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Perspective
Performance Improvement in Health Care — Seizing the Moment
We have an unprecedented opportunity to create a high-performance health system in the United States. Recent statutes, including the Affordable Care Act, the American Recovery and Reinvestment Act, and the Health Information Technology for Economic and Clinical Health Act, provide the federal…
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Sharing the Care to Improve Access to Primary Care
Gaining prompt access to primary care is a growing concern for all American adults. In Massachusetts, average wait times for new patients to obtain an internal-medicine appointment rose by 82% in the 2 years after health insurance coverage was expanded; current wait times average 36 days for family…
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Beyond the “R Word”? Medicine's New Frugality
Quietly, Washington policymakers have begun to concede the need to weigh health care's benefits against its costs if our country is to avert fiscal ruin. That costs must be counted against benefits is common sense in other domains — and among health policy professionals. But it's anathema in…
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From an Ethics of Rationing to an Ethics of Waste Avoidance
Bioethics has long approached cost containment under the heading of "allocation of scarce resources." Having thus named the nail, bioethics has whacked away at it with the theoretical hammer of distributive justice. But in the United States, ethical debate is now shifting from rationing to the…
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Primary Care Update — Light at the End of the Tunnel?
Primary care physicians, long in the doldrums over their incomes and challenging work–life balance, may be heartened by recent steps taken by policymakers and payers signaling the increased recognition of the foundational role they could play in a restructured health care delivery system. Hopeful…
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Biomarkers Unbound — The Supreme Court's Ruling on Diagnostic-Test Patents
In recent decades, biomarkers have become essential in diagnosing disease and assessing patients' responses to therapy. The increasing quantitative rigor and efficiency of these tests have led to the possibility of "personalized medicine." Despite such progress, the way in which a physician uses…
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Grief, Depression, and the DSM-5
Nearly 2.5 million Americans die each year, leaving behind an even larger group of grief-stricken people. Such a universal human experience as grief is recognized by the lay public and medical professionals alike as an entirely normal and expected emotional response to loss. Clinicians and…
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200th Anniversary Article: The Evolving Primary Care Physician
The primary care doctor is a rapidly evolving species — and in the future could become an endangered one. As the United States grapples with the dual challenges of making health care more widely available and reducing the national price tag, it's hard to say how primary care physicians will fit…
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Mental Illness — Comprehensive Evaluation or Checklist?
The debate over revising the Diagnostic and Statistical Manual of Mental Disorders (DSM) is of more than intramural interest, for the way in which the promised fifth edition (DSM-5) resolves the debate will shape the nature and scope of psychiatric services for years to come. Now established as the…
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Lost in Translation — ¿Cómo se dice, “Patient Protection and Affordable Care Act”?
The political seas roiled by the Affordable Care Act (ACA) have grown more volatile in the 2 years since its passage. Whether it is the constitutionality of the insurance mandate, the economic feasibility of the Medicaid expansion, or controversy over the conscience clauses, much has been said and…
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Emergency Departments, Medicaid Costs, and Access to Primary Care — Understanding the Link
In December, 2011, Washington State's Health Care Authority announced its intention to stop paying for emergency department (ED) visits by Medicaid beneficiaries "when those visits are not necessary for that place of service." To identify unnecessary visits, the state proposed a list of…
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HIV–HBV Coinfection — A Global Challenge
Human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV) exact a high toll worldwide. Both can lead to chronic disease, cancer, and death, and neither can be eradicated with the use of current therapies. Antiviral drug resistance often develops after patients have received treatment…
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Measles in the 21st Century
Barely 20 years ago, such a high proportion of childhood deaths globally was attributable to measles that the going estimate of more than 1 million measles-related deaths per year was almost certainly an underestimate. Pediatric wards in the developing world were filled with patients with measles…
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Implications for ACOs of Variations in Spending Growth
The Medicare Pioneer and Shared Savings Accountable Care Organization (ACO) programs offer health care provider organizations contracts with Medicare whereby the organizations assume financial risk and are rewarded for providing high-quality care at lower cost. ACO spending targets will be…
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Statins: Is It Really Time to Reassess Benefits and Risks?
No drug provides health benefits without some degree of risk, and risk–benefit assessments require ongoing review as new data become available. This is certainly the case for the use of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors — statins — and the risk of new-onset…
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Bisphosphonates for Osteoporosis — Where Do We Go from Here?
Osteoporosis, a disease characterized by reduced bone mass and increased skeletal fragility, affects 10 million Americans; another 34 million are at risk for it. Bisphosphonates are widely prescribed for osteoporosis; more than 150 million prescriptions were dispensed to outpatients between 2005…
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Continuing Bisphosphonate Treatment for Osteoporosis — For Whom and for How Long?
In the 21st century, osteoporosis, a disease once considered an inevitable consequence of aging, is both diagnosable and treatable. Large, randomized, controlled trials have shown that bisphosphonate therapy for 3 to 4 years is effective in reducing the risk of both nonvertebral and vertebral…
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Is Medicaid Constitutional?
Although the media and the U.S. public focused primarily on the minimum-coverage requirement, or individual mandate, during the recent oral arguments in the challenges to the Affordable Care Act (ACA) before the Supreme Court, the most important issue before the Court may well be the…
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Looking beyond Translation — Integrating Clinical Research with Medical Practice
One area of amazing recent medical advances has been childhood cancers, for which survival rates have quadrupled over the past four decades and now exceed 80%. This progress has been driven not only by the introduction of novel therapies but also by the remarkable level of patient and physician…
Perspective
Becoming a Physician: Freedom from the Tyranny of Choice — Teaching the End-of-Life Conversation
Thirty years ago, an intern had a conversation with a patient that he regrets to this day. The patient, a young man with widely metastatic lymphoma, unresponsive to chemotherapy, now had progressive dyspnea. The intern knew that even with intubation, his patient would soon die. Although the norm at…







