To the Editor: In the Maintenance and Intermittent Inhaled Corticosteroids in Wheezing Toddlers (MIST) trial (ClinicalTrials.gov number, NCT00675584), Zeiger et al. (Nov. 24 issue)¹ suggest that intermittent high-dose budesonide was equal in efficacy to ...

The relationship between levels of serum and cerebrospinal fluid glucose in children is carefully examined in this study, which included more than 19,000 children.

To the Editor: Dooley et al. (Nov. 17 issue)¹ report the efficacy of mycophenolate mofetil versus azathioprine as maintenance therapy for lupus nephritis and declare mycophenolate superior. Yet azathioprine was prescribed according to body weight, ...

To the Editor: In the Mechanisms of Disease article on systemic lupus erythematosus (SLE), Tsokos (Dec. 1 issue)¹ notes that a lack of C1q leads to deficient clearance of waste material. I would like to add the role of C1q in the regulation of interferon-...

To the Editor: While summarizing the use of extracorporeal membrane oxygenation (ECMO) in the acute respiratory distress syndrome (ARDS), Brodie and Bacchetta (Nov. 17 issue)¹ suggest venoarterial ECMO as an alternative approach to standard venovenous ...

The BRAF inhibitor, vemurafenib, is associated with photosensitivity. This small study identifies ultraviolet A (UVA) as the active agent. UVA blockers may be effective in preventing photosensitivity among patients taking vemurafenib.

To the Editor: The study reported by Mathurin et al. (Nov. 10 issue)¹ could have a strong impact on living-donor liver transplantation.

Mandatory alcohol abstinence before deceased-donor liver transplantation serves two purposes: evaluation of compliance,...

In this case report, Staphylococcus aureus was found to persist in an 85-year-old woman 75 years after the successful treatment of osteomyelitis during her childhood.

To the Editor: Three randomized trials reported by Blanc et al.,¹ Havlir et al.,² and Abdool Karim et al.³ (Oct. 20 issue) consolidate the evidence base underpinning recommendations on when to start antiretroviral therapy (ART) in patients with human ...

To the Editor: The study by Nguyen-Khac et al. (Nov. 10 issue)¹ sidesteps old contentious issues regarding the use of glucocorticoid therapy in alcoholic hepatitis. Among the 8 references cited in support of glucocorticoid treatment, 2 in fact concluded ...

To the Editor: Palefsky et al. (Oct. 27 issue)¹ report an efficacy of 74.9% for the quadrivalent human papillomavirus (HPV) vaccine against anal intraepithelial neoplasia grade 2 or 3 related to HPV-6, 11, 16, or 18 in the per-protocol population of ...

To the Editor: Reich and colleagues (Oct. 27 issue)¹ concluded that briakinumab was more effective than methotrexate in patients with moderate-to-severe psoriasis and that the higher incidence of serious infections and cancers observed in the briakinumab ...

Lymphatic malformations are rare but can cause significant clinical problems in addition to cosmetic disfigurement. Sildenafil was used in a child whose pulmonary hypertension was caused by lymphatic malformation; the result was a marked decrease in the lymphatic malformation.

To the Editor: Vesikari et al. (Oct. 13 issue)¹ report an efficacy of 89% for a trivalent inactivated vaccine with an oil-in-water adjuvant (ATIV) in children 6 to 71 months of age against vaccine-matched strains. However, the efficacy of the trivalent ...

To the Editor: Sumithran et al. (Oct. 27 issue)¹ describe the long-term persistence of hormonal adaptations to weight loss. We believe that the results of this study could support alternative conclusions. In our opinion, the sustained hormonal changes ...

To the Editor: Understanding the role of medications in preventing hospital-acquired Clostridium difficile infections is important. The article by Loo et al. (Nov. 3 issue)¹ raises two questions. First, we submit that it is not only the patient's ...

A hexanucleotide repeat expansion in the gene C9ORF72 has been implicated in the development of amyotrophic lateral sclerosis and frontotemporal dementia. The variant has also been found in a small percentage of patients with probable late-onset Alzheimer's disease.

To the Editor: The Perspective article by Curfman and Redberg (Sept. 15 issue)¹ is much too optimistic, as is the Institute of Medicine (IOM) report² on which it is based. Both fail to acknowledge that the 510(k) process that the Food and Drug ...