Although exogenous antibodies have been used for therapeutic purposes for several decades,¹ the concept of use of hapten-specific antibodies to reverse toxic effects of a drug has been advanced only recently.^{2 3 4 5} Severe, life-threatening digitalis ...

Excessive nocturnal gastric secretion is often found in patients with duodenal-ulcer disease and has been implicated in its pathogenesis¹. During most of the night, because the stomach is empty of food, gastric contents entering the duodenum are ...

Excessive, chronic vitamin A intake by human beings produces distinct toxic manifestations, including pseudotumor cerebri, skeletal pain, desquamative dermatitis and hepatic inflammation.^{1 2 3 4 5 6} Under normal circumstances, vitamin A is transported in ...

The interest in nonspecific and specific immunotherapy as an adjunct in tumor therapy evolved during the last 10 years.

Levamisole, a widely used anthelmintic drug, appears to improve host defense mechanisms by stimulating phagocytes and lymphocytes when ...

Kevin Bullard, a shy boy and a first-rate student in the sixth grade at Grant School, was killed yesterday, stabbed to death by a classmate in a corner of the blacktop schoolyard near Perry Street. His little sister, Kisha, saw it happen....Kevin was 11 ...

Despite many dramatic and rapid advances in the treatment of cancer during the last 20 years, the management of ovarian cancer remains unsatisfactory. Although surgical and radiotherapeutic technics have improved, the survival figures for ovarian cancer ...

Interest in the hyperlipidemias comes from their association with coronary heart disease. The high frequency of atherosclerosis in modern Western societies has led to intensive studies in a search for predisposing risk factors. Current data leave little ...

The introduction of chromosome analysis in various blood disorders has proved the high specificity of the Philadelphia chromosome — a G22 member with deleted long arms — in the diagnosis of chronic myelocytic leukemia.^{1 , 2} More recently, using Giemsa and ...

Pain more than "health" has been a central concern of the physician as his guide to internal disorders, for to patient and physician alike, pain usually means disease or disorder of some kind. Yet, talk with a philosopher who has abdominal pain, and you ...

Presentation of Case

First admission. A 53-year-old woman was admitted to the hospital because of proteinuria.

She was well until three years previously, when hypertension was discovered; alpha-methyldopa was given for the next 19 months. Seventeen ...

Diseases caused by the environment — for some reason called environmental rather than envirogenic — are prime public concerns. Hardly a day passes without some pesticide, industrial agent, drug or apparatus being indicted as responsible for some human ...

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When should we treat patients and under what circumstances should we refuse them treatment? In the last 10 years there has been a tendency to think of these issues as ethical problems. It is not that physicians failed to think in value terms or failed to ...

Edwin Bennett Astwood was born and raised in Bermuda, where as a boy he studied the stars through homemade telescopes and lived close to the sea. In 1972, he returned to Bermuda to practice medicine. He died on February 17, 1976, of cancer at the age of ...

Motor-vehicle accidents in Massachusetts last year claimed on the order of 31,000 years of potential life¹ (Table 1), second for that dubious distinction only to ischemic heart disease. Accidents in general rank fourth among major causes of death in ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

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To the Editor: Lawrence and Autian concluded that cardiotoxic substances were leached from a commercial dialyzer (N Engl J Med 292:1356, 1975). They observed that circulation of Chenoweth's solution (J Lab Clin Med 31:600, 1946) through the dialyzer ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Despite the relatively high prevalence of narcolepsy (0.09 per cent)¹ little is known about the pathophysiology of this disorder. Therefore, it is not surprising that most of the various treatments proposed are unsatisfactory.¹ Several ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

WILLIAM P. BUFFUM ORATION

The third William P. Buffum Oration, sponsored by the Rhode Island Society of Allergy and the Allergy Division of Rhode Island Hospital, will be delivered by Dr. Kimishige Ishizaka, in the George Building Auditorium, Rhode Island ...

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No extract is available for articles shorter than 400 words.