The two potentially limiting drawbacks in treatment of Parkinson's disease with levodopa, either alone¹ or combined with an inhibitor,² are the erratic loss of symptomatic control ("on-off" phenomenon) and the episodic occurrence of involuntary movements (...

Adult-onset acid maltase deficiency, a defect in glycogenolysis, is a disease presenting clinically as skeletal-muscle weakness in the third to the fifth decade.^{1 2 3 4 5} In the case reported below, reproduction in cultured skeletal-muscle fibers of the ...

In chronic active hepatitis delayed hypersensitivity against liver-specific membrane antigen can be detected.^{1 , 2} However, liver-specific autoantibodies have proved difficult to demonstrate. In previous studies, antibodies against liverspecific antigens ...

The lack of measuring sticks of accomplishment has bedeviled all concerned with the improvement of medical care. If the objective of medical care is the maintenance of health and the prevention and treatment of disease, we are constantly faced with a ...

Enzyme Induction and Drug Metabolism

The simultaneous administration of two or more drugs may result in interactions that increase or decrease the intended effects of one or both drugs.⁴⁴ These interactions are often the result of induced alterations in ...

Chromosomal abnormalities or variations are related to genetics in three ways: they involve the genetic material, and in that sense are always "genetic"; most of the variants and a proportion of the structural rearrangements are directly transmitted from ...

Disseminated gonococcal infection has been increasingly recognized as a cause of acute septic arthritis and tenosynovitis.^{1 2 3 4} However, despite recent improvements in culture technics, which have allowed more frequent isolation of Neisseria gonorrhoeae,...

When you are confronted by any complicated living system, a seaboard city, for instance, or the United Nations, or even a hamster, with things about it that you're dissatisfied with and anxious to fix up, you cannot just step in and set about adjusting ...

Presentation of Case

A 24-year-old woman was admitted to the hospital because of abdominal pain.

She was well until six weeks previously, when her menstrual period occurred at the normal time but was heavier and more prolonged than usual. One week later ...

Two unsolved problems interfere with the rational management of hepatitis. One is ignorance about the pathogenesis of hepatic necrosis and the other is the lack of information about why some cases of acute hepatitis heal and others proceed to chronic ...

Among the publications that the AMA is shedding is Today's Health. Somewhat ironically, this action is taking place at a time when emphasis on health education for the laity is peaking, for instructing people about their health is exactly what Today's ...

IN getting my thoughts together recently for a conference on the subject Has the Physician a Right to Strike? I tried to clarify in my mind the various roles played by resident physicians, or house officers, in the modern university teaching hospital. ...

A previous column¹ traced the impetus for a program to improve the quality of emergency medical care in Massachusetts. Co-ordinated by the Department's Office of Emergency Medical Services, the program's objectives are to upgrade resources of personnel ...

No extract is available for articles shorter than 400 words.

To the Editor: It is known that a patient with Bartter's syndrome is normotensive, although the renin–angiotensin–aldosterone system is extremely active. Unresponsiveness of the arteriolar wall to endogenous angiotensin II is a possible explanation.¹ Our ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The report by Johnson et al. (N Engl J Med 293:675–680, 1975) creates in us a certain sense of déjà vu and anxiety. In recent years, the scientific community has become aware of some of the potential problems to the offspring that follow ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Recognition of the distinctive character of medical genetics has been painfully slow. It is, by clinical standards, an extraordinarily precise field and has brought sharply into focus the inadequacies of clinical medicine on the subject. Yet, although ...

No extract is available for articles shorter than 400 words.

Reading and handling this volume for about six months has only strenghthened my opinion that it is the best book I know of on two nonspecific inflammatory disorders of the colon: ulcerative colitis and Crohn's disease of the colon. Having said this, I ...

No extract is available for articles shorter than 400 words.

The title of this volume describes its contents quite explicitly. The material is presented in the standard topographic format, with individual chapters on the conjunctiva, cornea, sclera, anterior chamber, iris, ciliary body, lens, vitreous, retina, ...

No extract is available for articles shorter than 400 words.

Sequential analysis, the statistical technic of analyzing data as they become available, has, as the author states in his preface to this volume, "...an immediate appeal in clinical research," particularly in the conduct of clinical trials. The first ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

History

A Centennial Review, 1873–...

FREDERICK STOHLMAN, JR., MEMORIAL SYMPOSIUM

The Leukemia Society of America, Tufts University School of Medicine, and St. Elizabeth's Hospital will present the annual Frederick Stohlman, Jr., Memorial Symposium, entitled "The Etiology and Treatment of ...