Browse Allergy

Showing 1 to 20 of 433 Articles

Filter Results

By Date: Past 10 years; Past 20 years; Past 50 years; Past 100 years; Complete archive (1812-present); Specific date range

Show Only Articles with CME

Sort By:

Review Article
Mechanisms of Disease: Filaggrin Mutations Associated with Skin and Allergic Diseases
Mutations in the filaggrin gene (FLG) are among the most common and profound single-gene defects identified to date in the causation and modification of disease. FLG encodes an important epidermal protein abundantly expressed in the outer layers of the epidermis. Approximately 10% of persons of…
- October 6, 2011
- Irvine A.D., McLean W.H.I., Leung D.Y.M.
- N Engl J Med 2011; 365:1315 - 1327
Mutations in the filaggrin gene are associated with a broad range of skin and allergic diseases. The biology of this molecule and the role of mutations in its altered function offer new insights into a range of conditions not previously thought to be related to one another.
- PDF
- Save
Images in Clinical Medicine
Angioedema
Figure 1.
- July 14, 2011
- Bramante R.M. and Rand M.
- N Engl J Med 2011; 365:e4
- Free Full Text
A 71-year-old man presented to the ER with rapidly progressive tongue swelling. Examination revealed a swollen tongue and no hypotension, rash, bronchospasm, urticaria, or flushing. The patient had no recent exposures to known food allergens, new medications, or insect stings.
- PDF
- Save
Perspective
Access to Safety Data — Stockholders versus Prescribers
The legal and medical systems both strive for truth while acknowledging that there are no absolutes. Both systems require evidence, which they categorize in a hierarchy of levels, on which to base decisions that can have major effects on the quality and even quantity of people's lives. In law, the…
- July 7, 2011
- Pfeffer M.A. and Bowler M.B.
- N Engl J Med 2011; 365:1 - 3
- Free Full Text
In the recent Matrixx case, the Supreme Court decided that drug-company investors require increased access to statistically nonsignificant information regarding adverse drug experiences. Prescribers' access to the same level of information should also be increased.
- PDF
- Save
Images in Clinical Medicine
Laryngopharyngeal Edema
Figure 1.
- June 23, 2011
- Watanabe K. and Nakaya M.
- N Engl J Med 2011; 364:e55
- Free Full Text
After undergoing sinus surgery a week earlier, a 77-year-old woman presented to our outpatient clinic for nasal suctioning. Before undergoing the procedure, she received topical analgesia consisting of a mixture of a 4% lidocaine solution and a 1:5000 ...
- PDF
- Save
Clinical Problem-Solving
A Recurrent Problem
Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors' commentary follows. Stage. A 50-year-old woman from Texas had…
- June 2, 2011
- Vikram H.R., Dhaliwal G., Saint S., Simpson C.B.
- N Engl J Med 2011; 364:2148 - 2154
- CME
- Video
A 50-year-old woman from Texas had nasal stuffiness, postnasal drip, myalgias, cough, and hoarseness in early winter. Six weeks later, her nonproductive cough and hoarseness persisted. She had no fever, chills, night sweats, pain, weight loss, nausea, vomiting, or rash.
- PDF
- Save
Original Article
Effect of Bronchoconstriction on Airway Remodeling in Asthma
Asthma is a common chronic respiratory condition characterized clinically by an excessive tendency toward reversible airway narrowing. This may arise in response to everyday environmental exposure and is worsened both by intercurrent infection and, in sensitized persons, by allergen exposure. In…
- May 26, 2011
- Grainge C.L., Lau L.C.K., Ward J.A., et al.
- N Engl J Med 2011; 364:2006 - 2015
- Free Full Text
Airway remodeling in asthma has been classically considered to be the result of inflammatory changes. In this study, the investigators show that bronchoconstriction alone can result in changes consistent with airway remodeling.
- PDF
- Save
Editorial
Physical Forces and Airway Remodeling in Asthma
Asthma is a disease of the airways characterized by variable airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Asthma is also accompanied by changes to the structure and composition of the airway walls, collectively termed airway remodeling. Cardinal features of airway…
- May 26, 2011
- Tschumperlin D.J.
- N Engl J Med 2011; 364:2058 - 2059
Asthma is a disease of the airways characterized by variable airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Asthma is also accompanied by changes to the structure and composition of the airway walls, collectively termed ...
- PDF
- Save
Correspondence
Anaphylaxis from Passive Transfer of Peanut Allergen in a Blood Product
To the Editor: Anaphylactic reactions to blood transfusions are rare and their causes often remain elusive. The inducement of clinically relevant allergic reactions by means of the passive transfer of IgE in blood products has been well documented. In an editorial comment written in 2003, Erick…
- May 19, 2011
- N Engl J Med 2011; 364:1981 - 1982
- Free Full Text
Anaphylactic transfusion reactions from passive transfer of IgE have been documented, but a case is now reported in which the eliciting factor was a food allergen in peanuts ingested by blood donors before donation.
- PDF
- Save
Case Records of the Massachusetts General Hospital
Case 9-2011 — A 37-Year-Old Man with Flushing and Hypotension
Presentation of Case. Dr. Leana S. Wen (Emergency Medicine): A 37-year-old man was admitted to the hospital because of flushing and hypotension. That morning, sneezing, rhinorrhea, scratchy throat, and subjective fever had developed. After lunch, he took an over-the-counter cold preparation that…
- March 24, 2011
- Murali M.R., Castells M.C., Song J.Y., Dudzinski D.M., Hasserjian R.P.
- N Engl J Med 2011; 364:1155 - 1165
- CME
- Video
A 37-year-old man was admitted to the hospital because of flushing and hypotension with near-syncope. Similar episodes had occurred with increasing frequency during the past 12 years. A test result was received.
- PDF
- Save
Case Records of the Massachusetts General Hospital
Case 7-2011 — A 52-Year-Old Man with Upper Respiratory Symptoms and Low Oxygen Saturation Levels
Presentation of Case. Dr. Roby P. Bhattacharyya (Medicine): A 52-year-old man was seen in the urgent care outpatient medical clinic at this hospital because of upper respiratory symptoms. The patient had been in his usual state of health until 3 days earlier, when subjective fever, fatigue,…
- March 10, 2011
- Pallais J.C., Mackool B.T., Pitman M.B.
- N Engl J Med 2011; 364:957 - 966
A 52-year-old man had low oxygen saturation by pulse oximetry, without other evidence of hypoxemia. He had dermatitis herpetiformis, treated with dapsone, and type 1 diabetes mellitus, with normal hemoglobin A_1c levels despite poor glycemic control. A diagnostic test was performed.
- PDF
- Save
Editorial
Barnyard Microbes and Childhood Asthma
It is easy to imagine why children who are raised on farms might grow up healthy: there is plenty of fresh air, exercise, and exposure to sunlight. In fact, studies from Europe, North America, and Australasia provide convincing evidence that allergic diseases and asthma are less likely to develop…
- February 24, 2011
- Gern J.E.
- N Engl J Med 2011; 364:769 - 770
It is easy to imagine why children who are raised on farms might grow up healthy: there is plenty of fresh air, exercise, and exposure to sunlight. In fact, studies from Europe, North America, and Australasia provide convincing evidence that allergic ...
- PDF
- Save
Original Article
Exposure to Environmental Microorganisms and Childhood Asthma
Environmental exposure to microorganisms has repeatedly been found to be inversely related to the manifestation of atopic diseases such as asthma and hay fever. This observation has been made in various contexts, including the studies conducted in the Republic of Karelia (Russia) and North Karelia (…
- February 24, 2011
- Ege M.J., Mayer M., Normand A.-C., et al.
- N Engl J Med 2011; 364:701 - 709
- Free Full Text
Growing up on a farm protects children from asthma. In this study, the investigators show that the diversity of microbial exposure of farm children as compared with children in the reference group can explain the observed protective effect.
- PDF
- Save
Correspondence
Aprepitant for Erlotinib-Induced Pruritus
To the Editor: Aprepitant is the first commercially available drug of a new class of neurokinin-1–receptor antagonists for treating chemotherapy-induced nausea and vomiting. The dominant ligand for the neurokinin-1 receptor is substance P. An increase in the number of neurokinin-1 receptors on…
- July 22, 2010
- N Engl J Med 2010; 363:397 - 398
- Free Full Text
To the Editor: Aprepitant is the first commercially available drug of a new class of neurokinin-1–receptor antagonists for treating chemotherapy-induced nausea and vomiting. The dominant ligand for the neurokinin-1 receptor is substance P.¹,² An increase ...
- PDF
- Save
Images in Clinical Medicine
Antrochoanal Polyp
Figure 1.
- June 3, 2010
- Lee J.-C. and Chou Y.-L.
- N Engl J Med 2010; 362:2113
- Free Full Text
A 19-year-old healthy man with a history of allergic rhinitis presented with a 6-month history of snoring and a sensation of having a foreign body in his mouth. The symptoms were associated with difficulty swallowing and foul-smelling breath. For 2 years ...
- PDF
- Save
Correspondence
COX-2 Inhibitors in Patients with Sensitivity to Nonselective NSAIDs
To the Editor: Controlled oral challenge is the only definitive way to detect sensitivity to nonsteroidal antiinflammatory drugs (NSAIDs) in patients with adverse reactions to these agents. Patients who have adverse reactions to nonselective NSAIDs have very limited analgesic and antiinflammatory…
- November 26, 2009
- N Engl J Med 2009; 361:2197 - 2198
- Free Full Text
To the Editor: Controlled oral challenge is the only definitive way to detect sensitivity to nonsteroidal antiinflammatory drugs (NSAIDs) in patients with adverse reactions to these agents.¹ Patients who have adverse reactions to nonselective NSAIDs have ...
- PDF
- Save
Correspondence
Hypersensitivity to Generic Drugs with Soybean Oil
To the Editor: The use of generic drugs has increased in the European Union in recent years. The main regulatory requirement for these products is that they be bioequivalent to the branded drug. However excipients such as soybean oil can be a cause of hypersensitivity reactions,; the protein…
- September 24, 2009
- N Engl J Med 2009; 361:1317 - 1318
- Free Full Text
The authors report on two women who presented with anaphylaxis a few minutes after ingesting a generic omeprazole capsule. The generic drug that each of the women took contained approved soybean oil as an excipient.
- PDF
- Save
Images in Clinical Medicine
Tattoo Allergy
Figure 1.
- July 2, 2009
- Cook J. and Metcalf J.
- N Engl J Med 2009; 361:e1
- Free Full Text
A 40-year-old man presented with a 4-month history of intractable pruritus within portions of a tattoo imprinted with red ink. Topical and intralesional corticosteroids had no effect.
- PDF
- Save
Correspondence
Nickel Allergy in Danish Women before and after Nickel Regulation
To the Editor: Over the 20th century, the prevalence of nickel allergy increased in Western Europe and the United States; this increase has been attributed to increased skin exposure to nickel in buttons, zippers, and other objects, earrings in particular. Nickel allergy may lead to nickel…
- May 21, 2009
- N Engl J Med 2009; 360:2259 - 2260
- Free Full Text
To the Editor: Over the 20th century, the prevalence of nickel allergy increased in Western Europe and the United States¹; this increase has been attributed to increased skin exposure to nickel in buttons, zippers, and other objects, earrings in ...
- PDF
- Save
Images in Clinical Medicine
Keyhole Pupils
Figure 1.
- April 16, 2009
- Negi S.I. and Krishnaswamy G.
- N Engl J Med 2009; 360:1655
- Free Full Text
A 60-year-old man was evaluated for nasal congestion and ocular itchiness that had been ongoing for several years. Examination was unremarkable, showing normal visual acuity, except for symmetric defects in the iris of both eyes (Panels A and B). The ...
- PDF
- Save
Case Records of the Massachusetts General Hospital
Case 33-2008 — A 63-Year-Old Woman with Dyspnea on Exertion
Presentation of Case. Dr. Andrew Tinsley (Medicine): A 63-year-old woman was admitted to this hospital because of dyspnea on exertion. The patient had been in her usual state of health until approximately 3 weeks before admission, when dyspnea developed. Approximately 1 week later, she began to…
- October 23, 2008
- Wiener C.M., Muse V.V., Mark E.J.
- N Engl J Med 2008; 359:1823 - 1832
A 63-year-old woman was admitted to the hospital because of a 3-week history of dyspnea on exertion, associated left subscapular burning pain, and a mild dry cough. She had a history of ulcerative colitis, which was most recently treated with azathioprine and infliximab. On examination, there were inspiratory wheezes and rales, without expiratory wheezes. Chest imaging showed ground-glass opacities in both lower lobes. A diagnostic procedure was performed.
- PDF
- Save

Page

Medical Meetings Conferences and Meetings

American Association for the Study of Liver Diseases

The following courses will be offered in Atlanta, unless otherwise indicated: "Hepatitis Single Topic Conference: HCV Direct Antiviral Agents (DAA): Concepts, Development and Optimal Use" (March 16 and 17); "The Henry M. and Lillian Stratton Basic Research Single Topic Conference: Mitochondria and Hepatotoxicity" (June 8 and 9); "Clinical Research Single Topic Conference: Acetaminophen Poisoning" (June 9 and 10); and "63rd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012" (Boston, Nov. 9-13).

Contact AASLD, 1001 North Fairfax St., Suite 400, Alexandria, VA 22314; or call (703) 299-9766; or see http://www.aasld.org .

More Medical Meetings

Trends: Most Viewed (Last Week)

A Startling Decline

February 9, 2012
Deep Sulcus Sign

February 9, 2012
IgG4-Related Disease

February 9, 2012

More Trends