CONGENITAL disorders caused by defects in each of the five enzymes of the Krebs-Henseleit urea cycle have been described.¹ The clinical and biochemical manifestations differ somewhat among these syndromes, but all are characterized by hyperammonemia, ...

THE finding of microangiopathic hemolytic anemia, thrombocytopenia and renal failure, (hemolyticurcmic syndrome) in the three siblings described below stimulated a study of kindreds with sibling involvement. This analysis of 41 families in whom two or ...

Haemophilus influenzae Type b (HITB) is the leading cause of endemic bacterial meningitis and the etiologic agent of other serious diseases in the United States and other countries.^{1 2 3 4 5 6} Attempts at preventive immunization with purified HITB ...

THE biochemical methods for the study of certain abnormalities of hemoglobin synthesis in the fetus are now available. Abnormalities that have been detected in early and mid-trimester fetuses include sickle-cell trait, sickle-cell-β thalassemia, α-...

INDWELLING arterial catheters are being used with increasing frequency in the management of acutely ill patients in intensive-care units. Their use offers several advantages, including accurate blood-pressure monitoring, readily obtainable arterial-blood ...

MORPHINE is a clinically important drug with major applications as an analgesic and in the treatment of acute pulmonary edema. It is also a potent respiratory depressant, this being one of its most important side effects, but the mechanism of this ...

(First of Two Parts)

THE emergence of oncology as a medical subspecialty has been closely allied to the development of effective antineoplastic chemotherapy. Basic research into tumor-cell biochemistry and the effects of various antitumor agents have ...

NEWBORN intensive-care units have made great strides in treatment of premature infants with respiratory-distress syndrome. Although many such infants can adequately be handled by pediatricians in intermediate-care nurseries, transfer of certain infants ...

EXACERBATIONS of acute intermittent porphyria are provoked by many commonly used drugs known to stimulate hepatic porphyrin-heme synthesis. In the patient described below, surreptitious ingestion of a seemingly innocuous agent — a mouthwash preparation — ...

CANNULA-related sepsis is acknowledged to be a major complication of intravenous therapy¹; the risk appears highest with plastic catheters. Catheter-associated sepsis usually responds rapidly to removal of the catheter.¹ In contrast, suppurative phlebitis ...

Presentation of Case

A 40-year-old man was admitted to the hospital because of dermatitis and weight loss.

He was well until two years previously, when he began to limit his caloric intake to lose weight. After losing the desired 10 kg he resumed his ...

The attenuated microbes used as vaccines have been derivatives or close relatives of the virulent organism, retaining enough immunologic similarity to induce specific immunity. Schneerson and Robbins, in this issue of the Journal, describe an interesting ...

Prenatal diagnosis of severe genetic disorders, such as Down's syndrome and Tay-Sachs disease, has helped many couples at high risk of conceiving a defective child to have normal children. These diagnoses have depended upon ability to obtain amniotic ...

Three years ago, this journal published a widely noted article, "Iatrogenic Problems in End-Stage Renal Failure," by Chad H. Calland, M.D. Dr. Calland related his own experience of chronic renal failure, dialysis and five kidney transplants. "As physician-...

Rocky Mountain spotted fever has three salient and disturbing features: the incidence of reported cases has risen dramatically since the late 1960's (Fig. 1); the disease might more logically be called "Non-Rocky Mountain spotted fever" or "Eastern ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: "It is the policy of the Department of Army to make a sustained effort to prevent alcohol abuse, alcoholism, and abuse of and dependency on other drugs..."¹ As with the implementation of any public-health program, the effect of the alcohol ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

DESENSITIZATION TRAINING FOR ADDICTS

A course entitled "Desensitization Training for Drug Abuse Addicts" will be given in the Teaching Center Auditorium, Long Island Jewish-Hillside Medical Center, New Hyde Park, New York, on Tuesday, June 3, from 10 a.m. ...

An enduring quality of the public process in Washington is its incapacity for focusing on matters that occupy the broad range between cosmic catastrophe and inconsequential trivia.

The fall of Saigon or a senator's carping at a bit of research money for ...