Original Article

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

Charles M. Rudin, M.D., Ph.D., Christine L. Hann, M.D., Ph.D., John Laterra, M.D., Ph.D., Robert L. Yauch, Ph.D., Christopher A. Callahan, M.D., Ph.D., Ling Fu, M.D., Thomas Holcomb, M.S., Jeremy Stinson, B.S., Stephen E. Gould, Ph.D., Barbara Coleman, R.N., C.C.R.P., Patricia M. LoRusso, D.O., Daniel D. Von Hoff, M.D., Frederic J. de Sauvage, Ph.D., and Jennifer A. Low, M.D., Ph.D.

N Engl J Med 2009; 361:1173-1178September 17, 2009