THE high morbidity and mortality of herpes simplex virus encephalitis^{1 2 3} has prompted many attempts to develop a successful form of therapy.^{4 5 6 7 8 9 10 11 12} During the past decade, therapeutic approaches have involved the use of inhibitors of ...

AN estimated 16 million Americans have gallstones, 85 per cent of which are composed predominantly of cholesterol. A prerequisite for the formation of cholesterol gallstones is saturated bile containing insufficient bile acid and lecithin in proportion to ...

COXSACKIEVIRUS myositis is well recognized in experimental pathology of mice,^{1 , 2} but its human counterpart is only infrequently documented. In 1952, Freudenberg et al.³ isolated coxsackievirus from the muscle of an infant with congenital myositis. With ...

INFANTS who are small for gestational age have a higher incidence of neonatal hypoglycemia.^{1 , 2} The predisposition to hypoglycemia is generally attributed to decreased hepatic glycogen reserve,^{3 , 4} although data in human⁵ and in animal models⁶ have ...

HOSPITAL outpatient departments today face growing demands for service. Since 1954, the number of outpatient visits has tripled, far exceeding the rate of growth in population and the general increase in visits to physicians. In 1970 there were 180 ...

THE nearly universal association of Epstein–Barr virus (EBV) with African Burkitt's lymphoma has been established by serologic procedures,¹ demonstration of viral DNA in tumor biopsies by nucleic acid hybridization technics^{2 3 4 5} and detection of EBV-...

THE use of aerosols containing fluorocarbons has been implicated as being responsible for deaths in specific environmental exposures. Excess mortality in asthmatic children and young adults in England and Wales was associated with the use of fluorocarbon-...

COMPOUNDS that inhibit the enzyme, xanthine oxidase, are useful in the treatment of disorders of purine metabolism. They are of particular value in disorders resulting from the overproduction of uric acid. Xanthine oxidase is inhibited by both allopurinol ...

ROUTINE oral cholecystography consists of one-day application of 3 g (6 tablets) of iopanoic acid.* Twenty-five to 30 per cent of these patients, however, require another dose of 3 g of contrast medium on the following day because of poor or no ...

THE purpose of this presentation is to discuss the mechanisms of anergy, defined here as a patient's failure to react to skin tests to which he has previously reacted. Anergy is differentiated from tolerance in that anergy is nonspecific, is usually ...

Presentation of Case

A 17-month-old boy was admitted to the hospital because of respiratory difficulty.

He had experienced four attacks of otitis media, two episodes of bronchitis and one of croup. During the two months before admission he lost 0.5 kg in ...

Polymyositis and dermatomyositis are acute or chronic diseases of human beings that may occur at any age and may follow either an acute or a clinically indolent course. The principal clinical feature is proximal muscle weakness involving the upper and ...

Delivery, among other things, entails a sudden cutoff of a steady flow of nutrients. The newborn has now to fend for itself until an adequate food supply is once again established. The sequence of events envisaged at present is as follows: a decrease in ...

For a number of years, I had disability insurance that included a $20-a-day item to help defray hospitalization costs. The insurance, originally sponsored by the Massachusetts Medical Society, was underwritten by Lumbermens Mutual Casualty Insurance ...

LAWRENCE R. DAME, M.D.

Lawrence Raymond Dame died in August, 1974, while on a camping trip with his family in Wisconsin, a victim of (as far as is known) his first coronary attack. Thus ended a long and productive career in medicine and community life. ...

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To the Editor: We recently treated a physician in whom Rocky Mountain spotted fever developed, and who had no recent history of tick bite, tick contact or contact with dogs. Circumstantial evidence indicated that he had acquired his infection through an ...

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Therapeutic innovation — the trial of new drugs, operations or medical procedures — involves many difficult decisions, both technical in nature, and human or emotional. It is a feature of medical life that must be nurtured, cherished, supported and made ...

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The emergence of progressive subclassifications of the causes of scoliosis represents a great advance in the understanding of this spinal deformity. Thirteen authors, outstanding in the fields of neurology, orthopedic surgery and anesthesiology, with the ...

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COURSE IN OPHTHALMOLOGIC SURGERY

"Trauma Surgery for the Practicing Ophthalmologist," a postgraduate course sponsored by the Oculoplastic Department of Wills Eye Hospital, Philadelphia, will be given at the Bellevue Stratford Hotel, Philadelphia, on April ...