In 1972 we described the findings in 25 patients from a single institution who had an apparently distinct rheumatic-disease syndrome that we termed mixed connective-tissue disease.¹ The cases in that study were primarily identified by the presence of a ...

Over the past 15 years, less than 2 per cent of maternal deaths have been related to spontaneous abortion.¹ Recent recognition of a new risk factor — the intrauterine device (IUD) — has rekindled interest in mortality from spontaneous abortion.^{2 3} A ...

Immunotherapy for ragweed pollinosis is an effective form of therapy for the atopic person as indicated by studies recently reviewed.¹ However, the use of immunotherapy is limited by local and systemic reactions. Efforts to improve immunotherapy have ...

IN the prenatal diagnosis of hereditary hemoglobin disorders^{1 , 2} the method currently employed depends on the acquisition of fetal blood and the study of globin-chain synthesis. Homozygous β-thalassemia and sickle-cell anemia have been diagnosed in utero ...

(First of Two Parts)

The discovery of hepatitis B antigen^{1 2 3 4} has led to studies of the physical and chemical nature of the antigen and to the discovery of different structural forms of the antigen, some of which have properties of an incomplete virus ...

Blood-pressure reduction by specific angiotensin II inhibition with Sar¹-Ala⁸-angiotensin II (saralasin acetate, P113) has been extensively employed to identify renin-dependent forms of hypertension.^{1 2 3 4} Stimulation of the renin-angiotensin system by ...

Meprobamate, a widely used sedative, causes an increasing percentage of poisonings,¹ although deaths have been rare.^{2 , 3} Individual patient response varies — death has been reported after ingestion of 12 g,^{4 , 5} although patients have survived after ...

Systemic mastocytosis is associated with excessive production of histamine, which would be expected to result in gastric acid hypersecretion.¹ However, acid hypersecretion is rarely observed in these patients.² The patient described below, who had ...

The syndrome of idiopathic intestinal pseudoobstruction, described by Naish et al. in 1960,¹ consists of repeated bouts of idiopathic intestinal pseudo-obstruction accompanied by diarrhea and at times steatorrhea. Despite clinical and radiographic ...

During an immune response, small subpopulations of lymphocytes are stimulated selectively by antigen to divide and differentiate. This effect results in a marked increase in sensitized cells and leads to effective cellular and humoral immunity. Recently, ...

Presentation of Case

First admission. A 46-year-old black woman was admitted to the hospital because of abdominal pain and diarrhea.

She was well until eight years previously, when a rash and arthralgia developed. Evaluation revealed impaired renal ...

Although the nature of systemic lupus erythematosus still poses many mysteries, substantial progress has been made in defining specific autoantigens reactive with the serum of patients with this disease.¹ Foremost among the antinuclear antibodies, the ...

The paper by Metzger et al. in this issue of the Journal is an excellent example of the continuing research aimed at improving the immunotherapy of allergic disorders and better understanding of the mechanisms whereby favorable clinical results occur. ...

The DNA of mammalian cells contains two complementary strands of polydeoxynucleotides wound about each other in the form of a double helix. The term "complementary" describes the fact that the adenine bases of the nucleotides in either strand are opposite ...

To the Editor: We have previously reported in the Journal ¹ that a cardioselective beta blocker, atenolol, then referred to as ICI 66,082, did not provoke statistically significant changes in the plasma renin concentration in the group of patients ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

In the midst of the recent advances in understanding human purine metabolism, it is timely that a book has been written to review the field of gout and uric acid metabolism. The authors appropriately dedicated this book to the late Dr. Alexander B. Gutman ...

This book is a review of both the theory and empirical testing of relations between medical insurance, both public and private, and the utilization, prices and allocation of medical care. The focus is on the distribution of medical services among ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Anesthesiology

Clinical ...

SEMINARS IN MEDICINE OF THE BETH ISRAEL HOSPITAL

Seminars in Medicine of the Beth Israel Hospital will be held in the George Sherman Auditorium, Beth Israel Hospital, Boston on the following Tuesdays at 4 p.m.

SYMPOSIUM ON ADVANCES IN THYROID DISEASE

A ...