by Krieger and her co-workers and the subsequent correspondence^{2 , 3} we report a case that raises questions about the site and mode of action of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

TRAINING COURSE IN CANCER RESEARCH

The fourth Training Course in Cancer Research, sponsored by the International Union against Cancer, Research Institute of Oncopathology, National Institute of Oncology, will be held in Budapest, September 4–17. The ...

No extract is available for articles shorter than 400 words.