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  • Correspondence

    To the Editor: Human infections with novel avian-origin influenza A (H7N9) virus were recently identified in March 2013, in China. As of May 17, a total of 131 human infections and 36 fatal cases have been reported. Nearly 84% of confirmed human cases (110 of 131) were from eastern China. The…

    • June 13, 2013
    • N Engl J Med 2013; 368:2339-2340
    • Free Full Text

    Complete atrioventricular block developed in a 26-year-old woman, and she was found to have antinuclear antibodies, including antibodies against Ro52. Treatment with methylprednisolone and azathioprine restored normal atrioventricular conduction.

  • Correspondence

    To the Editor: A recent outbreak of a previously unrecognized novel reassortant avian influenza A (H7N9) virus in China had resulted in 131 documented cases and 36 deaths as of May 16. Although some patients had a history of contact with live poultry or visiting live-animal markets before the onset…

    • June 13, 2013
    • N Engl J Med 2013; 368:2337-2339
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    A novel avian influenza A (H7N9) virus has shown the ability to infect humans. As described in this letter, human infection may be occurring because of multiple cross-species jumps from birds to humans.

  • Correspondence

    To the Editor: Transplacental transfer of anti-Ro antibodies is a well-known cause of conduction defects and permanent atrioventricular block in newborns. In adults, conduction disturbances related to these antibodies are rare. We report a case of a 26-year-old woman with no history of this…

    • June 13, 2013
    • N Engl J Med 2013; 368:2335-2337
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    To the Editor: Transplacental transfer of anti-Ro antibodies is a well-known cause of conduction defects and permanent atrioventricular block in newborns.1 In adults, conduction disturbances related to these antibodies are rare.2

    We report a case of a ...

  • Correction

    Transfusion Strategies for Acute Upper Gastrointestinal Bleeding Original Article, N Engl J Med 2013;368:11-21. In the Abstract (page 11), the end of the first sentence under Results should have read, ". . . as compared with 61 assigned to the liberal strategy (14%), did not receive transfusions (…

    • June 13, 2013
    • N Engl J Med 2013; 368:2341
    • Free Full Text

    Transfusion Strategies for Acute Upper Gastrointestinal Bleeding Original Article, N Engl J Med 2013;368:11-21. In the Abstract (page 11), the end of the first sentence under Results should have read, “. . . as compared with 61 assigned to the liberal ...

  • Correspondence

    To the Editor: Kelton et al. (Feb. 21 issue) recommend fondaparinux for the management of heparin-induced thrombocytopenia in patients with normal renal function because of its ease of use and familiarity, but it has another advantage as well: cost. At our institution, 10 days of treatment with…

    • June 13, 2013
    • N Engl J Med 2013; 368:2333-2334
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    To the Editor: Kelton et al. (Feb. 21 issue)1 recommend fondaparinux for the management of heparin-induced thrombocytopenia in patients with normal renal function because of its ease of use and familiarity, but it has another advantage as well: cost. At ...

  • Correspondence

    To the Editor: The benefit of chlorhexidine bathing reported by Climo and colleagues (Feb. 7 issue) appears to be a reduction in the rate of bloodstream infections due to coagulase-negative staphylococci. As the authors note, the National Healthcare Safety Network (NHSN) definition of a central…

    • June 13, 2013
    • N Engl J Med 2013; 368:2330-2332
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    To the Editor: The benefit of chlorhexidine bathing reported by Climo and colleagues (Feb. 7 issue)1 appears to be a reduction in the rate of bloodstream infections due to coagulase-negative staphylococci. As the authors note, the National Healthcare ...

  • Correspondence

    To the Editor: In their review article, Giannakopoulos and Krilis (March 14 issue) do not include drugs as a possible trigger of the antiphospholipid syndrome. Indeed, several drugs — such as chlorpromazine, oral contraceptives, procainamide, quinine, amoxicillin, phenytoin, propylthiouracil,…

    • June 13, 2013
    • N Engl J Med 2013; 368:2334-2335
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    To the Editor: In their review article, Giannakopoulos and Krilis (March 14 issue)1 do not include drugs as a possible trigger of the antiphospholipid syndrome. Indeed, several drugs — such as chlorpromazine, oral contraceptives, procainamide, quinine, ...

  • Correspondence

    To the Editor: Schulman et al. (Feb. 21 issue) report the results of the RE-MEDY and RE-SONATE trials. In these trials, there was a significantly higher number of acute coronary events in patients who received dabigatran than in patients who received warfarin and the same number of acute coronary…

    • June 13, 2013
    • N Engl J Med 2013; 368:2328-2329
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    To the Editor: Schulman et al. (Feb. 21 issue)1 report the results of the RE-MEDY and RE-SONATE trials. In these trials, there was a significantly higher number of acute coronary events in patients who received dabigatran than in patients who received ...

  • Correction

    Effect of Daily Chlorhexidine Bathing on Hospital-Acquired Infection Original Article, N Engl J Med 2013;368:533-542. In the lower portion of Figure 1 (page 538), all the values given for No. at Risk and for Total Cumulative No. of Primary BSIs were incorrect. The figure has been replaced, and the…

    • June 13, 2013
    • N Engl J Med 2013; 368:2341
    • Free Full Text

    Effect of Daily Chlorhexidine Bathing on Hospital-Acquired Infection Original Article, N Engl J Med 2013;368:533-542. In the lower portion of Figure 1 (page 538), all the values given for No. at Risk and for Total Cumulative No. of Primary BSIs were ...

  • CorrectionOnline First

    Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia Original Article, N Engl J Med 2013;368:2059-2074. The source footnote (page 2059) and the Appendix (page 2073) should have begun, "The authors (members of the Cancer Genome Atlas Research Network) . . . ," rather than "The…

    • June 13, 2013
    • 10.1056/NEJMx130028
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    Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia Original Article, N Engl J Med 2013;368:2059-2074. The source footnote (page 2059) and the Appendix (page 2073) should have begun, “The authors (members of the Cancer Genome Atlas ...

  • Correction

    Omalizumab for the Treatment of Chronic Idiopathic or Spontaneous Urticaria Original Article, N Engl J Med 2013;368:924-935. In the Abstract (page 924), the final sentence under Background should have begun, "In phase 2 trials, omalizumab, an anti-IgE monoclonal antibody . . . ," rather than, "…

    • June 13, 2013
    • N Engl J Med 2013; 368:2340-2341
    • Free Full Text

    Omalizumab for the Treatment of Chronic Idiopathic or Spontaneous Urticaria Original Article, N Engl J Med 2013;368:924-935. In the Abstract (page 924), the final sentence under Background should have begun, “In phase 2 trials, omalizumab, an anti-IgE ...

  • Correspondence

    To the Editor: We analyzed plasma samples for the presence of JC virus antibodies and viral DNA. The samples were obtained from separate cohorts of patients with multiple sclerosis who received monthly infusions of natalizumab. Blood samples were obtained from 26 patients immediately before the…

    • June 6, 2013
    • N Engl J Med 2013; 368:2240-2241
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    JC virus in the peripheral circulation increases the risk of PML among natalizumab-treated patients. In this study, a PCR assay detected viral DNA, an indication of infection, in some persons in whom tests for seropositivity for antibodies to the virus were negative.

  • Correspondence

    To the Editor: In their article on the Oscillation for Acute Respiratory Distress Syndrome Treated Early (OSCILLATE) study, Ferguson et al. (Feb. 28 issue) report increased mortality in patients with the acute respiratory distress syndrome (ARDS) who underwent high-frequency oscillatory ventilation…

    • June 6, 2013
    • N Engl J Med 2013; 368:2231-2234
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    To the Editor: In their article on the Oscillation for Acute Respiratory Distress Syndrome Treated Early (OSCILLATE) study, Ferguson et al. (Feb. 28 issue)1 report increased mortality in patients with the acute respiratory distress syndrome (ARDS) who ...

  • Correspondence

    To the Editor: Casazza et al. (Jan. 31 issue) state that the common notion that "regularly eating (versus skipping) breakfast is protective against obesity" because people who skip breakfast may overeat later in the day is currently nothing more than a presumption. However, the evidence they cite…

    • June 6, 2013
    • N Engl J Med 2013; 368:2234-2237
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    To the Editor: Casazza et al. (Jan. 31 issue)1 state that the common notion that “regularly eating (versus skipping) breakfast is protective against obesity” because people who skip breakfast may overeat later in the day is currently nothing more than a ...

  • Correspondence

    To the Editor: We agree with the Perspective article by Lehman and Guercio (March 7 issue) that national clinical exams are expensive. We also agree with First et al. that such exams positively shape the educational and assessment programs of medical schools, promote standardization of…

    • June 6, 2013
    • N Engl J Med 2013; 368:2239-2240
    • Free Full Text

    To the Editor: We agree with the Perspective article by Lehman and Guercio (March 7 issue)1 that national clinical exams are expensive. We also agree with First et al.2 that such exams positively shape the educational and assessment programs of medical ...

  • Correspondence

    To the Editor: In the Case Record, Greka et al. (Jan. 31 issue) describe a 50-year-old man with flank pain due to renal infarction secondary to bacterial endocarditis, and they report that viridans group streptococci are the most common cause of native-valve infective endocarditis in adults.…

    • June 6, 2013
    • N Engl J Med 2013; 368:2237
    • Free Full Text

    To the Editor: In the Case Record, Greka et al. (Jan. 31 issue)1 describe a 50-year-old man with flank pain due to renal infarction secondary to bacterial endocarditis, and they report that viridans group streptococci are the most common cause of native-...

  • Correction

    Enteropathogens and Chronic Illness in Returning Travelers Review Article, N Engl J Med 2013;368:1817-1825. In Table 1 (page 1819), the images for Entamoeba histolytica and Strongyloides were transposed. The article is correct at NEJM.org.

    • June 6, 2013
    • N Engl J Med 2013; 368:2242
    • Free Full Text

    Enteropathogens and Chronic Illness in Returning Travelers Review Article, N Engl J Med 2013;368:1817-1825. In Table 1 (page 1819), the images for Entamoeba histolytica and Strongyloides were transposed. The article is correct at NEJM.org.

  • Correspondence

    To the Editor: In their Perspective article, De Cock and El-Sadr (March 7 issue) highlight the need for data on when to start antiretroviral therapy (ART) for HIV-infected people in Africa who have CD4+ counts above 350 cells per cubic millimeter. However, their proposed solution — a new…

    • June 6, 2013
    • N Engl J Med 2013; 368:2238
    • Free Full Text

    To the Editor: In their Perspective article, De Cock and El-Sadr (March 7 issue)1 highlight the need for data on when to start antiretroviral therapy (ART) for HIV-infected people in Africa who have CD4+ counts above 350 cells per cubic millimeter. ...

  • CorrespondenceOnline First

    To the Editor: We are a group of scholars and leaders in bioethics and pediatrics with extensive experience in ethical and regulatory issues in pediatrics and human subjects research. We urge the Office for Human Research Protections (OHRP) to withdraw its notification to the institutions involved…

    • June 5, 2013
    • 10.1056/NEJMc1307008
    • Free Full Text

    To the Editor: We are a group of scholars and leaders in bioethics and pediatrics with extensive experience in ethical and regulatory issues in pediatrics and human subjects research. We urge the Office for Human Research Protections (OHRP) to withdraw ...

  • Correspondence

    To the Editor: Postpartum hemorrhage is a major cause of maternal death worldwide, particularly in developing countries. Oxytocin ampules are included on the World Health Organization list of essential medicines used in the active management of the third stage of labor to prevent postpartum…

    • May 30, 2013
    • N Engl J Med 2013; 368:2145-2146
    • Free Full Text

    Researchers found that oxytocin concentrations in ampules remained stable after exposure to freezing temperatures. These results should reassure health care workers and skilled birth attendants that oxytocin ampules can be safely used even if temporarily frozen during transportation or storage.

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