The production of adult hemoglobin has been demonstrated in fetuses as early as five weeks' gestation.^{1 , 2} The expressions of the sickle and thalassemia genes have also been detected in the first trimester.^{3 4 5 6} Fetal blood can be obtained in utero by ...

Hereditary angioedema is characterized by episodic swelling of the extremities, face, abdominal viscera or airway.^{1 2 3} In some patients with this disorder minor trauma may lead to the development of extensive subcutaneous edema; anxiety and emotional ...

Most mammalian cells are capable of synthesizing their required purine ribonucleotides de novo and of salvaging preformed purine bases or ribonucleosides. The role of the purine salvage pathways is unclear, but in the last decade hypoxanthineguanine ...

Early studies on the cerebrospinal fluid of patients with multiple sclerosis showed the presence of elevated protein or IgG or both.¹ However, patients with nondemyelinative neurologic disease also had increased levels of cerebrospinal-fluid protein and ...

Ever since the publication of Adam Smith's much-talked-about Powers of the Mind some months ago, people have written to ask whether his account of my recovery from a supposedly incurable illness¹ was accurately reported. In particular, readers have been ...

Except that hepatic excretory function is frequently disturbed during the course of many illnesses, attempts by investigators to understand the physiologic mechanisms governing bile formation might better be delayed until more fundamental knowledge has ...

Presentation of Case

A five-year-old boy was admitted to the hospital because of meningitis.

He was well until 10 days previously, when a sore throat and fever developed. He was seen at another hospital, where erythromycin was prescribed. The sore throat ...

Under normal conditions, an alpha globulin designated as C1̄ inhibitor (C1̄-INH) inhibits the activated first component of complement (C1̄). In hereditary angioneurotic edema, which is transmitted as classic Mendelian autosomal dominant, the serum of ...

The March 24, 1966 issue of the Journal contained a paper entitled "Listen: The patient." The author was Eric Hodgins, a well known editor (managing editor of Fortune, vice-president of Time, Inc.) and writer ("Mr. Blandings Builds His Dream House"), who ...

In a formal medical syllabus it is difficult to provide an opportunity for the discussion of broader cultural, philosophical and personal issues relevant to doctorship. In particular, it is a delicate task to create an environment in which the students ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The editor of this series plans to publish a systematic presentation of cancer, including etiology, biology and therapeutics. This first volume deals with causes other than viral, the second volume covers viruses and cancer, and the third and fourth are ...

This book begins with a very up-to-date and all-inclusive account of the biochemical changes of cell surfaces that accompany transformation by tumor viruses and a good general introduction to membrane biochemistry, with heavy emphasis on the present ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This being a holiday season, I solicit a gift of tolerance from editors and readers so that I may depart from the rigors of dispassionate inquiry and exposition that normally characterize writings in this journal and address myself to subjects on which ...