The discovery of proinsulin, the biosynthetic precursor of insulin, by Steiner and Oyer¹ has led to speculations regarding the existence of abnormalities in proinsulin structure or in its conversion to insulin (or both). In the kindred described below, ...

Drugs can produce hemolytic anemia by a variety of mechanisms, including oxidant injury as in G-6-PD deficiency¹ or immunologic injury as in hemolysis induced by methyldopa (Aldomet)² or penicillin.³ By still another potential mechanism described below, ...

IN recent years physicians have become increasingly aware of the pulmonary complications of drug therapy. Several current reviews of the subject serve to emphasize the multiplicity of drugs capable of inducing pulmonary injury and the varied clinical ...

The presence of hepatitis B core antigen (HB_c Ag) in hepatocytic nuclei and of hepatitis B surface antigen (HB_s Ag) in hepatocytic cytoplasm of HB_s Ag-seropositive patients has been well established by immunofluorescence, electron microscopy and ...

Multiphasic screening has advanced technically to the point that many laboratory tests can be performed quickly and at a relatively low unit cost. As a result, automated multiphasic health testing has been proposed as an efficient means of triaging ...

With heightened awareness of the need for better treatment of millions of hypertensive patients, physicians have markedly increased their use of antihypertensive drugs in the past few years. Empirical use of agents now available can control the blood ...

Cystic fibrosis was described as a specific entity in 1936. The failure to recognize it before then was a consequence of the fact that the clinical manifestations are common to many other disorders in infancy. Andersen, at Columbia University, and Fanconi,...

Hydrazine (H₂N-NH₂), a volatile chemical deoxygenator, is widely used in industry as a corrosion inhibitor and in the military as a rocket propellant.¹ In laboratory animals it produces convulsions, circulatory collapse, pulmonary edema, hypoglycemia, ...

Polyarteritis nodosa is a rare disease of infancy that frequently affects the coronary arteries. In the infant with this syndrome described below, the diagnosis was confirmed by root flush coronary arteriography. Multiple coronary-artery aneurysms ...

Obstruction of the trachea by tumor poses grave problems in management that are directly proportional to the extent of the block. Not only is elective treatment difficult but even the emergency establishment of an adequate airway may prove formidable. In ...

WE have suggested the term "platypnea" to describe dyspnea produced by the assumption of an erect position and relieved by a recumbent one.^{1 , 2} The term "orthodeoxia" is now suggested to describe accentuated arterial oxygen unsaturation in the erect ...

Presentation of Case

A 19-year-old woman was admitted to the hospital because of hemoptysis.

She was well until one month earlier, when she began to experience morning stiffness in the fingers and knees, accompanied by intermittent swelling of the wrists, ...

Insulin, like all proteins, is susceptible to mutational change. However, efforts to find abnormal insulin molecules have been unsuccessful mainly because of severe limitations in the availability of material for study. Thus, although over 150 hemoglobin ...

A growing number of chemical materials, including pharmaceutical agents, have been associated with acute diffuse lung injury with mild to moderate symptoms sometimes progressing to respiratory insufficiency. When biopsies are performed the pathologic ...

Cat fever is a new disease entity that has a broad clinical spectrum. The predominant symptom appears as a feverish impulse to own, operate, exploit, or write about what has been known as Computerized Axial Tomography (CAT) but has now been renamed ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Dr. Miles (N Engl J Med 294:399, 1976) asks about respiratory therapists. Respiratory therapists and technicians are being trained to work under the direction of physicians. This training is part of the ethical code of members of the ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

DIAGNOSTIC ULTRASOUND CONFERENCE

The Los Angeles Radiological Society will present a diagnostic ultrasound conference at the Century Plaza Hotel, Los Angeles, May 14–16. Registration is limited.

SOCIETY FOR ADOLESCENT MEDICINE

The spring meeting of the ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

It is difficult to find commercial television programs that do not contain messages for remedies to tighten dentures, loosen bowels, defeat flatulence, retain lovability, and induce or delay slumber.

The reason it is difficult is that commercial ...