Transient myocardial ischemia has traditionally been considered to represent an imbalance between a fixed, restricted myocardial oxygen supply and enhanced metabolic demand. Variations in the tone of large coronary arteries have been documented ...

Severe combined immunodeficiency disease is characterized by the absence of both humoral and cell-mediated immunity. Affected infants manifest lymphopenia, thymic aplasia or hypoplasia and absence of delayed hypersensitivity as well as defective ...

The term "variant angina" was introduced by Prinzmetal et al. in 1959¹ to denote angina-like chest pain occurring without provocation and associated with ST-segment elevation. They postulated proximal severe lesions in one major coronary branch with "...

Many concepts of hemiballismus are based upon scattered reports gathered in an era of markedly different medical care. Most reported cases have resulted from acute vascular lesions, usually infarction, of the subthalamic nucleus or its connections.¹ The ...

Implicit in currently available remedies for medical errors is the belief that man is perfectable and his errors can be eliminated by training or coercion. Postgraduate training and recertification can eliminate errors caused by ignorance. Professional ...

In the broadest sense, current hospital therapy of acute myocardial infarction attempts to prevent, or promptly and effectively treat, the electrical and mechanical consequences of regional myocardial ischemia or infarction, while preserving jeopardized ...

Epidemiology and Pathology

AS the lethal activities of man decreased in the closing months of World War I, a new lethal agent emerged that killed 20 million people around the world.¹ The disease was pandemic influenza, and the agent a new influenza virus.^...

Presentation of Case

A 22-year-old graduate student was admitted to the hospital because of a pericardial effusion.

He was well until three months previously, when, during a visit to his home in southern California, he became fatigued, with a low-grade ...

During the course of evolution, some remarkable mechanisms have developed to ensure the cellular production of substances that are essential components of DNA and RNA. For example, two complicated series of metabolic steps, beginning with simpler ...

Renegade vascular smooth muscle is either culprit or accomplice in causing a variety of human ills — essential hypertension, primary pulmonary hypertension and Raynaud's disease, to name a few. In recent years it has become apparent that the muscular coat ...

F.J. Ingelfinger: We here at the Journal office are tickled pink to hear that you, Dick Wolfe, have been given an appointment named in honor of the Journal's former editor, Dr. Joseph Garland.

Richard J. Wolfe: Yes — the Boston Medical Library has just ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The recent report¹ of the association of diabetes mellitus with aldosterone biosynthetic defects emphasizes the need to define more critically the diagnostic criteria of such defects. The notion that low excretion of the metabolites of ...

No extract is available for articles shorter than 400 words.

JOHNS HOPKINS UNIVERSITY PROGRAMS

Johns Hopkins University School of Medicine, Baltimore, Maryland, will present two courses in the coming month: "Theory and Practice of Echocardiography" will be held January 26–29. The program has been approved for 26 ...