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Campion EW
... Journal, including review articles, for all issues since 1993. Additional features for subscribers are a full-text search capacity and a personal archive for saving articles and search results of interest. Using free software, subscribers can download articles and print them out in a format that is virtually ...
N Engl J Med 339:629, August 27, 1998 Editorial
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Phimister EG
Human immunodeficiency virus type 1 (HIV-1) is notorious for its ability to evade the immune system. A recent study by Kwong and colleagues 1 has uncovered a new molecular mechanism of antibody evasion that points toward a better strategy for the development of a vaccine. The authors explored the ...
N Engl J Med 348:643, February 13, 2003 Clinical Implications of Basic Research
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Carapetis JR
... topic in the Journal. A PubMed search for articles on rheumatic fever published between 1967 and 1976 returned 55 New England Journal of Medicine articles — fewer than for endocarditis (77) but more than for stroke and syphilis (24 entries each). A similar PubMed search for the decade 1997 through 2006 ...
N Engl J Med 357:439, August 2, 2007 Perspective
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Rother KI
... Publilius Syrus declared, “Better use medicines at the outset than at the last moment.” His recommendation may serve as a motto for our continued search for an optimal remedy for diabetes.
N Engl J Med 356:1499, April 12, 2007 Perspective
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Malloy MH
... of SIDS is not all that remains unknown about this syndrome. A clearer, more identifiable presentation and a more precise definition would also be helpful. In the meantime, one hopes that as death-scene investigations and autopsy procedures become more thorough and widespread, the number of infant deaths ...
N Engl J Med 351:957, September 2, 2004 Perspective
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Drazen JM
... problem, I could not find a true solution to it. In medical school, I was lucky enough to study with a professor of physiology who taught me that the search for truth meant accumulating an understanding that would let one reason from observations to root causes. All these teachers were nurturing in that ...
N Engl J Med 355:1374, September 28, 2006 Editorial
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Litvin CB
... ventilated patient to the CT scanner for new views of his brain. These days, we can find the answer to almost any question immediately by doing a Google search, but unfathomably, it is still not possible for a physician in Manhattan to obtain a timely report of a study performed in another New York borough ...
N Engl J Med 356:2454, June 14, 2007 Perspective
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Lindberg DAB, Sack J, Steinbrook R
... identify additional referrals from PubMed that were previously unattributable to that source. We can now show the portion of referrals from major search engines with more accuracy. Figure 1 shows the data for February 2006., Dr. Steinbrook replies: My article included incomplete data on referrals from ...
N Engl J Med 354:2393, June 1, 2006 Correspondence
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Taqueti VR
... furiously to maintain forward blood flow. Mr. Perez's blood pressure, at 110/40, was classic for a patient with chronic aortic insufficiency. Our team searched for physical findings associated with widened pulse pressure, careful not to appear too eager. At the attending's urging, we gathered around Mr. Perez's ...
N Engl J Med 357:213, July 19, 2007 Perspective
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Hunter DJ, Kraft P
... statistical techniques are adequate for the analysis and interpretation of these initial studies. But as we delve further into the genome in the search for networks of interacting gene variants and interactions between these networks and environmental factors, 5 much more sophisticated methods of statistical ...
N Engl J Med 357:436, August 2, 2007 Perspective
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Melton DA, Daley GQ, Jennings CG
... support the search for alternative methods to derive pluripotent human cells, but no such method currently exists. In our opinion, Hurlbut's proposal is a distraction from the central issue, which is whether it is morally justifiable to use preimplantation-stage human embryos in the search to understand ...
N Engl J Med 351:2791, December 30, 2004 Perspective
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Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, Konig IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H
... coronary artery disease to a similar extent in women and in men (Table 5 in the Supplementary Appendix). Candidate-Gene Analysis From a literature search, we identified 142 SNPs, in 91 candidate genes, that had been reported to be associated with coronary artery disease or myocardial infarction. Only ...
N Engl J Med 357:443, August 2, 2007 Original Article
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Lee TH
... , too, should go down this road. Those who examine it closely will quickly discover that the program is less about cardiac surgery than about the search for an alternative to traditional fee-for-service care. The basic concept is far from radical. The seven cardiac surgeons in the Geisinger delivery ...
N Engl J Med 357:531, August 9, 2007 Perspective
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Eremeeva ME, Gerns HL, Lydy SL, Goo JS, Ryan ET, Mathew SS, Ferraro MJ, Holden JM, Nicholson WL, Dasch GA, Koehler JE
... of the Supplementary Appendix), a finding that is consistent with the proposed criteria for a new bartonella species. 21 Searching with the use of the Basic Local Alignment Search Tool revealed that the 1439-bp fragment of the 16S-23S intergenic spacer region was most similar to that of the uncultured ...
N Engl J Med 356:2381, June 7, 2007 Original Article
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Maron BA, Haas TS, Maron BJ
... purposes. These cases were assembled prospectively and retrospectively and were identified from news-media accounts, personal communications, Internet searches, and the LexisNexis database. Detailed information was obtained by interviewing rescuers and witnesses, when possible. The victims ranged in age from ...
N Engl J Med 356:2655, June 21, 2007 Correspondence
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Salamon F, Hirsch R, Tur-Kaspa R, Kramer MR
In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors' commentary follows. A 58-year-old woman was hospitalized for the ...
N Engl J Med 354:957, March 2, 2006 Clinical Problem-Solving
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Schiffer CA
... her further treatment and, in particular, the advisability of allogeneic stem-cell transplantation. She has no siblings, and a preliminary computer search of the worldwide donor list suggests that there may be only one or two fully histocompatible donors. The Clinical Problem CML is a myeloproliferative ...
N Engl J Med 357:258, July 19, 2007 Clinical Therapeutics
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Nissen SE, Wolski K
Thiazolidinedione drugs are widely used to lower blood glucose levels in patients with type 2 diabetes mellitus. In the United States, three such agents have been introduced: troglitazone, which was removed from the market because of hepatotoxicity, and two currently available agents, rosiglitazone ...
N Engl J Med 356:2457, June 14, 2007 Original Article
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Laine C, Horton R, DeAngelis CD, Drazen JM, Frizelle FA, Godlee F, Haug C, Hebert PC, Kotzin S, Marusic A, Sahni P, Schroeder TV, Sox HC, Van Der Weyden MB, Verheugt FWA
... efforts, through the ICTRP, to develop a coordinated process for identifying, gathering, deduplicating, and searching trials from registries around the world, thus eventually providing a one-stop search portal for those seeking information about clinical trials. In addition to the five existing registries ...
N Engl J Med 356:2734, June 28, 2007 Editorial
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Kyle RA, Remstein ED, Therneau TM, Dispenzieri A, Kurtin PJ, Hodnefield JM, Larson DR, Plevak MF, Jelinek DF, Fonseca R, Melton LJ 3rd, Rajkumar SV
... protein level of 3 g per deciliter or more. Methods Study Cohort After the study was approved by the Mayo Clinic's institutional review board, we searched a computerized database and reviewed the medical records of all patients who had been seen at the Mayo Clinic within 30 days after detection of an ...
N Engl J Med 356:2582, June 21, 2007 Original Article
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