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  • Perspective

    Few factors influence health care standards in the United States today more than the actions of the Joint Commission (formerly the Joint Commission on Accreditation of Healthcare Organizations). And few opportunities hold more promise for increasing the rate of tobacco-use cessation than patient…

    • March 29, 2012
    • Fiore M.C., Goplerud E., Schroeder S.A.
    • N Engl J Med 2012; 366:1172-1174
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    • Audio

    Few factors influence health care standards in the United States today more than the actions of the Joint Commission (formerly the Joint Commission on Accreditation of Healthcare Organizations). And few opportunities hold more promise for increasing the ...

  • Perspective

    There are two principal causes of elephantiasis, or lymphedema, in the tropics. The most common cause and a significant public health problem is lymphatic filariasis due to the parasitic nematode Wuchereria bancrofti (and, in Asia, Brugia malayi and B. timori), which is transmitted by mosquitoes.…

    • March 29, 2012
    • Molyneux D.H.
    • N Engl J Med 2012; 366:1169-1171

      Lymphedema in the tropics has two main causes: lymphatic filariasis caused by the parasitic nematode Wuchereria bancrofti, transmitted by mosquitoes, and podoconiosis, caused by microsilica particles from red-clay volcanic soil that enter the skin of the feet.

    • Case Records of the Massachusetts General Hospital

      Presentation of Case. Dr. Jacob Soumerai (Internal Medicine): A 53-year-old man with Crohn's disease who was receiving immunosuppressive therapy was admitted to this hospital because of diarrhea, fever, and bacteremia. The patient had been in his usual state of health until 2 days before admission,…

      • March 15, 2012
      • Hohmann E.L. and Kim J.
      • N Engl J Med 2012; 366:1039-1045
      • CME

      A 53-year-old man with Crohn's disease receiving immunosuppressive therapy was admitted to the hospital because of diarrhea, fever, and bacteremia. A diagnostic test result was received.

    • Perspective

      On August 31, 2011, a 24-year-old soldier from California died from complications of rabies treatment. He was infected months earlier, from a dog bite he sustained in Afghanistan. His death provides a glimpse of the risk of disease and non-battle injuries that service members face in war. Although…

      • February 23, 2012
      • Chretien J.-P.
      • N Engl J Med 2012; 366:677-679

        Although traumatic brain injury and traumatic amputations may be signature wounds of the Afghanistan and Iraq wars, the toll on military personnel from diseases and nonbattle injuries is substantial — and largely preventable. The critical element is command support.

      • Perspective

        It is time to sound the alarm. During the past 3 years, the wily gonococcus has become less susceptible to our last line of antimicrobial defense, threatening our ability to cure gonorrhea and prevent severe sequelae. Gonorrhea is the second most commonly reported communicable disease in the United…

        • February 9, 2012
        • Bolan G.A., Sparling P.F., Wasserheit J.N.
        • N Engl J Med 2012; 366:485-487

          Gonorrhea, which disproportionately affects marginalized populations, is the second most commonly reported communicable disease in the United States. Over the past 3 years, the gonococcus has shown decreased susceptibility to our last line of antimicrobial defense.

        • Perspective

          Faced with the growing pressure to reduce the federal budget deficit, government leaders have increasingly turned their attention to reducing health expenditures. In this atmosphere of austerity, public health programs are likely to be hit particularly hard as they compete for funds against the…

          • February 2, 2012
          • Stine N.W. and Chokshi D.A.
          • N Engl J Med 2012; 366:395-397
          • Free Full Text

          Government austerity is likely to hit public health programs hard, as these programs compete for funds against the health care delivery juggernaut. But such an approach seems likely to hamper efforts to improve population health and reduce medical spending.

        • Perspective

          Recently, the mother of a young child confessed to me that she didn't know any parents who were following the recommended immunization schedule for their children. She said that when she told her pediatrician she'd like to follow an alternative schedule, the physician had simply acquiesced, leading…

          • February 2, 2012
          • Diekema D.S.
          • N Engl J Med 2012; 366:391-393
          • Free Full Text

          U.S. parents who decline or delay selected vaccinations or refuse to vaccinate their children are a diverse group. Vaccine coverage can be increased by focusing on parents who encounter barriers to obtaining vaccines or hesitate because of fears about safety.

        • Perspective

          Recently, a well-respected dietary-supplement company in Utah announced the recall of Zotrex, a sexual enhancement supplement labeled as containing "Ophioglossum polyphyllous." The problem with Zotrex was twofold: not only is no species of ophioglossum (adder's tongue) an established dietary…

          • February 2, 2012
          • Cohen P.A.
          • N Engl J Med 2012; 366:389-391
          • Audio

          By law, dietary supplements whose ingredients were not sold in the United States before 1994 require demonstration of a “reasonable expectation of safety” — a currently unenforced requirement. Will the FDA's proposed new guidance in this area be adequate?

        • Perspective

          Clinical trials of implantable cardioverter–defibrillators (ICDs) continue to drive expanding indications for these devices. More than 100,000 ICDs are implanted in the United States annually. Of these procedures, at least 25% are generator replacements required as a result of depleted battery…

          • January 26, 2012
          • Kramer D.B., Buxton A.E., Zimetbaum P.J.
          • N Engl J Med 2012; 366:291-293
          • Free Full Text

          Of the 100,000-plus implantable cardioverter–defibrillators (ICDs) implanted in the United States annually, at least 25% are generator replacements required for depleted batteries. Should all those patients be receiving replacement ICDs?

        • Perspective

          When Artur, a former KGB agent in Ukraine, developed prostate cancer that metastasized to his bones, his pain grew so intense that he moved hours away from his family so they would not witness his suffering. "I don't want them to see me cry," he said. Lacking access to the opioid regimens that we…

          • January 19, 2012
          • Lamas D. and Rosenbaum L.
          • N Engl J Med 2012; 366:199-201
          • Free Full Text

          Whereas effective treatment for noncommunicable diseases may be too costly to disseminate globally, opioids for pain control are cheap to produce. Yet 80% of the population, including millions of patients with terminal cancer, lacks adequate access to pain treatment.

        • Perspective

          The magnitude of pain in the United States is astounding. More than 116 million Americans have pain that persists for weeks to years. The total financial costs of this epidemic are $560 billion to $635 billion per year, according to Relieving Pain in America, the recent report of an Institute of…

          • January 19, 2012
          • Pizzo P.A. and Clark N.M.
          • N Engl J Med 2012; 366:197-199

            An Institute of Medicine committee has found that the magnitude of pain in the United States is vast — and costly. It concluded that relieving acute and chronic pain is a significant overlooked problem and that education is key to the cultural transformation required.

          • Perspective

            On December 7, 2011, Health and Human Services (HHS) Secretary Kathleen Sebelius instructed Food and Drug Administration (FDA) Commissioner Margaret Hamburg not to approve the application for over-the-counter sales of Plan B One-Step, a single-dose emergency contraceptive. Dr. Hamburg issued her…

            • January 12, 2012
            • Wood A.J.J., Drazen J.M., Greene M.F.
            • N Engl J Med 2012; 366:101-102
            • Free Full Text

            On December 7, Health and Human Services Secretary Kathleen Sebelius overruled an FDA decision to approve over-the-counter sales of Plan B One-Step. Although the drug can be used safely without medical supervision, it apparently poses unacceptable political risks.

          • Correspondence

            To the Editor: Oseltamivir-resistant prepandemic seasonal influenza A (H1N1) viruses with a H275Y neuraminidase substitution spread globally in 2008, reducing the effectiveness of oseltamivir. Although oseltamivir-resistant pandemic 2009 A (H1N1) viruses, now known as A(H1N1)pdm09, have been…

            • December 29, 2011
            • N Engl J Med 2011; 365:2541-2542
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            Community circulation of an oseltamivir-resistant strain of the novel pandemic influenza A (H1N1) virus has been identified in Australia.

          • Perspective

            You might think Linda Ezekiel would always be in a hurry. As the first nephrologist in Tanzania, she started and now runs her country's only public-sector dialysis unit. She is currently spearheading Tanzania's first renal transplantation program. And she manages the postoperative care of 80…

            • December 22, 2011
            • Rosenbaum L. and Lamas D.
            • N Engl J Med 2011; 365:2345-2348

              In September, representatives from 192 countries met at a UN conference on noncommunicable diseases, turning international attention from the devastation wrought by well-known epidemics such as those of AIDS and malaria to a quieter, though no less dangerous, threat.

            • Perspective

              The World Health Organization (WHO) estimates that the world faces a shortage of 4.3 million health professionals required for delivering essential health care services to populations in need. This shortage constitutes a major barrier to the provision of essential lifesaving health services, such…

              • December 22, 2011
              • Taylor A.L., Hwenda L., Larsen B.-I., Daulaire N.
              • N Engl J Med 2011; 365:2348-2351
              • Free Full Text

              The world faces a shortage of about 4.3 million health professionals required for delivering essential services. The WHO Global Code of Practice on the International Recruitment of Health Personnel addresses the migration of health workers from lower-income countries.

            • Perspective

              Somalia has been in the grips of disaster for two decades. Throughout this past summer, the human catastrophe dramatically worsened. War and drought have driven hundreds of thousands of people from their homes in south and central Somalia, with some families walking for more than a week across the…

              • November 17, 2011
              • Cabrol J.-C.
              • N Engl J Med 2011; 365:1856-1858
              • Free Full Text
              • Slideshow

              Somalia has been in the grips of disaster for two decades. Throughout this past summer, the human catastrophe dramatically worsened. Severe malnutrition and measles are rampant among Somali refugees in Kenya and Ethiopia and internally displaced people within Somalia.

            • Perspective

              Vaccination policy is driven by several factors, including vaccine safety and efficacy, avertable disease burden, acceptability, and societal value. One measure of value is an intervention's cost-effectiveness, defined as the additional cost required per additional unit of health benefit produced…

              • November 10, 2011
              • Kim J.J.
              • N Engl J Med 2011; 365:1760-1761
              • Free Full Text

              One of the factors driving vaccination policy is societal value, one measure of which is cost-effectiveness. Unlike most U.S. public health institutions, the Advisory Committee on Immunization Practices explicitly considers cost-effectiveness in making recommendations.

            • Perspective

              The 2010 U.S. Dietary Guidelines were issued earlier this year, though they received little notice in the press. The lack of attention is troubling in a country in the throes of a nutritional crisis manifested most conspicuously in the form of an obesity epidemic that threatens to reverse recent…

              • October 27, 2011
              • Willett W.C. and Ludwig D.S.
              • N Engl J Med 2011; 365:1563-1565
              • Free Full Text

              The new U.S. dietary guidelines may have limited direct educational influence, but they will affect Americans' diets through federal food policies and food-assistance programs. The new guidelines represent a mix of progress and lost opportunities.

            • Perspective

              Chronic illness accounts for as much as three quarters of the cost of medical care in the United States, and diseases such as obesity, hypertension, and diabetes, although complex in etiology, are at least partially rooted in our unhealthy diet. The routine overconsumption of foods containing large…

              • October 27, 2011
              • Lewis K.H. and Rosenthal M.B.
              • N Engl J Med 2011; 365:1561-1563
              • Free Full Text

              Overconsumption of foods containing excessive salt, sugar, and unhealthful fats poses a public health threat in the United States. A possible policy approach to addressing the threat that recognizes our free-market ideals is “cap and trade” of unhealthy ingredients.

            • Special Article

              Many observational studies have shown that neighborhood attributes such as poverty and racial segregation are associated with increased risks of obesity and diabetes, even after adjustment for observed individual and family-related factors.– In response, the U.S. surgeon general has called for…

              • October 20, 2011
              • Ludwig J., Sanbonmatsu L., Gennetian L., et al.
              • N Engl J Med 2011; 365:1509-1519
              • Free Full Text
              • CME

              In this study, women with children were enabled to move from poor neighborhoods to neighborhoods with lower poverty rates. The moves were associated with modest but potentially important reductions in the prevalence of extreme obesity and diabetes.

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            Medical Meetings Pediatrics Conferences and Meetings

            2012 Certifying Examinations of the American Board of Pediatrics

            The general pediatrics examination will be held in various cities, Oct. 16-18. Registration for first-time applicants is ongoing through May 3. Registration for re-registrants is ongoing through May 24. The following subspecialty examinations will be held in various cities: "Hospice and Palliative Medicine" (Oct. 4); "Pediatric Transplant Hepatology" (Oct. 11); "Pediatric Cardiology" (Nov. 7); "Pediatric Pulmonology" (Nov. 8); "Medical Toxicology" (Nov. 12); and "Pediatric Critical Care Medicine" (Nov. 14). Registration for first-time applicants is ongoing through April 30. Registration for re-registrants is ongoing through June 15.

            Contact the American Board of Pediatrics, 111 Silver Cedar Court, Chapel Hill, NC 27514-1513; or call (919) 929-0461; or fax (919) 918-7114 or (919) 929-9255; or see http://www.abp.org .

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