Diminished pulmonary vital capacity has long been recognized to be a consequence of serious heart disease.^{1 2 3} The belief that it might be an antecedent or predictor of coronary heart disease is a more recent development, stemming initially from ...

Bone-marrow transplantation has been and remains the treatment of choice for patients with severe combined immunodeficiency disease whenever histocompatible donors are available.^{1 , 2} Owing to the laws governing the inheritance of the major ...

Twenty years after the description of the obesity-hypoventilation syndrome,¹ its pathogenesis remains obscure. Various theories advanced to explain the alveolar hypoventilation have included the abnormal chest-wall mechanics^{2 , 3} and excessive work of ...

Since Barlow's description in 1963,¹ the midsystolic click, either as an isolated physical finding or in association with a late systolic murmur, has been recognized as representing prolapse of the mitral-valve leaflets. Electrocardiographic abnormalities ...

Despite the large amount of money involved and the controversies surrounding government policies, comparatively little is known about physician fee patterns throughout the United States. This lack of information is surprising since expenditures for ...

IN 1902, Bayliss and Starling¹ demonstrated that the introduction of hydrochloric acid into a denervated loop of small intestine elicited the brisk secretion of pancreatic juice. The implications of this observation were appreciated immediately, and they ...

Isolated polyps in the gastrointestinal tract, particularly in the colon, are relatively common, whereas only occasionally do patients have large numbers of polyps. Many of these patients have one of the genetic gastrointestinal-polyposis syndromes, so ...

Rifampin alters the clinical efficacy of oral contraceptive and anticoagulant drugs by mechanisms not completely understood. These effects may be due in part to acceleration of their elimination by enhancement of hepatic microsomal drug-metabolizing ...

The role of the observer in biologic research is complicated but not bizarre: he or she simply observes, describes, interprets, maybe once in a while emits a hoarse shout, but that is that; the act of observing does not alter fundamental aspects of the ...

Presentation of Case

A 19-year-old man was admitted to the hospital for a second renal transplant.

He was well until the age of 14 years, when the nephrotic syndrome developed. Prednisone, 60 mg daily, was given. The edema improved, but the proteinuria ...

IT has been recognized for a number of years that infants with congenital T-cell defects (cellular immune deficiencies) will readily accept various allogeneic grafts. Immunologic reconstitution of these infants by transplantation of appropriate lymphoid ...

Definition of an association between non-ejection clicks and late systolic murmurs, and the observation that patients with these physical findings usually do not manifest clinically important cardiac dysfunction are attributable to Gallavardin in the ...

Since the consumer is particularly blind in purchasing medical care, and his vital interests are often at stake, those who are in a position to screen for aptitude and competence in medicine have a grave moral responsibility. In accepting this ...

No extract is available for articles shorter than 400 words.

As public health turns its attention increasingly (and appropriately) to the question of diminishing returns in therapeutic medicine,¹ it has an equally important responsibility to focus on improving the outcomes of therapy. An example of the latter ...

To the Editor: Dr. Harvey J. Weiss, in the second part of his article, "Platelets: Physiology and abnormalities of function," which appeared in the September 18, 1975, issue of the Journal, described a patient with isolated platelet factor 3 deficiency ...

No extract is available for articles shorter than 400 words.

To the Editor: Recent data concerning the effect of aspirin on platelet function have suggested therapeutic circumstances in which aspirin may be proscribed. Despite the potential clinical importance of a number of demonstrated in vitro effects of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: We have been following a case of congenital folate deficiency in which an unusual neurologic deficit developed, because of inadequate folate therapy. The nature of this patient's impairment was not mentioned in Dr. Erbe's article¹ or in ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: There are two major methodologic problems in the article, "Evaluation of an Ambulatory Medical-Care Delivery System" (N Engl J Med 294:426–431, 1976) by Garfield et al.

First of all, it is impossible to analyze the implications of their ...

To the Editor: Social changes, scientific progress and modern technology create new problems in human relations, and we expect medical ethics to guide us — to help us to distinguish the right from the wrong. Dr. Clouser's article¹ on medical ethics is a "...

No extract is available for articles shorter than 400 words.

When faced with the task of reviewing a 1376 page textbook of radiology, it becomes easy indeed to sympathize with the authors, who must have spent an enormous amount of time assembling such a massive tome. Edited by David Sutton, this second edition of ...

Dr. Cranley's most recent book is the sequel to a volume on arterial disease. Divided into 11 chapters, it begins with an exposition of the anatomy and physiology of the venous circulation that is informative and complete, but unfortunately not presented ...

PEDIATRIC REFRESHER SEMINAR

A pediatric refresher seminar, sponsored by the Bureau of Maternal and Child Health of the State of New York, the Department of Pediatrics, School of Medicine, State University of New York at Buffalo and Buffalo Children's ...