Original Article
Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery
N Engl J Med 2010; 363:1597-1607October 21, 2010DOI: 10.1056/NEJMoa1008232
- Abstract
Background
Many patients with severe aortic stenosis and coexisting conditions are not candidates for surgical replacement of the aortic valve. Recently, transcatheter aortic-valve implantation (TAVI) has been suggested as a less invasive treatment for high-risk patients with aortic stenosis.
Methods
We randomly assigned patients with severe aortic stenosis, whom surgeons considered not to be suitable candidates for surgery, to standard therapy (including balloon aortic valvuloplasty) or transfemoral transcatheter implantation of a balloon-expandable bovine pericardial valve. The primary end point was the rate of death from any cause.
Results
A total of 358 patients with aortic stenosis who were not considered to be suitable candidates for surgery underwent randomization at 21 centers (17 in the United States). At 1 year, the rate of death from any cause (Kaplan–Meier analysis) was 30.7% with TAVI, as compared with 50.7% with standard therapy (hazard ratio with TAVI, 0.55; 95% confidence interval [CI], 0.40 to 0.74; P<0.001). The rate of the composite end point of death from any cause or repeat hospitalization was 42.5% with TAVI as compared with 71.6% with standard therapy (hazard ratio, 0.46; 95% CI, 0.35 to 0.59; P<0.001). Among survivors at 1 year, the rate of cardiac symptoms (New York Heart Association class III or IV) was lower among patients who had undergone TAVI than among those who had received standard therapy (25.2% vs. 58.0%, P<0.001). At 30 days, TAVI, as compared with standard therapy, was associated with a higher incidence of major strokes (5.0% vs. 1.1%, P=0.06) and major vascular complications (16.2% vs. 1.1%, P<0.001). In the year after TAVI, there was no deterioration in the functioning of the bioprosthetic valve, as assessed by evidence of stenosis or regurgitation on an echocardiogram.
Conclusions
In patients with severe aortic stenosis who were not suitable candidates for surgery, TAVI, as compared with standard therapy, significantly reduced the rates of death from any cause, the composite end point of death from any cause or repeat hospitalization, and cardiac symptoms, despite the higher incidence of major strokes and major vascular events. (Funded by Edwards Lifesciences; ClinicalTrials.gov number, NCT00530894.)
Media in This Article
Video
Two Videos Showing Fluoroscopy and Animation of the TAVI Procedure.
Figure 1
Time-to-Event Curves for the Primary End Point and Other Selected End Points.Article Activity
- Article
Video
Two Videos Showing Fluoroscopy and Animation of the TAVI Procedure.
Aortic stenosis is an insidious disease with a long latency period1 followed by rapid progression after the appearance of symptoms,2-5 resulting in a high rate of death (approximately 50% in the first 2 years after symptoms appear) among untreated patients.1,6-8 Surgical replacement of the aortic valve reduces symptoms and improves survival in patients with aortic stenosis,9-11 and in the absence of serious coexisting conditions, the procedure is associated with low operative mortality.12,13 However, in clinical practice, at least 30% of patients with severe symptomatic aortic stenosis do not undergo surgery for replacement of the aortic valve, owing to advanced age, left ventricular dysfunction, or the presence of multiple coexisting conditions.14-17 For these patients, who are at high surgical risk,18,19 a less invasive treatment may be a worthwhile alternative.
Transcatheter aortic-valve implantation (TAVI) is a new procedure, in which a bioprosthetic valve is inserted through a catheter and implanted within the diseased native aortic valve. Since 2002, when the procedure was first performed,20,21 there has been rapid growth in its use throughout the world for the treatment of severe aortic stenosis in patients who are at high surgical risk.22-32 The most recent clinical studies showed that the rate of death from any cause at 1 year among patients treated with TAVI was approximately 25%.27-29,31 Thus far, all the studies of TAVI have been observational registry studies, without standardization of end-point definitions33,34 (and unpublished data) and without control populations. There is a paucity of rigorous, evidence-based clinical data to substantiate the incremental benefits of TAVI as compared with current standard therapies.
The Placement of Aortic Transcatheter Valves (PARTNER) trial was a multicenter, randomized clinical trial comparing TAVI with standard therapy in high-risk patients with severe aortic stenosis, including a prespecified cohort of patients who were not considered to be suitable candidates for surgery. In this article, we report the outcomes with TAVI as compared with standard therapy among the patients in the PARTNER trial who were not suitable candidates for surgery.
Methods
Patient Selection
We enrolled in the PARTNER trial patients with severe aortic stenosis and cardiac symptoms for whom conventional surgery to replace the aortic valve was associated with high risk. Severe aortic stenosis was defined as an aortic-valve area of less than 0.8 cm2, a mean aortic-valve gradient of 40 mm Hg or more, or a peak aortic-jet velocity of 4.0 m per second or more. All the patients had New York Heart Association (NYHA) class II, III, or IV symptoms. Patients were divided into two cohorts: those who were considered to be candidates for surgery despite the fact that they were at high surgical risk, as defined by a Society of Thoracic Surgeons (STS) risk score of 10% or higher35 (on a scale of 0% to 100%, with higher scores indicating greater surgical risk) or by the presence of coexisting conditions that would be associated with a predicted risk of death by 30 days after surgery of 15% or higher, and those who were not considered to be suitable candidates for surgery because they had coexisting conditions that would be associated with a predicted probability of 50% or more of either death by 30 days after surgery or a serious irreversible condition. At least two surgeon investigators had to agree that the patient was not a suitable candidate for surgery. In this article, we report the results for the patients with aortic stenosis who were not considered to be suitable candidates for surgery. The randomized trial involving patients at high surgical risk who were nevertheless considered to be candidates for surgery (also NCT00530894) is ongoing.
Pertinent exclusion criteria were a bicuspid or noncalcified aortic valve, acute myocardial infarction, substantial coronary artery disease requiring revascularization, a left ventricular ejection fraction of less than 20%, a diameter of the aortic annulus of less than 18 mm or more than 25 mm, severe (>3+) mitral or aortic regurgitation, a transient ischemic attack or stroke within the previous 6 months, and severe renal insufficiency. The complete list of inclusion and exclusion criteria is provided in Table 1 in the Supplementary Appendix, available with the full text of this article at NEJM.org.
After investigators screened the patients for eligibility, Web-based conference calls were conducted by the executive committee to further review and approve the selection of all patients before randomization. Of the 3105 patients with aortic stenosis who were screened by the investigators and the executive committee, approximately 12% ultimately underwent randomization as part of the PARTNER trial and were assigned to the cohort of patients who were not considered to be suitable candidates for surgery.
Study Device and Procedure
The Edwards SAPIEN heart-valve system (Edwards Lifesciences) consists of a trileaflet bovine pericardial valve and a balloon-expandable, stainless-steel support frame. The heart valve is shown in Figure 1 in the Supplementary Appendix. The TAVI procedure was performed in a sterile environment (catheterization laboratory or operating room), with the patient under general anesthesia; the procedure was performed with the use of transesophageal echocardiography. A standard balloon aortic valvuloplasty was performed, followed by transfemoral insertion of either a 22- or 24-French sheath, depending on the selected size of the valve (23 mm or 26 mm). The bioprosthetic heart valve, crimped onto a balloon catheter, was advanced across the native aortic valve. During rapid right ventricular pacing, balloon inflation of the crimped heart valve and support frame simultaneously deployed the bioprosthetic valve and expanded the frame, which was secured to the underlying aortic-valve annulus and leaflets (see videos 1 and 2, available at NEJM.org). Adjunctive pharmacologic therapy included heparin during the procedure and dual antiplatelet therapy (aspirin and clopidogrel) for 6 months after the procedure.
Study Design and Oversight
The PARTNER study incorporated two parallel prospective, multicenter, randomized, active-treatment–controlled clinical trials. The overall study design is shown in Figure 2 in the Supplementary Appendix. Patients were randomly assigned with the use of a computer-generated scheme, blocked separately at each participating site and for each of the trial cohorts. The PARTNER study was approved by the institutional review board at each participating site, and all patients provided written informed consent.
The trial was designed by the sponsor (Edwards Lifesciences) and members of the executive committee, which included the two academic coprincipal investigators, three interventional cardiologists, and three cardiac surgeons. The sponsor funded the studies and participated in the selection and management of the sites and the collection and monitoring of the data. The executive committee met in person every 6 to 8 weeks to monitor all aspects of the conduct of the trial. The coprincipal investigators and the executive committee had unrestricted access to the data after the database was locked, made the decision to submit the manuscript for publication, prepared all drafts of the manuscript, and attest to the integrity of the trial and the completeness and accuracy of the reported data, as well as to the fidelity of the report to the trial protocol. The protocol, including the statistical analysis plan, is available at NEJM.org.
Data Management
All serious adverse events were adjudicated by an independent clinical events committee. A data and safety monitoring board met frequently and had access to all study data and treatment assignments when requested; the board recommended after each meeting that the study be continued without modification. All data were sent for analysis to independent consulting biostatisticians. Independent core laboratories analyzed all echocardiograms and electrocardiograms. The members of the committees, the institutions, and the research organizations participating in the PARTNER trial are listed in Table 2 in the Supplementary Appendix.
Study End Points
The primary end point was the rate of death from any cause over the duration of the trial. All patients were followed for at least 1 year, and crossover from the standard-therapy group to the TAVI group was not permitted. The coprimary end point was the rate of a hierarchical composite of the time to death from any cause or the time to the first occurrence of repeat hospitalization (after the index procedure) due to valve-related or procedure-related clinical deterioration. This composite end point was also reported with the use of more conventional Kaplan–Meier nonhierarchical analytical methods. Prespecified secondary end points included the rate of death from cardiovascular causes, NYHA functional class, the rate of repeat hospitalization due to valve-related or procedure-related clinical deterioration, the distance covered during a 6-minute walk test,36 valve performance (assessed by echocardiography), and the rates of myocardial infarction, stroke, acute kidney injury, vascular complications, and bleeding. A major stroke was defined as a focal or global neurologic deficit associated with a score of 2 or higher on the modified Rankin scale, which has a range of 0 to 6, with 0 indicating no symptoms and 6 indicating death. Specific definitions of other important end points are provided in Table 3 in the Supplementary Appendix. All patients were followed during the index hospitalization; at 30 days, 6 months, and 1 year; and yearly thereafter.
Statistical Analysis
We estimated that with a sample of 350 patients, the study would have at least 85% power to show the superiority of TAVI over standard treatment with respect to the primary end point, assuming that 1-year mortality would be 37.5% in the standard-treatment group and 25% in the TAVI group. In calculating the size of the sample, we also assumed that deaths would follow a constant hazard distribution, that follow-up would continue for 12 months after the last patient was enrolled, and that the rate of loss to follow-up would be 10%.
The analysis of the coprimary end point — the hierarchical composite of death or repeat hospitalization — was performed with the use of a nonparametric method described by Finkelstein and Schoenfeld.37 With this method, multiple pairwise comparisons are performed for all patient pairs, first with respect to the time to death and then with respect to the time to repeat hospitalization, if necessary. On the basis of a simulation with the use of SAS software, we estimated that with a total sample of 350 patients, the power for this coprimary end point would be more than 95%. The Hochberg procedure was used to make multiple corrections of the primary and coprimary end points.
Categorical variables were compared with the use of Fisher's exact test. A generalized linear model was used to calculate risk ratios in the subgroup analysis and to test for interactions. Continuous variables, which are presented as means (±SD), were compared with the use of Student's t-test. All the analyses were performed with data from the intention-to-treat population, which included all patients who underwent randomization, regardless of the treatment actually received. Survival curves for time-to-event variables were constructed on the basis of all available follow-up data with the use of Kaplan–Meier estimates and were compared with the use of the log-rank test. A two-sided alpha level of 0.05 was used for all superiority testing. All statistical analyses were performed with the use of SAS software, version 9.2.
Results
Patients and Enrollment
Between May 11, 2007, and March 16, 2009, a total of 358 patients with severe aortic stenosis who were not suitable candidates for surgery were enrolled at 21 sites (17 in the United States) and were randomly assigned to TAVI (179 patients) or standard therapy (179 patients). All the patients were followed for at least 1 year (median follow-up period, 1.6 years; maximum, 2.8 years). The numbers of patients who underwent randomization and follow-up are shown in Figure 3 in the Supplementary Appendix.
The baseline characteristics of the patients in the two groups were generally well balanced (Table 1Table 1
Baseline Characteristics of the Patients and Echocardiographic Findings.). The overall patient population was at high risk (STS score, 11.6±6.0%). However, there were many patients with low STS scores but with coexisting conditions that contributed to the surgeons' determination that the patient was not a suitable candidate for surgery, including an extensively calcified (porcelain) aorta (15.1%), chest-wall deformity or deleterious effects of chest-wall irradiation (13.1%), oxygen-dependent respiratory insufficiency (23.5%), and frailty, as determined by the surgeons according to prespecified criteria (23.1%).Procedural Outcomes
Of the 179 patients assigned to TAVI, 6 (3.4%) did not receive a transcatheter heart valve (2 patients died before the scheduled implantation, transfemoral access was unsuccessful in 2 patients, and the intraprocedural annulus measurement was too large in 2 patients). After randomization, the median time to TAVI was 6 days (interquartile range, 3 to 11). During the TAVI procedure or in the first 24 hours after the procedure, 2 patients (1.1%) died, 3 (1.7%) had major strokes, 1 (0.6%) had a valve embolization, and 2 (1.1%) underwent multiple (≥2) valve implantations; no patient underwent urgent cardiac surgery to manage complications. In the first 30 days after the procedure, 11 of the 173 patients who underwent TAVI (6.4%) died.
Of the 179 patients assigned to standard therapy, balloon aortic valvuloplasty was performed in 114 patients (63.7%) during the 30 days after randomization and in an additional 36 patients (20.1%) more than 30 days after randomization. Despite the fact that all the patients in this cohort of the PARTNER study were determined not to be suitable candidates for surgery, 12 of the patients who were assigned to standard therapy (6.7%) underwent aortic-valve replacement, 5 (2.8%) underwent placement of a conduit from the left ventricular apex to the descending aorta plus aortic-valve replacement, and 4 (2.2%) underwent TAVI at a nonparticipating site outside the United States. The 1-year rates of death among patients in the standard-therapy group who underwent aortic-valve replacement, conduit plus aortic-valve replacement, or TAVI at a nonparticipating site outside the United States were 33%, 80%, and 0%, respectively.
Rates of Death, Repeat Hospitalization, and Stroke
At 30 days after randomization, the rate of death from any cause was 5.0% in the TAVI group as compared with 2.8% in the standard-therapy group (P=0.41) (Table 2Table 2
Clinical Outcomes at 30 Days and 1 Year.). At the 1-year follow-up, the rate of death from any cause (the primary end point), as calculated with the use of a Kaplan–Meier analysis, was 30.7% in the TAVI group, as compared with 50.7% in the standard-therapy group (hazard ratio, 0.55; 95% confidence interval [CI], 0.40 to 0.74; P<0.001) (Figure 1AFigure 1Time-to-Event Curves for the Primary End Point and Other Selected End Points.). The rate of death from cardiovascular causes at 1 year (Kaplan–Meier analysis) was also lower in the TAVI group than in the standard-therapy group (20.5% vs. 44.6%; hazard ratio, 0.39; 95% CI, 0.27 to 0.56; P<0.001) (Figure 1B). The specific cardiovascular and noncardiovascular causes of death are shown in Table 4 in the Supplementary Appendix.The superiority of TAVI with respect to the coprimary end point (the rate of the hierarchical composite of death from any cause or repeat hospitalization) was confirmed by the Finkelstein–Schoenfeld analysis (P<0.001). In addition, the rate of the nonhierarchical composite of death from any cause or repeat hospitalization at the 1-year follow-up (Kaplan–Meier analysis) was 42.5% with TAVI as compared with 71.6% with standard therapy (hazard ratio, 0.46; 95% CI, 0.35 to 0.59; P<0.001) (Figure 1C).
Major strokes were observed more frequently in the TAVI group than in the standard-therapy group at 30 days (5.0% vs. 1.1%, P=0.06) and at 1 year (7.8% vs. 3.9%, P=0.18). However, the rate of the composite of major stroke or death from any cause (Kaplan–Meier analysis) was still significantly lower in the TAVI group than in the standard-therapy group (33.0% vs. 51.3% at 1 year; hazard ratio, 0.58; 95% CI, 0.43 to 0.78; P<0.001) (Figure 1D). A more detailed analysis of the neurologic events is shown in Table 5 in the Supplementary Appendix.
Subgroup analyses with interaction testing were performed to determine whether the reduction in the primary end point (the rate of death from any cause) after TAVI was consistent across 10 important subgroups (Figure 2Figure 2
Subgroup Analyses of the Primary End Point of Death from Any Cause.). No significant interactions were observed.Other Clinical Outcomes
The frequencies of other important clinical events at 30 days and at 1 year are shown in Table 2. Major vascular complications and major bleeding events were more frequent in the TAVI group than in the standard-therapy group. At 30 days, 6 months, and 1 year, symptoms were significantly reduced in the TAVI group (P<0.001 for all three comparisons) (Figure 3Figure 3
Symptom Status over Time.). At 1 year, 74.8% of the surviving patients who had undergone TAVI, as compared with 42.0% of the surviving patients who had received standard therapy, were asymptomatic or had mild symptoms (NYHA class I or II) (P<0.001). The 6-minute walk test could be performed in only a subgroup of patients, owing to the presence of coexisting conditions in many of the patients. At 1 year, a paired analysis of the distance covered during a 6-minute walk test showed that there was significant improvement after TAVI (P=0.002) and no change after standard therapy (P=0.67).Echocardiographic Findings
Echocardiographic findings are shown in Table 6 in the Supplementary Appendix. Among patients who underwent TAVI, the mean aortic-valve area increased from 0.6±0.2 cm2 at baseline to 1.5±0.5 cm2 at 30 days (P<0.001), and the mean aortic-valve gradient decreased from 44.5±15.7 mm Hg to 11.1±6.9 mm Hg (P<0.001). At the 1-year follow-up assessment, the improvement in aortic-valve area and mean gradient was maintained.
Moderate or severe paravalvular aortic regurgitation was present in 11.8% of the patients in the TAVI group at 30 days and in 10.5% at 1 year. There were no substantial changes (i.e., changes of more than one grade) in paravalvular aortic regurgitation in the TAVI group during the 1-year follow-up period. The incidence of moderate or severe transvalvular aortic regurgitation was 1.3% at 30 days and 4.2% at 1 year among patients in the TAVI group, as compared with 16.9% and 15.2%, respectively, among patients in the standard-therapy group. Three patients in the TAVI group (1.7%) had to undergo an additional procedure (repeat TAVI) to treat clinically significant aortic regurgitation (paravalvular in two patients and transvalvular in one).
Discussion
The main results from the PARTNER trial in the cohort of patients with aortic stenosis who were not suitable candidates for surgery can be summarized as follows. First, standard medical therapy (including balloon aortic valvuloplasty, which was performed in 83.8% of the patients in the standard-therapy group) did not alter the natural history of severe aortic stenosis; at the end of 1 year, the rate of death from any cause was 50.7%, and the rate of death from cardiovascular causes was 44.6%. Second, transfemoral TAVI was superior to standard therapy, markedly reducing the rate of death from any cause (the primary end point), the rate of death from cardiovascular causes, and the rate of repeat hospitalization. In the first year, only five patients needed to be treated with TAVI to prevent one death, and only three patients needed to be treated to prevent either a death or repeat hospitalization. Third, the rate of death at 30 days among patients who underwent TAVI (5.0% in the intention-to-treat population, and 6.4% among patients who underwent TAVI) did not differ significantly from that among patients who received standard therapy in this cohort of patients who were not suitable candidates for surgery, despite the use of early-generation systems for TAVI and minimal operator experience with the TAVI procedure before the trial was initiated. Fourth, TAVI was also associated with a significant reduction in symptoms, as assessed with the use of the NYHA classification system and the results of a 6-minute walk test. Fifth, there were more neurologic events (including all strokes and major strokes), major vascular complications, and major bleeding events in the TAVI group than in the standard-therapy group. Sixth, echocardiographic findings after TAVI indicated that the hemodynamic performance of the bioprosthetic valve was excellent and that there was no evidence of deterioration in the first year. TAVI was accompanied by the frequent occurrence of paravalvular regurgitation, which was usually mild, remained stable during the 1-year follow-up period, and rarely required further treatment for worsening symptoms.
The early clinical outcomes (at ≤30 days) after transfemoral TAVI were similar to those seen in other recent studies of the same balloon-expandable bovine pericardial heart valve.28,29,31,32 Undoubtedly, the large femoral access sheaths that are required to insert this TAVI system contributed to the frequent occurrence of vascular complications and bleeding events. Ongoing studies are assessing the use of a lower-profile valve and support frame, which may reduce vascular complications, allow patients who have smaller iliofemoral arteries than did patients in this study to undergo this procedure, and facilitate percutaneous access and closure.
Strokes remain a troublesome adverse effect following TAVI; strokes occur more frequently among patients who undergo TAVI than among patients who receive standard therapy. Recently, diffusion-weighted magnetic resonance imaging studies have shown that there are new perfusion deficits in many patients after TAVI, presumably due to atherothrombotic emboli.38,39 The combination of smaller, less traumatic TAVI systems than the ones currently in use and novel cerebral protection devices is being evaluated in an effort to reduce the frequency of embolic neurologic events associated with TAVI. Additional randomized clinical trials are needed to compare the frequency of procedural strokes after TAVI with the frequency after surgical aortic-valve replacement.
Our study has several limitations. The protocol-mandated selection criteria excluded important patient subgroups, such as patients requiring treatment of coronary stenoses and patients with severe peripheral vascular disease. An assessment of the durability and the long-term clinical safety and effectiveness of the bioprosthetic valves will require more prolonged follow-up of patients who participated in the PARTNER trial and in other clinical trials of TAVI. Because TAVI was a relatively new procedure in the United States at the time the PARTNER trial was conducted, there was still a learning curve for most of the surgeons and interventional cardiologists who performed TAVI in the United States, and this relative inexperience was compounded by the use of an earlier-generation delivery system that was more likely to cause complications.
On the basis of a rate of death from any cause at 1 year that was 20 percentage points lower with TAVI than with standard therapy, balloon-expandable TAVI should be the new standard of care for patients with aortic stenosis who are not suitable candidates for surgery (like the patients enrolled in this study). These results cannot be extrapolated to other patients with aortic stenosis. Additional randomized trials are needed to compare TAVI with aortic-valve replacement among high-risk patients with aortic stenosis for whom surgery is a viable option and among low-risk patients with aortic stenosis.
Sponsored by Edwards Lifesciences.
Dr. Leon reports receiving consulting fees from Medtronic and owning stock options in Sadra Medical; Dr. Moses, receiving buyout of options in Heart Leaflet Technologies from Bracco; Dr. Wang, receiving grant support from Edwards Lifesciences; Dr. Mack, receiving lecture fees from Edwards Lifesciences and consulting fees from Medtronic; Dr. Miller, receiving consulting fees from Medtronic and St. Jude Medical; Dr. Webb, receiving grant support, consulting fees, and travel reimbursement from Edwards Lifesciences; Dr. Pocock, receiving grant support and consulting fees from Edwards Lifesciences; Dr. Makkar, receiving consulting fees, grant support, and lecture fees from Abbott, Medtronic, and Lilly, consulting fees and grant support from Johnson & Johnson and Daiichi Sankyo, and grant support from St. Jude Medical; Dr. Fontana, receiving consulting fees and lecture fees from Sorin Medical, consulting fees from and stock options in Entourage Medical Technologies, and consulting fees from St. Jude Medical; Dr. Block, receiving board membership fees from Medtronic and CoreValve, consulting fees from and stock options in Medtronic and Direct Flow Medical, and lecture fees from Edwards Lifesciences; Dr. Pichard, being employed as director of the Catheterization Laboratory at Washington Hospital Center and receiving lecture fees from St. Jude Medical; Dr. Bavaria, receiving grant support from Edwards Lifesciences; Ms. Akin, being employed by, owning stock options in, and receiving travel reimbursement from Edwards Lifesciences; Dr. Anderson, receiving consulting fees from and stock options in Edwards Lifesciences; and Dr. Douglas, receiving grant support from Edwards Lifesciences.
Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.
No other potential conflict of interest relevant to this article was reported.
This article (10.1056/NEJMoa1008232) was published on September 22, 2010, at NEJM.org.
Source Information
From Columbia University Medical Center/NewYork–Presbyterian Hospital, New York (M.B.L., C.R.S., J.W.M.); Medical City Dallas, Dallas (M.M., D.L.B.); Stanford University Medical School, Stanford (D.C.M.), and Edwards Lifesciences, Irvine (J.J.A., W.N.A.) — both in California; Cleveland Clinic Foundation, Cleveland (L.G.S., E.M.T.); University of British Columbia and St. Paul's Hospital, Vancouver, Canada (J.G.W.); Cedars–Sinai Medical Center, Los Angeles (G.P.F., R.R.M.); Emory University School of Medicine, Atlanta (P.C.B., R.A.G.); Washington Hospital Center, Washington, DC (A.D.P.); Hospital of the University of Pennsylvania, Philadelphia (J.E.B., H.C.H.); Duke University Medical Center, Durham, NC (P.S.D., J.L.P.); and London School of Hygiene and Tropical Medicine, London (D.W., S.P.).
Address reprint requests to Dr. Leon at Columbia University Medical Center/NewYork–Presbyterian Hospital, 173 Fort Washington Ave., Heart Center, 2nd Fl., New York, NY 10032, or at ml2398@columbia.edu.
The investigators, institutions, and research organizations participating in the Placement of Aortic Transcatheter Valves (PARTNER) trial are listed in the Supplementary Appendix, available at NEJM.org.
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- Citing Articles (760)
Citing Articles
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Alexander W. Leber, Markus Kasel, Thomas Ischinger, Ulrich H. Ebersberger, Diethmar Antoni, Martin Schmidt, Gotthard Riess, Vivian Renz, Armin Huber, Thomas Helmberger, Ellen Hoffmann. (2013) Aortic valve calcium score as a predictor for outcome after TAVI using the CoreValve revalving system. International Journal of Cardiology 166:3, 652-657
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Erin A. Bohula May, David Faxon. (2013) Transcatheter aortic valve replacement: History and current status. Trends in Cardiovascular Medicine 23:5, 172-178
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Mario Gössl, David R. Holmes. (2013) An Update on Transcatheter Aortic Valve Replacement. Current Problems in Cardiology 38:7, 245-283
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T. A. Fairbairn, D. M. Meads, C. Hulme, A. N. Mather, S. Plein, D. J. Blackman, J. P. Greenwood. (2013) The cost-effectiveness of transcatheter aortic valve implantation versus surgical aortic valve replacement in patients with severe aortic stenosis at high operative risk. Heart 99:13, 914-920
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Renato D. Lopes, Richard C. Becker, L. Kristin Newby, Eric D. Peterson, Elaine M. Hylek, Robert Giugliano, Christopher B. Granger, Kenneth W. Mahaffey, Antonio C. Carvalho, Otavio Berwanger, Roberto R. Giraldez, Gilson Soares Feitosa-Filho, Marcia M. Barbosa, Maria da Consolacao V. Moreira, Renato A. K. Kalil, Marildes Freitas, Joao Carlos Campos Guerra, Marcio Vinicius Lins Barros, Thiago da Rocha Rodrigues, Antonio C. Lopes, David A. Garcia. (2013) Highlights from the fifth international symposium of thrombosis and anticoagulation (ISTA V), october 18–19, 2012, Belo Horizonte, Minas Gerais, Brazil. Journal of Thrombosis and Thrombolysis 36:1, 115-130
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M. Wilbring, S.-M. Tugtekin, K. Alexiou, G. Simonis, K. Matschke, U. Kappert. (2013) Transapical transcatheter aortic valve implantation vs conventional aortic valve replacement in high-risk patients with previous cardiac surgery: a propensity-score analysis. European Journal of Cardio-Thoracic Surgery 44:1, 42-47
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Brett Doble, Gord Blackhouse, Ron Goeree, Feng Xie. (2013) Cost-effectiveness of the Edwards SAPIEN transcatheter heart valve compared with standard management and surgical aortic valve replacement in patients with severe symptomatic aortic stenosis: A Canadian perspective. The Journal of Thoracic and Cardiovascular Surgery 146:1, 52-60.e3
8
B. Borz, E. Durand, M. Godin, C. Tron, A. Canville, P.-Y. Litzler, J.-P. Bessou, A. Cribier, H. Eltchaninoff. (2013) Incidence, predictors and impact of bleeding after transcatheter aortic valve implantation using the balloon-expandable Edwards prosthesis. Heart 99:12, 860-865
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Holger Hetterich, Stefan Wirth, Thorsten R. Johnson, Fabian Bamberg. (2013) High-Pitch Dual Spiral Cardiovascular Computed Tomography. Current Cardiovascular Imaging Reports 6:3, 251-258
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Jian Ye, John G. Webb, Anson Cheung, Jia Lin Soon, David Wood, Christopher R. Thompson, Brad Munt, Robert Moss, Samuel V. Lichtenstein. (2013) Transapical transcatheter aortic valve-in-valve implantation: Clinical and hemodynamic outcomes beyond 2 years. The Journal of Thoracic and Cardiovascular Surgery 145:6, 1554-1562
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H. De Praetere, A. Ciarka, C. Dubois, P. Herijgers. (2013) Transapical transcatheter aortic valve implantation in a heart transplant recipient with severely depressed left ventricular function. Interactive CardioVascular and Thoracic Surgery 16:6, 906-908
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Lars G. Svensson, David H. Adams, Robert O. Bonow, Nicholas T. Kouchoukos, D. Craig Miller, Patrick T. O'Gara, David M. Shahian, Hartzell V. Schaff, Cary W. Akins, Joseph E. Bavaria, Eugene H. Blackstone, Tirone E. David, Nimesh D. Desai, Todd M. Dewey, Richard S. D'Agostino, Thomas G. Gleason, Katherine B. Harrington, Susheel Kodali, Samir Kapadia, Martin B. Leon, Brian Lima, Bruce W. Lytle, Michael J. Mack, Michael Reardon, T. Brett Reece, G. Russell Reiss, Eric E. Roselli, Craig R. Smith, Vinod H. Thourani, E. Murat Tuzcu, John Webb, Mathew R. Williams. (2013) Aortic Valve and Ascending Aorta Guidelines for Management and Quality Measures. The Annals of Thoracic Surgery 95:6, S1-S66
13
Sameer Khan, Michael M. Koerner, Walter Pae, Edward R. Stephenson, Howard Weber, Christoph Brehm, Aly El-Banayosy. (2013) Successful percutaneous transcatheter aortic valve replacement in multi-organ failure due to aortic bioprosthesis regurgitation in a patient with continuous-flow LVAD. The Journal of Heart and Lung Transplantation 32:6, 659-663
14
Lucy J. Boothroyd, Marco Spaziano, Jason R. Guertin, Laurie J. Lambert, Josep Rodés-Cabau, Nicolas Noiseux, Michel Nguyen, Éric Dumont, Michel Carrier, Benoit de Varennes, Reda Ibrahim, Giuseppe Martucci, Yongling Xiao, Jean E. Morin, Peter Bogaty. (2013) Transcatheter Aortic Valve Implantation: Recommendations for Practice Based on a Multidisciplinary Review Including Cost-Effectiveness and Ethical and Organizational Issues. Canadian Journal of Cardiology 29:6, 718-726
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Sharif A. Halim, Todd L. Kiefer, G. Chad Hughes, Lynne M. Hurwitz, J. Kevin Harrison. (2013) Transcatheter Aortic Valve Replacement: An Update. Current Cardiology Reports 15:6,
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Daniel Wendt, Susanne Pasa, Philipp Kahlert, Stéphane Delaloye, Fadi Al-Rashid, Vivien Price, Rolf-Alexander Jánosi, Nicolas Borenstein, Luc Behr, Thomas Konorza, Raimund Erbel, Heinz Jakob, Matthias Thielmann. (2013) A New self-expandable transcatheter aortic valve for transapical implantation: feasibility in acute and chronic animal experiments. Scandinavian Cardiovascular Journal 47:3, 145-153
17
Ulrich Gerckens, George Latsios, Luciano Pizzulli. (2013) Percutaneous treatment of a post-TAVI ventricular septal defect: A successful combined procedure for an unusual complication. Catheterization and Cardiovascular Interventions 81:7, E274-E277
18
Andrej Alfirevic, Anand R. Mehta, Lars G. Svensson. (2013) Transcatheter Aortic Valve Replacement. Anesthesiology Clinics 31:2, 355-381
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Chiara Fraccaro, Massimo Napodano, Giuseppe Tarantini. (2013) Conduction disorders in the setting of transcatheter aortic valve implantation: a clinical perspective. Catheterization and Cardiovascular Interventions 81:7, 1217-1223
20
C. Berry, S. M. Lloyd, Y. Wang, A. MacDonald, I. Ford. (2013) The changing course of aortic valve disease in Scotland: temporal trends in hospitalizations and mortality and prognostic importance of aortic stenosis. European Heart Journal 34:21, 1538-1547
21
Isaac Pascual, Pablo Avanzas, Antonio J. Muñoz-García, Diego López-Otero, Manuel F. Jimenez-Navarro, Belén Cid-Alvarez, Raquel del Valle, Juan H. Alonso-Briales, Raimundo Ocaranza-Sanchez, Fernando Alfonso, José M. Hernández, Ramiro Trillo-Nouche, César Morís. (2013) Percutaneous Implantation of the CoreValve® Self-expanding Valve Prosthesis in Patients With Severe Aortic Stenosis and Porcelain Aorta: Medium-term Follow-up. Revista Española de Cardiología (English Edition)
22
Joel A. Lardizabal, Brian P. O'Neill, Harit V. Desai, Conrad J. Macon, Alexis P. Rodriguez, Claudia A. Martinez, Carlos E. Alfonso, Martin S. Bilsker, Roger G. Carillo, Mauricio G. Cohen, Alan W. Heldman, William W. O'Neill, Donald B. Williams. (2013) The Transaortic Approach for Transcatheter Aortic Valve Replacement. Journal of the American College of Cardiology 61:23, 2341-2345
23
Isaac Pascual, Pablo Avanzas, Antonio J. Muñoz-García, Diego López-Otero, Manuel F. Jimenez-Navarro, Belén Cid-Alvarez, Raquel del Valle, Juan H. Alonso-Briales, Raimundo Ocaranza-Sanchez, Fernando Alfonso, José M. Hernández, Ramiro Trillo-Nouche, César Morís. (2013) Implante percutáneo de la válvula autoexpandible CoreValve® en pacientes con estenosis aórtica grave y aorta de porcelana: seguimiento a medio plazo. Revista Española de Cardiología
24
Hemang B. Panchal, Vatsal Ladia, Saurabh Desai, Tejaskumar Shah, Vijay Ramu. (2013) A Meta-Analysis of Mortality and Major Adverse Cardiovascular and Cerebrovascular Events Following Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement for Severe Aortic Stenosis. The American Journal of Cardiology
25
A. Ungar, P. Bramlage, M. Thoenes, S. Zannoni, J.-P. Michel. (2013) A call to action - Geriatricians’ experience in treatment of aortic stenosis and involvement in transcatheter aortic valve implantation. European Geriatric Medicine 4:3, 176-182
26
Romain Chopard, Nicolas Meneveau, Philoktimon Plastaras, Sebastien Janin, Marie-France Seronde, Fiona Ecarnot, Francois Schiele. (2013) Invasive Assessment of Doubtful Aortic Stenosis by Measuring Simultaneous Transaortic Gradient With a Pressure Wire. The American Journal of Cardiology 111:12, 1772-1777
27
Kentaro Meguro, Nicolas Lellouche, Masanori Yamamoto, Emilie Fougeres, Jean-Luc Monin, Pascal Lim, Gauthier Mouillet, Jean-Luc Dubois-Rande, Emmanuel Teiger. (2013) Prognostic Value of QRS Duration After Transcatheter Aortic Valve Implantation for Aortic Stenosis Using the CoreValve. The American Journal of Cardiology 111:12, 1778-1783
28
Henrik Fox, Stefan Büttner, Katrin Hemmann, Aida Asbe-Vollkopf, Mirko Doss, Andres Beiras-Fernandez, Anton Moritz, Andreas M. Zeiher, Ernst Scheuermann, Helmut Geiger, Stephan Fichtlscherer, Ingeborg A. Hauser, Ralf Lehmann. (2013) Transcatheter aortic valve implantation improves outcome compared to open-heart surgery in kidney transplant recipients requiring aortic valve replacement. Journal of Cardiology 61:6, 423-427
29
N. Perrin, M. Roffi, A. Frei, S. Noble. (2013) Combined complex PCI and TAVI procedure in a 94-year-old man: Two more 4000-meter summits to go. European Geriatric Medicine
30
Daniel B Spoon, Brandon J Tefft, Amir Lerman, Robert D Simari. (2013) Challenges of biological valve development. Interventional Cardiology 5:3, 319-334
31
Catherine Y Wong, Philip Green, Mathew Williams. (2013) Decision-making in transcatheter aortic valve replacement: the impact of frailty in older adults with aortic stenosis. Expert Review of Cardiovascular Therapy 11:6, 761-772
32
Kevin L. Greason, Rakesh M. Suri, Marianne Huebner, Guy S. Reeder, Eric E. Williamson, Vuyisile T. Nkomo, Charanjit S. Rihal, Verghese Mathew. (2013) Vascular Access Site Injury After Transfemoral Transcatheter Aortic Valve Insertion. Journal of Cardiac Surgeryn/a-n/a
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Suwako Fujita, Kenichi Sugioka, Yoshiki Matsumura, Asahiro Ito, Takeshi Hozumi, Takao Hasegawa, Akihisa Hanatani, Takahiko Naruko, Makiko Ueda, Minoru Yoshiyama. (2013) Impact of Concomitant Coronary Artery Disease on Atherosclerotic Plaques in the Aortic Arch in Patients With Severe Aortic Stenosis. Clinical Cardiology 36:6, 352-357
34
Bernard Iung. (2013) Rétrécissement aortique du sujet âgé : chirurgie ou TAVI. Les nouvelles recommandations européennes. La Presse Médicale 42:6, 986-994
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Ruben L.J. Osnabrugge, Alan M. Speir, Stuart J. Head, Clifford E. Fonner, Edwin Fonner, Gorav Ailawadi, A. Pieter Kappetein, Jeffrey B. Rich. (2013) Costs for Surgical Aortic Valve Replacement According to Preoperative Risk Categories. The Annals of Thoracic Surgery
36
Massimo Mancone, Mauro Pennacchi, Gennaro Sardella. (2013) Percutaneous coronary intervention in TAVI: The “proboscis” catheter. Catheterization and Cardiovascular Interventionsn/a-n/a
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Brian D. Hoit. (2013) Evaluating the Results of Transcatheter Versus Surgical Aortic Valve Replacement. Journal of the American College of Cardiology 61:25, 2522-2524
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Rebecca T. Hahn, Philippe Pibarot, William J. Stewart, Neil J. Weissman, Deepika Gopalakrishnan, Martin G. Keane, Saif Anwaruddin, Zuyue Wang, Martin Bilsker, Brian R. Lindman, Howard C. Herrmann, Susheel K. Kodali, Raj Makkar, Vinod H. Thourani, Lars G. Svensson, Jodi J. Akin, William N. Anderson, Martin B. Leon, Pamela S. Douglas. (2013) Comparison of Transcatheter and Surgical Aortic Valve Replacement in Severe Aortic Stenosis. Journal of the American College of Cardiology 61:25, 2514-2521
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Moritz Seiffert, Patrick Diemert, Dietmar Koschyk, Johannes Schirmer, Lenard Conradi, Renate Schnabel, Stefan Blankenberg, Hermann Reichenspurner, Stephan Baldus, Hendrik Treede. (2013) Transapical Implantation of a Second-Generation Transcatheter Heart Valve in Patients With Noncalcified Aortic Regurgitation. JACC: Cardiovascular Interventions 6:6, 590-597
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David A. Roy, Paul Bhamra-Ariza, Andrew Asherson, Raj Sharma, Marjan Jahangiri, Stephen Brecker. (2013) First-in-Man Use of Aortic Valve Ultrasound for Assessment of Aortic Valve Anatomy Pre- and Post-Transcatheter Aortic Valve Implantation. JACC: Cardiovascular Interventions 6:6, 634-635
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Hiroshi Furukawa, Kazuo Tanemoto. (2013) Current status and future perspectives of prosthetic valve selection for aortic valve replacement. General Thoracic and Cardiovascular Surgery
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N. M. Van Mieghem, P. W. Serruys. (2013) The art of risk stratification in TAVI. European Heart Journal
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M. Y. Emmert, B. Weber, L. Behr, S. Sammut, T. Frauenfelder, P. Wolint, J. Scherman, D. Bettex, J. Grunenfelder, V. Falk, S. P. Hoerstrup. (2013) Transcatheter aortic valve implantation using anatomically oriented, marrow stromal cell-based, stented, tissue-engineered heart valves: technical considerations and implications for translational cell-based heart valve concepts. European Journal of Cardio-Thoracic Surgery
44
Abhishek Sharma, Armin Arbab-Zadeh, Divyanshu Dubey, Jacob Shani, Jason Lazar, Robert Frankel. (2013) Access site bleeding after transcatheter aortic valve implantation. Journal of Thrombosis and Thrombolysis
45
Mattias Neyt, Hans Van Brabandt. (2013) TAVI: reveal the truth, the whole truth, and nothing but the truth. Journal of Medical Economics 16:5, 581-585
46
Itsik Ben-Dor, Augusto D. Pichard, Ron Waksman. (2013) Ischemic colitis after transcatheter aortic valve implantation. Catheterization and Cardiovascular Interventions 81:6, 1067-1071
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Peter Blom Jensen, Claus Andersen, Henrik Nissen. (2013) Transcatheter Aortic valve implantation in a patient with circulatory collapse, using the lucas® chest compression system. Catheterization and Cardiovascular Interventions 81:6, 1084-1086
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Manolis Vavuranakis, Konstantinos Kalogeras, Dimitrios Vrachatis, Maria Kariori, Vasilios Voudris, Konstantinos Aznaouridis, Carmen Moldovan, Sophia Vaina, Georgios Lazaros, Konstantina Masoura, Sophia Thomopoulou, Christodoulos Stefanadis. (2013) Inferior epigastric artery as a landmark for transfemoral TAVI. Optimizing vascular access?. Catheterization and Cardiovascular Interventions 81:6, 1061-1066
49
Pierre-Yves Etienne, Spiridon Papadatos, Patrick Mailleux, Denis Pieters, Elie El Khoury, David Glineur, Parla Astarci. (2013) Exclusive Percutaneous Approach for Surgical Transaortic Transcatheter Valve Replacement. The Annals of Thoracic Surgery 95:5, 1812-1814
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Pablo Codner, Abid Assali, Danny Dvir, Hana Vaknin-Assa, Eyal Porat, Yaron Shapira, Marina Kupershmidt, Tamir Bental, Alexander Battler, Alexander Sagie, Ran Kornowski. (2013) Two-Year Outcomes for Patients With Severe Symptomatic Aortic Stenosis Treated With Transcatheter Aortic Valve Implantation. The American Journal of Cardiology 111:9, 1330-1336
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Marco Luciano Rossi, Roberto Bocchi, Cristina Barbaro, Paolo Pagnotta, Marco Mennuni, Dennis Zavalloni, Gabriele Gasparini, Patrizia Presbitero. (2013) Successful Treatment by Transcatheter Aortic Valve Implantation of Severe Aortic Regurgitation in a Patient with Ascending Aorta Prosthesis. Heart, Lung and Circulation 22:5, 383-385
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Israel M. Barbash, Danny Dvir, Ron Waksman. (2013) Overview of the 2012 Food and Drug Administration Circulatory System Devices Panel of the Medical Devices Advisory Committee meeting on the Edwards SAPIEN transcatheter heart valve for high-risk aortic stenosis patients. American Heart Journal 165:5, 710-715
53
Nicolas Dumonteil, Robert M.A. van der Boon, Didier Tchetche, Alaide Chieffo, Nicolas M. Van Mieghem, Bertrand Marcheix, Gill L. Buchanan, Olivier Vahdat, Patrick W. Serruys, Jean Fajadet, Antonio Colombo, Peter P.T. de Jaegere, Didier Carrié. (2013) Impact of preoperative chronic kidney disease on short- and long-term outcomes after transcatheter aortic valve implantation: A Pooled-RotterdAm-Milano-Toulouse In Collaboration Plus (PRAGMATIC-Plus) initiative substudy. American Heart Journal 165:5, 752-760
54
Qingsheng Lu, Jiaxuan Feng, Jian Zhou, Zhiqing Zhao, Junmin Bao, Rui Feng, Liangxi Yuan, Xiang Feng, Lefeng Qu, Yifei Pei, Zhijun Mei, Zaiping Jing. (2013) Endovascular Repair of Ascending Aortic Dissection. Journal of the American College of Cardiology 61:18, 1917-1924
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Guy D. Lenders, Bernard P. Paelinck, Kristien Wouters, Marc J. Claeys, Inez E. Rodrigus, Paul L. Van Herck, Christiaan J. Vrints, Johan M. Bosmans. (2013) Transesophageal Echocardiography for Cardiac Thromboembolic Risk Assessment in Patients With Severe, Symptomatic Aortic Valve Stenosis Referred for Potential Transcatheter Aortic Valve Implantation. The American Journal of Cardiology 111:10, 1470-1474
56
Nazario Carrabba, Renato Valenti, Angela Migliorini, Ruben Vergara, Guido Parodi, David Antoniucci. (2013) Prognostic Value of Myocardial Injury Following Transcatheter Aortic Valve Implantation. The American Journal of Cardiology 111:10, 1475-1481
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Kelly M. W. McDonnell, Richard K. Shepard. (2013) Conduction Disorders after Transcatheter Aortic Valve Implantation: A Focused Review. Current Treatment Options in Cardiovascular Medicine
58
David Leibowitz, Jochanan Stessman, Jeremy M. Jacobs, Irit Stessman-Lande, Dan Gilon. (2013) Prevalence and Prognosis of Aortic Valve Disease in Subjects Older than 85 Years of Age. The American Journal of Cardiology
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Kevin L. Greason, John F. Bresnahan, Paul Sorajja, Rakesh M. Suri, Charanjit S. Rihal, Verghese Mathew. (2013) Transcatheter Aortic Valve Insertion Catastrophe in Inoperable Patients: Should Aortic Valve Replacement Be Denied?. Journal of Cardiac Surgeryn/a-n/a
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Oliver Husser, Andreas Holzamer, Markus Resch, Dierk H. Endemann, Julio Nunez, Vicente Bodi, Christof Schmid, Günter A.J. Riegger, Holger Gössmann, Okka Hamer, Christian Stroszczynski, Andreas Luchner, Michael Hilker, Christian Hengstenberg. (2013) Prosthesis sizing for transcatheter aortic valve implantation — Comparison of three dimensional transesophageal echocardiography with multislice computed tomography. International Journal of Cardiology
61
Henrique Barbosa Ribeiro, Luis Nombela-Franco, Marina Urena, Michael Mok, Sergio Pasian, Daniel Doyle, Robert DeLarochellière, Mélanie Côté, Louis Laflamme, Hugo DeLarochellière, Ricardo Allende, Eric Dumont, Josep Rodés-Cabau. (2013) Coronary Obstruction Following Transcatheter Aortic Valve Implantation. JACC: Cardiovascular Interventions 6:5, 452-461
62
Oliver Husser, Julio Núñez, Eduardo Núñez, Andreas Holzamer, Daniele Camboni, Andreas Luchner, Juan Sanchis, Vicente Bodi, Günter A.J. Riegger, Christof Schmid, Michael Hilker, Christian Hengstenberg. (2013) Tumor Marker Carbohydrate Antigen 125 Predicts Adverse Outcome After Transcatheter Aortic Valve Implantation. JACC: Cardiovascular Interventions 6:5, 487-496
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Darryl P. Leong, Majo X. Joseph, Ajay Sinhal, Joseph B. Selvanayagam. (2013) The Evolving Role of Cardiac Imaging in Percutaneous Valvular Intervention. Heart, Lung and Circulation
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Luca Testa, Guido Gelpi, Francesco Bedogni. (2013) Transcatheter aortic valve implantation in a patient with mechanical mitral prosthesis: A lesson learned from an intraventricular clash. Catheterization and Cardiovascular Interventionsn/a-n/a
65
Irene Franzoni, Azeem Latib, Francesco Maisano, Charis Costopoulos, Luca Testa, Filippo Figini, Francesco Giannini, Sandeep Basavarajaiah, Marco Mussardo, Massimo Slavich, Maurizio Taramasso, Micaela Cioni, Matteo Longoni, Santo Ferrarello, Andrea Radinovic, Simone Sala, Silvia Ajello, Alessandro Sticchi, Manuela Giglio, Eustachio Agricola, Alaide Chieffo, Matteo Montorfano, Ottavio Alfieri, Antonio Colombo. (2013) Comparison of Incidence and Predictors of Left Bundle Branch Block After Transcatheter Aortic Valve Implantation Using the CoreValve Versus the Edwards Valve. The American Journal of Cardiology
66
Philip Green, David J. Cohen, Philippe Généreux, Tom McAndrew, Suzanne V. Arnold, Maria Alu, Nirat Beohar, Charanjit S. Rihal, Michael J. Mack, Samir Kapadia, Danny Dvir, Mathew S. Maurer, Mathew R. Williams, Susheel Kodali, Martin B. Leon, Ajay J. Kirtane. (2013) Relation Between Six-Minute Walk Test Performance and Outcomes After Transcatheter Aortic Valve Implantation (from the PARTNER Trial). The American Journal of Cardiology
67
Danny Dvir, Israel M. Barbash, Itsik Ben-Dor, Rebecca Torguson, Salem Badr, Sa'ar Minha, Lakshmana K. Pendyala, Joshua P. Loh, Augusto D. Pichard, Ron Waksman. (2013) Paravalvular regurgitation after transcatheter aortic valve replacement: Diagnosis, clinical outcome, preventive and therapeutic strategies. Cardiovascular Revascularization Medicine 14:3, 174-181
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Jonathan D. Harrison, Craig H. Selzman, Heather F. Thiesset, Terry Box, William R. Hutson, Jeffrey K. Lu, Jeffrey Campsen, John B. Sorensen, Robin D. Kim. (2013) Minimally invasive aortic valve replacement with orthotopic liver transplantation: report of a case. Surgery Today
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L. A. Smith, M. J. Monaghan. (2013) Monitoring of procedures: peri-interventional echo assessment for transcatheter aortic valve implantation. European Heart Journal - Cardiovascular Imaging
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Ziad Sergie, Thierry Lefèvre, Eric Van Belle, Socrates Kakoulides, Usman Baber, Efthymios N. Deliargyris, Roxana Mehran, Eberhard Grube, Jochen Reinöhl, George D. Dangas. (2013) Current periprocedural anticoagulation in transcatheter aortic valve replacement: could bivalirudin be an option? Rationale and design of the BRAVO 2/3 studies. Journal of Thrombosis and Thrombolysis
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Michael G. Bateman, Alexander J. Hill, Jason L. Quill, Paul A. Iaizzo. (2013) The Clinical Anatomy and Pathology of the Human Arterial Valves: Implications for Repair or Replacement. Journal of Cardiovascular Translational Research 6:2, 166-175
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Lars G. Svensson, David H. Adams, Robert O. Bonow, Nicholas T. Kouchoukos, D. Craig Miller, Patrick T. O'Gara, David M. Shahian, Hartzell V. Schaff, Cary W. Akins, Joseph Bavaria, Eugene H. Blackstone, Tirone E. David, Nimesh D. Desai, Todd M. Dewey, Richard S. D'Agostino, Thomas G. Gleason, Katherine B. Harrington, Susheel Kodali, Samir Kapadia, Martin B. Leon, Brian Lima, Bruce W. Lytle, Michael J. Mack, T. Brett Reece, George R. Reiss, Eric Roselli, Craig R. Smith, Vinod H. Thourani, E. Murat Tuzcu, John Webb, Mathew R. Williams. (2013) Aortic Valve and Ascending Aorta Guidelines for Management and Quality Measures: Executive Summary. The Annals of Thoracic Surgery 95:4, 1491-1505
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Maximilian Scherner, Navid Madershahian, Justus T. Strauch, Jens Wippermann, Thorsten Wahlers. (2011) Transapical Valve Implantation and Resuscitation: Risk of Valve Destruction. The Annals of Thoracic Surgery 92:5, 1909-1910
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Holger Eggebrecht, Ulrich Schäfer, Hendrik Treede, Peter Boekstegers, Jörg Babin-Ebell, Markus Ferrari, Helge Möllmann, Helmut Baumgartner, Thierry Carrel, Philipp Kahlert, Philipp Lange, Thomas Walther, Raimund Erbel, Rajendra H. Mehta, Matthias Thielmann. (2011) Valve-in-Valve Transcatheter Aortic Valve Implantation for Degenerated Bioprosthetic Heart Valves. JACC: Cardiovascular Interventions 4:11, 1218-1227
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Damien Kenny, Ziyad M. Hijazi, Saibal Kar, John Rhodes, Michael Mullen, Raj Makkar, Girish Shirali, Mark Fogel, John Fahey, Mary G. Heitschmidt, Christopher Cain. (2011) Percutaneous Implantation of the Edwards SAPIEN Transcatheter Heart Valve for Conduit Failure in the Pulmonary Position. Journal of the American College of Cardiology 58:21, 2248-2256
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Francesco Bedogni, Maria Luisa Laudisa, Samuele Pizzocri, Corrado Tamburino, Gian Paolo Ussia, Anna Sonia Petronio, Massimo Napodano, Angelo Ramondo, Patrizia Presbitero, Federica Ettori, Gennaro Santoro, Silvio Klugman, Federico De Marco, Nedy Brambilla, Luca Testa. (2011) Transcatheter Valve-in-Valve Implantation Using CoreValve Revalving System for Failed Surgical Aortic Bioprostheses. JACC: Cardiovascular Interventions 4:11, 1228-1234
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Manuel Martínez Sellés. (2011) Estenosis aórtica en el anciano. FMC - Formación Médica Continuada en Atención Primaria 18:9, 536-541
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Matthias Hammerer, Jochen Schuler, Johann Altenberger, Johannes Kraus, Erika Prinz, Melinda Matzinger, Maximilian Pichler, Matthias Heigert. (2011) Rehospitalization rates after transcatheter aortic valve implantation. Wiener klinische Wochenschrift
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Christine S. Zuern, Christian Eick, Konstantinos Rizas, Cosmina Stoleriu, Barbara Woernle, Stephen Wildhirt, Christian Herdeg, Ulrich Stock, Meinrad Gawaz, Axel Bauer. (2011) Prognostic value of mild-to-moderate pulmonary hypertension in patients with severe aortic valve stenosis undergoing aortic valve replacement. Clinical Research in Cardiology
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H. Mudra, S. Sack, M. Haude, U. Gerckens, K.-H. Kuck, R. Hambrecht, H. Sievert, G. Richardt, V. Schächinger, C. Naber, U. Sechtem, R. Zahn, J. Brachmann. (2011) Strukturelle und organisatorische Voraussetzungen zur Durchführung des Transkatheter-Aortenklappenersatzes (TAVI). Der Kardiologe 5:5, 366-371
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Hans Henrik Møller Nielsen, Leif Thuesen, Henrik Egeblad, Steen Hvitfeldt Poulsen, Kaj-Erik Klaaborg, Carl-Johan Jakobsen, Henning Rud Andersen, Vibeke Elisabeth Hjortdal. (2011) Single center experience with transcatheter aortic valve implantation using the Edwards SAPIEN™ Valve. Scandinavian Cardiovascular Journal 45:5, 261-266
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(2011) The New Paradigm for the Management of Valvular Heart Disease: the Multi-Disciplinary Heart Team. Journal of the American Society of Echocardiography 24:10, A28
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See Hooi Ewe, Victoria Delgado, Arnold C.T. Ng, M. Louisa Antoni, Frank van der Kley, Nina Ajmone Marsan, Arend de Weger, Giuseppe Tavilla, Eduard R. Holman, Martin J. Schalij, Jeroen J. Bax. (2011) Outcomes After Transcatheter Aortic Valve Implantation: Transfemoral Versus Transapical Approach. The Annals of Thoracic Surgery 92:4, 1244-1251
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J C Kovacic, V Fuster. (2011) From Treating Complex Coronary Artery Disease to Promoting Cardiovascular Health: Therapeutic Transitions and Challenges, 2010–2020. Clinical Pharmacology & Therapeutics 90:4, 509-518
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Augusto D’Onofrio, Paolo Rubino, Melissa Fusari, Loris Salvador, Francesco Musumeci, Mauro Rinaldi, Ettore O. Vitali, Mattia Glauber, Roberto Di Bartolomeo, Ottavio R. Alfieri, Elvio Polesel, Marco Aiello, Riccardo Casabona, Ugolino Livi, Claudio Grossi, Mauro Cassese, Aniello Pappalardo, Tiziano Gherli, Guglielmo Stefanelli, Giuseppe G. Faggian, Gino Gerosa. (2011) Clinical and hemodynamic outcomes of “all-comers” undergoing transapical aortic valve implantation: Results from the Italian Registry of Trans-Apical Aortic Valve Implantation (I-TA). The Journal of Thoracic and Cardiovascular Surgery 142:4, 768-775
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Axel Unbehaun, Miralem Pasic, Thorsten Drews, Stephan Dreysse, Marian Kukucka, Roland Hetzer, Semih Buz. (2011) Analysis of Survival in 300 High-Risk Patients up to 2.5 Years After Transapical Aortic Valve Implantation. The Annals of Thoracic Surgery 92:4, 1315-1323
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Gabriele Crimi, Giancarlo Passerone, Paolo Rubartelli. (2011) Trans-apical aortic valve implantation complicated by left main occlusion. Catheterization and Cardiovascular Interventions 78:4, 656-659
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Peter J. Cawley, Catherine M. Otto. (2011) Valvular Heart Disease in the Elderly. Current Cardiovascular Risk Reports 5:5, 413-421
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Peter A. Knight, Jude S. Sauer, James W. Kaufer, Candice L. Wilshire. (2011) Automated Remote Transapical Wound Closure System Study. The Annals of Thoracic Surgery 92:4, 1494-1498
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Robert J. Siegel, Rajendra Makkar, Aik Doumanian, Swaminatha V. Gurudevan. (2011) Transcatheter Aortic Valve Implantation Three-Dimensional Echo Monitoring and Guidance. Current Cardiovascular Imaging Reports 4:5, 335-348
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Francesco Saia, Cinzia Marrozzini, Carolina Moretti, Cristina Ciuca, Nevio Taglieri, Barbara Bordoni, Gianni Dall’Ara, Laura Alessi, Valerio Lanzillotti, Maria Letizia Bacchi-Reggiani, Angelo Branzi, Antonio Marzocchi. (2011) The role of percutaneous balloon aortic valvuloplasty as a bridge for transcatheter aortic valve implantation. EuroIntervention 7:6, 723-729
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Jose M. de la Torre Hernandez, Gonzalo Martin Gorria, Jose A. Vazquez de Prada, Javier Zueco. (2011) Papillary muscle rupture. Catheterization and Cardiovascular Interventions 78:4, 647-649
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Marie-Annick Clavel, Josep Rodés-Cabau, Éric Dumont, Rodrigo Bagur, Sébastien Bergeron, Robert De Larochellière, Daniel Doyle, Éric Larose, Jean G. Dumesnil, Philippe Pibarot. (2011) Validation and Characterization of Transcatheter Aortic Valve Effective Orifice Area Measured by Doppler Echocardiography. JACC: Cardiovascular Imaging 4:10, 1053-1062
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P.-G. Guinot, J.-P. Depoix, L. Tini, A. Vahanian, J.-M. Desmonts, P. Montravers, D. Longrois. (2011) Implantation valvulaire aortique percutanée : prise en charge par l’anesthésiste-réanimateur. Annales Françaises d'Anesthésie et de Réanimation 30:10, 734-742
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J.-J. Lehot, C. Saroul, G. Rioufol, J.-F. Obadia. (2011) Interventions valvulaires minimalement invasives : c’était impossible… mais comme ils ne le savaient pas, ils l’ont fait. Annales Françaises d'Anesthésie et de Réanimation 30:10, 711-713
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Mariam Samim, Pieter R. Stella, Pierfrancesco Agostoni, Jolanda Kluin, Faiez Ramjankhan, Gertjan Sieswerda, Riccardo Budde, Marijke van der Linden, Morsal Samim, Marieke Hillaert, Lex van Herwerden, Pieter A.M. Doevendans, Eric van Belle. (2011) Transcatheter aortic implantation of the Edwards-SAPIEN bioprosthesis: Insights on early benefit of TAVI on mitral regurgitation. International Journal of Cardiology 152:1, 124-126
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(2011) Transcatheter Aortic-Valve Replacement. New England Journal of Medicine 365:10, 958-959
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Carl Schultz, Alexia Rossi, Nicolas van Mieghem, Robert van der Boon, Stella-Lida Papadopoulou, Ron van Domburg, Adriaan Moelker, Nico Mollet, Gabriel Krestin, Robert-Jan van Geuns, Koen Nieman, Pim de Feyter, Patrick Serruys, Peter de Jaegere. (2011) Aortic annulus dimensions and leaflet calcification from contrast MSCT predict the need for balloon post-dilatation after TAVI with the Medtronic CoreValve prosthesis. EuroIntervention 7:5, 564-572
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George J. Arnaoutakis, Timothy J. George, Diane E. Alejo, Christian A. Merlo, William A. Baumgartner, Duke E. Cameron, Ashish S. Shah. (2011) Society of Thoracic Surgeons Risk Score predicts hospital charges and resource use after aortic valve replacement. The Journal of Thoracic and Cardiovascular Surgery 142:3, 650-655
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Jose L. Zamorano, Luigi P. Badano, Charles Bruce, Kwan-Leung Chan, Alexandra Gonçalves, Rebecca T. Hahn, Martin G. Keane, Giovanni La Canna, Mark J. Monaghan, Petros Nihoyannopoulos, Frank E. Silvestry, Jean-Louis Vanoverschelde, Linda D. Gillam. (2011) EAE/ASE Recommendations for the Use of Echocardiography in New Transcatheter Interventions for Valvular Heart Disease. Journal of the American Society of Echocardiography 24:9, 937-965
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Sam Chitsaz, Nicolas Jaussaud, Edward Chau, Kimberly S. Yan, Ali N. Azadani, Mark B. Ratcliffe, Elaine E. Tseng. (2011) Operative Risks and Survival in Veterans With Severe Aortic Stenosis: Surgery Versus Medical Therapy. The Annals of Thoracic Surgery 92:3, 866-872
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Bertrand Marcheix, Etienne Grunenwald, Didier Carrie, Nicolas Dumonteil. (2011) Implantation of a Sapien XT aortic bioprosthesis with the NovaFlex catheter through a subclavian access. The Journal of Thoracic and Cardiovascular Surgery
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Edward J. McNulty, William Ng, John A. Spertus, Jonathan G. Zaroff, Robert W. Yeh, Xiushi M. Ren, Robert J. Lundstrom. (2011) Surgical Candidacy and Selection Biases in Nonemergent Left Main Stenting. JACC: Cardiovascular Interventions 4:9, 1020-1027
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Timothy J. George, George J. Arnaoutakis, Ashish S. Shah. (2011) Surgical Treatment of Advanced Heart Failure: Alternatives to Heart Transplantation and Mechanical Circulatory Assist Devices. Progress in Cardiovascular Diseases 54:2, 115-131
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Gustavo Pires de Morais, Nuno Bettencourt, Guida Silva, Nuno Ferreira, Olga Sousa, Daniel Caeiro, João Rocha, Mónica Carvalho, Daniel Leite, Pedro Braga, Conceição Fonseca, Vasco Gama. (2011) Tomografia computorizada multicorte na avaliação de candidatos a implantação de prótese aórtica percutânea. Revista Portuguesa de Cardiologia 30:9, 717-726
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Gill Louise Buchanan, Alaide Chieffo, Matteo Montorfano, Francesco Maisano, Azeem Latib, Cosmo Godino, Micaela Cioni, Maria Angela Gullace, Annalisa Franco, Chiara Gerli, Ottavio Alfieri, Antonio Colombo. (2011) The role of sex on VARC outcomes following transcatheter aortic valve implantation with both Edwards SAPIEN™ and Medtronic CoreValve ReValving System® devices: the Milan registry. EuroIntervention 7:5, 556-563
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Gian Ussia, Marco Barbanti, Valeria Cammalleri, Marilena Scarabelli, Massimiliano Mulè, Patrizia Aruta, Anna Maria Pistritto, Sebastiano Immè, Davide Capodanno, Kunal Sarkar, Simona Gulino, Corrado Tamburino. (2011) Quality-of-life in elderly patients one year after transcatheter aortic valve implantation for severe aortic stenosis. EuroIntervention 7:5, 573-579
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Felix Woitek, Gerhard C. Schuler. (2011) Coronary artery disease and aortic stenosis: small steps to cross the border to full interventional treatment in selected high-risk patients. EuroIntervention 7:5, 533-535
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Paul Schoenhagen, Samir R. Kapadia, Sandra S. Halliburton, Lars G. Svensson, E. Murat Tuzcu. (2011) Computed tomography evaluation for transcatheter aortic valve implantation (TAVI): Imaging of the aortic root and iliac arteries. Journal of Cardiovascular Computed Tomography 5:5, 293-300
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Shahbudin H. Rahimtoola. (2011) The Year in Valvular Heart Disease. Journal of the American College of Cardiology 58:12, 1197-1207
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J. L. Zamorano, L. P. Badano, C. Bruce, K.-L. Chan, A. Goncalves, R. T. Hahn, M. G. Keane, G. La Canna, M. J. Monaghan, P. Nihoyannopoulos, F. E. Silvestry, J.-L. Vanoverschelde, L. D. Gillam, , A. Vahanian, V. Di Bello, T. Buck, . (2011) EAE/ASE recommendations for the use of echocardiography in new transcatheter interventions for valvular heart disease. European Heart Journal 32:17, 2189-2214
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Mathieu Gautier, Marion Pepin, Dominique Himbert, Gregory Ducrocq, Bernard Iung, Marie-Pierre Dilly, David Attias, Patrick Nataf, Alec Vahanian. (2011) Impact of coronary artery disease on indications for transcatheter aortic valve implantation and on procedural outcomes. EuroIntervention 7:5, 549-555
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(2011) CardioPulse Articles * EHJ's new deputy editor Gerhard Hindricks * NEW EAE/ASE recommendations for the use of echocardiography in new transcatheter interventions for valvular heart disease * The PARTNER trial after 1 year * Book review * Stress Echocardiography: Essential Guide and DVD * King's College London, a cardiac centre of excellence * Will it only be possible to deliver the best cardiovascular medicine in 'capital cities' in the future? * Russian Cardiology Journal celebrates its 15th anniversary this year * The Estonian Society of Cardiology * The London Marathon debate. European Heart Journal 32:17, 2087-2095
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Sea Hing Ong, Harald Beucher, Ralf Mueller, Ulrich Gerckens, Peter Boekstegers. (2011) Percutaneous Double-Valve Interventions for Aortic Stenosis and Pure Mitral Regurgitation. The American Journal of Cardiology 108:6, 893-895
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Nikolaos Tsirikos Karapanos, Scott H. Suddendorf, Zhuo Li, Marianne Huebner, Soon J. Park, Lyle D. Joyce, Richard C. Daly. (2011) The Off-Pump Implantation of an Apicoaortic Valved Graft Is Safe and Has No Negative Impact on Coronary Flow and Hemodynamics. Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 6:5, 298-304
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R. Roudaut, M. Dijos, F. Arsac, P. Réant, S. Lafitte. (2011) Pathologie valvulaire : 50 ans de progrès !. Archives des Maladies du Coeur et des Vaisseaux - Pratique 2011:200, 21-23
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Bas T.G. van der Lienden, Ben M. Swinkels, Robin H. Heijmen, E. Gijs Mast, Thom L. De Kroon, Jurriën M. ten Berg. (2011) First Valve-in-Valve Direct Transaortic CoreValve Implantation in an Insufficient Sapien Valve. JACC: Cardiovascular Interventions 4:9, 1049-1050
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Peter Wenaweser, Thomas Pilgrim, Enio Guerios, Stefan Stortecky, Christoph Huber, Ahmed A. Khattab, Alexander Kadner, Lutz Buellesfeld, Steffen Gloekler, Bernhard Meier, Thierry Carrel, Stephan Windecker. (2011) Impact of coronary artery disease and percutaneous coronary intervention on outcomes in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation. EuroIntervention 7:5, 541-548
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Usman Baber, Annapoorna S. Kini, Pedro R. Moreno, Samin K. Sharma. (2011) Calcific Aortic Stenosis: Pathology and Role of Balloon Aortic Valvuloplasty. Interventional Cardiology Clinics
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Rodrigo Bagur, Josep Rodés-Cabau. (2011) Appropriate Assessment of Operative Risk in Patients With Severe Symptomatic Aortic Stenosis: Importance for Patient Selection in the Era of Transcatheter Aortic Valve Implantation. The Annals of Thoracic Surgery 92:3, 1157-1158
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Gustavo Pires de Morais, Nuno Bettencourt, Guida Silva, Nuno Ferreira, Olga Sousa, Daniel Caeiro, João Rocha, Mónica Carvalho, Daniel Leite, Pedro Braga, Conceição Fonseca, Vasco Gama. (2011) Multislice computed tomography in the selection of candidates for transcatheter aortic valve implantation. Revista Portuguesa de Cardiologia (English Edition) 30:9, 717-726
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David Liff, Vasilis Babaliaros, Peter Block. (2011) Transcatheter aortic valve replacement: the changing paradigm of aortic stenosis treatment. Expert Review of Cardiovascular Therapy 9:9, 1127-1135
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K Wenger Nanette. (2011) Science and the practice of cardiovascular medicine in the geriatric population. Journal of Geriatric Cardiology 8:2, 67-71
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R.-J. Nuis, N. M. Van Mieghem, C. J. Schultz, A. Tzikas, R. M. Van der Boon, A.-M. Maugenest, J. Cheng, N. Piazza, R. T. van Domburg, P. W. Serruys, P. P. de Jaegere. (2011) Timing and potential mechanisms of new conduction abnormalities during the implantation of the Medtronic CoreValve System in patients with aortic stenosis. European Heart Journal 32:16, 2067-2074
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Jennifer Higgins, Jian Ye, Karin H. Humphries, Anson Cheung, David A. Wood, John G. Webb, Samuel V. Lichtenstein. (2011) Early clinical outcomes after transapical aortic valve implantation: A propensity-matched comparison with conventional aortic valve replacement. The Journal of Thoracic and Cardiovascular Surgery 142:2, e47-e52
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Pierre-Yves Etienne, Spiridon Papadatos, Elie El Khoury, Denis Pieters, Joel Price, David Glineur. (2011) Transaortic Transcatheter Aortic Valve Implantation With the Edwards Sapien Valve: Feasibility, Technical Considerations, and Clinical Advantages. The Annals of Thoracic Surgery 92:2, 746-748
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Kentaro Hayashida, Thierry Lefèvre, Bernard Chevalier, Thomas Hovasse, Mauro Romano, Philippe Garot, Darren Mylotte, Jhonathan Uribe, Arnaud Farge, Patrick Donzeau-Gouge, Erik Bouvier, Bertrand Cormier, Marie-Claude Morice. (2011) Transfemoral Aortic Valve Implantation. JACC: Cardiovascular Interventions 4:8, 851-858
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Dimitri Kalavrouziotis, Josep Rodés-Cabau, Rodrigo Bagur, Daniel Doyle, Robert De Larochellière, Philippe Pibarot, Eric Dumont. (2011) Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis and Small Aortic Annulus. Journal of the American College of Cardiology 58:10, 1016-1024
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Michael Gotzmann, Andreas Mügge. (2011) Fatal prosthetic valve endocarditis of the CoreValve ReValving System. Clinical Research in Cardiology 100:8, 715-717
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Remo D. Covello, Giovanni Landoni, Alberto Zangrillo. (2011) Anesthetic management of transcatheter aortic valve implantation. Current Opinion in Anaesthesiology 24:4, 417-425
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Mélanie Paysant, Jean-François Obadia, Gilles Aulagner, Xavier Armoiry. (2011) Nouveauté dans le remplacement valvulaire aortique : les valves cardiaques à déploiement rapide sans suture. Actualités Pharmaceutiques Hospitalières 7:27, 31-32
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Jia Lin Soon, Jian Ye, Samuel V. Lichtenstein, David Wood, John G. Webb, Anson Cheung. (2011) Transapical Transcatheter Aortic Valve Implantation in the Presence of a Mitral Prosthesis. Journal of the American College of Cardiology 58:7, 715-721
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Damien Kenny, Ziyad M. Hijazi, Kevin P. Walsh. (2011) Transcatheter tricuspid valve replacement With the Edwards SAPIEN valve. Catheterization and Cardiovascular Interventions 78:2, 267-270
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J. L. Zamorano, L. P. Badano, C. Bruce, K.-L. Chan, A. Goncalves, R. T. Hahn, M. G. Keane, G. La Canna, M. J. Monaghan, P. Nihoyannopoulos, F. E. Silvestry, J.-L. Vanoverschelde, L. D. Gillam, , A. Vahanian, V. Di Bello, T. Buck, . (2011) EAE/ASE recommendations for the use of echocardiography in new transcatheter interventions for valvular heart disease. European Journal of Echocardiography 12:8, 557-584
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Ali N. Azadani, Nicolas Jaussaud, Liang Ge, Sam Chitsaz, Timothy A.M. Chuter, Elaine E. Tseng. (2011) Valve-in-Valve Hemodynamics of 20-mm Transcatheter Aortic Valves in Small Bioprostheses. The Annals of Thoracic Surgery 92:2, 548-555
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Jack C.J. Sun, Ravi K. Ghanta, Michael J. Davidson. (2011) Highlights from the Transcatheter Cardiovascular Therapeutics Conference 2010: Washington, DC, September 21–25, 2010. The Journal of Thoracic and Cardiovascular Surgery 142:2, 468-471
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Subhashni D. Singh Joy. (2011) New Procedure for Aortic Stenosis Patients Who Can't Have Surgery. AJN, American Journal of Nursing 111:8, 56-57
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Charles F. Jackson, Nanette K. Wenger. (2011) Enfermedad cardiovascular en el anciano. Revista Española de Cardiología 64:8, 697-712
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Nuria Miranda, Omar A. Araji, María A. Gutiérrez-Martín, Emiliano A. Rodríguez-Caulo, José M. Barquero, Luis F. Valenzuela. (2011) Spontaneous Closure of Pseudoaneurysm After Transapical Aortic Valve Implantation. The Annals of Thoracic Surgery 92:2, 729-731
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Charles F. Jackson, Nanette K. Wenger. (2011) Cardiovascular Disease in the Elderly. Revista Española de Cardiología (English Edition) 64:8, 697-712
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Philippe Genereux, Susheel Kodali, Martin B. Leon, Craig R. Smith, Yanai Ben-Gal, Ajay J. Kirtane, Benoit Daneault, George R. Reiss, Jeffrey W. Moses, Mathew R. Williams. (2011) Clinical Outcomes Using a New Crossover Balloon Occlusion Technique for Percutaneous Closure After Transfemoral Aortic Valve Implantation. JACC: Cardiovascular Interventions 4:8, 861-867
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L. M. Forsberg, E. Tamas, F. Vanky, N. E. Nielsen, J. Engvall, E. Nylander. (2011) Left and right ventricular function in aortic stenosis patients 8 weeks post-transcatheter aortic valve implantation or surgical aortic valve replacement. European Journal of Echocardiography 12:8, 603-611
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Michael Gotzmann, Azem Pljakic, Waldemar Bojara, Michael Lindstaedt, Aydan Ewers, Alfried Germing, Andreas Mügge. (2011) Transcatheter aortic valve implantation in patients with severe symptomatic aortic valve stenosis—predictors of mortality and poor treatment response. American Heart Journal 162:2, 238-245.e1
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Tamim M Nazif, Ajay J Kirtane, Martin B Leon, Susheel K Kodali. (2011) A new standard of care for inoperable, severe aortic stenosis: implications of the PARTNER trial. Interventional Cardiology 3:4, 441-449
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Eberhard Grube, Christoph Naber, Alexandre Abizaid, Eduardo Sousa, Oscar Mendiz, Pedro Lemos, Roberto Kalil Filho, Jose Mangione, Lutz Buellesfeld. (2011) Feasibility of Transcatheter Aortic Valve Implantation Without Balloon Pre-Dilation. JACC: Cardiovascular Interventions 4:7, 751-757
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L. Henry Edmunds. (2011) The Fork in the Road. The Annals of Thoracic Surgery 92:1, 1-2
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Marco Mussardo, Azeem Latib, Alaide Chieffo, Cosmo Godino, Alfonso Ielasi, Micaela Cioni, Kensuke Takagi, Giedrius Davidavicius, Matteo Montorfano, Francesco Maisano, Mauro Carlino, Annalisa Franco, Remo D. Covello, Pietro Spagnolo, Antonio Grimaldi, Ottavio Alfieri, Antonio Colombo. (2011) Periprocedural and Short-Term Outcomes of Transfemoral Transcatheter Aortic Valve Implantation With the Sapien XT as Compared With the Edwards Sapien Valve. JACC: Cardiovascular Interventions 4:7, 743-750
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Arnaud Van Linden, Jörg Kempfert, Johannes Blumenstein, David Holzhey, Ardawan J. Rastan, Friedrich W. Mohr, Thomas Walther. (2011) Transapical Aortic Valve Implantation Off-Pump in Patients With Impaired Left Ventricular Function. The Annals of Thoracic Surgery 92:1, 18-23
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John W. Moore. (2011) Transcatheter Valve Technology. Journal of the American College of Cardiology 58:2, 123-124
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H.- J. Priebe. (2011) Preoperative cardiac management of the patient for non-cardiac surgery: an individualized and evidence-based approach. British Journal of Anaesthesia 107:1, 83-96
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Thomas Hovasse, Thierry Lefèvre, Marie-claude Morice, Bernard Chevalier, Kentaro Hayashida, Philippe Garot, Mauro Romano, Patrick Donzeau-Gouge, Arnaud Farge, Erik Bouvier, Bertrand Cormier. (2011) Valves aortiques percutanées : résultats actuels et perspectives. La Presse Médicale 40:7-8, 732-739
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David R. Holmes, Michael J. Mack. (2011) Transcatheter Valve Therapy: A Professional Society Overview from the American College of Cardiology Foundation and The Society of Thoracic Surgeons. The Annals of Thoracic Surgery 92:1, 380-389
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David R. Holmes, Michael J. Mack. (2011) Transcatheter Valve Therapy. Journal of the American College of Cardiology 58:4, 445-455
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John B. Garner, Paul A. Grayburn, Clyde W. Yancy. (2011) Best Clinical Trials Reported in 2010. The American Journal of Cardiology 108:1, 162-168
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