PROGERIA is a rare disease, initially manifested during infancy as severe stunting of growth, followed by the appearance of premature and accelerated aging.^{1 , 2} Current evidence suggests that it may be inherited as an autosomal recessive condition. ...

THE measurement of platelet life-span has provided the investigator with facts concerning the physiologic processes underlying platelet destruction and has served as a valuable aid to the clinician in defining the nature of the pathologic process in ...

SEVERAL steroids with anabolic and progestational activity have been shown to lower plasma triglyceride levels in normal and hypertriglyceridemic subjects.^{1 2 3 4 5} The mechanism of this effect is not clear, but attention has been called to an increase in ...

A SEPARATION of careers into community-oriented primary and continuing care of ambulatory patients and hospital-based intensive care of acutely ill patients in bed is logical. It is, perhaps, a little recognized factor in the natural evolution of health-...

(First of Two Parts)

Chemistry and Physiology

Historical

WHEN Bayliss and Starling¹ discovered secretin in 1902, they quickly saw that they had uncovered not just a new substance but a new concept with broad biologic implications. They regarded secretin ...

IN view of man's evolutionary origins, it is clear that our ancestors who emerged from the sodium-rich environment of the oceans to dry land had to develop a mechanism to control internal salinity. Different species have developed different modes for ...

Presentation of Case

A 53-year-old man was admitted to the hospital because of chest pain.

He was well until four weeks earlier, when he began to experience bouts of substernal pressure that usually followed exertion and subsided in two or three minutes. ...

There is now available a bewildering array of platelet-function studies to further bedevil the many clinicians who struggle to understand hemostasis and thrombosis. Platelet aggregation, glass-bead retention, determination of ¹⁴C-serotonin release, assay ...

A heterogeneous group of enzymes, including hepatic and extrahepatic lipases, monoglyceride hydrolase, and phospholipase, are released into plasma after heparin injection, and may function in clearance of plasma triglycerides, which are transported by ...

Underlying the methods most widely advocated at present for implementation of patient-care-evaluation studies is the assumption that medical practice is best assessed in relation to a diagnosis and to the processes deemed appropriate to the diagnosis.

The ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In recent studies (supported by NIH contract NO1-AM-4–2219) to evaluate the biocompatibility of materials used in hemodialysis, an isolated, perfused rabbit-heart preparation has been included as one of the test procedures. Previously, ...

No extract is available for articles shorter than 400 words.

To the Editor: I should like to comment on the paper, "Politics in the Development of a Migrant Health Center" (N Engl J Med 292:890–895, 1975), by Dans and Johnson. We have an identical program established in late 1972 with an H.E.W. Migrant Grant in ...

To the Editor: The opinions expressed recently by Dr. O'Brien in the interesting correspondence concerning the merits of the British NHS (N Engl J Med 292:1036, 1975) deserve some not-unbiased criticism. Despite his professed experience under both ...

No extract is available for articles shorter than 400 words.

PATHOLOGY IN PEDIATRICS

A postgraduate course entitled "Pathology in Pediatrics" will be held at the Given Institute of Pathobiology, Aspen, Colorado, August 28–31. The course will emphasize recent advances in pediatric pathology and their application to ...