Familial dysautonomia (Riley-Day syndrome1a), an autosomal, recessively inherited disease found in Ashkenazi Jews,² is characterized by autonomic instability, impaired perception of pain, temperature, and taste, absent overflow tears, feeding problems ...

3′,5′Cyclic adenosine monophosphate (cAMP) and 3′,5′ cyclic guanosine monophosphate (cGMP) are produced by the enzymes adenylate cyclase and guanylate cyclase respectively. cAMP, cGMP and the enzymes that synthesize them are widely distributed in the ...

Since its description by Hudson et al. in 1957,¹ approximately 70 cases of selective hypoaldosteronism have been reported. Unexplained hyperkalemia and its consequences represent the major clinical manifestations.

Diabetes mellitus of either juvenile or ...

Studies using tissue cultures of the central nervous system as a model system have added substantially to an understanding of the pathophysiology of multiple sclerosis. Bornstein and his collaborators have shown that serum specimens obtained from patients ...

Biomedical and behavioral research involving human subjects and supported by the United States Department of Health, Education, and Welfare (HEW) is subject to several kinds of institutional control complementary to the informed judgment of those who ...

There is an increasing frequency of mycotic infections in patients with leukemia and other hematologic neoplasia.^{1 2 3} Aspergillosis is second only to candidiasis in frequency of opportunistic fungal disease among such patients.^{2 3 4 5 6} Invasive ...

A few years ago, a teacher who was planning a course in physiology might have allowed an hour to cover the action of antidiuretic hormone. This would have been a reasonable allotment of time; the topic seemed simple and straightforward, especially in ...

Presentation of Case

A 49-year-old man was admitted to the hospital because of pain in the right lower quadrant of the abdomen.

He was well until eight months previously, when he had a brief bout of chills, fever and sweats that were ascribed to "the flu."...

I have been invited to comment on the article published in this issue on "Increased Nerve-Growth-Factor β-Chain Cross-reacting Material in Familial Dysautonomia." In view of my life-long commitment to the study of this remarkable protein molecule and of ...

Biomedical research is now under serious and sustained challenge from many quarters to justify the risks that it entails for the human subjects who are essential to its success in creating more effective medical care. This challenge has at least two ...

No extract is available for articles shorter than 400 words.

In March, 1975, shortly after leaving the post of Assistant Secretary for Health, I offered some observations on the federal health effort in an article appearing in the Journal (N Engl J Med 292:559–562, 1975). At that time, I raised the question whether ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Case 14–1976 of the Case Records of the Massachusetts General Hospital (N Engl J Med 294:772–777, 1976) raised the question of the efficacy of topically applied 5-fluorouracil (5-FU) for the treatment of the basal-cell-nevus syndrome. In ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In any attempt to define standards of good medical care, one method is to survey a group of doctors and adopt the group's opinion as the standard. A recent Journal article¹ calls attention to limitation of this method — namely, that the ...

The first edition of this book appeared in 1964; now the second edition, nearly tripled in size and in two volumes, is here. Volume 1 covers red-cell synthesis, composition, morphology, metabolism and preservation. This review is confined to Volume 2, but ...

This is a very good book. Its deficiencies are almost entirely those of omission. From the point of view of the musculoskeletal system it is excellent, from that of the nervous system, good, and from that of the vascular system, fair.

A large number of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Anatomy and Histology

Explorations in Developmental Biology. By Chandler Fulton; and Attila O. Klein. 704 pp., illustrated. Cambridge, Massachusetts: Harvard University Press, 1976.

Histocompatibility. By George D. Snell; Jean Dausset; and Stanley ...

COURSE IN NUCLEAR MEDICINE

The Division of Nuclear Medicine, Johns Hopkins University School of Medicine will present a course, entitled "In Vitro Nuclear Medicine," October 11–13. This course has been approved for 21 hours of continuing-education credit ...

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