THE classic form of Tay—Sachs disease and a variant form, named Sandhoff's disease, are characterized by the accumulation of gangliosideG_M2. In the two disorders there is a strongly diminished activity of lysosomal N-acetyl-β-hexosaminidase, which ...

BENIGN cystic teratomas (dermoid cysts) of the human ovary are composed of mature histologic structures of ectodermal, mesodermal and endodermal origin. Generally, they contain a cyst filled with sebaceous material, desquamated squamous cells and hair. ...

OF the therapeutic programs for hypertension currently in use, diuretic agents serve as the cornerstone of most regimens. They are often used as the sole therapy in patients with mild hypertension or with other antihypertensive drugs in patients whose ...

THE role of the thymus in the development of competent cellular immunity has been established by studies of animals¹ and man.^{2 , 3} Both cellular and humoral factors appear important. Studies in animals, thymectomized at birth and then reconstituted ...

THE medical literature has increasingly dealt with the utility and versatility of prenatal diagnosis for the detection of a variety of inborn errors of metabolism,^{1 2 3 4 5 6} chromosomal abnormalities and variants^{7 8 9 10 11 12} and polygenic conditions (...

THE distinction between active and passive euthanasia is thought to be crucial for medical ethics. The idea is that it is permissible, at least in some cases, to withhold treatment and allow a patient to die, but it is never permissible to take any direct ...

(First of Two Parts)

THE pioneering work of Verney and his co-workers¹ defined a very delicate mechanism that maintains the constancy of the osmotic pressure of body fluids by regulating the release of vasopressin. These investigators clearly showed that ...

THE conventional approach to the differential diagnosis of oliguria (50 to 400 ml of urine per day) focuses first on establishing the anatomic location of the initiating disturbance. Within this framework, the causes of acute oliguria can be grouped into ...

ELECTRON microscopy has only recently been applied to "idiopathic" interstitial pulmonary reactions. In 1971, we described a patient with interstitial granulomas and fibrosis indistinguishable from sarcoidosis.¹ A history of occupational exposure impelled ...

THE brightest and most optimistic of my presentiments about the future of human health always seems to arouse a curious mixture of resentment and dismay among some very intelligent listeners. It is as though I'd said something bad about the future. ...

Presentation of Case

An 81-year-old man was admitted to the hospital because of arthritis.

Twenty-two years previously he was evaluated elsewhere because of weakness, and the diagnoses of pernicious anemia and hypothyroidism were made. The 24-hour ...

Benign cystic teratomas of the ovary, the so-called dermoid cysts of the ovary, are the most common type of teratoma. They occur in women during the years of active ovulation, a fact that has suggested that these tumors might arise from a meiotic cell. ...

Complete acceptance of transplanted organs can easily be accomplished without the need for immunosuppression in patients who lack a thymus gland. In these cases, then, the defect allows a simple cure. It was predicted in 1968 that isolated thymic (T-cell) ...

There is clearly more to the pathogenesis of coronary heart disease in all its manifestations than just fatty arteries, but if we assume the validity of the general relation of the disease to atherosclerosis where do we stand with respect to its ...

JOSEPH TARTAKOFF, M.D.

Dr. Joseph Tartakoff, the teacher, scholar, humanitarian, surgeon who marshaled the friends and staff of the Mount Auburn Hospital in the development of the presently modernized Cambridge teaching medical center, died on June 23, ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Van Slyck, Waldmann and Rebuck, in their letter to the Editor (N Engl J Med 291:261, 1974), noted characteristic Prussian-blue-positive cells¹ in an adult with Gaucher's disease despite severe iron deficiency secondary to a bleeding ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: My weekly delight with the general excellence of the Journal has been shattered just as frequently by the phrase, "X???, before reproduction" (the?'s represent digits), in the captions of micrographs. The folly and danger of this practice ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

LATIN AMERICAN MEDICAL SOCIETY

The Latin American Medical Society will hold its first annual meeting, in the Minot Room of the Countway Library, 10 Shattuck Street, Boston, on Wednesday, January 15, at 7 p.m.

Further information may be obtained from Dr. ...