CARCINOEMBRYONIC antigen, an oncofetal antigen¹ of the gastrointestinal tract, was described as a glycoprotein associated with the surface membrane of neoplastic and embryonic cells of the colonic mucosa^{2 , 3} and more recently recognized in adult colonic ...

CONGESTIVE heart failure due to the development of acute aortic regurgitation is currently the leading cause of death from infective endocarditis.^{1 , 2} Since the mortality with medical therapy alone is extremely high, early aortic-valve replacement has ...

MOST current therapeutic regimens for childhood acute lymphocytic leukemia include "prophylactic" irradiation of the central nervous system soon after the initial hematologic remission to prevent meningeal leukemia and thus to prolong the remission of ...

PREVENTION of disease is receiving high priority by health-policy makers.^{1 , 2} Screening of asymptomatic but affected predisposed persons, therefore, will command much more attention as a component of health care than has been the case in the past.

To ...

CONSIDERABLE attention has been devoted in recent public discussions to the issue of progress, or lack of it, in improving the survival of patients with cancer. Greenberg^{1 , 2} contends that improvements did occur during the 1940's and early 1950's, but ...

(Third of Three Parts)

Effect of Coronary-Artery Bypass on Longevity

The lack of controlled randomized studies comparing long-term survival in medically versus surgically treated patients with coronary-artery disease makes statistical analysis difficult. ...

ESOPHAGEAL achalasia has characteristic clinical, radiographic, manometric¹ and methacholine (Mecholyl)² test findings. Although achalasia is usually of idiopathic origin, cases of Chagas disease³ and, rarely, gastric carcinoma^{4 , 5} may be almost ...

ALTHOUGH the cause of systemic lupus erythematosus remains elusive, considerable research has led to an understanding of the pathogenetic mechanisms responsible for the principal lesions. In addition, recent findings in animal models and clinical studies ...

Presentation of Case

A 52-year-old woman entered the hospital for a lung biopsy.

She was well until 16 years earlier, when the first of multiple crops of purpuric lesions of the legs developed. During the next five years these episodes were accompanied by ...

IN the current issue of the Journal, Edgington et al. report an assay for an isomeric species of carcinoembryonic antigen (CEA-S), a glycoprotein similar to carcinoembryonic antigen (CEA) isolated from colonic cancer that appears to be at least as ...

IN the March 27 issue of the Journal, Mr. Greenberg presents a sweeping indictment of the National Cancer Program.¹ His most specific criticism is that there has been no progress during the past 20 years in treatment (as measured by survival) for types of ...

Ironic, is it not, that people seem to blur the distinctions between health and disease so severely that the concepts have come to be used interchangeably, in fact, synonymously? This despite the obvious reality that health is the opposite of disease, and ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Most cases of Fanconi's anemia are associated with various congential abnormalities, but there are some reports indicating the distribution of certain elements of this constitutional disease among several members of a family rather than ...

To the Editor: It has been suggested that tardive dyskinesia results from an imbalance between striatal dopaminergic and cholinergic activities. This hypothesis finds support in pharmacologic attempts to alter central cholinergic activity in patients ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

CURRENT CONCEPTS IN FAMILY MEDICINE

The sixth annual refresher course on "Current Concepts in Family Medicine," sponsored by the Massachusetts Academy of Family Physicians, will be held at the Sheraton-Boston Hotel, September 17–20.

Further information ...

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