PATIENTS with multiple myeloma demonstrate impaired antibody formation after antigenic stimulation, have depressed polyclonal (non-paraprotein) immunoglobulin levels in their serum, and are readily susceptible to infection with highly pathogenic bacteria.^...

THE concept of central neurotransmitter regulation of different aspects of ACTH release (basal, circadian, stress induced and feedback) is generally accepted.¹ Cholinergic, adrenergic and serotoninergic involvement has been demonstrated. Different ...

IT is now generally accepted that caffeine is a stimulant of acid secretion in man.^{1 2 3 4 5 6 7} This action of caffeine has led to the recommendation that regular coffee should not be used by patients with peptic-ulcer disease or symptomatic ...

THE diagnostic criteria for homozygous familial hypercholesterolemia include a plasma cholesterol concentration about twice that of heterozygotes in the same kindred, the appearance of xanthomas before the age of 10 years, and hypercholesterolemia in both ...

IN recent years there has been a renaissance of interest in the role of the general practitioner or primary-care physician, both in the United States and abroad. Although there are many reasons for this renaissance, a dominant one is a concern about the ...

(Second of Three Parts)

Appendix

Acute Appendicitis

To consider the nonoperative treatment of appendicitis in a paper on advances in surgery seems to be a contradiction; yet this is the method by which many patients are treated in the People's Republic of ...

A HAZARD of suboptimal antimicrobial therapy is the potential of creating an environment conducive to the growth of resistant organisms. This risk is potentially present in infants with meningitis caused by enteric gram-negative bacteria because of the ...

THE purpose of this report is to call attention to a pupillary sign of dominantly inherited amyloidosis. We encountered the sign, reported in 1952 by Andrade,¹ in one of two brothers who were already known to have amyloidosis. Its presence in a woman with ...

ALL the signs and symptoms of the syndrome of inappropriate secretion of antidiuretic hormone result from excessive retention of water. Accordingly, adequate restriction of water and fluid intake prevents the hyponatremia and the associated clinical ...

LEUKOCYTE alkaline phosphatase scores are often lower than control values in patients with sickle-cell anemia.^{1 , 2} This difference is especially marked in such patients with leukocytosis, in whom we have observed that leukocyte alkaline phosphatase ...

THE number of women being admitted to British medical schools is increasing steadily. Thus, in 1970 women made up 29 per cent of the total, intake; by 1974 the proportion had risen to 34 per cent, and since there is no longer any quota system restricting ...

Presentation of Case

A 35-year-old woman was referred to the hospital because of renal failure. She was well until three months previously, when mild hypertension was discovered and treated with a-methyldopa and a diuretic. Approximately two weeks before ...

Much of our information about the structure, function, genetics and metabolism of immunoglobulins has come from studies of the homogeneous immunoglobulins associated with malignant diseases of the plasma cell or lymphocyte. Similarly, our understanding of ...

IN 1969 Liddle and Shute divided the historical evolution of Cushing's syndrome as a clinical entity into four phases.¹ During the first phase, Harvey Cushing described the syndrome in patients with basophilic pituitary adenomas. During the second phase, ...

The We-All-Know syndrome is quite common in clinical medicine, especially in the area of diet therapy. We All Know that ulcers will be soothed and healed by the calming effects of a bland diet. We All Know that the tender pockets of diverticular disease ...

Amniocentesis for prenatal genetic studies is now a well established diagnostic tool in the obstetrician's armamentarium. This technic, in general use for about six years, however, is grossly under-utilized. In Massachusetts, for example, where 3979 women ...

APPLICANTS FOR FELLOWSHIP

Published in Accordance with the Provisions of Chapter II, Section 2.301 (3), of the Bylaws

Barnstable

Acheson, George Hawkins, 4 Bramble Bush Park, Falmouth 02540.

Harvard Medical School, 1937.

Osler, Geoffrey Frank, 66 Crowell ...

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The above letter was referred to the author of the article in question, who offers the following reply:

To the Editor: The "laborious" skin test procedure using several concentrations of penicillin and penicilloyl-polylysine was directed primarily toward ...

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No extract is available for articles shorter than 400 words.

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To appreciate this book, one should understand what it is not, as well as what it is. Despite its comprehensive title, it is not an anthology of the most important papers in the development of cardiovascular physiology. One would look in vain for writings ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

SOCIAL-WORK-PRACTICE SEMINARS

The Department of Social Work Services, Long Island Jewish-Hillside Medical Center, will sponsor two seminars on social-work practice in the health-care system to be held in the Teaching Auditorium, New Hyde Park, New York. "...