Join the 200th Anniversary Celebration

Follow Topic:

SpecialtySurgery

Ulipristal Acetate vs. Placebo for Fibroids
original article

In this trial involving women with symptomatic fibroids who were planning to undergo surgery, treatment with the selective progesterone-receptor modulator ulipristal acetate was effective in controlling excessive bleeding and reducing fibroid size at 13 weeks.

Related Editorial

Deep Sulcus Sign
images in clinical medicine

A 23-year-old man who had been a passenger in a minivan was brought to the ER after a high-speed road accident. He had transient hypotension and tachycardia, which improved after the administration of intravenous fluids.

  • Free Full Text

Interactive Feature

A Problem in Gestation
Interactive Medical Case

This interactive feature presents the case of a 39-year-old woman at 32 weeks of gestation with lower and middle back pain that radiated to the upper abdomen and episodes of vomiting.

Direct the investigation of the case, test your diagnostic and therapeutic skills, and compare your performance with that of others.

Ulipristal Acetate vs. Leuprolide Acetate for Fibroids
original article

In this trial comparing oral ulipristal acetate (5 mg or 10 mg daily) with once-monthly leuprolide acetate in women with symptomatic uterine fibroids before planned surgery, both doses of ulipristal acetate were noninferior to leuprolide acetate in controlling uterine bleeding.

  • CME

Related Editorial

correspondence

In this case report, Staphylococcus aureus was found to persist in an 85-year-old woman 75 years after the successful treatment of osteomyelitis during her childhood.

  • Free Full Text
original article

According to Rachet, Küssmaul in 1868 was the first to practice gastroscopy, the subject of his experiment having been a professional sword-swallower. In 1933, a Wolf-Schindler flexible gastroscope was used in 75 patients without ill effect in any way, and was helpful in gastritis, gastric ulcer, and benign and malignant tumors of the stomach.

More Archive Articles

Featured Multimedia

Showing 1 to 20 of 581 Articles

Sort By:

  • Images in Clinical Medicine

    Figure 1.

    • February 9, 2012
    • Sabbar S. and Nilles E.J.
    • N Engl J Med 2012; 366:552
    • Free Full Text

    A 23-year-old man who been a passenger in a minivan was brought to the ER after a high-speed road accident. He had transient hypotension and tachycardia, which improved after the administration of intravenous fluids.

  • Images in Clinical Medicine

    Figure 1.

    • February 2, 2012
    • Diabira S. and Morandi X.
    • N Engl J Med 2012; 366:462
    • Free Full Text

    An 18-year-old man with no notable medical history had sudden transient tetraplegia after heading a soccer ball. Ten minutes later, he had recovered normal strength. On examination, he had intense cervical pain, paresthesias on his shoulders and arms, and no other neurologic deficits.

  • Original Article

    Uterine leiomyomas, or fibroids, are benign, hormone-sensitive, smooth-muscle tumors that occur in 20 to 40% of women of reproductive age. The most common symptoms are menorrhagia and iron-deficiency anemia, which may lead to chronic fatigue that may not be adequately controlled with iron…

    • February 2, 2012
    • Donnez J., Tatarchuk T.F., Bouchard P., et al.
    • N Engl J Med 2012; 366:409 - 420

      In this trial involving women with symptomatic fibroids who were planning to undergo surgery, treatment with the selective progesterone-receptor modulator ulipristal acetate was effective in controlling excessive bleeding and reducing fibroid size at 13 weeks.

    • Editorial

      The 2011 report from the Agency for Healthcare Research and Quality on comparative management of uterine fibroids noted, "Despite the prevalence and possible complications of uterine fibroids, few published studies examining the effectiveness of treatment strategies exist." Few therapies are…

      • February 2, 2012
      • Stewart E.A.
      • N Engl J Med 2012; 366:471 - 473

        The 2011 report from the Agency for Healthcare Research and Quality on comparative management of uterine fibroids noted, “Despite the prevalence and possible complications of uterine fibroids, few published studies examining the effectiveness of treatment ...

      • Correspondence

        To the Editor: In 1934, a 10-year-old girl was hospitalized at the Children's Hospital of Boston for 1 1/2 years for Staphylococcus aureus osteomyelitis of the left femur. This was the preantibiotic era, so she did not receive any antibiotic therapy at that time but, instead, underwent multiple…

        • February 2, 2012
        • N Engl J Med 2012; 366:481 - 482
        • Free Full Text

        In this case report, Staphylococcus aureus was found to persist in an 85-year-old woman 75 years after the successful treatment of osteomyelitis during her childhood.

      • Original Article

        Uterine leiomyomas, or fibroids, are the most common benign uterine tumors in women of reproductive age. In addition to anemia caused by heavy bleeding, fibroids can cause pelvic pain, pressure, dysmenorrhea, reduced quality of life, and infertility. Current management strategies consist mainly of…

        • February 2, 2012
        • Donnez J., Tomaszewski J., Vázquez F., et al.
        • N Engl J Med 2012; 366:421 - 432
        • CME

        In this trial comparing oral ulipristal acetate (5 mg or 10 mg daily) with once-monthly leuprolide acetate in women with symptomatic uterine fibroids before planned surgery, both doses of ulipristal acetate were noninferior to leuprolide acetate in controlling uterine bleeding.

      • Correspondence

        To the Editor: Lymphatic malformations are uncommon congenital vascular anomalies that can cause complications including obstruction of vital organs and their function, recurrent infection, and disfigurement. Current procedural treatments are only partially successful, and lymphatic malformations…

        • January 26, 2012
        • N Engl J Med 2012; 366:384 - 386
        • Free Full Text

        Lymphatic malformations are rare but can cause significant clinical problems in addition to cosmetic disfigurement. Sildenafil was used in a child whose pulmonary hypertension was caused by lymphatic malformation; the result was a marked decrease in the lymphatic malformation.

      • Images in Clinical Medicine

        Figure 1.

        • January 26, 2012
        • Chu H. and Chung W.-H.
        • N Engl J Med 2012; 366:e8
        • Free Full Text
        • Video

        A 42-year-old man presented with severe nausea and vertigo, which were precipitated by the application of pressure just anterior to the left external auditory canal. Otoscopic examination revealed a cholesteatoma arising from the pars flaccida of the left tympanic membrane.

      • Case Records of the Massachusetts General Hospital

        Presentation of Case. Dr. Rebecca C. Bell (Pediatrics): A 6-day-old boy was admitted to this hospital because of vomiting, diarrhea, and abdominal distention. The patient was born at another hospital to a teenaged primigravida by vaginal delivery after a full-term, uncomplicated gestation. The…

        • January 26, 2012
        • Melendez E., Goldstein A.M., Sagar P., Badizadegan K.
        • N Engl J Med 2012; 366:361 - 372

          A 6-day-old boy was admitted to the hospital because of vomiting, diarrhea, and abdominal distention, which had begun earlier that day and worsened. On admission, he showed signs of sepsis. Imaging showed narrowing of the rectosigmoid colon.

        • Case Records of the Massachusetts General Hospital

          Presentation of Case. Dr. Susan K. Mathai (Internal Medicine): A 63-year-old woman was admitted to this hospital because of rapidly progressive respiratory failure. The patient had a history of Poland syndrome (agenesis of the right breast, pectoralis muscle, and the third and fourth costal…

          • January 19, 2012
          • Kotton D.N., Muse V.V., Nishino M.
          • N Engl J Med 2012; 366:259 - 269

            A 63-year-old woman was admitted to the hospital because of respiratory failure. She had a history of granulomatous polyangiitis and a breast implant that had recently become painful. Imaging revealed bilateral pulmonary infiltrates and a soft-tissue mass extending from the implant through the chest wall.

          • Review Article

            Patients referred for coronary revascularization procedures are older and are likely to have more extensive extracardiac vascular disease than those referred for such procedures in the past. Despite these trends, mortality rates for coronary-artery bypass grafting (CABG), without concurrent…

            • January 19, 2012
            • Selnes O.A., Gottesman R.F., Grega M.A., et al.
            • N Engl J Med 2012; 366:250 - 257
            • CME

            For patients undergoing coronary-artery bypass grafting (CABG), adverse neurologic outcomes, including stroke and cognitive decline, are major concerns. Even mild cognitive deficits before surgery may be a marker for cerebrovascular disease and increased risk.

          • Correspondence

            To the Editor: Patients with hemophilia A (a deficiency of factor VIII [FVIII]) have spontaneous bleeding because of abnormal thrombin generation, which results in the formation of weak, unstable clots. The formation of these weak clots is also the result of delayed and reduced activation of…

            • January 19, 2012
            • N Engl J Med 2012; 366:281 - 283
            • Free Full Text

            One facet of the clotting abnormality in factor VIII deficiency is clot instability. Factor XIII stabilizes clots. The authors show that augmenting factor XIII levels can stabilize clot formation even when factor VIII levels are low.

          • Images in Clinical Medicine

            Figure 1.

            • January 19, 2012
            • Tourtier J.-P. and Cottez S.
            • N Engl J Med 2012; 366:258
            • Free Full Text

            A 61-year-old man with spinal cord compression underwent therapeutic laminectomy of the fifth vertebra and laminectomy and vertebroplasty of the fourth vertebra. During the vertebroplasty, polymethylmethacrylate cement leaked into the paravertebral vascular system.

          • Images in Clinical Medicine

            Figure 1.

            • January 12, 2012
            • Senguttuvan N.B. and Karthikeyan G.
            • N Engl J Med 2012; 366:e5
            • Free Full Text
            • Video

            An 18-year-old man presented with a history of progressive anasarca and exertional dyspnea. His jugular venous pressure was elevated and showed prominent systolic pulsations that were eliminated when gentle pressure was applied at the base of the neck.

          • Correspondence

            To the Editor: Regular exercise reduces the incidence of coronary atherosclerotic disease and decreases mortality after myocardial infarction, but vigorous activity increases the risk of myocardial infarction and sudden death among patients with occult and diagnosed coronary artery disease. We…

            • January 12, 2012
            • N Engl J Med 2012; 366:184 - 185
            • Free Full Text

            Three well-conditioned men who ran the 2011 Boston Marathon had acute coronary thrombosis shortly after completing the marathon. The authors discuss possible explanations for the occurrence of coronary thrombosis after prolonged exertion.

          • Clinical Practice

            Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations. Stage. A 36-year-old…

            • January 12, 2012
            • Jemec G.B.E.
            • N Engl J Med 2012; 366:158 - 164
            • CME

            Hidradenitis suppurativa, a chronic inflammatory disease of apocrine gland–bearing skin, is characterized by recurrent nodules, sinus tracts, and abscesses. Possible treatment approaches are reviewed, as are the few randomized trials and the limitations of available data.

          • Images in Clinical Medicine

            Figure 1.

            • January 5, 2012
            • Pickert A.J. and Nguyen X.
            • N Engl J Med 2012; 366:e2
            • Free Full Text

            A woman was referred to the dermatology department for evaluation of swelling and nodules in the right foot, which had been present for 11 years. The nodules were painful, drained material periodically, and made weight-bearing difficult.

          • Images in Clinical Medicine

            Figure 1.

            • January 5, 2012
            • O'Shea M. and Cleasby M.
            • N Engl J Med 2012; 366:74
            • Free Full Text

            A 40-year-old woman with asthma presented with pleuritic chest pain of acute onset. She had been coughing markedly for 2 weeks and had been treated with antibiotics for a lower respiratory tract infection. There was no history of trauma.

          • Perspective

            This interactive timeline represents all the research and review articles and case reports published in the New England Journal of Medicine from 1812 to 2012. The expanding navigation panel at the top of the timeline is an overview of the 200 years, with articles color-coded by medical specialty.…

            • January 5, 2012
            • Müller D.C., Duff E.M.C., Stern K.L.
            • N Engl J Med 2012; 366:e3
            • Free Full Text
            • Interactive/Multimedia

            This interactive timeline represents all the research and review articles and case reports published in the New England Journal of Medicine from 1812 to 2012. The expanding navigation panel at the top of the timeline is an overview of the 200 years, with ...

          • Review Article

            The remarkable facts, that the paroxysm, or indeed the disease itself, is excited more especially upon walking up hill, and after a meal; that thus excited, it is accompanied with a sensation, which threatens instant death if the motion is persisted in; and, that on stopping, the distress…

            • January 5, 2012
            • Nabel E.G. and Braunwald E.
            • N Engl J Med 2012; 366:54 - 63
            • Free Full Text

            In this review of heart disease, Nabel and Braunwald focus on two themes — coronary artery disease and myocardial infarction — and explain how our understanding has evolved over the past two centuries. The authors consider therapies that have led to improved survival.

          Page

          Medical Meetings Surgery Conferences and Meetings

          75th Annual University of Minnesota Colon and Rectal Surgery Current Principles & Practice

          The course will be offered in Minneapolis, Oct. 24-27.

          Contact Colleen Jensen, Colon & Rectal Surgery Principles Course, P.O. Box 314, Lakeland, MN 55043; or call (612) 670-7810; or fax (612) 677-3200; or e-mail info@colonrectalcourse.org; or see http://www.colonrectalcourse.org .

          More Medical Meetings

          Trends: Most Viewed (Last Week)

          More Trends