Twenty-seven years ago, Heusner reviewer 20 patients with spinal epidural infections treated between 1930 and 1948.¹ His plea for celerity in diagnosis before the onset of serious neurologic deficit was clearly stated. Subsequent publications on spinal ...

IDIOPATHIC lactic acidosis (Huckabee's Group 2B), a rare clinical entity of uncertain origin and pathogenesis, is an almost uniformly fatal disorder.^{1 2 3 4 5} The administration of sodium bicarbonate to reverse the acidemia and of methylene blue to aid in ...

THE development of gram-negative bacillary pneumonia in a critically ill patient is a serious complication associated with a high mortality rate. During the first 2 1/2 years of operation of our respiratory-surgical intensive-care unit the mortality rate ...

IN the course of studying the metabolic effects of somatostatin (somatotrophin-release inhibiting factor) in baboons^{1 2 3 4 5} we noted the possible association of excess mortality and accompanying pulmonary hemorrhage. The impression that a hemostatic ...

SOMATOSTATIN is a hypothalamic peptide that inhibits the release of human growth hormone,¹ thyrotropin,² and, under certain conditions, prolactin and adrenocorticotropin³ from the pituitary. In addition, it is a potent inhibitor of human pancreatic ...

MYOGLOBINURIA is generally considered uncommon, although it has been reported in a wide variety of clinical conditions.¹ The potential for acute tubular necrosis and renal failure associated with myoglobinuria is widely recognized. However, little ...

THE Zollinger- Ellison syndrome¹ is a clinical entity^{2 3 4} associated with multiple endocrine adenomas.⁵ The purpose of this report is to present a case of the syndrome associated with a mucinous cystadenocarcinoma of the ovary containing a large quantity ...

ANTIHISTAMINIC-sympathomimetic drug combinations, widely used for symptomatic treatment of upper-respiratory-tract congestion, are considered to have few serious side effects. In the following cases persistent involuntary movements of the face and mouth ...

A finding of "mental illness" alone cannot justify a State's locking up a person against his will and keeping him indefinitely in simple custodial confinement. [Mr. Justice Stewart]

THE idea of a constitutional right to psychiatric treatment has been ...

MACROPHAGES participate in all types of inflammation and predominate as the inflammation resolves or becomes chronic. They are produced in the bone marrow, enter the bloodstream in a relatively immature state and emigrate into inflammatory sites, where, ...

Presentation of Case

First admission. A 40-year-old woman was admitted to the hospital because of a pericardial effusion.

She was well until eight days previously, when she had an attack of sharp anterior chest pain that was aggravated by respiration and ...

In evaluating the overall utility of a pharmacologic agent, safety rather than efficacy is often of primary concern. No one questions, for example, the sedative effects of certain tranquilizers, the hypotensive action of reserpine, or the stimulation ...

Measurement of delayed skin-test responses is a basic clinical procedure, originally used for identification of infection with microbial agents. More recently, skin testing with a battery of antigens has had wide application in the evaluation of cellular ...

Nearly 60 years ago, the Medical and Chirurgical Faculty of Maryland was issued a warning strikingly relevant today:

With the appropriations for health insurance running into millions of dollars annually it goes without saying that legislative bodies will ...

IMPACT OF THE REGULATORY PROCESS ON MEDICAL PRACTICE IN MASSACHUSETTS*

The hospital licensure law enacted by the General Court of Massachusetts in 1941 was perhaps the first such legislation in the entire country. The framers of the law were convinced ...

To the Editor: Recent findings of reduced levels of y-aminobutyric acid (GABA) and of its synthesizing enzyme, glutamic acid decarboxylase, in autopsied brains of patients with Huntington's disease^{1 2 3} suggest that drugs that facilitate GABA-mediated ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The editorial on more blood for the anticoagulant battle¹ interested me because I had the opportunity, so to speak, to be present at the inception of oral anticoagulants. In a recent editorial Dr. Rosemary Biggs² writes, "Throughout all of ...

No extract is available for articles shorter than 400 words.

To the Editor: The issues raised by Ms. Franzke in her letter advocating the disclosure of karyotype information to the parents of XYY sons (N Engl J Med 293:100, 1975) contradict both published reports and our own experience. Though this area has been ...

To the Editor: I take issue with the blanket statement of the Boston Interhospital Virus Study Group and the NIAID-sponsored associates(N Engl J Med 292:1355, 1975)that "...potentially toxic drugs of unproved efficacy must be evaluated by means of ...

To the Editor: The recent article, "Role of Behavior Modification in Preventive Medicine," by Pomerleau et al. (N Engl J Med 292:24, 1975), although praiseworthy in its view that health practices in Western industrial nations must change if a significant ...

No extract is available for articles shorter than 400 words.

To the Editor: As a pediatrician serving with the American forces in Europe, I really had to laugh when I came across a full-page advertisement for Air Force career physicians in my recent issue of the Journal. It never ceases to amaze me how flagrant a ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This book, despite the inclusive title and 37 respected contributors, is not encyclopedic in its approach to cancer epidemiology or prevention. The concepts reviewed are not novel to those conversant in detail with the various fields presented. However, ...

This much needed volume fills a void of at least eight years' standing in the current obstetric and gynecologic and surgical literature. In-depth discussion of many diseases complicating pregnancy as well as complications of pregnancy are discussed by ...

This manual from Charity Hospital in New Orleans will interest most pediatric house officers as the newest in pocket references. The foreword characterizes the book as unique. "It combines the day to day experiences of the enthusiastic young house officer,...

The busy doctor who wants to understand, without excessive expenditure of time or labor, the theories and methods of the new breed of economists and other social scientists who have lately invaded the field of health care could do no better than tackle ...

GRADUATE STUDIES IN HEALTH CARE ORGANIZATION

The Department of Health Care Organization at Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, announces the availability of individualized graduate programs in organization, ...