Among the mechanisms leading to the development of the respiratory-distress syndrome of the newborn, inadequate pulmonary surfactant is thought to have a primary role.^{1 , 2} Several factors are in turn believed to influence surfactant production: ...

Of the accidental varieties of man, which would occur among the first few and scattered inhabitants of the middle regions of Africa, some one would be better fitted than the others to bear the diseases of the country. This race would consequently multiply,...

The recent finding of a new polymorphic system of antigens that is present on human B lymphocytes, but not on T lymphocytes,^{1 2 3 4 5} has necessitated a re-examination of the lymphocytotoxic antibodies in recipients of kidney transplants. From what is ...

Methylmalonic acid, an intermediate in the conversion of propionate to succinate, is normally present in the urine in minute concentrations.^{1 , 2} In adults, elevated urinary excretion ordinarily signifies vitamin B₁₂ deficiency,^{3 4 5} and in infancy or ...

An Annual Oration or Discourse has been delivered by distinguished members of the Massachusetts Medical Society in almost uninterrupted sequence since the year 1804. For the 195th Anniversary Meeting, I am the 166th Orator, and the second to be selected ...

Hydralazine (1-hydrazinophthalazine) (Fig. 1) has been used in the therapy of hypertension for 25 years. In combination with other drugs it is very useful for treating chronically hypertensive patients. The role of hydralazine in antihypertensive therapy ...

Of the various endogenous hormones and exogenous drugs, few have more widespread and potent effects than the catecholamines. It is therefore not surprising that natural and synthetic catecholamines and a variety of compounds that antagonize or block their ...

Presentation of Case

A 52-year-old woman was admitted to the hospital because of collapse of the left lung.

She was well until 15 years previously, when she began to have mild episodes of wheezing that responded to treatment for asthma. Three years before ...

Idiopathic respiratory-distress syndrome (RDS) generally occurs in premature infants, whose immature lungs may not contain an adequate amount of the surface-active, lecithin-laden layer of surfactant lining the alveoli. The surfactant normally functions ...

The malarial parasite must enter the erythrocyte of its host before it is able to undergo multiplication. In the absence of this replicative step, malarial infection would be a trivial, self-limited condition. Invasion of the erythrocyte is obviously a ...

Perhaps it is their national penchant for under statement, or perhaps the conviction that "he that hath knowledge spareth his words," — whatever the reason, the British are rather reticent about the editors of their principal medical publications. Open ...

A normal 23-year-old gravida 3, para 2 was admitted to the hospital at term in early labor with the cervix dilated to admit 1 1/2 fingers, the head engaged and all vital signs normal. The membranes were ruptured artificially and 5 units of oxytocin in 500 ...

To the Editor: The recent report of Favus et al. (N Engl J Med 294:1019–1025, 1976) sheds much light on the nature of the "epidemic" of radiation induced-thyroid carcinoma in the Chicago area. Forty-nine of their 60 cases are "occult" thyroid carcinoma (...

No extract is available for articles shorter than 400 words.

To the Editor: A close association between HLA B27 and ankylosing spondylitis has been demonstrated in several studies.¹ A family with two siblings affected with both ankylosing spondylitis and iritis and the third affected with iritis only, has been ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

As the preface points out, this volume is the result of 10 years of work by a large number of renowned specialists in kidney disease from many countries and representing many of the subdivisions of the discipline. As an officer of the International ...

The editors of this book wanted to provide a clinical textbook with ready reference to information "for the most part buried in the existing texts on renal diseases." In fact, much of what they present is not buried but can be found in good, readily ...

In this exquisitely tight review of mammalian somatic cells in culture, Littlefield attempts to relate the in vitro cellular phenomena of variation, senescence and neoplasia. Beginning with the classic experiments on spontaneous drug-resistant variants in ...

This superb book should be of value to any and all in cardiac electrophysiology — students, investigators or clinicians. Dr. Cranefield, who is a long established and well recognized leader in the field, has contributed a major work that brings together a ...

Neurology and Neurosurgery

Advances in Neurosurgery. Vol. 3. Brain Hypoxia; Pain. Edited by H. Penzholz; M. Brock; J. Hamer; et al. 460 pp., illustrated. New York: Springer-Verlag, 1975. $33.70.

Essentials of Neurology. Fourth edition. By John N. Walton, ...

EMERGENCY MEDICINE SYMPOSIA

The University of California, San Diego, School of Medicine will sponsor a symposia program providing a complete survey of the academic knowledge necessary for the practice of emergency medicine. Each symposium is five days ...