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  • Original Article

    The risk of recurrence of venous thromboembolism persists for many years after anticoagulant treatment is withdrawn. This risk is particularly high among patients with unprovoked venous thromboembolism, about 20% of whom have a recurrence within 2 years after treatment with vitamin K antagonists…

    • May 24, 2012
    • Becattini C., Agnelli G., Schenone A., et al.
    • N Engl J Med 2012; 366:1959-1967
    • CME

    About 20% of patients with venous thrombosis or embolism but no defined risk factors have a recurrence within the first 2 years after stopping anticoagulation therapy. These authors report that 100 mg of aspirin a day nearly halved the risk of recurrence, with no increase in bleeding.

  • Editorial

    Venous thromboembolism, including deep-vein thrombosis and pulmonary embolism, is a common condition, with an annual incidence of 2 to 3 cases per 1000 in the general population. Although the risk of recurrence is only about 1% per year in patients with a transient risk factor (provoked venous…

    • May 24, 2012
    • Becker R.C.
    • N Engl J Med 2012; 366:2028-2030

      Venous thromboembolism, including deep-vein thrombosis and pulmonary embolism, is a common condition, with an annual incidence of 2 to 3 cases per 1000 in the general population.1 Although the risk of recurrence is only about 1% per year in patients with ...

    • Perspective

      Gaining prompt access to primary care is a growing concern for all American adults. In Massachusetts, average wait times for new patients to obtain an internal-medicine appointment rose by 82% in the 2 years after health insurance coverage was expanded; current wait times average 36 days for family…

      • May 24, 2012
      • Ghorob A. and Bodenheimer T.
      • N Engl J Med 2012; 366:1955-1957
      • Free Full Text

      Gaining prompt access to primary care is a growing concern for all American adults. In Massachusetts, average wait times for new patients to obtain an internal-medicine appointment rose by 82% in the 2 years after health insurance coverage was expanded; ...

    • Images in Clinical Medicine

      Figure 1.

      • May 24, 2012
      • Lin L.-Y. and Wong J.-U.
      • N Engl J Med 2012; 366:2017
      • Free Full Text

      A 19-year-old woman with type 1 diabetes mellitus and suspected cystic fibrosis presented with a 1-day history of acute abdominal pain. Plain radiography revealed a typical mechanical obstruction.

    • Images in Clinical Medicine

      Figure 1.

      • May 24, 2012
      • Weibel L. and Spinas R.
      • N Engl J Med 2012; 366:e32
      • Free Full Text

      A 17-year-old girl presented with a 10-year history of transient excessive wrinkling of her palms after brief exposure to water and sweating. She reported some uncomfortable tightness of the skin during these epi¬sodes.

    • Case Records of the Massachusetts General Hospital

      Presentation of Case. Dr. Steven Jay Isakoff (Hematology–Oncology): A 32-year-old woman was seen in the outpatient cancer center at this hospital because of infiltrating ductal carcinoma of the right breast. The patient had been well until 2 months before admission, when she became aware of a…

      • May 24, 2012
      • Baselga J., Smith B.L., Rafferty E.A., Bombonati A.
      • N Engl J Med 2012; 366:2018-2026
      • CME

      A 32-year-old woman noted a crease in her right breast. Imaging studies showed a suspicious mass, and a biopsy specimen revealed infiltrating ductal carcinoma, positive for HER2. Staging showed liver lesions consistent with metastases. Management decisions were made.

    • PerspectiveOnline First

      Primary care physicians, long in the doldrums over their incomes and challenging work–life balance, may be heartened by recent steps taken by policymakers and payers signaling the increased recognition of the foundational role they could play in a restructured health care delivery system. Hopeful…

      • May 23, 2012
      • Iglehart J.K.
      • 10.1056/NEJMp1205537
      • Free Full Text

      Primary care physicians, long in the doldrums over their incomes and challenging work–life balance, may be heartened by recent steps taken by policymakers and payers signaling the increased recognition of the foundational role they could play in a ...

    • Original ArticleOnline First

      Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Colorectal-cancer mortality– and incidence, are reduced with screening by means of fecal occult-blood testing. Endoscopic screening with flexible sigmoidoscopy or colonoscopy is more sensitive than fecal…

      • May 21, 2012
      • Schoen R.E., Pinsky P.F., Weissfeld J.L., et al.
      • 10.1056/NEJMoa1114635
      • Free Full Text

      Colorectal cancer is the second leading cause of cancer-related deaths in the United States.1 Colorectal-cancer mortality24 and incidence5,6 are reduced with screening by means of fecal occult-blood testing. Endoscopic screening with flexible ...

    • EditorialOnline First

      The clinical outcomes of colorectal-cancer screening in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, now presented by Schoen et al. in the Journal, show that the programmatic use of flexible sigmoidoscopy reduced colorectal-cancer incidence by 21%, with a benefit…

      • May 21, 2012
      • Inadomi J.M.
      • 10.1056/NEJMe1204099
      • Free Full Text

      The clinical outcomes of colorectal-cancer screening in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, now presented by Schoen et al. in the Journal,1 show that the programmatic use of flexible sigmoidoscopy reduced colorectal-...

    • Clinical Practice

      Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations. Stage. A 62-year-old…

      • May 17, 2012
      • Davis S.M. and Donnan G.A.
      • N Engl J Med 2012; 366:1914-1922
      • CME
      • Full Text Audio

      This article reviews recommended strategies to reduce the risk of a subsequent stroke in patients with a history of transient ischemic attack (TIA) or stroke.

    • Original Article

      Coffee is one of the most widely consumed beverages, both in the United States and worldwide. Since coffee contains caffeine, a stimulant, coffee drinking is not generally considered to be part of a healthy lifestyle. However, coffee is a rich source of antioxidants and other bioactive compounds,…

      • May 17, 2012
      • Freedman N.D., Park Y., Abnet C.C., Hollenbeck A.R., Sinha R.
      • N Engl J Med 2012; 366:1891-1904

        In this study involving long-term follow-up of more than 400,000 adults, coffee consumption was inversely associated with total mortality and mortality due to heart disease, respiratory disease, stroke, injuries and accidents, diabetes, and infections, but not cancer.

      • Images in Clinical Medicine

        Figure 1.

        • May 17, 2012
        • O'Connell M. and Goulden V.
        • N Engl J Med 2012; 366:e31
        • Free Full Text

        A 66-year-old man presented with an acute pustular eruption. On examination, an annular rash with multiple blisters was seen on the patient's trunk; the blisters contained both clear and yellow fluid. He had no associated cutaneous or systemic symptoms, ...

      • Perspective

        The primary care doctor is a rapidly evolving species — and in the future could become an endangered one. As the United States grapples with the dual challenges of making health care more widely available and reducing the national price tag, it's hard to say how primary care physicians will fit…

        • May 17, 2012
        • Okie S.
        • N Engl J Med 2012; 366:1849-1853
        • Free Full Text
        • Audio

        The primary care doctor is a rapidly evolving species — and could become an endangered one. As we grapple with making health care more widely available and reducing its cost, it's hard to say how primary care physicians will fit into emerging delivery models.

      • Images in Clinical Medicine

        Figure 1.

        • May 17, 2012
        • Cifuentes L. and Ziai M.
        • N Engl J Med 2012; 366:1923
        • Free Full Text

        A 6-year-old girl who was born with a plaque on her forehead presented to the clinic. The plaque was smooth, elevated, and arranged in a linear pattern on the forehead.

      • Images in Clinical Medicine

        Figure 1.

        • May 10, 2012
        • Petrov D.B.
        • N Engl J Med 2012; 366:1824
        • Free Full Text

        A 62-year-old man with chronic renal insufficiency reported having reduced exercise tolerance for the previous week. The physical examination was unremarkable, but oxygen saturation was diminished.

      • Case Records of the Massachusetts General Hospital

        Presentation of Case. Dr. Sarah Gee (Dermatology): A 43-year-old woman was admitted to the hospital because of fever and a generalized rash. The patient had a history of atopic dermatitis and had been in her usual health until approximately 1 week before admission, when a painful, pruritic rash…

        • May 10, 2012
        • Mackool B.T., Goverman J., Nazarian R.M.
        • N Engl J Med 2012; 366:1825-1834
        • CME

        A 43-year-old woman with a history of atopic dermatitis was admitted to the hospital because of fever and a generalized painful, pruritic rash involving the entire body. Examination revealed vesicles, pustules, and erosions with scalloped borders. A diagnostic test result was received.

      • Images in Clinical Medicine

        Figure 1.

        • May 10, 2012
        • Tsai P.-Y. and Tzeng W.-S.
        • N Engl J Med 2012; 366:e30
        • Free Full Text

        A 3-year-old girl presented with a 3-week history of low back pain. Physical examination revealed mild tenderness over the upper lumbar spine.

      • Clinical Problem-Solving

        Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors' commentary follows. Stage. A 38-year-old woman living in…

        • May 3, 2012
        • Solomon D.A., Fanta C.H., Levy B.D., Loscalzo J.
        • N Engl J Med 2012; 366:1725-1730
        • CME

        Shortness of breath, fever, and cough productive of yellow sputum developed in a 38-year-old woman soon after the birth of her third child. Although her symptoms initially resolved with antibiotics, an intermittent nonproductive cough, wheezing, and shortness of breath soon followed.

      • Images in Clinical Medicine

        Figure 1.

        • May 3, 2012
        • Orme C. and Imaeda S.
        • N Engl J Med 2012; 366:e28
        • Free Full Text

        A 78-year-old man presented for his yearly skin exam and was noted to have an oval-shaped, green-black eschar on his midback. A pink, atrophic scar was located nearby, in addition to a medicated patch of similar size.

      • Perspective

        Thirty years ago, an intern had a conversation with a patient that he regrets to this day. The patient, a young man with widely metastatic lymphoma, unresponsive to chemotherapy, now had progressive dyspnea. The intern knew that even with intubation, his patient would soon die. Although the norm at…

        • May 3, 2012
        • Lamas D. and Rosenbaum L.
        • N Engl J Med 2012; 366:1655-1657

          Paternalism in discussing resuscitation status has given way to an approach in which patients may be asked to choose from a bewildering array of medical options, but physicians-in-training are rarely taught how to lead such conversations confidently and effectively.

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        Medical Meetings Pediatrics Conferences and Meetings

        2012 Certifying Examinations of the American Board of Pediatrics

        The general pediatrics examination will be held in various cities, Oct. 16-18. Registration for first-time applicants is ongoing through May 3. Registration for re-registrants is ongoing through May 24. The following subspecialty examinations will be held in various cities: "Hospice and Palliative Medicine" (Oct. 4); "Pediatric Transplant Hepatology" (Oct. 11); "Pediatric Cardiology" (Nov. 7); "Pediatric Pulmonology" (Nov. 8); "Medical Toxicology" (Nov. 12); and "Pediatric Critical Care Medicine" (Nov. 14). Registration for first-time applicants is ongoing through April 30. Registration for re-registrants is ongoing through June 15.

        Contact the American Board of Pediatrics, 111 Silver Cedar Court, Chapel Hill, NC 27514-1513; or call (919) 929-0461; or fax (919) 918-7114 or (919) 929-9255; or see http://www.abp.org .

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