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Perspective
200th Anniversary Article: The Evolving Primary Care Physician
The primary care doctor is a rapidly evolving species — and in the future could become an endangered one. As the United States grapples with the dual challenges of making health care more widely available and reducing the national price tag, it's hard to say how primary care physicians will fit…
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Review Article
200th Anniversary Article: Two Hundred Years of Surgery
Surgery is a profession defined by its authority to cure by means of bodily invasion. The brutality and risks of opening a living person's body have long been apparent, the benefits only slowly and haltingly worked out. Nonetheless, over the past two centuries, surgery has become radically more…
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Perspective
Becoming a Physician: Freedom from the Tyranny of Choice — Teaching the End-of-Life Conversation
Thirty years ago, an intern had a conversation with a patient that he regrets to this day. The patient, a young man with widely metastatic lymphoma, unresponsive to chemotherapy, now had progressive dyspnea. The intern knew that even with intubation, his patient would soon die. Although the norm at…
Perspective
Becoming a Physician: Lecture Halls without Lectures — A Proposal for Medical Education
The last substantive reform in medical student education followed the Flexner Report, which was written in 1910. In the ensuing 100 years, the volume of medical knowledge has exploded, the complexity of the health care system has grown, pedagogical methods have evolved, and unprecedented…
Perspective
Evidence, Preferences, Recommendations — Finding the Right Balance in Patient Care
A 75-year-old man was admitted to the hospital for the third time in 3 months for congestive heart failure. His ejection fraction was 15%, and he was receiving state-of-the-science treatment, including intravenous inotropic agents. He was not a candidate for a heart transplant, but the possibility…
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Perspective
Financing Graduate Medical Education — Mounting Pressure for Reform
Disparate voices from the White House, a national fiscal commission, Congress, a Medicare advisory body, private foundations, and academic medical leaders are advocating changes to Medicare's investment in graduate medical education (GME), which currently totals $9.5 billion annually. They offer…
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Perspective
200th Anniversary Article: The Evolving Roles of the Medical Journal
As Chicago physician J.H. Salisbury remarked in 1906, the influence of the medical journal on the life of the physician is unparalleled: "Medical school is attended, as a rule, but once in a lifetime; the meetings of the medical society are usually infrequent, but the medical journal, like the…
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Interactive Medical Case
Whistling in the Dark
A 38-year-old woman in Florida presented to her primary care physician with shortness of breath, fever, and a cough productive of yellow sputum. She was treated empirically with antibiotics for a presumed respiratory tract infection, and her symptoms resolved. She returned a few weeks later with an…
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- CME
A 38-year-old woman had shortness of breath, fever, and cough with yellow sputum soon after childbirth. Her symptoms initially resolved with antibiotics, but she soon had nonproductive cough, wheeze, and shortness of breath. Test your diagnostic and therapeutic skills at NEJM.org.
Review Article
200th Anniversary Article: What We Don't See
Sixty-eight years after the inaugural issue of The New England Journal of Medicine and Surgery, Sir William Osler introduced the term "pediatrics." Although "diseases peculiar to children" had figured in Benjamin Rush's lectures at the University of Pennsylvania since 1789, most physicians in the…
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Perspective
Building a Better Physician — The Case for the New MCAT
The Medical College Admission Test (MCAT), a prerequisite for admission to U.S. medical schools, currently consists of four sections: physical sciences, verbal reasoning, a writing sample, and biologic sciences. A 2004 Institute of Medicine report on "Improving Medical Education" and several years…
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Perspective
Industry Support of CME — Are We at the Tipping Point?
In the 1970s and 1980s, industry-sponsored junkets for physicians, thinly disguised as educational events, were common. Increasing public scrutiny and the threat of government regulation and legal action led physicians' organizations and the pharmaceutical industry to adopt increasingly restrictive…
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Perspective
200th Anniversary Article: Major Trends in the U.S. Health Economy since 1950
Rapid advances in medical science and technology, substantial gains in health outcomes attributable to medical care, and budget-busting increases in health care expenditures fueled by private and public insurance have marked the past six decades of health care in the United States. As the country…
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Special Report
The Next GME Accreditation System — Rationale and Benefits
In 1999, the Accreditation Council for Graduate Medical Education (ACGME) introduced the six domains of clinical competency to the profession, and in 2009, it began a multiyear process of restructuring its accreditation system to be based on educational outcomes in these competencies. The result of…
Review Article
200th Anniversary Article: A Patient with Asthma Seeks Medical Advice in 1828, 1928, and 2012
People have suffered from asthma for millennia. Although the clinical presentation of asthma has probably changed little, there are many more people who now bear its consequences than there were 200 years ago. As a result of an intense interest in the condition, our understanding of its…
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Perspective
Becoming a Physician: What Life Is Like
The summer before I began medical school, the handyman working in our kitchen told me exactly how many more refrigerators he needed to repair in order to afford his coronary-artery bypass surgery. My excitement about having achieved a lifelong dream was suddenly displaced by doubt. What if the…
Perspective
200th Anniversary Article: Patients and Doctors — The Evolution of a Relationship
The relationship between patients and doctors is at the core of medical ethics, serving as an anchor for many of the most important debates in the field. Over the past several decades, this relationship has evolved along three interrelated axes — as it is defined in clinical care, research, and…
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Interactive Medical Case
A Startling Decline
An 89-year-old man presented with changes in cognition and personality. Six months earlier, he began to require help managing his finances and operating his computer. His family observed that he had a poor memory for recent events and found it difficult to express himself. During the next few…
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An 89-year-old man was brought to the ER for evaluation of changes in his cognition and personality. He exhibited poor memory for recent events and difficulty expressing himself. Test your diagnostic and therapeutic skills at NEJM.org.
Review Article
200th Anniversary Article: The Perpetual Challenge of Infectious Diseases
Among the many challenges to health, infectious diseases stand out for their ability to have a profound impact on the human species. Great pandemics and local epidemics alike have influenced the course of wars, determined the fates of nations and empires, and affected the progress of civilization,…
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During the past 200 years, our understanding of infectious diseases has radically evolved from the identification of microbes, to defining their genetic structure, to the development of focused antimicrobial therapies, to the realization of vector biology. This article highlights the tremendous advances that have been made in the field.
Perspective
Painful Inequities — Palliative Care in Developing Countries
When Artur, a former KGB agent in Ukraine, developed prostate cancer that metastasized to his bones, his pain grew so intense that he moved hours away from his family so they would not witness his suffering. "I don't want them to see me cry," he said. Lacking access to the opioid regimens that we…
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