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Original Article
Aspirin for Preventing the Recurrence of Venous Thromboembolism
The risk of recurrence of venous thromboembolism persists for many years after anticoagulant treatment is withdrawn. This risk is particularly high among patients with unprovoked venous thromboembolism, about 20% of whom have a recurrence within 2 years after treatment with vitamin K antagonists…
- CME
Editorial
Aspirin and the Prevention of Venous Thromboembolism
Venous thromboembolism, including deep-vein thrombosis and pulmonary embolism, is a common condition, with an annual incidence of 2 to 3 cases per 1000 in the general population. Although the risk of recurrence is only about 1% per year in patients with a transient risk factor (provoked venous…
Perspective
Sharing the Care to Improve Access to Primary Care
Gaining prompt access to primary care is a growing concern for all American adults. In Massachusetts, average wait times for new patients to obtain an internal-medicine appointment rose by 82% in the 2 years after health insurance coverage was expanded; current wait times average 36 days for family…
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Case Records of the Massachusetts General Hospital
Case 16-2012 — A 32-Year-Old Woman with HER2-Positive Breast Cancer
Presentation of Case. Dr. Steven Jay Isakoff (Hematology–Oncology): A 32-year-old woman was seen in the outpatient cancer center at this hospital because of infiltrating ductal carcinoma of the right breast. The patient had been well until 2 months before admission, when she became aware of a…
- CME
Perspective

Primary Care Update — Light at the End of the Tunnel?
Primary care physicians, long in the doldrums over their incomes and challenging work–life balance, may be heartened by recent steps taken by policymakers and payers signaling the increased recognition of the foundational role they could play in a restructured health care delivery system. Hopeful…
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Original Article

Colorectal-Cancer Incidence and Mortality with Screening Flexible Sigmoidoscopy
Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Colorectal-cancer mortality– and incidence, are reduced with screening by means of fecal occult-blood testing. Endoscopic screening with flexible sigmoidoscopy or colonoscopy is more sensitive than fecal…
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Editorial

Why You Should Care about Screening Flexible Sigmoidoscopy
The clinical outcomes of colorectal-cancer screening in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, now presented by Schoen et al. in the Journal, show that the programmatic use of flexible sigmoidoscopy reduced colorectal-cancer incidence by 21%, with a benefit…
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Clinical Practice
Secondary Prevention after Ischemic Stroke or Transient Ischemic Attack
Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations. Stage. A 62-year-old…
- CME
- Full Text Audio
Original Article
Association of Coffee Drinking with Total and Cause-Specific Mortality
Coffee is one of the most widely consumed beverages, both in the United States and worldwide. Since coffee contains caffeine, a stimulant, coffee drinking is not generally considered to be part of a healthy lifestyle. However, coffee is a rich source of antioxidants and other bioactive compounds,…
Perspective
200th Anniversary Article: The Evolving Primary Care Physician
The primary care doctor is a rapidly evolving species — and in the future could become an endangered one. As the United States grapples with the dual challenges of making health care more widely available and reducing the national price tag, it's hard to say how primary care physicians will fit…
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- Audio
Case Records of the Massachusetts General Hospital
Case 14-2012 — A 43-Year-Old Woman with Fever and a Generalized Rash
Presentation of Case. Dr. Sarah Gee (Dermatology): A 43-year-old woman was admitted to the hospital because of fever and a generalized rash. The patient had a history of atopic dermatitis and had been in her usual health until approximately 1 week before admission, when a painful, pruritic rash…
- CME
Clinical Problem-Solving
Whistling in the Dark
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors' commentary follows. Stage. A 38-year-old woman living in…
- CME
Perspective
Becoming a Physician: Freedom from the Tyranny of Choice — Teaching the End-of-Life Conversation
Thirty years ago, an intern had a conversation with a patient that he regrets to this day. The patient, a young man with widely metastatic lymphoma, unresponsive to chemotherapy, now had progressive dyspnea. The intern knew that even with intubation, his patient would soon die. Although the norm at…







