Severe hypothyroidism has long been known to produce abnormalities of cardiac structure and function.^{1 2 3} Studies in human subjects have documented reduced cardiac output,^{4 , 5} pericardial effusions^{6 7 8 9 10 11} and cardiomegaly.^{1 2 3 4 5 6 7 8 9 10 11 ...}

Hypothalamic hamartomas are often associated with precocious puberty,^{1 2 3 4 5} but the mechanisms that induce early sexual maturation remain unknown. One theory suggests that neurons within the hamartoma actively stimulate the hypothalamus or that the ...

Acquired aplastic anemia represents a group of disorders characterized by peripheral blood pancytopenia in association with varying degrees of diminished granulocytic, erythroid and megakaryocytic elements in the bone marrow.¹ There is a high degree of ...

The impaired capacity of most patients with advanced chronic renal failure to reduce sodium excretion to less than approximately 20 to 30 meq daily regardless of the salt intake^{1 2 3 4 5 6 7} — the so-called "saltlosing" tendency — has important ...

THE randomized clinical trial (RCT) is the only scientifically reliable method for assessment of the efficacy (and risks) of most clinical treatments. The status of the RCT in a medical discipline may be used as an index of the scientific standard of ...

Patients with fever of undetermined origin are often perplexing, but perhaps most challenging are those with factitious or spurious fever.^{1 2 3} The ways in which patients may inject or ingest pyrogenic materials or, much more commonly, manipulate ...

The literature of the medical malpractice crisis has been reaching overkill proportions. Yet the amount of fundamental research is still very, very thin in many areas. The darkest corners are still reserved for insurance practices and the volume and ...

The kidneys participate to a major extent in the pathogenesis of congestive heart failure. When the heart fails as a pump, a complex alteration of homeostatic mechanisms results. Among the adjustments that occur are changes in the hemodynamic and hormonal ...

Presentation of Case

A 45-year-old man was admitted to the hospital after collapsing.

The patient was apparently well until one day before admission, when he experienced pain in the right leg. On the next day he recalled sitting down somewhere and ...

The pathogenesis of most cases of aplastic anemia has been enigmatic. To be sure, in some patients direct damage to stem cells by poisons, toxins or drugs can be assumed. But even in circumstances in which a specific toxin or drug can be implicated, the ...

It has always seemed remarkable that most patients with severe impairment of kidney function maintain normal sodium balance even though the amount of sodium filtered by their kidneys is reduced to a tiny fraction of normal. It is true that patients with ...

When Congress created the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (PL 93–348, signed July 12, 1974), its goals were recognized as laudable, but its practical usefulness seemed doubtful to some. ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Grupe et al. (N Engl J Med 295:746, 1976) demonstrated the beneficial effect of chlorambucil in frequently relapsing nephrosis. Despite their excellent results and the good tolerance of the drug, the authors gave strong advice against the ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Peripheral blood lymphocyte surface markers of patients with systemic lupus erythematosus have been well studied. However, the distribution of the different lymphocytes in the sites of lesion in these patients has not been described.

We ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In 1971 Mjølnerød et al. reported the birth of an abnormal child to a mother who had received large doses of D-penicillamine during pregnancy for cysteinuria.¹ The baby, who showed features of a generalized connective-tissue disorder, with ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In view of the favorable reports concerning the use of cyproheptadine in Cushing's disease,^{1 , 2} we wish to record the failure of this therapy to alter either clinical expression or biochemical data in a recently diagnosed case of Cushing'...

AMERICAN MEDICAL WRITERS ASSOCIATION CHAPTER MEETING

The American Medical Writers Association, New England Chapter, will hold a dinner meeting at the Cottage Crest Restaurant, Waltham, Massachusetts, on Wednesday, January 19 at 6:00 p.m. John Langone, ...

No extract is available for articles shorter than 400 words.

Manuscripts

Manuscripts of Original and Special Articles are accepted for consideration with the understanding that they, or their essential substance, tables or figures, have been neither published in nor submitted to any type of publication circulated ...