Original Article
Hepatocytes and Epithelial Cells of Donor Origin in Recipients of Peripheral-Blood Stem Cells
N Engl J Med 2002; 346:738-746March 7, 2002
- Abstract
Background
Bone marrow contains stem cells with the potential to differentiate into mature cells of various organs. We determined whether circulating stem cells have a similar potential.
Methods
Biopsy specimens from the liver, gastrointestinal tract, and skin were obtained from 12 patients who had undergone transplantation of hematopoietic stem cells from peripheral blood (11 patients) or bone marrow (1 patient). Six female patients had received transplants from a male donor. Five had received a sex-matched transplant, and one had received an autologous transplant. Hematopoietic stem-cell engraftment was verified by cytogenetic analysis or restriction-fragment–length polymorphism analysis. The biopsies were studied for the presence of donor-derived epithelial cells or hepatocytes with the use of fluorescence in situ hybridization of interphase nuclei and immunohistochemical staining for cytokeratin, CD45 (leukocyte common antigen), and a hepatocyte-specific antigen.
Results
All six recipients of sex-mismatched transplants showed evidence of complete hematopoietic donor chimerism. XY-positive epithelial cells or hepatocytes accounted for 0 to 7 percent of the cells in histologic sections of the biopsy specimens. These cells were detected in liver tissue as early as day 13 and in skin tissue as late as day 354 after the transplantation of peripheral-blood stem cells. The presence of donor cells in the biopsy specimens did not seem to depend on the intensity of tissue damage induced by graft-versus-host disease.
Conclusions
Circulating stem cells can differentiate into mature hepatocytes and epithelial cells of the skin and gastrointestinal tract.
Media in This Article
Figure 3
Donor-Derived Mucosal Cells in the Gastric Cardia in a Female Recipient (Patient 7) of Peripheral-Blood Stem Cells from a Male Donor.Figure 2
Donor-Derived Hepatocytes in the Liver of a Female Recipient (Patient 7) of Peripheral-Blood Stem Cells from a Male Donor.Article Activity
- Article
Pluripotent bone marrow stem cells have the capacity for self-renewal and can differentiate into hematopoietic or mesenchymal1 cell lineages. Studies in laboratory animals and humans indicate that bone marrow stem cells can give rise to hepatic oval cells, hepatocytes, cholangiocytes,2-4 skeletal-muscle cells,5,6 astrocytes, and neurons.7-9 To investigate whether such progenitor cells circulate in the blood, we studied biopsy specimens of skin, liver, and gastrointestinal tract from recipients of peripheral-blood stem cells from HLA-matched, sex-mismatched siblings for the presence of donor-derived epithelial cells and hepatocytes.
Methods
Characteristics of the Donors and Recipients
Eleven patients received high-dose chemotherapy alone or chemotherapy combined with radiotherapy, followed by a transplant of allogeneic peripheral-blood stem cells (in 10 patients) or autologous peripheral-blood stem cells (in 1 patient) for the treatment of hematologic cancers or breast cancer. One patient underwent allogeneic bone marrow transplantation. Both myeloablative and nonmyeloablative10 regimens were used before transplantation. All allogeneic grafts were derived from HLA-matched siblings. The peripheral-blood stem cells were obtained by apheresis after the donor had been treated for four days with recombinant human granulocyte colony-stimulating factor at a dose of 12 μg per kilogram of body weight per day. The total number of CD34+ cells transplanted ranged from 3.9×106 per kilogram of the recipient's body weight to 14.8×106 per kilogram.
Six women received stem cells from a brother; five patients received sex-matched stem cells, and one woman received autologous stem cells. The latter six patients served as controls. Hematopoietic stem-cell engraftment was verified by cytogenetic analysis or restriction-fragment–length polymorphism (RFLP) analysis.11 In three control patients, engraftment was documented on the basis of the recovery of peripheral-blood cells alone.
Tissue Specimens
After stem-cell transplantation, tissue specimens were obtained by a needle or punch biopsy that was performed for diagnostic purposes. All 12 patients gave informed consent for biopsies to be performed for diagnostic purposes. By the time our study began, all patients had died. The retrospective analysis of biopsy specimens was approved by the internal review board of the M.D. Anderson Cancer Center. All biopsies were performed for the purpose of establishing the diagnosis of graft-versus-host disease.
A total of five consecutive sections were obtained from each biopsy specimen. Each section was 4 μm thick, which is approximately half the thickness of a nucleus, with neighboring sections cut 4 μm apart. The sections closest to the center section that was used for fluorescence in situ hybridization were those stained for cytokeratin and CD45 (leukocyte common antigen), followed by those stained with hematoxylin and eosin and with a hepatocyte-specific antigen. This procedure allowed matching fields to be as close to each other as possible.
Immunohistochemistry
Pretreatment of Slides
After removal of paraffin with xylene, tissue sections were rehydrated with graded alcohols (100 percent, 90 percent, and 70 percent ethanol in distilled water) and washed with water and phosphate-buffered saline. Endogenous peroxidase activity was blocked by the application of 0.3 percent hydrogen peroxide in methanol for 15 minutes at room temperature, and the slides were washed in phosphate-buffered saline again. Tissues were then digested with 0.2 percent ficin (Sigma, St. Louis) in distilled water for 15 minutes at room temperature and washed in phosphate-buffered saline.
Staining for Cytokeratin
For staining for cytokeratin, antigen retrieval was performed by incubating the tissue for eight minutes in 0.01 M citrate buffer in a microwave oven. Blocking serum (bovine serum albumin) was applied to the slides for 30 minutes at room temperature, and the slides were then incubated for 60 minutes at room temperature with monoclonal mouse antihuman cytokeratin antibodies (CAM 5.2 [25 μg per milliliter; Becton Dickinson, San Jose, Calif.] at a dilution of 1:5 plus AE1/AE3 [1 mg per milliliter; Boehringer Mannheim, Indianapolis] at a dilution of 1:480).
Staining for CD45
For staining for CD45, antigen retrieval was performed by incubating the tissue for 45 minutes in TRIS-EDTA buffer in a steamer. Blocking serum (bovine serum albumin) was applied to the slides for 30 minutes at room temperature, and the slides were then incubated with monoclonal mouse antibodies against CD45 (clones PD7/26 and 2B11, Dako, Carpinteria, Calif.) at a dilution of 1:300 for 45 minutes. To detect the antigen–antibody reaction, a streptavidin–biotin detection system (Super Sensitive Immunodetection System, Biogenex, San Ramon, Calif.) was used according to the manufacturer's instructions. Sections from tonsils and peripheral-blood smears were used as positive controls.
Staining for Hepatocytes
For staining for hepatocytes, antigen retrieval was performed by incubating the tissue for 45 minutes in TRIS-EDTA buffer in the steamer. Blocking serum (bovine serum albumin) was applied to the slides for 30 minutes at room temperature, and then slides were incubated with a monoclonal mouse IgG antihuman hepatocyte antibody (clone OCH1E5, Dako) at a dilution of 1:50 for 60 minutes. To detect the antigen–antibody reaction, we used a streptavidin–biotin detection system (Super Sensitive Immunodetection System, Biogenex) according to the manufacturer's instructions.
Fluorescence in Situ Hybridization
Paraffin-embedded slides were deparaffinized by baking in an oven overnight at 56°C and then clearing in xylene three times, for 10 minutes each, for a total of 30 minutes; they were then dehydrated and air-dried. Slides were pretreated in 0.2 N hydrochloric acid for 20 minutes, washed with water, and rinsed in 2× saline sodium citrate (SSC) (1× SSC is 0.15 M sodium chloride and 0.015 M sodium citrate) for 3 minutes at room temperature. Slides were then incubated in 1 M sodium thiocyanate in distilled water at 80°C for 30 minutes, washed with water, washed with 2× SSC for 3 minutes, and air-dried. Tissue was digested with 1.5 μg of proteinase K (Sigma) per milliliter in 0.2 N hydrochloric acid, pH 2.0, at 37°C for 1 hour, washed with water, and then rinsed in 2× SSC for 3 minutes, air-dried, and fixed in Carnoy's solution (methanol and acetic acid in a 3:1 ratio) for 10 minutes. Slides were then denatured with 70 percent formamide in 2× SSC at 73°C for five minutes and rinsed with 70 percent ethanol for three minutes, dehydrated, and air-dried. The mixture of probes for the X and Y chromosomes (Vysis, Downers Grove, Ill.) was denatured at 74°C for five minutes and applied to the denatured tissue. The slides were covered with a coverslip, sealed with rubber cement, and incubated in a humid chamber overnight at 37°C for hybridization. After 16 hours of hybridization, slides were washed in 0.4× SSC containing 0.3 percent Nonidet P-40 for two minutes at 73°C, transferred to 2× SSC containing 0.1 percent Nonidet P-40 for one minute at room temperature, and drained. Slides were then counterstained with 10 μl of 4',6-diamidine-2-phenylidole dihydrochloride (DAPI, Boehringer Mannheim) at a concentration of 14 μg per milliliter of VectaShield mounting medium (Vector Laboratories, Burlingame, Calif.), and a coverslip was applied.
Quantification of XY-Positive, Donor-Derived Nonlymphohematopoietic Cells
The slides were scanned at a magnification of 100 under a fluorescence microscope (Leica, Wetzlar, Germany) equipped with an epi-illumination system, a 100-W mercury lamp, and a set of filters, including DAPI single-bandpass (DAPI counterstain), Spectrum Orange single-bandpass, Spectrum Green single-bandpass, and Red/Green dual-bandpass filters (all from Vysis). A total of 200 nonoverlapping cells and nuclei with distinct cells were counted, and the Y-positive (red) and X-positive (green) signals were identified. The percentage of cells that were XY-positive or XX-positive was less than 100 percent because of the truncation of nuclei during sectioning and incomplete hybridization. The stringent criteria used in counting positive signals led to an underestimation of the percentages of XX- or XY-positive cells in cases of female-to-female or male-to-male transplantation. Fields were matched to the corresponding fields in photomicrographs of the variously stained slides according to the location and architecture of the tissue on the slide. Matching microscopic fields were either 4 μm apart (in the slides stained with antibodies against cytokeratin or CD45) or 8 μm apart (in the slides stained with hematoxylin and eosin or the anti-hepatocyte antibody). The slides stained with hematoxylin and eosin and with antibody against CD45 were carefully evaluated to exclude the presence of lymphocytes, monocytes, and granulocytes, and XY-positive epithelial cells were identified with the use of only those cells that could reliably be classified on the basis of their staining properties.
Staining for Cytokeratin and Fluorescence in Situ Hybridization
Slides were prepared for staining for cytokeratin as described above. They were then washed in 1× phosphate-buffered saline for 5 minutes, and Texas Red–conjugated donkey antimouse IgG (Jackson ImmunoResearch Laboratories, West Grove, Pa.) at a dilution of 1:200 was applied for 60 minutes. After they had been washed in phosphate-buffered saline for five minutes, the slides were counterstained with 10 μl of DAPI at a concentration of 14 μg per milliliter of VectaShield antifade solution (Vector Laboratories). After they were stained for cytokeratin, the sections were systematically scanned and photographed at a magnification of 63 with the use of a calibrated and automated motorized stage. Next, the slides were washed in phosphate-buffered saline for five minutes and prepared for fluorescence in situ hybridization as outlined above. The slides were then scanned for XY-positive cells; pictures were taken at a magnification of 63 and were matched with the stored cytokeratin images.
Results
Characteristics of Patients and Transplantations
The characteristics of the donors and recipients, the type of regimen used before transplantation, and the quantity of CD34+ cells transfused are presented in Table 1Table 1
Characteristics of the Donors and the Recipients..Hematopoietic Chimerism after Allogeneic Stem-Cell Transplantation
Complete hematopoietic chimerism was demonstrated by RFLP analysis in four of the six recipients of sex-mismatched stem cells (Patients 7, 8, 10, and 12) and by cytogenetic analysis of bone marrow cells in all six (Table 2Table 2
Incidence of Donor Chimerism and Biopsy Reports.). In three of the six control patients, donor chimerism was documented by RFLP analysis.Donor-Derived Epithelial Cells and Hepatocytes in Recipients of Sex-Mismatched Stem Cells
We studied biopsy specimens of skin, liver, and gastrointestinal tract for the presence of donor-derived epithelial cells and hepatocytes. Whereas a DNA probe specific for the centromeres detected X and Y chromosomes in 35 to 75 percent of cells in biopsy specimens from the three male patients who received an allograft from a male donor (Patients 4, 5, and 6) (Table 3Table 3
Percentage of XY-Positive Cells in Various Tissue Biopsy Specimens from Six Control Recipients of Sex-Matched Stem-Cell Allografts or Autograft and Six Recipients of Sex-Mismatched Stem-Cell Allografts.), they did not detect XY-positive cells in any biopsy specimens from women who received a stem-cell transplant from a sister (Patients 1 and 2) or the woman who received her own cells (Patient 3). By contrast, XY-positive cells were present in biopsy specimens of the skin, liver, or gastrointestinal tract from the five female recipients of peripheral-blood stem cells from male donors (Patients 7, 8, 10, 11, and 12) and in the female recipient of a bone marrow allograft from her brother (Patient 9).In epidermal tissue of the skin, donor-derived cells were located in the deep layer of Malpighi (the stratum spinosum of the stratum germinativum), close to the dermal–epidermal junction and the stratum granulosum (Figure 1Figure 1
Donor-Derived Epidermal Cells in the Skin of a Female Recipient (Patient 10) of Peripheral-Blood Stem Cells from a Male Donor.). In the liver, XY-positive hepatocytes were distinguished by large, round nuclei and abundant granular cytoplasm (Figure 2Figure 2Donor-Derived Hepatocytes in the Liver of a Female Recipient (Patient 7) of Peripheral-Blood Stem Cells from a Male Donor.). In the glandular epithelium of the gastric cardia, cells containing the Y chromosome were found in the foveolae or tubular pits of the superficial glandular layer, which is composed of mucus-containing cells lining the foveolae (Figure 3Figure 3Donor-Derived Mucosal Cells in the Gastric Cardia in a Female Recipient (Patient 7) of Peripheral-Blood Stem Cells from a Male Donor.). The organ specificity of these cells was indicated by their location, staining for cytokeratins and hepatocytes (in the liver), and the absence of CD45.We also analyzed slides from biopsy specimens of all three organs after they had been stained with anti-cytokeratin antibodies and examined by fluorescence in situ hybridization with probes for the X and Y chromosomes. XY-positive signals in cytokeratin-positive cells would indicate the epithelial character of donor-derived cells. As demonstrated in epidermal cells in skin (Figure 1E and Figure 1F), hepatocytes (Figure 2E and Figure 2F) and mucosal cells of the gastrointestinal tract (Figure 3E and Figure 3F), XY-positive signals were detectable in cytokeratin-positive cells.
The frequency of XY-positive cells in biopsy specimens from female recipients of grafts from male donors ranged from 0 to 7 percent (Table 3). XY-positive cells were detected in liver tissue as early as 13 days after transplantation (in Patient 8) and were seen in skin tissue 354 days after transplantation of peripheral-blood stem cells (in Patient 10) and 867 days after transplantation of bone marrow (in Patient 9). The biopsy reports and the patients' clinical status at the time of biopsy did not suggest that donor-cell engraftment was more likely in tissues injured by graft-versus-host disease than in other tissues (as shown by the results for Patients 7, 10, 11, and 12 in Table 2).
Discussion
Circulating blood is known to contain stem cells that can completely restore hematopoiesis after ablation of the bone marrow.12,13 Recently, mesenchymal stem cells with a capacity for self-renewal and the potential to differentiate into bone, cartilage, fat, tendon, muscle, or marrow stroma have been identified in human bone marrow.1,14 Whether such stem cells circulate in the blood is unsettled.15-17 A stem cell in rat bone marrow has been found to differentiate into the epithelial lineage that generates hepatic oval cells,2 and in mice with a metabolic defect that impairs liver function, the infusion of purified hematopoietic stem cells can restore both hematopoiesis and liver function.18 Progenitors in mouse bone marrow have also been shown to be myogenic and can induce muscle regeneration.5,6
The existence of stem cells with multiple differentiating capabilities19 was conclusively demonstrated by Krause et al.,20 who showed that a single bone marrow stem cell not only can restore hematopoiesis in mice that have received otherwise lethal doses of radiation but also can differentiate into mature epithelial cells of the skin, lungs, and gastrointestinal tract. Moreover, human progenitor cells transplanted into fetal sheep have been reported to differentiate into hematopoietic cells and hepatocytes.21 There is also evidence that human kidney,22 liver, and muscle cells23 can transform into blood-forming cells. Moreover, two groups have reported the presence of donor-derived hepatocytes and cholangiocytes in recipients of sex-mismatched bone marrow transplants.3,4
Our findings indicate that human blood contains stem cells that can differentiate into cells of the liver, gastrointestinal tract, and skin. The origin of these stem cells and the way in which they generate hepatocytes and epithelial cells are unknown. It is possible that multiple lineage-restricted stem cells in the circulating blood can differentiate independently into their corresponding mature tissue. Alternatively, primitive adult multipotent stem cells may give rise to differentiated, lineage-restricted stem cells that can generate mature cells. It is also possible that stem cells that are committed to differentiation primarily along a particular pathway (e.g., hematopoiesis) can switch to another lineage under the influence of signals of the local microenvironment. Beltrami and coworkers24 have postulated that circulating stem cells differentiate into dividing myocytes that repair necrotic myocardium after infarction in humans. It is also conceivable that, in addition to mobilizing hematopoietic stem cells, recombinant human granulocyte colony-stimulating factor mobilizes clonogenic cells of epithelial origin into the peripheral blood.25
Technically, our studies of thin tissue sections are not infallible. Nonhematopoietic tissue may harbor a few lymphohematopoietic cells that standard histologic staining techniques fail to detect. In our study, we used a restricted number of consecutive tissue sections and used stringent criteria in the enumeration of XY-positive cells. Furthermore, to ensure that the X- and Y-chromosome signals on fluorescence in situ hybridization were indeed detected in cytokeratin-positive cells, we used sequential staining of the same tissue sections. This procedure, however, exposed the tissue to rough conditions, which may have led us to underestimate the numbers of donor-derived cells in tissue sections.
Tissue damage caused by radiation, chemotherapy, or graft-versus-host disease, among other causes, is believed to be responsible for the homing of peripheral-blood stem cells and their differentiation into various solid-organ–specific tissues.19 Our results indicate a rather uniform pattern of engraftment of donor-derived hepatocytes and epithelial cells irrespective of the presence or absence of tissue damage caused by graft-versus-host disease. In conclusion, our findings suggest the existence of a population of circulating stem cells with the capacity to differentiate into epithelial cells and hepatocytes. The physiologic role of these cells is currently unknown.
We are indebted to Drs. S. Giralt, I. Khouri, K. vanBesien, R. Mehra, D. Przepiorka, J. Gajewski, and D. Claxton of the University of Texas M.D. Anderson Cancer Center Bone Marrow Transplant Service for their clinical contributions; to Drs. H. Zang and F. Jiang for their technical expertise; and to Ms. K. Suilleabhain for editing the manuscript.
Source Information
From the Departments of Blood and Marrow Transplantation (M.K., G.R., R.E.C.), Pathology (R.L.K., A.K., A.C.R.), Hematopathology (M.A.), and Bioimmunotherapy (Z.E.), University of Texas M.D. Anderson Cancer Center, Houston.
Address reprint requests to Dr. Körbling at the University of Texas M.D. Anderson Cancer Center, Department of Blood and Marrow Transplantation, Box 423, 1515 Holcombe Blvd., Houston, TX 77030, or at mkorblin@mdanderson.org.
- References
References
1
Pittenger MF ,Mackay AM ,Beck SC , et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147
CrossRef | Web of Science | Medline2
Petersen BE ,Bowen WC ,Patrene KD , et al. Bone marrow as a potential source of hepatic oval cells. Science 1999;284:1168-1170
CrossRef | Web of Science | Medline3
Alison MR ,Poulsom R ,Jeffery R , et al. Hepatocytes from non-hepatic adult stem cells. Nature 2000;406:257-257
CrossRef | Web of Science | Medline4
Theise ND ,Nimmakayalu M ,Gardner R , et al. Liver from bone marrow in humans. Hepatology 2000;32:11-16
CrossRef | Web of Science | Medline5
Ferrari G ,Cusella-De Angelis G ,Coletta M , et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998;279:1528-1530[Erratum, Science 1998;281:923.]
CrossRef | Web of Science | Medline6
Gussoni E ,Soneoka Y ,Strickland CD , et al. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature 1999;401:390-394
Web of Science | Medline7
Kopen GC ,Prockop DJ ,Phinney DG . Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci U S A 1999;96:10711-10716
CrossRef | Web of Science | Medline8
Li Y ,Chen J ,Wang L ,Lu M ,Chopp M . Treatment of stroke in rat with intracarotid administration of marrow stromal cells. Neurology 2001;56:1666-1672
Web of Science | Medline9
Fuchs E ,Segre JA . Stem cells: a new lease on life. Cell 2000;100:143-155
CrossRef | Web of Science | Medline10
Giralt S ,Estey E ,Albitar M , et al. Engraftment of allogeneic hematopoietic progenitor cells with purin-analog containing chemotherapy: harnessing graft-versus-leukemia without myeloablative therapy. Blood 1997;89:4531-4536
Web of Science | Medline11
Knowlton RG ,Brown VA ,Braman JC , et al. Use of highly polymorphic DNA probes for genotypic analysis following bone marrow transplantation. Blood 1986;68:378-385
Web of Science | Medline12
Korbling M ,Przepiorka D ,Huh YO , et al. Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma: potential advantage of blood over marrow allografts. Blood 1995;85:1659-1665
Web of Science | Medline13
Bensinger WI ,Martin PJ ,Storer B , et al. Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers. N Engl J Med 2001;344:175-181
Full Text | Web of Science | Medline14
Horwitz EM ,Prockop DJ ,Fitzpatrick LA , et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999;5:309-313
CrossRef | Web of Science | Medline15
Fernandez M ,Simon V ,Herrera G ,Cao C ,Del Favero H ,Minguell JJ . Detection of stromal cells in peripheral blood progenitor cell collections from breast cancer patients. Bone Marrow Transplant 1997;20:265-271
CrossRef | Web of Science | Medline16
Lazarus HM ,Haynesworth SE ,Gerson SL ,Caplan AI . Human bone marrow-derived mesenchymal (stromal) progenitor cells (MPCs) cannot be recovered from peripheral blood progenitor cell collections. J Hematother 1997;6:447-455
Medline17
Huss R ,Lange C ,Weissinger EM ,Kolb HJ ,Thalmeier K . Evidence of peripheral blood-derived, plastic-adherent CD34-/low hematopoietic stem cell clones with mesenchymal stem cell characteristics. Stem Cells 2000;18:252-260
CrossRef | Web of Science | Medline18
Lagasse E ,Connors H ,Al-Dhalimy M , et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000;6:1229-1234
CrossRef | Web of Science | Medline19
Anderson DJ ,Gage FH ,Weissman IL . Can stem cells cross lineage boundaries? Nat Med 2001;7:393-395
CrossRef | Web of Science | Medline20
Krause DS ,Theise ND ,Collector MI , et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001;105:369-377
CrossRef | Web of Science | Medline21
Zanjani ED ,Porada CD ,Crapnell KB , et al. Production of human hepatocytes by human Lin-, CD34+/- cells in vivo. Blood 2000;96:494a-494a abstract.
Web of Science22
Almeida-Porada G ,Porada CD ,Zanjani ED . Differentiation potential of human metanephric stem cells: from mesenchyme to blood and liver. Blood 2000;96:494a-494a abstract.
Web of Science23
Farace F ,Guillier M ,Elias D ,Guinebretiere JM ,Vainchenker W ,Turhan AG . In vitro and in vivo evaluation of the hematopoietic potential of liver and muscle. Blood 2000;96:494a-495a abstract.
Web of Science24
Beltrami AP ,Urbanek K ,Kajstura J , et al. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 2001;344:1750-1757
Full Text | Web of Science | Medline25
Brugger W ,Bross KJ ,Glatt M ,Weber F ,Mertelsmann R ,Kanz L . Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors. Blood 1994;83:636-640
Web of Science | Medline
- Citing Articles (283)
Citing Articles
1
Madhava Pai, Duncan Spalding, Feng Xi, Nagy Habib. (2012) Autologous Bone Marrow Stem Cells in the Treatment of Chronic Liver Disease. International Journal of Hepatology 2012, 1-7
CrossRef2
Krisztian Nemeth, Sharon Key, Gyula Bottlik, Tamas Masszi, Eva Mezey, Sarolta Karpati. (2012) Analyses of Donor-Derived Keratinocytes in Hairy and Nonhairy Skin Biopsies of Female Patients Following Allogeneic Male Bone Marrow Transplantation. Stem Cells and Development 21:1, 152-157
CrossRef3
Hui-Ju Ch’ang, Li-Mei Lin, Pu-Yuan Chang, Chi-Wen Luo, Ya-Hui Chang, Chuan-Kai Chou, Helen H. Chen. (2012) Bone marrow transplantation enhances trafficking of host-derived myelomonocytic cells that rescue intestinal mucosa after whole body radiation. Radiotherapy and Oncology
CrossRef4
Chia-Chun Ang, Yong-Kwang Tay. (2011) Hematological abnormalities and the use of granulocyte-colony-stimulating factor in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. International Journal of Dermatology 50:12, 1570-1578
CrossRef5
Kathrin I. Odörfer, Monika Egerbacher, Nina J. Unger, Karin Weber, Angelika Jamnig, Günter Lepperdinger, Miriam Kleiter, Eric P. Sandgren, Reinhold G. Erben. (2011) Hematopoietic bone marrow cells participate in endothelial, but not epithelial or mesenchymal cell renewal in adult rats. Journal of Cellular and Molecular Medicine 15:10, 2232-2244
CrossRef6
Jakub Tolar, Bruce R. Blazar, John E. Wagner. (2011) Concise Review: Transplantation of Human Hematopoietic Cells for Extracellular Matrix Protein Deficiency in Epidermolysis Bullosa. STEM CELLS 29:6, 900-906
CrossRef7
Ashish Kumar, Nirupama Trehan Pati, Shiv Kumar Sarin. (2011) Use of Stem Cells for Liver Diseases—Current Scenario. Journal of Clinical and Experimental Hepatology 1:1, 17-26
CrossRef8
F M Khan, S Sy, P Louie, M Smith, J Chernos, J A Russell, J Storek. (2011) Epithelial cells in PBSC grafts: Source of donor-type epithelial cells after allogeneic transplantation?. Bone Marrow Transplantation
CrossRef9
K. Tamai, T. Yamazaki, T. Chino, M. Ishii, S. Otsuru, Y. Kikuchi, S. Iinuma, K. Saga, K. Nimura, T. Shimbo, N. Umegaki, I. Katayama, J.-i. Miyazaki, J. Takeda, J. A. McGrath, J. Uitto, Y. Kaneda. (2011) PDGFR -positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia. Proceedings of the National Academy of Sciences 108:16, 6609-6614
CrossRef10
Lei Zhang, Wen Kang, Yan Lei, Qunying Han, Guoyu Zhang, Yi Lv, Zhu Li, Sai Lou, Zhengwen Liu. (2011) Granulocyte colony-stimulating factor treatment ameliorates liver injury and improves survival in rats with d-galactosamine-induced acute liver failure. Toxicology Letters
CrossRef11
Miguel Waterhouse, Maria Themeli, Hartmut Bertz, Nicholas Zoumbos, Jürgen Finke, Alexandros Spyridonidis. (2011) Horizontal DNA Transfer from Donor to Host Cells as an Alternative Mechanism of Epithelial Chimerism after Allogeneic Hematopoietic Cell Transplantation. Biology of Blood and Marrow Transplantation 17:3, 319-329
CrossRef12
Simon D. Tran, Robert S. Redman, A. John Barrett, Steven Z. Pavletic, Sharon Key, Younan Liu, Ashley Carpenter, Hieu M. Nguyen, Yoshinori Sumita, Bruce J. Baum, Stanley R. Pillemer, Eva Mezey. (2011) Microchimerism in Salivary Glands after Blood- and Marrow-Derived Stem Cell Transplantation. Biology of Blood and Marrow Transplantation 17:3, 429-433
CrossRef13
Geom Seog Seo. (2011) Stem Cell Properties of Therapeutic Potential. The Korean Journal of Gastroenterology 58:3, 125
CrossRef14
Riichiro ABE. (2011) Therapy for skin disease using bone marrow cells. Japanese Journal of Clinical Immunology 34:2, 85-90
CrossRef15
Noritaka Oyama, Fumio Kaneko. (2011) Cell-Type-Specific Differentiation and Molecular Profiles in Skin Transplantation: Implication of Medical Approach for Genetic Skin Diseases. Journal of Transplantation 2011, 1-6
CrossRef16
Toru Nakamura, Victor Tsutsumi, Takuji Torimura, Masako Naitou, Hideki Iwamoto, Hiroshi Masuda, Osamu Hashimoto, Hironori Koga, Mitsuhiko Abe, Masaaki Ii, Atsuhiko Kawamoto, Takayuki Asahara, Takato Ueno, Michio Sata. (2011) Human peripheral blood CD34-positive cells enhance therapeutic regeneration of chronically injured liver in nude rats. Journal of Cellular Physiologyn/a-n/a
CrossRef17
B. Gridelli, G. Vizzini, G. Pietrosi, A. Luca, M. Spada, S. Gruttadauria, D. Cintorino, G. Amico, C. Chinnici, T. Miki, E. Schmelzer, P.G. Conaldi, F. Triolo, J.C. Gerlach. (2011) Efficient human fetal liver cell isolation protocol based on vascular perfusion for liver cell based therapy and a case report on cell transplantation. Liver Transplantationn/a-n/a
CrossRef18
Li Li, Masaki Hashiyada, Makoto Kume, Motoi Fukumoto, Yoichiro Yamamoto, Masato Funayama, Yuzo Yamamoto, Manabu Fukumoto. (2010) A case of hepatocellular carcinoma developed after allogeneic bone marrow transplantation. Pathology International 60:12, 795-797
CrossRef19
David Gomez-de-Antonio, Mercedes Zurita, Martin Santos, Isabel Salas, Jesús Vaquero, Andres Varela. (2010) Stem cells and bronchial stump healing. The Journal of Thoracic and Cardiovascular Surgery 140:6, 1397-1401
CrossRef20
Faisal M. Khan, Sarah Sy, Polly Louie, Megan Smith, Judy Chernos, Noureddine Berka, Gary D. Sinclair, Victor Lewis, James A. Russell, Jan Storek. (2010) Nasal Epithelial Cells of Donor Origin after Allogeneic Hematopoietic Cell Transplantation are Generated at a Faster Rate in the First 3 Months Compared with Later Posttransplantation. Biology of Blood and Marrow Transplantation 16:12, 1658-1664
CrossRef21
R Jacewicz, K Lewandowski, J Rupa-Matysek, M Jedrzejczyk, P M Brzezinski, T Dobosz, A Jonkisz, S Szram, M Komarnicki, J Berent. (2010) Donor-derived DNA in hair follicles of recipients after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplantation 45:11, 1638-1644
CrossRef22
David Gordon, Gordana Pavlovska, James B. Uney, David C. Wraith, Neil J. Scolding. (2010) Human Mesenchymal Stem Cells Infiltrate the Spinal Cord, Reduce Demyelination, and Localize to White Matter Lesions in Experimental Autoimmune Encephalomyelitis. Journal of Neuropathology and Experimental Neurology 69:11, 1087-1095
CrossRef23
Shenghong Ju, Gao-Jun Teng, Haihua Lu, JiYang Jin, Yu Zhang, Aifeng Zhang, Yicheng Ni. (2010) In Vivo Differentiation of Magnetically Labeled Mesenchymal Stem Cells Into Hepatocytes for Cell Therapy to Repair Damaged Liver. Investigative Radiology 45:10, 625-633
CrossRef24
Guodong Song, Dinh T. Nguyen, Giorgio Pietramaggiori, Saja Scherer, Bin Chen, Qian Zhan, Rei Ogawa, I.V. Yannas, Amy J. Wagers, Dennis P. Orgill, George F. Murphy. (2010) Use of the parabiotic model in studies of cutaneous wound healing to define the participation of circulating cells. Wound Repair and Regeneration 18:4, 426-432
CrossRef25
A. Spyridonidis. (2010) Update on stem cell "plasticity". memo - Magazine of European Medical Oncology 3:2, 77-80
CrossRef26
N. Bogdanova, U. Siebers, R. Kelsch, A. Markoff, A. Ropke, R. Exeler, J. Tsokas, P. Wieacker. (2010) Blood chimerism in a girl with Down syndrome and possible freemartin effect leading to aplasia of the Mullerian derivatives. Human Reproduction 25:5, 1339-1343
CrossRef27
Hilal Gul, Weibing Lu, Peng Xu, James Xing, Jie Chen. (2010) Magnetic carbon nanotube labelling for haematopoietic stem/progenitor cell tracking. Nanotechnology 21:15, 155101
CrossRef28
M Mirzania, A Ghavamzadeh, M Yaghmaie, N Sedighi, N Kamalian, K Alimoghaddam, S H Ghaffari, P Azimi, B Chahardouli. (2010) Hepatocytes of donor origin in recipient liver after hematopoietic SCT in β-thalassemia major patients. Bone Marrow Transplantation 45:4, 694-698
CrossRef29
Yoshiro Saikawa, Kazumasa Fukuda, Tsunehiro Takahashi, Rieko Nakamura, Hiroya Takeuchi, Yuko Kitagawa. (2010) Gastric carcinogenesis and the cancer stem cell hypothesis. Gastric Cancer 13:1, 11-24
CrossRef30
Ferenc Sipos, Györgyi Műzes, Orsolya Galamb, Sándor Spisák, Tibor Krenács, Kinga Tóth, Zsolt Tulassay, Béla Molnár. (2010) The Possible Role of Isolated Lymphoid Follicles in Colonic Mucosal Repair. Pathology & Oncology Research 16:1, 11-18
CrossRef31
Jeffrey H. Peters, N. Avisar. (2010) The Molecular Pathogenesis of Barrett’s Esophagus: Common Signaling Pathways in Embryogenesis Metaplasia and Neoplasia. Journal of Gastrointestinal Surgery 14:S1, 81-87
CrossRef32
Anna Chiara Piscaglia, Mariachiara Campanale, Antonio Gasbarrini, Giovanni Gasbarrini. (2010) Stem Cell-Based Therapies for Liver Diseases: State of the Art and New Perspectives. Stem Cells International 2010, 1-10
CrossRef33
Sophie Ferlicot, Amélia Vernochet, Serge Romana, Monique Ortin-Serrano, Alexia Letierce, Olivier Brégerie, Antoine Durrbach, Catherine Guettier. (2010) Microchimerism in renal allografts: clinicopathological associations according to the type of chimeric cells. Histopathology 56:2, 188-197
CrossRef34
Tomomi Ikoma, Satoru Kyo, Yoshiko Maida, Satoru Ozaki, Masahiro Takakura, Shinji Nakao, Masaki Inoue. (2009) Bone marrow–derived cells from male donors can compose endometrial glands in female transplant recipients. American Journal of Obstetrics and Gynecology 201:6, 608.e1-608.e8
CrossRef35
Shinichiro Ogawa, Shinichi Miyagawa. (2009) Potentials of regenerative medicine for liver disease. Surgery Today 39:12, 1019-1025
CrossRef36
Tomoyuki Okumura, Sophie SW Wang, Shigeo Takaishi, Shui Ping Tu, Vivian Ng, Russell E Ericksen, Anil K Rustgi, Timothy C Wang. (2009) Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium. Laboratory Investigation 89:12, 1410-1422
CrossRef37
A F Cristante, T E P Barros-Filho, N Tatsui, A Mendrone, J G Caldas, A Camargo, A Alexandre, W G J Teixeira, R P Oliveira, R M Marcon. (2009) Stem cells in the treatment of chronic spinal cord injury: evaluation of somatosensitive evoked potentials in 39 patients. Spinal Cord 47:10, 733-738
CrossRef38
Pedram Kharaziha, Per M. Hellström, Babak Noorinayer, Farivar Farzaneh, Katayoun Aghajani, Fereshteh Jafari, Mohammad Telkabadi, Amir Atashi, Maryam Honardoost, Mohammad Reza Zali, Masoud Soleimani. (2009) Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I–II clinical trial. European Journal of Gastroenterology & Hepatology 21:10, 1199-1205
CrossRef39
Feng Liu, Zhi-Da Liu, Nan Wu, Xu Cong, Ran Fei, Hong-Song Chen, Lai Wei. (2009) Transplanted endothelial progenitor cells ameliorate carbon tetrachloride-induced liver cirrhosis in rats. Liver Transplantation 15:9, 1092-1100
CrossRef40
Zeev Estrov. (2009) Stem Cells and Somatic Cells: Reprogramming and Plasticity. Clinical Lymphoma, Myeloma & Leukemia 9:0, S319-S328
CrossRef41
Akio Ido, Hirohito Tsubouchi. (2009) Translational research to identify clinical applications of hepatocyte growth factor. Hepatology Research 39:8, 739-747
CrossRef42
Rachel S. C. Friedman, Diane S. Krause. (2009) Regeneration and Repair. Annals of the New York Academy of Sciences 1172:1, 88-94
CrossRef43
Brent R. Weil, Troy A. Markel, Jeremy L. Herrmann, Aaron M. Abarbanell, Megan L. Kelly, Daniel R. Meldrum. (2009) Stem Cells in Sepsis. Annals of Surgery 250:1, 19-27
CrossRef44
Xiaobing Fu, Xiaoyan Sun. (2009) Can hematopoietic stem cells be an alternative source for skin regeneration?. Ageing Research Reviews 8:3, 244-249
CrossRef45
Kai-Hong JI, Jun XIONG, Li-Xing FAN, Kai-Meng HU, Hou-Qi LIU. (2009) Rat marrow-derived multipotent adult progenitor cells differentiate into skin epidermal cells in vivo. The Journal of Dermatology 36:7, 403-409
CrossRef46
Leigh A. May, Anthony Kicic, Paul Rigby, Kathryn Heel, Tracey-Lee Pullen, Maxine Crook, Adrian Charles, Balarka Banerjee, David Ravine, Alka Saxena, Michael Musk, Stephen M. Stick, Daniel C. Chambers. (2009) Cells of Epithelial Lineage Are Present in Blood, Engraft the Bronchial Epithelium, and Are Increased in Human Lung Transplantation. The Journal of Heart and Lung Transplantation 28:6, 550-557
CrossRef47
Irene Cervelló Alcaraz, Claudia Gil-Sanchis, Aymara Mas Perucho, Carlos Simón Valles. (2009) Current understanding of endometrial stem cells. Expert Review of Obstetrics & Gynecology 4:3, 273-282
CrossRef48
Kang Cheng, Sanjeev Gupta. (2009) Quantitative tools for assessing the fate of xenotransplanted human stem/progenitor cells in chimeric mice. Xenotransplantation 16:3, 145-151
CrossRef49
Annemieke J. Willemze, Astrid C. Bakker, Peter A. von dem Borne, Ingeborg M. Bajema, Jaak M. Vossen. (2009) The Effect of Graft-Versus-Host Disease on Skin Endothelial and Epithelial Cell Chimerism in Stem-Cell Transplant Recipients. Transplantation 87:7, 1096-1101
CrossRef50
Sung Soo Kim, Chang Keun Song, Sung Keun Shon, Kyu Yeol Lee, Chul Hong Kim, Myung Jin Lee, Lih Wang. (2009) Effects of human amniotic membrane grafts combined with marrow mesenchymal stem cells on healing of full-thickness skin defects in rabbits. Cell and Tissue Research 336:1, 59-66
CrossRef51
Valeria Sordi, Lorenzo Piemonti. (2009) The contribution of hematopoietic stem cells to beta-cell replacement. Current Diabetes Reports 9:2, 119-124
CrossRef52
Maija Kiuru, Julie L. Boyer, Timothy P. O'Connor, Ronald G. Crystal. (2009) Genetic Control of Wayward Pluripotent Stem Cells and Their Progeny after Transplantation. Cell Stem Cell 4:4, 289-300
CrossRef53
Philipp Eberwein, Philipp Faber, Thomas Reinhard, Juergen Finke, Alexandros Spyridonidis. (2009) Conjunctival Epithelial Cells With Donor-Derived Genome After Human Haematopoietic Stem-Cell Transplantation. Transplantation 87:6, 915-918
CrossRef54
A. Janin, H. Murata, C. Leboeuf, J.-M. Cayuela, E. Gluckman, L. Legres, A. Desveaux, M. Varna, P. Ratajczak, J. Soulier, H. de The, P. Bertheau, G. Socie. (2009) Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation. Blood 113:8, 1834-1840
CrossRef55
David Wu, Quynh Vu, Anhthu Nguyen, James R Stone, Hannah Stubbs, Georgiana Kuhlmann, Lynette M Sholl, A John Iafrate. (2009) In situ genetic analysis of cellular chimerism. Nature Medicine 15:2, 215-219
CrossRef56
Susumu Eguchi, Takashi Kanematsu. (2009) What is the real contribution of extrahepatic cells to liver regeneration?. Surgery Today 39:1, 1-4
CrossRef57
Jayesh Mehta, Jayesh Mehta, Olga Frankfurt, Jessica Altman, Andrew Evens, Martin Tallman, Leo Gordon, Stephanie Williams, Jane Winter, Jairam Krishnamurthy, Sara Duffey, Veerpal Singh, Richard Meagher, David Grinblatt, Lynne Kaminer, Seema Singhal. (2009) Optimizing the CD34 + cell dose for reduced-intensity allogeneic hematopoietic stem cell transplantation. Leukemia & Lymphoma 50:9, 1434-1441
CrossRef58
D Soldini, E Moreno, V Martin, A Gratwohl, C Marone, L Mazzucchelli. (2008) BM-derived cells randomly contribute to neoplastic and non-neoplastic epithelial tissues at low rates. Bone Marrow Transplantation 42:11, 749-755
CrossRef59
Shuji Terai, Isao Sakaida. (2008) Current status of autologous bone marrow cell infusion therapy for liver cirrhosis patients. Hepatology Research 38, S72-S75
CrossRef60
Troy A. Markel, Paul R. Crisostomo, Tim Lahm, Nathan M. Novotny, Frederick J. Rescorla, Joseph Tector, Daniel R. Meldrum. (2008) Stem cells as a potential future treatment of pediatric intestinal disorders. Journal of Pediatric Surgery 43:11, 1953-1963
CrossRef61
Kimie Tanaka, Masataka Sata. (2008) Contribution of circulating vascular progenitors in lesion formation and vascular healing: lessons from animal models. Current Opinion in Lipidology 19:5, 498-504
CrossRef62
Isao Sakaida. (2008) Autologous bone marrow cell infusion therapy for liver cirrhosis. Journal of Gastroenterology and Hepatology 23:9, 1349-1353
CrossRef63
Huey-Ling Chen, Renxue Wang, Hui-Ling Chen, Wuh-Liang Hwu, Yung-Ming Jeng, Mei-Hwei Chang, Victor Ling. (2008) Bone marrow transplantation results in donor-derived hepatocytes in an animal model of inherited cholestatic liver disease. Journal of Biomedical Science 15:5, 615-622
CrossRef64
Ping Wang, Haiyan Zhang, Weihong Li, Yongmei Zhao, Wei An. (2008) Promoter-defined isolation and identification of hepatic progenitor cells from the human fetal liver. Histochemistry and Cell Biology 130:2, 375-385
CrossRef65
Diarmaid Dominic Houlihan, Philip Noel Newsome. (2008) Critical Review of Clinical Trials of Bone Marrow Stem Cells in Liver Disease. Gastroenterology 135:2, 438-450
CrossRef66
Krisztina Hagymási, Béla Molnár, Zsolt Tulassay. (2008) Őssejt-transzplantáció a gyomor-bél rendszer betegségeinek kezelésében. Orvosi Hetilap 149:31, 1449-1455
CrossRef67
Li Yan, Ying Han, Jingbo Wang, Jingmei Liu, Yuanlong He, Honghong Wang, Daiming Fan. (2008) Peripheral blood monocytes from the decompensated liver cirrhosis could migrate into nude mouse liver with human hepatocyte-markers expression. Biochemical and Biophysical Research Communications 371:4, 635-638
CrossRef68
Alicia Rovó, Alois Gratwohl. (2008) Plasticity after allogeneic hematopoietic stem cell transplantation. Biological Chemistry 389:7, 825-836
CrossRef69
Susan Ellor, Thomas Shupe, Bryon Petersen. (2008) Stem cell therapy for inherited metabolic disorders of the liver. Experimental Hematology 36:6, 716-725
CrossRef70
Jan Storek. (2008) Immunological reconstitution after hematopoietic cell transplantation – its relation to the contents of the graft. Expert Opinion on Biological Therapy 8:5, 583-597
CrossRef71
Jan Kajstura, Toru Hosoda, Claudia Bearzi, Marcello Rota, Silvia Maestroni, Konrad Urbanek, Annarosa Leri, Piero Anversa. (2008) The Human Heart: A Self-Renewing Organ. Clinical and Translational Science 1:1, 80-86
CrossRef72
S. LORENZINI, A. ISIDORI, L. CATANI, A. GRAMENZI, S. TALARICO, F. BONIFAZI, V. GIUDICE, R. CONTE, M. BACCARANI, M. BERNARDI, S. J. FORBES, R. M. LEMOLI, P. ANDREONE. (2008) Stem cell mobilization and collection in patients with liver cirrhosis. Alimentary Pharmacology & Therapeutics 27:10, 932-939
CrossRef73
Derek Zieker, Richard Schäfer, Jörg Glatzle, Kay Nieselt, Stephan Coerper, Hinnak Northoff, Alfred Königsrainer, Thomas K. Hunt, Stefan Beckert. (2008) Lactate modulates gene expression in human mesenchymal stem cells. Langenbeck's Archives of Surgery 393:3, 297-301
CrossRef74
Isaac E. Sasson, Hugh S. Taylor. (2008) Stem Cells and the Pathogenesis of Endometriosis. Annals of the New York Academy of Sciences 1127:1, 106-115
CrossRef75
Sevgi Kalayoglu-Besisik, Fatma Savran Oguz, Filiz Aydin, Yeliz Duvarci, Deniz Sargin, Mahmut Carin. (2008) Tissue chimerism analysis after donor lymphocyte infusion: a case of deceptive evidence. Hematology 13:2, 92-94
CrossRef76
Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Il-Hoan Oh, Kun Ho Yoon, Seong Tae Park, Gi Dae Kim, Seh-Hoon Oh, Bryon E. Petersen. (2008) Thy1-positive bone marrow stem cells express liver-specific genes in vitro and can mature into hepatocytes in vivo. Hepatology International 2:1, 63-71
CrossRef77
E. Scott Swenson, Reiichiro Kuwahara, Diane S. Krause, Neil D. Theise. (2008) Physiological variations of stem cell factor and stromal-derived factor-1 in murine models of liver injury and regeneration. Liver International 28:3, 308-318
CrossRef78
Martin Körbling, Marcos J de Lima, Elizabeth Thomas, Abha Khanna, Amer M Najjar, Jun Gu, Juri G Gelovani, Russell Broaddus. (2008) Fusion of circulating blood cells with solid-organ tissue cells in clinical stem cell transplants: a potential therapeutic model?. Regenerative Medicine 3:2, 157-164
CrossRef79
David Campard, Philippe A. Lysy, Mustapha Najimi, Etienne Marc Sokal. (2008) Native Umbilical Cord Matrix Stem Cells Express Hepatic Markers and Differentiate Into Hepatocyte-like Cells. Gastroenterology 134:3, 833-848
CrossRef80
Koji Tomiyama, Noriko Murase, Donna Beer Stolz, Hideyoshi Toyokawa, Daniel R. O'Donnell, Darren M. Smith, Jason R. Dudas, J. Peter Rubin, Kacey G. Marra. (2008) Characterization of Transplanted Green Fluorescent Protein + Bone Marrow Cells into Adipose Tissue. Stem Cells 26:2, 330-338
CrossRef81
N. Levičar, M. Pai, N. A. Habib, P. Tait, L. R. Jiao, S. B. Marley, J. Davis, F. Dazzi, C. Smadja, S. L. Jensen, J. P. Nicholls, J. F. Apperley, M. Y. Gordon. (2008) Long-term clinical results of autologous infusion of mobilized adult bone marrow derived CD34+ cells in patients with chronic liver disease. Cell Proliferation 41, 115-125
CrossRef82
Yoko Ogawa, Shigeto Shimmura, Masataka Kuwana, Kazuto Yamazaki, Yutaka Kawakami, Kazuo Tsubota. (2008) Inflammation and pathogenic fibrosis in human ocular chronic graft versus host disease. Inflammation and Regeneration 28:6, 529-536
CrossRef83
Anna Chiara Piscaglia, Marialuisa Novi, Mariachiara Campanale, Antonio Gasbarrini. (2008) Stem cell‐based therapy in gastroenterology and hepatology. Minimally Invasive Therapy & Allied Technologies 17:2, 100-118
CrossRef84
Tomio Ogiso, Masahito Nagaki, Shinji Takai, Yoshihiko Tsukada, Tsuyoshi Mukai, Kiminori Kimura, Hisataka Moriwaki. (2007) Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1β. Journal of Hepatology 47:6, 816-825
CrossRef85
C. Di Campli, M.A. Zocco, N. Saulnier, A. Grieco, G. Rapaccini, G. Addolorato, C. Rumi, A. Santoliquido, G. Leone, G. Gasbarrini, A. Gasbarrini. (2007) Safety and efficacy profile of G-CSF therapy in patients with acute on chronic liver failure. Digestive and Liver Disease 39:12, 1071-1076
CrossRef86
Li Yan, Ying Han, Yuanlong He, Huahong Xie, Jingmei Liu, Lina Zhao, Jingbo Wang, Liuchun Gao, Daiming Fan. (2007) Cell Tracing Techniques in Stem Cell Transplantation. Stem Cell Reviews 3:4, 265-269
CrossRef87
Takashi Shimomura, Yoko Yoshida, Tomohiko Sakabe, Kyoko Ishii, Kazue Gonda, Rie Murai, Kazuko Takubo, Hiroyuki Tsuchiya, Yoshiko Hoshikawa, Akihiro Kurimasa, Ichiro Hisatome, Taro Uyama, Akihiro Umezawa, Goshi Shiota. (2007) Hepatic differentiation of human bone marrow-derived UE7T-13 cells: Effects of cytokines and CCN family gene expression. Hepatology Research 37:12, 1068-1079
CrossRef88
Alexandra Stolzing, Jürgen Hescheler, Sebastian Sethe. (2007) Fusion and Regenerative Therapies: Is Immortality Really Recessive?. Rejuvenation Research 10:4, 571-586
CrossRef89
Li Yan, Ying Han, Jingbo Wang, Jingmei Liu, Liu Hong, Daiming Fan. (2007) Peripheral blood monocytes from patients with HBV related decompensated liver cirrhosis can differentiate into functional hepatocytes. American Journal of Hematology 82:11, 949-954
CrossRef90
Y C Hong, H M Liu, P S Chen, Y J Chen, J Y Lyou, H Y Hu, M F Yi, J S Lin, C-H Tzeng. (2007) Hair follicle: a reliable source of recipient origin after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplantation 40:9, 871-874
CrossRef91
Y Metaxas, A Spyridonidis, H Bertz, J Finke, J Greiner. (2007) Donor-derived mucosal epithelial cells after human hematopoietic cell transplantation are not derived from the CD34-positive fraction of the graft. Leukemia 21:10, 2214-2216
CrossRef92
Mustapha Najimi, Françoise Smets, Etienne Sokal. (2007) Hepatocyte transplantation: current and future developments. Current Opinion in Organ Transplantation 12:5, 503-508
CrossRef93
E. R. Chernykh, N. M. Starostina, A. I. Paltsev, O. Yu. Leplina, E. Ya. Shevela, M. V. Shipunov, Yu. B. Selihova, A. D. Kulagin, I. A. Lisukov, S. D. Nikonov, A. A. Ostanin, V. A. Kozlov. (2007) Autologous bone marrow cells in the treatment of cirrhosis of the liver. Bulletin of Experimental Biology and Medicine 144:4, 640-645
CrossRef94
Abelardo Medina, Ruhangiz T. Kilani, Nicholas Carr, Erin Brown, Aziz Ghahary. (2007) Transdifferentiation of Peripheral Blood Mononuclear Cells into Epithelial-Like Cells. The American Journal of Pathology 171:4, 1140-1152
CrossRef95
A. Gasbarrini, G.L. Rapaccini, S. Rutella, M.A. Zocco, P. Tittoto, G. Leone, P. Pola, G. Gasbarrini, C. Di Campli. (2007) Rescue therapy by portal infusion of autologous stem cells in a case of drug-induced hepatitis. Digestive and Liver Disease 39:9, 878-882
CrossRef96
Teruko Soda, Hiroshi Suzuki, Yoshitaka Iso, Taro Kusuyama, Yasutoshi Omori, Takatoshi Sato, Makoto Shoji, Shinji Koba, Eiichi Geshi, Takashi Katagiri. (2007) Bone marrow cells contribute to neointimal formation after stent implantation in swine. International Journal of Cardiology 121:1, 44-52
CrossRef97
Stefania Lorenzini, Pietro Andreone. (2007) Stem Cell Therapy for Human Liver Cirrhosis: A Cautious Analysis of the Results. Stem Cells 25:9, 2383-2384
CrossRef98
Pelayo Correa, JeanMarie Houghton. (2007) Carcinogenesis of Helicobacter pylori. Gastroenterology 133:2, 659-672
CrossRef99
Christopher R. Cogle, Neil D. Theise, DongTao Fu, Deniz Ucar, Sean Lee, Steven M. Guthrie, Jean Lonergan, Witold Rybka, Diane S. Krause, Edward W. Scott. (2007) Bone Marrow Contributes to Epithelial Cancers in Mice and Humans as Developmental Mimicry. Stem Cells 25:8, 1881-1887
CrossRef100
Claudio Napoli, Ciro Maione, Concetta Schiano, Carmela Fiorito, Louis J. Ignarro. (2007) Bone marrow cell-mediated cardiovascular repair: potential of combined therapies. Trends in Molecular Medicine 13:7, 278-286
CrossRef101
JeanMarie Houghton, Alexei Morozov, Iva Smirnova, Timothy C. Wang. (2007) Stem cells and cancer. Seminars in Cancer Biology 17:3, 191-203
CrossRef102
Mehrnaz Gharaee-Kermani, Margaret R. Gyetko, Biao Hu, Sem H. Phan. (2007) New Insights into the Pathogenesis and Treatment of Idiopathic Pulmonary Fibrosis: A Potential Role for Stem Cells in the Lung Parenchyma and Implications for Therapy. Pharmaceutical Research 24:5, 819-841
CrossRef103
Akira Andoh, Shigeki Bamba, Mairi Brittan, Yoshihide Fujiyama, Nicholas A. Wright. (2007) Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut. Pharmacology & Therapeutics 114:1, 94-106
CrossRef104
Han Chun-mao, Wang Su-yi, Lai Ping-ping, Cen Hang-hui. (2007) Human bone marrow-derived mesenchymal stem cells differentiate into epidermal-like cells in vitro. Differentiation 75:4, 292-298
CrossRef105
A. A. Gumerova, M. A. Titova, A. P. Kiassov. (2007) Expression of different liver cell markers during the early prenatal human development. Cell and Tissue Biology 1:2, 143-150
CrossRef106
Krisztina Hagymási, Béla Molnár, Ferenc Sipos, Orsolya Galamb, Zsolt Tulassay. (2007) A colorectalis rák kialakulásának őssejtelmélete és összefüggése a molekuláris biológiai adatokkal. Orvosi Hetilap 148:17, 779-785
CrossRef107
Koji Tomiyama, Masahiro Miyazaki, Masataka Nukui, Mikiro Takaishi, Atsunori Nakao, Nobuyoshi Shimizu, Nam-ho Huh. (2007) Limited Contribution of Cells of Intact Extrahepatic Tissue Origin to Hepatocyte Regeneration in Transplanted Rat Liver. Transplantation 83:5, 624-630
CrossRef108
Seh–Hoon Oh, Rafal P. Witek, Si–Hyun Bae, Donghang Zheng, Youngmi Jung, Anna C. Piscaglia, Bryon E. Petersen. (2007) Bone Marrow–Derived Hepatic Oval Cells Differentiate Into Hepatocytes in 2-Acetylaminofluorene/Partial Hepatectomy–Induced Liver Regeneration. Gastroenterology 132:3, 1077-1087
CrossRef109
Ramazan Idilman, Esra Erden, Isınsu Kuzu, Sadik Ersoz, Selim Karayalcin. (2007) The fate of recipient-derived hepatocytes in sex-mismatched liver allograft following liver transplantation. Clinical Transplantation 21:2, 202-206
CrossRef110
Shi-ping Luh, Chi-huei Chiang. (2007) Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism, present strategies and future perspectives of therapies. Journal of Zhejiang University SCIENCE B 8:1, 60-69
CrossRef111
Qiling He, Chao Wan, Gang Li. (2007) Concise Review: Multipotent Mesenchymal Stromal Cells in Blood. Stem Cells 25:1, 69-77
CrossRef112
Kota Ishizawa, Hiroshi Kubo. (2007) Possibility of alveolar regeneration. Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics 44:1, 79-82
CrossRef113
Jisun Cha, Vincent Falanga. (2007) Stem cells in cutaneous wound healing. Clinics in Dermatology 25:1, 73-78
CrossRef114
Silvia Gaia, Susanna Cappia, Antonina Smedile, Elisa Bacillo, Ezio Gaia, Luciano Gubetta, Mario Rizzetto. (2006) Epithelial microchimerism: Consistent finding in human liver transplants. Journal of Gastroenterology and Hepatology 21:12, 1801-1806
CrossRef115
Roberto M. Lemoli, Lucia Catani, Simona Talarico, Elisabetta Loggi, Annagiulia Gramenzi, Umberto Baccarani, Miriam Fogli, Gian Luca Grazi, Michela Aluigi, Giulia Marzocchi, Mauro Bernardi, Antonio Pinna, Fabrizio Bresadola, Michele Baccarani, Pietro Andreone. (2006) Mobilization of Bone Marrow-Derived Hematopoietic and Endothelial Stem Cells After Orthotopic Liver Transplantation and Liver Resection. Stem Cells 24:12, 2817-2825
CrossRef116
Evangelia Yannaki, Achilles Anagnostopoulos, Demetrios Kapetanos, Angeliki Xagorari, Fotis Iordanidis, Ioannis Batsis, Panayotis Kaloyannidis, Evangelia Athanasiou, Georgios Dourvas, Georgios Kitis, Athanasios Fassas. (2006) Lasting amelioration in the clinical course of decompensated alcoholic cirrhosis with boost infusions of mobilized peripheral blood stem cells. Experimental Hematology 34:11, 1583-1587
CrossRef117
Mark A. Vickers, Sarah J. Canning, Wendy L. Craig, Neil M. Masson, Ian J. Wilson. (2006) X Inactivation Patterns of Closely, but Not Distantly, Related Cells Are Highly Correlated: Little Evidence for Stem Cell Plasticity in Normal Females. Stem Cells 24:11, 2398-2405
CrossRef118
Sajio Sumida. (2006) Transfusion and transplantation of cryopreserved cells and tissues. Cell and Tissue Banking 7:4, 265-305
CrossRef119
Wolf D. Kuhlmann, Peter Peschke. (2006) Hepatic progenitor cells, stem cells, and AFP expression in models of liver injury. International Journal of Experimental Pathology 87:5, 343-359
CrossRef120
H. C. Fiegel, Claudia Lange, U. Kneser, W. Lambrecht, A. R. Zander, X. Rogiers, D. Kluth. (2006) Fetal and adult liver stem cells for liver regeneration and tissue engineering. Journal of Cellular and Molecular Medicine 10:3, 577-587
CrossRef121
Aleksandra Habich, Marcin Jurga, Inga Markiewicz, Barbara Lukomska, Urszula Bany-Laszewicz, Krystyna Domanska-Janik. (2006) Early appearance of stem/progenitor cells with neural-like characteristics in human cord blood mononuclear fraction cultured in vitro. Experimental Hematology 34:7, 914-925
CrossRef122
Feng Liu, Xiaoben Pan, Guodong Chen, Dong Jiang, Xu Cong, Ran Fei, Lai Wei. (2006) Hematopoietic stem cells mobilized by granulocyte colony-stimulating factor partly contribute to liver graft regeneration after partial orthotopic liver transplantation. Liver Transplantation 12:7, 1129-1137
CrossRef123
Leonora Bużańska, Marcin Jurga, Ewa K. Stachowiak, Michal K. Stachowiak, Krystyna Domańska-Janik. (2006) Neural Stem-like Cell Line Derived from a Nonhematopoietic Population of Human Umbilical Cord Blood. Stem Cells and Development 15:3, 391-406
CrossRef124
Ryuichi OKAMOTO, Tomoko MATSUMOTO, Mamoru WATANABE. (2006) Regeneration of the intestinal epithelia: Regulation of bone marrow-derived epithelial cell differentiation towards secretory lineage cells. Human Cell 19:2, 71-75
CrossRef125
M Kucia, R Reca, F R Campbell, E Zuba-Surma, M Majka, J Ratajczak, M Z Ratajczak. (2006) A population of very small embryonic-like (VSEL) CXCR4+SSEA-1+Oct-4+ stem cells identified in adult bone marrow. Leukemia 20:5, 857-869
CrossRef126
Qingyuan Fan, Carole Lee Yee, Manabu Ohyama, Christine Tock, Guofeng Zhang, Thomas N. Darling, Jonathan C. Vogel. (2006) Bone marrow–derived keratinocytes are not detected in normal skin and only rarely detected in wounded skin in two different murine models. Experimental Hematology 34:5, 672-679
CrossRef127
Xiaobing Fu, Lijun Fang, Xiaokun Li, Biao Cheng, Zhiyong Sheng. (2006) Enhanced wound-healing quality with bone marrow mesenchymal stem cells autografting after skin injury. Wound Repair and Regeneration 14:3, 325-335
CrossRef128
Jaime Belkind-Gerson, Fiona Graeme-Cook, Harland Winter. (2006) Enteric Nervous System Disease and Recovery, Plasticity, and Regeneration. Journal of Pediatric Gastroenterology and Nutrition 42:4, 343-350
CrossRef129
Juliane MI Wiehe, Carola Niesler, Jan Torzewski, Oliver Zimmermann, Markus Wiesneth, Michael Schmitt, Klaus Schwarz, Hartmut Döhner, Vinzenz Hombach, Jochen Greiner. (2006) Efficient transient genetic labeling of human CD34 + progenitor cells for in vivo application. Regenerative Medicine 1:2, 223-234
CrossRef130
Regula J. Mueller, Georg Stussi, Bernhard Odermatt, Jorg Halter, Urs Schanz, Jorg D. Seebach. (2006) Major ABO-incompatible hematopoietic stem cell transplantation: study of post-transplant pure red cell aplasia and endothelial cell chimerism.. Xenotransplantation 13:2, 126-132
CrossRef131
Paola Romagnani, Laura Lasagni, Sergio Romagnani. (2006) Peripheral blood as a source of stem cells for regenerative medicine. Expert Opinion on Biological Therapy 6:3, 193-202
CrossRef132
Kiarash Khosrotehrani, Sarah Guegan, Sylvie Fraitag, Michèle Oster, Yves de Prost, Christine Bodemer, Selim Aractingi. (2006) Presence of Chimeric Maternally Derived Keratinocytes in Cutaneous Inflammatory Diseases of Children: The Example of Pityriasis Lichenoides. Journal of Investigative Dermatology 126:2, 345-348
CrossRef133
Edward T.H. Yeh, Sui Zhang. (2006) A novel approach to studying the transformation of human stem cells into cardiac cells in vivo. Canadian Journal of Cardiology 22, 66B-71B
CrossRef134
L KAMOLZ, A KOLBUS, N WICK, P MAZAL, B EISENBOCK, S BURJAK, G MEISSL. (2006) Cultured human epithelium: Human umbilical cord blood stem cells differentiate into keratinocytes under in vitro conditions. Burns 32:1, 16-19
CrossRef135
R Idilman, I Kuzu, E Erden, M Arat, E Soydan, I Soykan, G Akyol, S Karayalcin, H Akan, M Beksac. (2006) Evaluation of the effect of transplant-related factors and tissue injury on donor-derived hepatocyte and gastrointestinal epithelial cell repopulation following hematopoietic cell transplantation. Bone Marrow Transplantation 37:2, 199-206
CrossRef136
Isao Sakaida. (2006) Cell therapy with bone marrow cell for liver cirrhosis. Journal of Electrophoresis 50:1, 7-12
CrossRef137
M Kucia, Y P Zhang, R Reca, M Wysoczynski, B Machalinski, M Majka, S T Ildstad, J Ratajczak, C B Shields, M Z Ratajczak. (2006) Cells enriched in markers of neural tissue-committed stem cells reside in the bone marrow and are mobilized into the peripheral blood following stroke. Leukemia 20:1, 18-28
CrossRef138
Yasunori Iwata, Takashi Wada, Akio Uchiyama, Atsuo Miwa, Izaya Nakaya, Tadashi Tohyama, Yuhji Yamada, Toshiro Kurokawa, Takashi Yoshida, Satoshi Ohta, Hitoshi Yokoyama, Hiroyuki Iida. (2006) Remission of IgA Nephropathy after Allogeneic Peripheral Blood Stem Cell Transplantation Followed by Immunosuppression for Acute Lymphocytic Leukemia. Internal Medicine 45:22, 1291-1295
CrossRef139
Akira Andoh, Shigeki Bamba, Yoshihide Fujiyama, Mairi Brittan, Nicholas A. Wright. (2005) Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response. Journal of Gastroenterology 40:12, 1089-1099
CrossRef140
Isao Sakaida, Shuji Terai, Hiroshi Nishina, Kiwamu Okita. (2005) Development of cell therapy using autologous bone marrow cells for liver cirrhosis. Medical Molecular Morphology 38:4, 197-202
CrossRef141
Calin Stoicov, Hanchen Li, Jane Carlson, JeanMarie Houghton. (2005) Bone marrow cells as the origin of stomach cancer. Future Oncology 1:6, 851-862
CrossRef142
A.C. Piscaglia, M.A. Zocco, C. Di Campli, L. Sparano, S. Rutella, G. Monego, G. Bonanno, F. Michetti, S. Mancuso, P. Pola, G. Leone, G. Gasbarrini, A. Gasbarrini. (2005) How does human stem cell therapy influence gene expression after liver injury?. Digestive and Liver Disease 37:12, 952-963
CrossRef143
Wing–Yan Au, Annie Pang, Eunice C. Chan, Kent–Man Chu, Tony W.H. Shek, Yok–Lam Kwong. (2005) Epstein–Barr Virus–Related Gastric Adenocarcinoma: An Early Secondary Cancer Post Hemopoietic Stem Cell Transplantation. Gastroenterology 129:6, 2058-2063
CrossRef144
ERIC SANTONI-RUGIU, PETER JELNES, SNORRI S. THORGEIRSSON, HANNE CATHRINE BISGAARD. (2005) Progenitor cells in liver regeneration: molecular responses controlling their activation and expansion. APMIS 113:11-12, 876-902
CrossRef145
Belinda Knight, Vance B. Matthews, John K. Olynyk, George C. Yeoh. (2005) Jekyll and Hyde: Evolving perspectives on the function and potential of the adult liver progenitor (oval) cell. BioEssays 27:11, 1192-1202
CrossRef146
B. Dawn, R. Bolli. (2005) Adult bone marrow–derived cells: Regenerative potential, plasticity, and tissue commitment. Basic Research in Cardiology 100:6, 494-503
CrossRef147
John M. Luk, P. Ping Wang, Carol K. Lee, J.H. Wang, S.T. Fan. (2005) Hepatic potential of bone marrow stromal cells: Development of in vitro co-culture and intra-portal transplantation models. Journal of Immunological Methods 305:1, 39-47
CrossRef148
Stanley J. Miller, Robert M. Lavker, Tung-Tien Sun. (2005) Interpreting epithelial cancer biology in the context of stem cells: Tumor properties and therapeutic implications. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1756:1, 25-52
CrossRef149
Lopa Mishra, Kirti Shetty, Yi Tang, August Stuart, Stephen W Byers. (2005) The role of TGF-β and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene 24:37, 5775-5789
CrossRef150
Martin Coenen, Gesine Kögler, Peter Wernet, Oliver Brüstle. (2005) Transplantation of Human Umbilical Cord Blood-Derived Adherent Progenitors Into the Developing Rodent Brain. Journal of Neuropathology and Experimental Neurology 64:8, 681-688
CrossRef151
M Kucia, R Reca, V R Jala, B Dawn, J Ratajczak, M Z Ratajczak. (2005) Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells. Leukemia 19:7, 1118-1127
CrossRef152
Masataka Sata, Daiju Fukuda, Kimie Tanaka, Yukari Kaneda, Hisako Yashiro, Ibuki Shirakawa. (2005) The role of circulating precursors in vascular repair and lesion formation. Journal of Cellular and Molecular Medicine 9:3, 557-568
CrossRef153
Y Metaxas, R Zeiser, A Schmitt-Graeff, M Waterhouse, P Faber, M Follo, H Bertz, J Finke, A Spyridonidis. (2005) Human hematopoietic cell transplantation results in generation of donor-derived epithelial cells. Leukemia 19:7, 1287-1289
CrossRef154
Catherine Guettier, Mylène Sebagh, Jérôme Buard, Danielle Feneux, Monique Ortin-Serrano, Michele Gigou, Viviane Tricottet, Michel Reynès, Didier Samuel, Cyrille Féray. (2005) Male cell microchimerism in normal and diseased female livers from fetal life to adulthood. Hepatology 42:1, 35-43
CrossRef155
Mark JD Griffiths, Dominique Bonnet, Sam M Janes. (2005) Stem cells of the alveolar epithelium. The Lancet 366:9481, 249-260
CrossRef156
Shuji Terai, Isao Sakaida, Hiroshi Nishina, Kiwamu Okita. (2005) Lesson from the GFP/CCl4 model — Translational Research Project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis. Journal of Hepato-Biliary-Pancreatic Surgery 12:3, 203-207
CrossRef157
Takahisa Fujikawa, Seh-Hoon Oh, Tom Shupe, Bryon E. Petersen. (2005) Stem-cell therapy for hepatobiliary pancreatic disease. Journal of Hepato-Biliary-Pancreatic Surgery 12:3, 190-195
CrossRef158
Mairi Brittan, Victoria Chance, George Elia, Richard Poulsom, Malcolm R. Alison, Thomas T. MacDonald, Nicholas A. Wright. (2005) A Regenerative Role for Bone Marrow Following Experimental Colitis: Contribution to Neovasculogenesis and Myofibroblasts. Gastroenterology 128:7, 1984-1995
CrossRef159
Yunfang Wang, Xue Nan, Yanhua Li, Rui Zhang, Wen Yue, Fang Yan, Xuetao Pei. (2005) Induction of umbilical cord blood-derived β2m−c-Met+ cells into hepatocyte-like cells by coculture with CFSC/HGF cells. Liver Transplantation 11:6, 635-643
CrossRef160
Silvia Nava, Magnus Westgren, Marie Jaksch, Annika Tibell, Ulrika Broome, Bo-Goran Ericzon, Suchitra Sumitran-Holgersson. (2005) Characterization of cells in the developing human liver. Differentiation 73:5, 249-260
CrossRef161
Tomoko Matsumoto, Ryuichi Okamoto, Tomoharu Yajima, Takehiko Mori, Shinichiro Okamoto, Yasuo Ikeda, Makio Mukai, Motomi Yamazaki, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Takanori Kanai, Hideyuki Okano, Johji Inazawa, Toshifumi Hibi, Mamoru Watanabe. (2005) Increase of Bone Marrow–Derived Secretory Lineage Epithelial Cells During Regeneration in the Human Intestine. Gastroenterology 128:7, 1851-1867
CrossRef162
Barbara J. Crain, Simon D. Tran, Eva Mezey. (2005) Transplanted human bone marrow cells generate new brain cells. Journal of the Neurological Sciences 233:1-2, 121-123
CrossRef163
Dong-Nan He, Han Qin, Lianming Liao, Ning Li, Wei-Ming Zhu, Bao-Jun Yu, Xuefeng Wu, Robert Chunhua Zhao, Jie-Shou Li. (2005) Small Intestinal Organoid-Derived SP Cells Contribute to Repair of Irradiation-Induced Skin Injury. Stem Cells and Development 14:3, 285-291
CrossRef164
A. Bennaceur-Griscelli, W. Vainchenker. (2005) Limites et enjeux des thérapies cellulaires. Transfusion Clinique et Biologique 12:2, 73-76
CrossRef165
JeanMarie Houghton, Timothy C. Wang. (2005) Helicobacter pylori and Gastric Cancer: A New Paradigm For Inflammation-Associated Epithelial Cancers. Gastroenterology 128:6, 1567-1578
CrossRef166
Yuichi Tanaka, Hironori Haga, Hiroto Egawa, Tomoko Okuno, Aya Miyagawa-Hayashino, Tatsuaki Tsuruyama, Michiyo Kambe, Hiroyuki Marusawa, Tsutomu Chiba, Toshiaki Manabe. (2005) Intragraft expression of recipient-type ABO blood group antigens: Long-term follow-up and histological features after liver transplantation. Liver Transplantation 11:5, 547-554
CrossRef167
Claudius Conrad, Ralf Huss. (2005) Adult stem cell lines in regenerative medicine and reconstructive surgery. Journal of Surgical Research 124:2, 201-208
CrossRef168
Neil D. Theise. (2005) Stem Cell Plasticity: Tools for Investigation and Repair. Journal of Pediatric Gastroenterology and Nutrition 40:Supplement 1, S48-S49
CrossRef169
Jan Schulte am Esch, Wolfram Trudo Knoefel, Michael Klein, Ali Ghodsizad, Guenter Fuerst, Ludger W. Poll, Christoph Piechaczek, Elmar R. Burchardt, Niko Feifel, Volker Stoldt, Marcus Stockschläder, Nikolas Stoecklein, Roy Y. Tustas, Claus F. Eisenberger, Matthias Peiper, Dieter Häussinger, Stefan B. Hosch. (2005) Portal Application of Autologous CD133 + Bone Marrow Cells to the Liver: A Novel Concept to Support Hepatic Regeneration. Stem Cells 23:4, 463-470
CrossRef170
Valérie Gangji, Michel Toungouz, Jean-Philippe Hauzeur. (2005) Stem cell therapy for osteonecrosis of the femoral head. Expert Opinion on Biological Therapy 5:4, 437-442
CrossRef171
Xianghui He, Veronica Gonzalez, Amy Tsang, Jennifer Thompson, Tom C. Tsang, David T. Harris. (2005) Differential Gene Expression Profiling of CD34 + CD133 + Umbilical Cord Blood Hematopoietic Stem Progenitor Cells. Stem Cells and Development 14:2, 188-198
CrossRef172
M. Hermann, D. Pirkebner, A. Draxl, R. Margreiter, P. Hengster. (2005) In the Search of Potential Human Islet Stem Cells: Is Tetranectin Showing Us the Way?. Transplantation Proceedings 37:2, 1322-1325
CrossRef173
Joanna Laurson, Clare Selden, Humphrey J. F. Hodgson. (2005) Hepatocyte progenitors in man and in rodents - multiple pathways, multiple candidates. International Journal of Experimental Pathology 86:1, 1-18
CrossRef174
Harold Atkins, Mark Freedman. (2005) Immunoablative therapy as a treatment aggressive multiple sclerosis. Neurologic Clinics 23:1, 273-300
CrossRef175
Masamichi Kojiro. (2005) Histopathology of liver cancers. Best Practice & Research Clinical Gastroenterology 19:1, 39-62
CrossRef176
Daisuke Niino, Masahiro Nakashima, Hisayoshi Kondo, Masahiro Ito, Mutsumi Matsuu, Kazuko Shichijo, Toshiyuki Nakayama, Masao Tomonaga, Ichiro Sekine. (2005) Correlation of donor-derived keratinocytes and severity of graft-versus-host disease (GVHD) in epidermis. Pathology - Research and Practice 200:11-12, 775-781
CrossRef177
Magda Kucia, Janina Ratajczak, Mariusz Z. Ratajczak. (2005) Bone marrow as a source of circulating CXCR4+ tissue-committed stem cells. Biology of the Cell 97:2, 133
CrossRef178
M Körbling, S Robinson, Z Estrov, R Champlin, E Shpall. (2005) Umbilical cord blood-derived cells for tissue repair. Cytotherapy 7:3, 258-261
CrossRef179
Toshio Heike, Tatsutoshi Nakahata. (2005) Stem cell plasticity in hematopoietic system. Ensho Saisei 25:2, 90-101
CrossRef180
Mairi Brittan, Kristin M Braun, Louise E Reynolds, Francesco J Conti, Andrew R Reynolds, Richard Poulsom, Malcolm R Alison, Nicholas A Wright, Kairbaan M Hodivala-Dilke. (2005) Bone marrow cells engraft within the epidermis and proliferatein vivo with no evidence of cell fusion. The Journal of Pathology 205:1, 1-13
CrossRef181
Evangelia Yannaki, Evangelia Athanasiou, Angeliki Xagorari, Varnavas Constantinou, Ioannis Batsis, Panagiotis Kaloyannidis, Evangelia Proya, Achilles Anagnostopoulos, Athanasios Fassas. (2005) G-CSF–primed hematopoietic stem cells or G-CSF per se accelerate recovery and improve survival after liver injury, predominantly by promoting endogenous repair programs. Experimental Hematology 33:1, 108-119
CrossRef182
A Kessinger, B O'Kane Murphy, JD Jackson, JG Sharp. (2005) An ex vivo model of hematopoietic stem cell mobilization. Cytotherapy 7:6, 463-469
CrossRef183
Weimin Deng, Qin Han, Lianming Liao, Changhong Li, Wei Ge, Zhigang Zhao, Shengguo You, Hongye Deng, Ferid Murad, Robert C.H. Zhao. (2005) Engrafted Bone Marrow-Derived Flk-1 + Mesenchymal Stem Cells Regenerate Skin Tissue. Tissue Engineering 11:1-2, 110-119
CrossRef184
Uma Lakshmipathy, Catherine Verfaillie. (2005) Stem cell plasticity. Blood Reviews 19:1, 29-38
CrossRef185
Boon Chin Heng, Tong Cao, Hua Liu, Toan Thang Phan. (2005) Directing stem cells into the keratinocyte lineage in vitro. Experimental Dermatology 14:1, 1-16
CrossRef186
Isao Sakaida, Shuji Terai, Naoki Yamamoto, Koji Aoyama, Tsuyoshi Ishikawa, Hiroshi Nishina, Kiwamu Okita. (2004) Transplantation of bone marrow cells reduces CCl 4 -induced liver fibrosis in mice. Hepatology 40:6, 1304-1311
CrossRef187
Joel F. Habener. (2004) A perspective on pancreatic stem/progenitor cells. Pediatric Diabetes 5:s2, 29-37
CrossRef188
Timothy S. Sadiq, David A. Gerber. (2004) Stem cells in modern medicine: Reality or myth?. Journal of Surgical Research 122:2, 280-291
CrossRef189
Anne M Stevens, W Michael McDonnell, Meghan E Mullarkey, Jennifer M Pang, Wendy Leisenring, J Lee Nelson. (2004) Liver biopsies from human females contain male hepatocytes in the absence of transplantation. Laboratory Investigation 84:12, 1603-1609
CrossRef190
Ramazan Idilman, Esra Erden, Isnsu Kuzu, Sadik Ersoz, Zeki Karasu, Kaan Karayalcin, Gul Yuce, Yaman Tokat, Yasemin ??ahin, Ajlan Tukun, Ulus S. Akarca, Selim Karayalcin. (2004) Recipient-Derived Hepatocytes in Sex-Mismatched Liver Allografts after Liver Transplantation: Early versus Late Transplant Biopsies. Transplantation 78:11, 1647-1652
CrossRef191
Kuan-Der Lee, Tom Kwang-Chun Kuo, Jacqueline Whang-Peng, Yu-Fen Chung, Ching-Tai Lin, Shiu-Huey Chou, Jim-Ray Chen, Yi-Peng Chen, Oscar Kuang-Sheng Lee. (2004) In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 40:6, 1275-1284
CrossRef192
C E H Craig, A Quaglia, A P Dhillon. (2004) Extramedullary haematopoiesis in massive hepatic necrosis. Histopathology 45:5, 518-525
CrossRef193
Y. Yamaguchi, S. Yoshida, Y. Sumikawa, T. Kubo, K. Hosokawa, K. Ozawa, V.J. Hearing, K. Yoshikawa, S. Itami. (2004) Rapid healing of intractable diabetic foot ulcers with exposed bones following a novel therapy of exposing bone marrow cells and then grafting epidermal sheets. British Journal of Dermatology 151:5, 1019-1028
CrossRef194
Xiang Huiling, Mitsuhiro Inagaki, Jun Arikura, Atsuko Ozaki, Kazuhiko Onodera, Katsuhiro Ogawa, Shinichi Kasai. (2004) Hepatocytes derived from peripheral blood stem cells of granulocyte-colony stimulating factor treated F344 rats in analbuminemic rat livers1. Journal of Surgical Research 122:1, 75-82
CrossRef195
Alberto Grassi, Micaela Susca, Matteo Ravaioli, Gian Luca Grazi, Antonia D'Errico, Andrea Bontadini, Daniela Zauli, Antonio Pinna, Francesco B. Bianchi, Giorgio Ballardini. (2004) Detection of recipient's cells in liver graft using antibodies to mismatched HLA class I antigens. Liver Transplantation 10:11, 1406-1414
CrossRef196
M. Najimi, E. Sokal. (2004) Update on Liver Cell Transplantation. Journal of Pediatric Gastroenterology and Nutrition 39:4, 311-319
CrossRef197
Robert Sackstein. (2004) The Bone Marrow Is Akin to Skin: HCELL and the Biology of Hematopoietic Stem Cell Homing1. Journal of Investigative Dermatology Symposium Proceedings 9:3, 215-223
CrossRef198
Michael Mengel, Ulrich Lehmann, Danny Jonigk, Wolfram Kleeberger, Hans Kreipe. (2004) Role of stem cell trafficking and donor???recipient cellular chimerism in lung transplantation. Current Opinion in Organ Transplantation 9:3, 332-336
CrossRef199
C Di Campli, A.C Piscaglia, L Pierelli, S Rutella, G Bonanno, M.R Alison, A Mariotti, F.M Vecchio, M Nestola, G Monego, F Michetti, S Mancuso, P Pola, G Leone, G Gasbarrini, A Gasbarrini. (2004) A human umbilical cord stem cell rescue therapy in a murine model of toxic liver injury. Digestive and Liver Disease 36:9, 603-613
CrossRef200
Weimin Deng, Qin Han, Lianming Liao, Changhong Li, Wei Ge, Zhigang Zhao, Shengguo You, Hongye Deng, Robert C.H. Zhao. (2004) Allogeneic bone marrow–derived flk-1+Sca-1− mesenchymal stem cells leads to stable mixed chimerism and donor-specific tolerance. Experimental Hematology 32:9, 861-867
CrossRef201
Tania Roskams, David Cassiman, Rita De Vos, Louis Libbrecht. (2004) Neuroregulation of the neuroendocrine compartment of the liver. The Anatomical Record 280A:1, 910-923
CrossRef202
Joanna E. Grove, Emanuela Bruscia, Diane S. Krause. (2004) Plasticity of Bone Marrow-Derived Stem Cells. Stem Cells 22:4, 487-500
CrossRef203
Mehboob A Hussain, Neil D Theise. (2004) Stem-cell therapy for diabetes mellitus. The Lancet 364:9429, 203-205
CrossRef204
Jonas Mattsson, Monika Jansson, Annika Wernerson, Moustapha Hassan. (2004) Lung Epithelial Cells and Type II Pneumocytes of Donor Origin After Allogeneic Hematopoietic Stem Cell Transplantation. Transplantation 78:1, 154-157
CrossRef205
P.Ping Wang, Jian H Wang, Zhi P Yan, M.Y Hu, George K Lau, Sheung Tat Fan, John M Luk. (2004) Expression of hepatocyte-like phenotypes in bone marrow stromal cells after HGF induction. Biochemical and Biophysical Research Communications 320:3, 712-716
CrossRef206
Nelson Fausto. (2004) Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells. Hepatology 39:6, 1477-1487
CrossRef207
Te-Chao Fang, Malcolm R. Alison, Nicholas A. Wright, Richard Poulsom. (2004) Adult stem cell plasticity: will engineered tissues be rejected?. International Journal of Experimental Pathology 85:3, 115-124
CrossRef208
Markus Stoffel, Ludovic Vallier, Roger A Pedersen. (2004) Navigating the pathway from embryonic stem cells to beta cells. Seminars in Cell & Developmental Biology 15:3, 327-336
CrossRef209
Yoon-Young Jang, Michael I. Collector, Stephen B. Baylin, Anna Mae Diehl, Saul J. Sharkis. (2004) Hematopoietic stem cells convert into liver cells within days without fusion. Nature Cell Biology 6:6, 532-539
CrossRef210
Elisabeth H Javazon, Kirstin J Beggs, Alan W Flake. (2004) Mesenchymal stem cells: paradoxes of passaging. Experimental Hematology 32:5, 414-425
CrossRef211
Fernando D. Camargo, Milton Finegold, Margaret A. Goodell. (2004) Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. Journal of Clinical Investigation 113:9, 1266-1270
CrossRef212
Alexandros Spyridonidis, Annette Schmitt-Gräff, Tina Tomann, Anne Dwenger, Marie Follo, Dirk Behringer, Jürgen Finke. (2004) Epithelial Tissue Chimerism after Human Hematopoietic Cell Transplantation Is a Real Phenomenon. The American Journal of Pathology 164:4, 1147-1155
CrossRef213
Darrell N. Kotton, Ross Summer, Alan Fine. (2004) Lung stem cells: New paradigms. Experimental Hematology 32:4, 340-343
CrossRef214
Sanjeev Gupta, Mari Inada, Brigid Joseph, Vinay Kumaran, Daniel Benten. (2004) Emerging insights into liver-directed cell therapy for genetic and acquired disorders. Transplant Immunology 12:3-4, 289-302
CrossRef215
Carl Atkinson, Joanne Horsley, Susan Rhind-Tutt, Susan Charman, Colin J Phillpotts, John Wallwork, Martin J Goddard. (2004) Neointimal smooth muscle cells in human cardiac allograft coronary artery vasculopathy are of donor origin. The Journal of Heart and Lung Transplantation 23:4, 427-435
CrossRef216
Marc H. Dahlke, Felix C. Popp, Stephen Larsen, Hans J. Schlitt, John E.J. Rasko. (2004) Stem cell therapy of the liver? Fusion or fiction?. Liver Transplantation 10:4, 471-479
CrossRef217
Nathalie C. Lambert, Timothy D. Erickson, Zhen Yan, Jennifer M. Pang, Katherine A. Guthrie, Daniel E. Furst, J. Lee Nelson. (2004) Quantification of maternal microchimerism by HLA-specific real-time polymerase chain reaction: Studies of healthy women and women with scleroderma. Arthritis & Rheumatism 50:3, 906-914
CrossRef218
I. M. Ghobrial, T. J. Bunch, N. M. Caplice, W. D. Edwards, D. V. Miller, M. R. Litzow. (2004) Fatal Coronary Artery Disease After Unrelated Donor Bone Marrow Transplantation. Mayo Clinic Proceedings 79:3, 403-406
CrossRef219
M. Brittan, N. A. Wright. (2004) The gastrointestinal stem cell. Cell Proliferation 37:1, 35-53
CrossRef220
M. R. Alison, P. Vig, F. Russo, B. W. Bigger, E. Amofah, M. Themis, S. Forbes. (2004) Hepatic stem cells: from inside and outside the liver?. Cell Proliferation 37:1, 1-21
CrossRef221
F. D. Camargo, S. M. Chambers, M. A. Goodell. (2004) Stem cell plasticity: from transdifferentiation to macrophage fusion. Cell Proliferation 37:1, 55-65
CrossRef222
See-Ching Chan, Siu-Tim Cheung, Suet Yi Leung, Chi-Leung Liu, Sheung-Tat Fan, Chung-Mau Lo. (2004) De novo sarcoma of donor origin in a liver allograft determined by microsatellite analysis: A short report. Liver Transplantation 10:2, 320-323
CrossRef223
Finn Bowring. (2004) Therapeutic and reproductive cloning: a critique. Social Science & Medicine 58:2, 401-409
CrossRef224
Naoki Yamamoto, Shuji Terai, Shinya Ohata, Tomomi Watanabe, Kaoru Omori, Koh Shinoda, Koji Miyamoto, Toshiaki Katada, Isao Sakaida, Hiroshi Nishina, Kiwamu Okita. (2004) A subpopulation of bone marrow cells depleted by a novel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver. Biochemical and Biophysical Research Communications 313:4, 1110-1118
CrossRef225
Mikael Niku, Lotta Ilmonen, Tiina Pessa-Morikawa, Antti Iivanainen. (2004) Limited Contribution of Circulating Cells to the Development and Maintenance of Nonhematopoietic Bovine Tissues. Stem Cells 22:1, 12-20
CrossRef226
Toshio Heike, Tatsutoshi Nakahata. (2004) Stem Cell Plasticity in the Hematopoietic System. International Journal of Hematology 79:1, 7-14
CrossRef227
Kyung Sik Kim. (2004) Hepatic Stem Cell Transplantation in Liver Failure. Journal of the Korean Medical Association 47:10, 933
CrossRef228
Graça Almeida-Porada, Christopher Porada, Esmail D. Zanjani. (2004) Plasticity of Human Stem Cells in the Fetal Sheep Model of Human Stem Cell Transplantation. International Journal of Hematology 79:1, 1-6
CrossRef229
RG Edwards. (2004) Stem cells today: B1. Bone marrow stem cells. Reproductive BioMedicine Online 9:5, 541-583
CrossRef230
E. Martin-Rendon, S. M. Watt. (2003) Exploitation of stem cell plasticity. Transfusion Medicine 13:6, 325-349
CrossRef231
Baijun Fang, Mingxia Shi, Lianming Liao, Shaoguang Yang, Yuhao Liu, Robert Chunhua Zhao. (2003) Multiorgan Engraftment and Multilineage Differentiation by Human Fetal Bone Marrow Flk1+/CD31-/CD34- Progenitors. Journal of Hematotherapy <html_ent glyph="@amp;" ascii="&"/> Stem Cell Research 12:6, 603-613
CrossRef232
Erzsébet Szabó, Gabor Lotz, Csilla Páska, András Kiss, Zsuzsa Schaff. (2003) Viral hepatitis: New data on hepatitis C infection. Pathology & Oncology Research 9:4, 215-221
CrossRef233
E Horwitz. (2003) Stem cell plasticity: the growing potential of cellular therapy. Archives of Medical Research 34:6, 600-606
CrossRef234
Martin Raff. (2003) A
DULT STEM CELL PLASTICITY : Fact or Artifact?. Annual Review of Cell and Developmental Biology 19:1, 1-22
CrossRef235
J. Czyz, C. Wiese, A. Rolletschek, P. Blyszczuk, M. Cross, A. M. Wobus. (2003) Potential of Embryonic and Adult Stem Cells in vitro. Biological Chemistry 384:10-11, 1391-1409
CrossRef236
Martha Wadleigh, Vincent Ho, Parisa Momtaz, Paul Richardson. (2003) Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment. Current Opinion in Hematology 10:6, 451-462
CrossRef237
Neil D. Theise. (2003) Liver stem cells: The fall and rise of tissue biology. Hepatology 38:4, 804-806
CrossRef238
Irene Oi-Lin Ng, Kok-Lung Chan, Wai-Hung Shek, Joyce Man-Fong Lee, Daniel Yee-Tak Fong, Chung-Mau Lo, Sheung-Tat Fan. (2003) High frequency of chimerism in transplanted livers. Hepatology 38:4, 989-998
CrossRef239
Ken Kataoka, Reinhold J. Medina, Tomofumi Kageyama, Masahiro Miyazaki, Tadashi Yoshino, Teruhiko Makino, Nam-ho Huh. (2003) Participation of Adult Mouse Bone Marrow Cells in Reconstitution of Skin. The American Journal of Pathology 163:4, 1227-1231
CrossRef240
George Vassilopoulos, David W Russell. (2003) Cell fusion: an alternative to stem cell plasticity and its therapeutic implications. Current Opinion in Genetics & Development 13:5, 480-485
CrossRef241
N D Theise, J L Yao, K Harada, P Hytiroglou, B Portmann, S N Thung, W Tsui, H Ohta, Y Nakanuma. (2003) Hepatic 'stem cell' malignancies in adults: four cases. Histopathology 43:3, 263-271
CrossRef242
Enca Martin-Rendon, Suzanne M. Watt. (2003) Stem cell plasticity. British Journal of Haematology 122:6, 877-891
CrossRef243
Natalie C. Direkze, Stuart J. Forbes, Mairi Brittan, Toby Hunt, Rosemary Jeffery, Sean L. Preston, Richard Poulsom, Kairbaan Hodivala-Dilke, Malcolm R. Alison, Nicholas A. Wright. (2003) Multiple Organ Engraftment by Bone-Marrow-Derived Myofibroblasts and Fibroblasts in Bone-Marrow-Transplanted Mice. Stem Cells 21:5, 514-520
CrossRef244
C. Di Campli, G. Gasbarrini, A. Gasbarrini. (2003) Review article: a medicine based on cell transplantation - is there a future for treating liver diseases?. Alimentary Pharmacology and Therapeutics 18:5, 473-480
CrossRef245
Körbling, Martin, Estrov, Zeev, . (2003) Adult Stem Cells for Tissue Repair — A New Therapeutic Concept?. New England Journal of Medicine 349:6, 570-582
Full Text246
Iris Bittmann, Markus Hentrich, Karl Bise, Hans Jochem Kolb, Udo Lohrs. (2003) Endothelial Cells but Not Epithelial Cells or Cardiomyocytes Are Partially Replaced by Donor Cells after Allogeneic Bone Marrow and Stem Cell Transplantation. Journal of Hematotherapy <html_ent glyph="@amp;" ascii="&"/> Stem Cell Research 12:4, 359-366
CrossRef247
Te-Chao Fang, Richard Poulsom. (2003) Cell-based therapies for birth defects: A role for adult stem cell plasticity?. Birth Defects Research Part C: Embryo Today: Reviews 69:3, 238-249
CrossRef248
Christopher R. Cogle, Steven M. Guthrie, Ronald C. Sanders, William L. Allen, Edward W. Scott, Bryon E. Petersen. (2003) An Overview of Stem Cell Research and Regulatory Issues. Mayo Clinic Proceedings 78:8, 993-1003
CrossRef249
C. R. Cogle, S. M. Guthrie, R. C. Sanders, W. L. Allen, E. W. Scott, B. E. Petersen. (2003) An Overview of Stem Cell Research and Regulatory Issues. Mayo Clinic Proceedings 78:8, 993-1003
CrossRef250
Orit Kollet, Shoham Shivtiel, Yuan-Qing Chen, Jenny Suriawinata, Swan N. Thung, Mariana D. Dabeva, Joy Kahn, Asaf Spiegel, Ayelet Dar, Sarit Samira, Polina Goichberg, Alexander Kalinkovich, Fernando Arenzana-Seisdedos, Arnon Nagler, Izhar Hardan, Michel Revel, David A. Shafritz, Tsvee Lapidot. (2003) HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver. Journal of Clinical Investigation 112:2, 160-169
CrossRef251
Ryuichi Okamoto, Mamoru Watanabe. (2003) Prospects for regeneration of gastrointestinal epithelia using bone-marrow cells. Trends in Molecular Medicine 9:7, 286-290
CrossRef252
A.C Piscaglia, C Di Campli, G Gasbarrini, A Gasbarrini. (2003) Stem cells: new tools in gastroenterology and hepatology. Digestive and Liver Disease 35:7, 507-514
CrossRef253
Philip N Newsome, Ingolfur Johannessen, Shelagh Boyle, Evangelos Dalakas, Karen A Mcaulay, Kay Samuel, Frances Rae, Lesley Forrester, Marc L Turner, Peter C Hayes, David J Harrison, Wendy A Bickmore, John N Plevris. (2003) Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion. Gastroenterology 124:7, 1891-1900
CrossRef254
Neil D Theise. (2003) Liver stem cells: prospects for treatment of inherited and acquired liver diseases. Expert Opinion on Biological Therapy 3:3, 403-408
CrossRef255
Paolo A. Muraro, Riccardo Cassiani Ingoni, Roland Martin. (2003) Hematopoietic stem cell transplantation for multiple sclerosis: current status and future challenges. Current Opinion in Neurology 16:3, 299-305
CrossRef256
Margaret A. Goodell. (2003) Stem-cell “plasticity”: befuddled by the muddle. Current Opinion in Hematology 10:3, 208-213
CrossRef257
Andreea Ianus, George G. Holz, Neil D. Theise, Mehboob A. Hussain. (2003) In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. Journal of Clinical Investigation 111:6, 843-850
CrossRef258
Patrick Philip, Stephane Bermon. (2003) Intensive triathlon training induces low peripheral cd34+ stem cells. British Journal of Haematology 120:5, 914-915
CrossRef259
Jan Steffel, Marius Wernig, Ulrich Knauf, Santhosh Kumar, Otmar D. Wiestler, Anton Wernig, Oliver Brüstle. (2003) Migration and Differentiation of Myogenic Precursors Following Transplantation into the Developing Rat Brain. Stem Cells 21:2, 181-189
CrossRef260
Jiri Pomyje, Jan Zivny, Ludek Sefc, Magdalena Plasilova, Robert Pytlik, Emanuel Necas. (2003) Expression of genes regulating angiogenesis in human circulating hematopoietic cord blood CD34+/CD133+ cells. European Journal of Haematology 70:3, 143-150
CrossRef261
Edwin M. Horwitz. (2003) Stem cell plasticity: a new image of the bone marrow stem cell. Current Opinion in Pediatrics 15:1, 32-37
CrossRef262
Henning C. Fiegel, Michael V. Lioznov, Lourdes Cortes-Dericks, Claudia Lange, Dietrich Kluth, Boris Fehse, Axel R. Zander. (2003) Liver-Specific Gene Expression in Cultured Human Hematopoietic Stem Cells. Stem Cells 21:1, 98-104
CrossRef263
Nelson Fausto, Jean S. Campbell. (2003) The role of hepatocytes and oval cells in liver regeneration and repopulation. Mechanisms of Development 120:1, 117-130
CrossRef264
Timothy W. Austin, Eric Lagasse. (2003) Hepatic regeneration from hematopoietic stem cells. Mechanisms of Development 120:1, 131-135
CrossRef265
Masataka Sata. (2003) Molecular Strategies to Treat Vascular Diseases. Circulation Journal 67:12, 983-991
CrossRef266
Louis Libbrecht, Tania Roskams. (2002) Hepatic progenitor cells in human liver diseases. Seminars in Cell & Developmental Biology 13:6, 389-396
CrossRef267
Neil D Theise, Diane S Krause. (2002) Bone marrow to liver: the blood of Prometheus. Seminars in Cell & Developmental Biology 13:6, 411-417
CrossRef268
Sanjeev Gupta, Jayanta Roy Chowdhury. (2002) Therapeutic potential of hepatocyte transplantation. Seminars in Cell & Developmental Biology 13:6, 439-446
CrossRef269
Catherine M Verfaillie. (2002) Adult stem cells: assessing the case for pluripotency. Trends in Cell Biology 12:11, 502-508
CrossRef270
Mark A. LaBarge, Helen M. Blau. (2002) Biological Progression from Adult Bone Marrow to Mononucleate Muscle Stem Cell to Multinucleate Muscle Fiber in Response to Injury. Cell 111:4, 589-601
CrossRef271
Gitte S Jensen, Christian Drapeau. (2002) The use of in situ bone marrow stem cells for the treatment of various degenerative diseases. Medical Hypotheses 59:4, 422-428
CrossRef272
Sandeep Gupta, Catherine Verfaillie, David Chmielewski, Youngki Kim, Mark E. Rosenberg. (2002) A role for extrarenal cells in the regeneration following acute renal failure. Kidney International 62:4, 1285-1290
CrossRef273
Emanuela Gussoni, Richard R. Bennett, Kristina R. Muskiewicz, Todd Meyerrose, Jan A. Nolta, Irene Gilgoff, James Stein, Yiu-mo Chan, Hart G. Lidov, Carsten G. Bönnemann, Arpad von Moers, Glenn E. Morris, Johan T. den Dunnen, Jeffrey S. Chamberlain, Louis M. Kunkel, Kenneth Weinberg. (2002) Long-term persistence of donor nuclei in a Duchenne muscular dystrophy patient receiving bone marrow transplantation. Journal of Clinical Investigation 110:6, 807-814
CrossRef274
Marcos de Lima, Elizabeth J. Shpall. (2002) Cord blood transplantation. Current Opinion in Organ Transplantation 7:3, 286-293
CrossRef275
Wilson M.S. Tsui. (2002) Liver stem cells from an extrahepatic source. Advances in Anatomic Pathology 9:5, 324-325
CrossRef276
Abba C. Zubair, Leslie Silberstein, Jerome Ritz. (2002) Adult hematopoietic stem cell plasticity. Transfusion 42:8, 1096-1101
CrossRef277
Xin Wang, Eugenio Montini, Muhsen Al-Dhalimy, Eric Lagasse, Milton Finegold, Markus Grompe. (2002) Kinetics of Liver Repopulation after Bone Marrow Transplantation. The American Journal of Pathology 161:2, 565-574
CrossRef278
Peiman Hematti, Elaine M Sloand, Cristian A Carvallo, Michael R Albert, Carole L Yee, Monika M Fuehrer, Jan K Blancato, William G Kearns, John A Barrett, Richard W Childs, Jonathan C Vogel, Cynthia E Dunbar. (2002) Absence of donor-derived keratinocyte stem cells in skin tissues cultured from patients after mobilized peripheral blood hematopoietic stem cell transplantation. Experimental Hematology 30:8, 943-949
CrossRef279
(2002) Male Cells in Female Recipients of Hematopoietic-Cell Transplants. New England Journal of Medicine 347:3, 218-220
Full Text280
Richard Poulsom, Malcolm R. Alison, Stuart J. Forbes, Nicholas A. Wright. (2002) Adult stem cell plasticity. The Journal of Pathology 197:4, 441-456
CrossRef281
Mairi Brittan, Nicholas A. Wright. (2002) Gastrointestinal stem cells. The Journal of Pathology 197:4, 492-509
CrossRef282
Stuart Forbes, Pamela Vig, Richard Poulsom, Howard Thomas, Malcolm Alison. (2002) Hepatic stem cells. The Journal of Pathology 197:4, 510-518
CrossRef283
Abkowitz, Janis L., . (2002) Can Human Hematopoietic Stem Cells Become Skin, Gut, or Liver Cells?. New England Journal of Medicine 346:10, 770-772
Full Text
- Letters
