IN a historical cohort study of the Dutch famine of 1944–45, we examined prenatal and postnatal levels of nutrition as determinants of obesity in 19-year-old men. Early nutrition has been thought by some to influence adipose cell number and cell size, and ...

The anticoagulant effect of sodium warfarin in man is augmented by disulfiram (Antabuse).¹ The antiprotozoal agent metronidazole (Flagyl) has an "Antabuse-like" effect in man.² To evaluate whether metronidazole could augment the hypoprothrombinemia of ...

IN a variety of situations metabolic rate has been shown to influence ventilatory responses to hypoxia and hypercapnia in such a parallel fashion that an increased rate is associated with augmented responses,^{1 2 3} and a decreased rate is associated with ...

When advance life support and maximum therapeutic efforts are continued in a patient who is judged to be hopelessly ill and the anticipated outcome is death, serious medical, emotional, legal and economic questions concerning the justification for ...

Medical opinions on the inappropriateness of cardiopulmonary resuscitation of certain patients are now openly discussed, as acknowledged by the New Jersey Supreme Court in its recent Quinlan decision. As early as 1974 the AMA proposed that decisions not ...

THE concern with the conditions in which people approach death is growing. The plight of Karen Ann Quinlan and her family touched many readers. More than the fear of death itself, it is the fear of lingering before death and of creating heavy burdens for ...

(First of Two Parts)

Atherosclerosis is an arterial disease that is recognized to be the chief cause of death in the United States and in Western Europe.¹ Its importance as a principal cause of myocardial and cerebral infarction and thrombosis has been ...

New medical technologic advances may experience long delays before patients in general may benefit. The advent of prenatal genetic diagnosis a decade ago exemplifies the gap between the available technology and its use by society. In Massachusetts, for ...

Presentation of Case

A 31-year-old woman was admitted to the hospital because of obstruction of the superior vena cava.

At the age of 11 years she had an illness characterized by pleuritic pain and low-grade fever, without arthralgia, rash or signs of ...

I recently heard an undocumented but probably accurate estimate: two million clients visit Weight Watcher meetings each week! The only other commercial ventures that seem to inspire similar enthusiasm are roadside restaurants serving between-meal, high-...

The hospitals are coming out of the closet! It is an event of the first importance that responsible administrators at two great hospitals — independently, I believe — should promulgate and discuss publicly explicit policies about the deliberate withdrawal ...

Under the pressure generated by lobbies and various vested interests, Congress has displayed a growing tendency to write legislation specifically promoting disease-oriented and targeted research. Currently, for example, it is rumored that Congress is ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Recently, Krieger et al. (N Engl J Med 293:893–896, 1976) reported that cyproheptadine, a serotonin antagonist, was effective in the treatment of pituitary-dependent Cushing's disease. Shortly after publication of this study I encountered ...

To the Editor: Ascites may be caused by any neoplasm involving the peritoneal surface. Melanoma metastasizes most commonly to the lungs (87 per cent), liver (76 per cent) and lymph nodes (74 per cent), but can metastasize to any organ.¹ In one series of ...

To the Editor: The efficacy of the single 2-g dose of metronidazole for the treatment of trichomonal infections in both sexes has been reported.^{1 2 3 4} Treatment of 31 consecutive female patients and their consorts was previously reported in the Journal.^...

To the Editor: We read with interest the recent report relating the experience of the Center for Disease Control with rubella vaccine in pregnancy (Modlin JF, et al: Risk of congenital abnormality after inadvertent rubella vaccination of pregnant women. ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: One hundred and forty-seven critically ill patients in Class 4 (N Engl J Med 294:982–987, 1976) were treated in the Intensive Therapy Unit at the Cardiff Royal Infirmary from July, 1973, through June, 1974. Sixty-seven (45.6 per cent) died ...

This book, described in the foreword by Dr. Harvey Feigenbaum as a monograph by one of the most experienced echocardiographers in the field, is appropriately dedicated "To the cardiac patient." It is not a textbook on echocardiography, but a procedure ...

No extract is available for articles shorter than 400 words.

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Physiology

Organ Physiology: ...

COURSE IN GASTROENTEROLOGY

The University of California, Los Angeles, Department of Continuing Education in Health Sciences and the School of Medicine, in co-operation with the Los Angeles Academy of Family Physicians and the National Foundation of ...