…counseling of patients and their families, we studied the clinical records of 220 index patients, in whom the diagnosis was confirmed by biochemical analysis, and 199 of their affected relatives. Methods Study Subjects The 220 index patients included all 217 patients whose cultured fibroblasts synthesized abnormal…

…progressively younger ages. 1 In the United States, an estimated 19% of children 6 to 11 years of age are classified as overweight, with a body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) greater than the 95th percentile for their age and sex according to the…

…Task Force, with a body-mass index of 29.7. The Chicago Bulls drafted four rookies this year. Their body-mass indexes ranged from 27.3 to 29.8, perhaps another bad sign for season-ticket holders, but hardly a sign that these players are overweight. The body-mass index needs a simple correction factor…

…. The identification of persons at high risk for the disease may aid in disease prevention. A family history of diabetes, an increase in body-mass index (BMI, the weight in kilograms divided by the square of the height in meters), and impaired insulin secretion and action are risk factors for type 2…

…gradient of heart-failure risk across categories of body-mass index. To evaluate the risk of heart failure associated with varying degrees of obesity, we performed analyses that categorized the obese group into three classes with body-mass indexes of 30.0 to 34.9 (group 1), 35.0 to 39.9 (group 2), and 40…

…presence of hypoxemia or hypercapnia, 5 6 a short distance walked in a fixed time, 7 a high degree of functional breathlessness, 8 and a low body-mass index (the weight in kilograms divided by the square of the height in meters), 9 10 are also associated with an increased risk of death. We hypothesized that…

…allograft failures. 1 2 No measure accurately identifies patients at high risk for allograft loss. We recently found that a renal arterial resistance index of 80 or higher predicts a poor outcome of treatment after correction of renal-artery stenosis 3 and also predicts worsening renal function or death…

…within the prostate (called the index lesion) drives the natural history of prostate cancer. 5 The pathological characteristics of the index lesion — namely, the grade and the presence or absence of extracapsular extension — generally indicate the prognosis. Both the index-lesion hypothesis and the monoclonal…

…literacy was 6 percent higher, the mean birth weight was 32 g higher, and the mean birth length was 2 mm longer. The height, weight, and body-mass index (the weight in kilograms divided by the square of the height in meters) in childhood and adolescence were approximately 0.1 SD lower than in the original…

…determine the relations between body-mass index (the weight in kilograms divided by the square of the height in meters) and the risk of death from cancer at specific sites. This cohort has been used previously to examine the association of body-mass index and death from any cause. 5 Methods Study Population…

Anesthesia Awareness and the Bispectral Index (July 24, 2008;359:427-31) N Engl J Med 2008 July 24 359 17 427 431 . In the author list at the end of the fourth letter (page 429), “Panteli Eleftheria” should have read “Eleftheria Panteli.” The article has been corrected at NEJM.org.

Peripheral arterial disease affects more than 10 million people in the United States. In advanced stages, it may cause claudication and critical leg ischemia, defined as the presence of pain at rest in the leg or foot, ischemic ulcers, or gangrene. The presence of peripheral arterial disease leads…

…blood pressure improved after correction of the stenosis in patients with a resistance-index value of at least 80 in the segmental arteries of both kidneys, as measured by Doppler ultrasonography. 12 The resistance index is calculated with use of the following equation: [1 - (end-diastolic velocity ÷ maximal…

…public health problems in the United States. Approximately two thirds of Americans are classified as overweight or obese (defined as having a body-mass index [the weight in kilograms divided by the square of the height in meters] of 25 or higher), 1 and the vast majority do not engage in regular physical…

To the Editor: Radermacher et al. (July 10 issue) 1 assert that the renal arterial resistance index is associated with the prognosis for renal-transplant recipients. This study raises methodologic issues. Survival data are defined in terms of the time from an initiating event (the time origin) to some…

…index patient ranging from 3 to 100 percent. 4 5 6 7 No significant protection was found in two studies that involved concurrent treatment of ill household members who had index cases of influenza, 4 6 in part because of the rapid emergence of a drug-resistant strain of virus in the treated index cases…

…that mortality increases as body-mass index (the weight in kilograms divided by the square of the height in meters) increases for both black women and white women with body-mass indexes of 23.5 or higher. The relative risks associated with elevated body-mass index values were lower among black women than…

…obtained at an initial examination. In a subgroup of the men, who underwent multiple examinations, we also evaluated the effect of changes in body-mass index and blood pressure on the risk of kidney cancer. Methods The Study Cohort In 1968, Bygghälsan, the Swedish Foundation for Occupational Safety and…

…was accounted for by the inclusion of different random intercepts for sites and for surgeons within site. Linear and quadratic effects of body-mass index on the composite end point were considered, since the unadjusted analysis showed a quadratic relationship. For multivariable models, a stepwise variable…

…centimeters); skin-fold thickness (in millimeters) of the biceps, triceps, and subscapular and suprailiac areas with use of a caliper; and body-mass index, which was calculated as the weight in kilograms divided by the square of the height in meters. After the assessment of blood pressure and habitus,…