Reproductive factors and ovarian hormones have long been implicated in the origin of breast cancer.^{1 2 3 4} As a result, the giving of estrogens to healthy women is controversial.^{5 , 6} This question has led to intensive epidemiologic evaluation of users of ...

Pyroglutamic acidemia, a metabolic disorder, was described in a Norwegian patient in 1970.¹ Five additional cases have now been recognized in other counties, of which only two (both Swedish) have been described.^{2 3 4} The disorder, which appears to be ...

Theophylline (1,3-dimethylxanthine) exhibits a variety of pharmacologic actions, including augmentation of cardiac chronotropy and inotropy, Central-nervous-system stimulation, smooth muscle relaxation and diuresis. The capacity of theophylline to ...

The introduction of insulin in 1922 by Banting and Best¹ seemed to offer the ideal therapy for the treatment of diabetes mellitus: replacement of the missing hormone. Indeed, in the past 50 years, the judicious use of insulin has made it possible to ...

(Second of Two Parts)

The Response-to-Injury Hypothesis

The response-to-injury hypothesis dates back to the pioneering work of Virchow.¹²⁰ Since then, it has been modified and extended by many investigators, including Duguid,¹²¹ French²⁰ and Mustard and ...

Patients with acute leukemia and lymphoma are at increased risk of invasive pulmonary fungal infection.^{1 , 2} Among the opportunistic fungi responsible for these infections, aspergillus species are especially common.^{3 4 5 6} Invasive aspergillus pneumonia ...

The action of thrombin on fibrinogen and platelets is thought to play a critical part in thrombosis. Thrombin action has been implicated in the pathogenesis of disseminated intravasacular coagulation and of certain chronic renal diseases, and it may also ...

Presentation of Case

A 52-year-old woman was admitted to the hospital because of hypercalcemia.

She was well until several months previously, when polyuria and polydipsia developed. Ten days before entry there was the onset of cough, fever, progressive ...

Numerous hereditary enzyme deficiencies have been identified in red blood cells. Some of these, such as deficiency of glyoxylase II or acetylcholinesterase, seem not to be associated with any disease. In others, as in galactosemia, no hematologic disease ...

Considerable controversy has marked the relation of blood glucose control to the long-term development of diabetic complications.¹ A consensus on a convincing long-term beneficial relation is still lacking, a situation due primarily to inability to ...

Programs of continuing education in medicine are less than optimally effective. Why should this be? Teachers speak of "conditions for learning," and in adult education it has been suggested that the conditions necessary to encourage learning are the ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In providing medical care for outdoor rock-music concerts, we have noted large numbers of young people with a current history of having "over-amped" on cocaine. These patients are noted to exhibit rather profound sympathetic ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The Epstein–Barr virus (EBV) provides a good example of direct interference by a virus with human B-cell and T-cell function. The main target of this virus is the B lymphocyte.¹ It induces an antigenic alteration in the B cell's ...

No extract is available for articles shorter than 400 words.

To the Editor: Petechiae are small capillary hemorrhages that are characteristic of severe thrombocytopenic states. In the following patient with a normal platelet count a petechial eruption developed as a result of medications that impair platelet ...

No extract is available for articles shorter than 400 words.

To the Editor: The article of Sherwin et al. (N Engl J Med 294:455–461, 1976) and Levine's editorial (N Engl J Med 294:494–495, 1976) resulted in letters from Swenson, Alsever and Unger (N Engl J Med 294:1238–1239, 1976).

For a number of years I have ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: I have read and re-read the letter of medical student Julia Frank (N Engl J Med 294:1464, 1976), and believe there is a misunderstanding of the theory, practice and potential of physical diagnosis. For the medical student the course should ...

No extract is available for articles shorter than 400 words.

Pediatric gastroenterology is coming of age. In recent years several new textbooks have appeared, of which this one is unique — limiting its scope entirely to the small bowel. The goal as stated by the author is to provide an up-to-date review of small-...

Most medical scientists appreciate the prodigious scientific output of Dr. Selye throughout his long career. This volume, an encyclopedia of stress research, is typical of his labors. He states in the epilogue, "As I approach the end of my career, I do ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Only a few psychiatrists are experienced and knowledgeable in the emotional care of victims of thermal injury, and Dr. Bernstein is foremost among them. In this book he shares his 12 years of experience in this area by giving examples of what happened to ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Anatomy and Histology

Functional ...

METABOLIC RESEARCH STUDY

The co-operation of physicians is requested in the referral of individuals with ideopathic osteoporosis for evaluation of therapy with low dose hPTH (1–34). This study is being conducted on the Metabolic Research Ward at the ...