Original Article

Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

Takashi Kei Kishimoto, Ph.D., Karthik Viswanathan, Ph.D., Tanmoy Ganguly, Ph.D., Subbiah Elankumaran, Ph.D., Sean Smith, B.S., Kevin Pelzer, Ph.D., Jonathan C. Lansing, Ph.D., Nammalwar Sriranganathan, Ph.D., Ganlin Zhao, M.D., Zoya Galcheva-Gargova, Ph.D., Ali Al-Hakim, Ph.D., Gregory Scott Bailey, B.S., Blair Fraser, Ph.D., Sucharita Roy, Ph.D., Thomas Rogers-Cotrone, M.S., Lucinda Buhse, Ph.D., Mark Whary, Ph.D., James Fox, Ph.D., Moheb Nasr, Ph.D., Gerald J. Dal Pan, M.D., Zachary Shriver, Ph.D., Robert S. Langer, Sc.D., Ganesh Venkataraman, Ph.D., K. Frank Austen, M.D., Janet Woodcock, M.D., and Ram Sasisekharan, Ph.D.

N Engl J Med 2008; 358:2457-2467June 5, 2008